GR3024745T3 - Pharmaceutical formulations - Google Patents

Pharmaceutical formulations

Info

Publication number: GR3024745T3
Authority: GR; Greece
Prior art keywords: biologically active; pharmaceutical formulations; lecithins; bioavailable; calcitonin
Prior art date: 1990-03-29

Application number

GR970402390T

Other languages

English (en)

Inventor

Young W Cho

Michael John Flynn

Thomas Smith Shepherd

Original Assignee

Skua Investments Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-29

Filing date

1997-09-17

Publication date

1997-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10673486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3024745(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-09-17 Application filed by Skua Investments Ltd filed Critical Skua Investments Ltd

1997-12-31 Publication of GR3024745T3 publication Critical patent/GR3024745T3/el

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000055006 Calcitonin Human genes 0.000 abstract 1
108060001064 Calcitonin Proteins 0.000 abstract 1
102000003951 Erythropoietin Human genes 0.000 abstract 1
108090000394 Erythropoietin Proteins 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
239000011149 active material Substances 0.000 abstract 1
230000000975 bioactive effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229960004015 calcitonin Drugs 0.000 abstract 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
229940105423 erythropoietin Drugs 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
210000002490 intestinal epithelial cell Anatomy 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Nanotechnology (AREA)
Crystallography & Structural Chemistry (AREA)
Dispersion Chemistry (AREA)
Medical Informatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

GR970402390T 1990-03-29 1997-09-17 Pharmaceutical formulations GR3024745T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909007052A GB9007052D0 (en)	1990-03-29	1990-03-29	Pharmaceutical formulations
PCT/GB1991/000510 WO1991014454A1 (en)	1990-03-29	1991-04-02	Pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
GR3024745T3 true GR3024745T3 (en)	1997-12-31

Family

ID=10673486

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970402390T GR3024745T3 (en)	1990-03-29	1997-09-17	Pharmaceutical formulations

Country Status (24)

Country	Link
US (1)	US5665700A (el)
EP (1)	EP0521994B1 (el)
JP (1)	JPH05505192A (el)
KR (1)	KR100197915B1 (el)
AT (1)	ATE154515T1 (el)
AU (1)	AU656134B2 (el)
CA (1)	CA2079233A1 (el)
CS (1)	CS88091A2 (el)
DE (1)	DE69126609T2 (el)
DK (1)	DK0521994T3 (el)
ES (1)	ES2104697T3 (el)
FI (1)	FI101043B (el)
GB (1)	GB9007052D0 (el)
GR (1)	GR3024745T3 (el)
HK (1)	HK1004531A1 (el)
HU (2)	HUT63341A (el)
IE (1)	IE911086A1 (el)
NO (1)	NO923768L (el)
NZ (1)	NZ237667A (el)
PT (1)	PT97199B (el)
RU (1)	RU2104715C1 (el)
SG (1)	SG54998A1 (el)
WO (1)	WO1991014454A1 (el)
ZA (1)	ZA912411B (el)

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1990
- 1990-03-29 GB GB909007052A patent/GB9007052D0/en active Pending
1991
- 1991-03-28 PT PT97199A patent/PT97199B/pt not_active IP Right Cessation
- 1991-03-28 ZA ZA912411A patent/ZA912411B/xx unknown
- 1991-03-28 IE IE108691A patent/IE911086A1/en unknown
- 1991-03-29 CS CS91880A patent/CS88091A2/cs unknown
- 1991-04-02 JP JP3506507A patent/JPH05505192A/ja active Pending
- 1991-04-02 HK HK98103678A patent/HK1004531A1/en not_active IP Right Cessation
- 1991-04-02 KR KR1019920070234A patent/KR100197915B1/ko not_active Expired - Lifetime
- 1991-04-02 WO PCT/GB1991/000510 patent/WO1991014454A1/en not_active Ceased
- 1991-04-02 ES ES91907052T patent/ES2104697T3/es not_active Expired - Lifetime
- 1991-04-02 SG SG1996000854A patent/SG54998A1/en unknown
- 1991-04-02 AU AU75842/91A patent/AU656134B2/en not_active Ceased
- 1991-04-02 HU HU9330A patent/HUT63341A/hu unknown
- 1991-04-02 DK DK91907052.4T patent/DK0521994T3/da active
- 1991-04-02 CA CA002079233A patent/CA2079233A1/en not_active Abandoned
- 1991-04-02 RU SU5053188A patent/RU2104715C1/ru active
- 1991-04-02 EP EP91907052A patent/EP0521994B1/en not_active Revoked
- 1991-04-02 AT AT91907052T patent/ATE154515T1/de not_active IP Right Cessation
- 1991-04-02 DE DE69126609T patent/DE69126609T2/de not_active Revoked
- 1991-04-03 NZ NZ237667A patent/NZ237667A/en unknown
1992
- 1992-09-28 FI FI924340A patent/FI101043B/fi active
- 1992-09-28 NO NO92923768A patent/NO923768L/no unknown
1994
- 1994-08-15 US US08/290,293 patent/US5665700A/en not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00724P patent/HU211962A9/hu unknown
1997
- 1997-09-17 GR GR970402390T patent/GR3024745T3/el unknown

Also Published As

Publication number	Publication date
JPH05505192A (ja)	1993-08-05
KR100197915B1 (ko)	1999-06-15
RU2104715C1 (ru)	1998-02-20
NZ237667A (en)	1994-01-26
PT97199A (pt)	1991-11-29
CA2079233A1 (en)	1991-09-30
HUT63341A (en)	1993-08-30
SG54998A1 (en)	1998-12-21
DE69126609D1 (de)	1997-07-24
FI924340L (fi)	1992-09-28
US5665700A (en)	1997-09-09
FI101043B (fi)	1998-04-15
EP0521994A1 (en)	1993-01-13
ES2104697T3 (es)	1997-10-16
DK0521994T3 (da)	1997-07-07
NO923768D0 (no)	1992-09-28
ATE154515T1 (de)	1997-07-15
EP0521994B1 (en)	1997-06-18
DE69126609T2 (de)	1998-01-02
AU656134B2 (en)	1995-01-27
IE911086A1 (en)	1991-10-09
GB9007052D0 (en)	1990-05-30
HU9203093D0 (en)	1992-12-28
WO1991014454A1 (en)	1991-10-03
HU211962A9 (en)	1996-01-29
ZA912411B (en)	1992-11-25
AU7584291A (en)	1991-10-21
NO923768L (no)	1992-09-28
HK1004531A1 (en)	1998-11-27
FI924340A0 (fi)	1992-09-28
CS88091A2 (en)	1991-11-12
PT97199B (pt)	1998-07-31

Publication	Publication Date	Title
GB9007052D0 (en)	1990-05-30	Pharmaceutical formulations
AU2581888A (en)	1989-05-25	Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations
WO1990003164A3 (en)	1990-06-14	Pharmaceutical formulations
AU1099288A (en)	1989-02-09	Drug delivery system and method of making the same
AU7315496A (en)	1997-05-07	Delivery of biologically active polypeptides
ATE91903T1 (de)	1993-08-15	Pharmazeutische kombinationspraeparate und deren verwendung als antineoplastische arzneimittel.
PT693924E (pt)	2004-09-30	Processos para administracao (in vivo) de substancias biologicas e composicoes utilizadas nestes processos
PT97160A (pt)	1991-11-29	Processo para a preparacao de composicoes estaveis para administracao parenterica contendo uma proteina, peptideo ou polipeptideo biologicamente activo
HU906177D0 (en)	1991-08-28	Process for the production of peptide derivatives and medical and diagnostical preparations containing such derivatives
LTIP1652A (en)	1995-08-25	Protein, biologically active hormone, method for protein production, pharmaceutical preparation
AU3951489A (en)	1990-02-15	Pharmaceutical formulation for the treatment of diabetes mellitus
AU1111695A (en)	1995-06-13	Composition for the production of therapeutic products in vivo
ES2141496T3 (es)	2000-03-16	Preparacion de formulaciones para la administracion de medicamento mediante electrotransporte.
AU8096591A (en)	1992-06-25	Composition for solid pharmaceutical preparations containing active vitamins d3 and process for preparation thereof
HUT56856A (en)	1991-10-28	Process for producing biologically active stable somatotropins and pharmaceutical compositions comprising same asa active ingredient
CA2087543A1 (en)	1992-01-20	Heterocyclic compounds
IL87778A (en)	1993-05-13	Topical pharmaceutical compositions in the form of a hydrogel containing stabilized therapeutically active proteins and their preparation
AU536582B2 (en)	1984-05-10	Plenylpiperazine derivatives of 1,3,4-oxiadiazolylphends
FR2684878B1 (fr)	1994-02-11	Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.
GR3002665T3 (en)	1993-01-25	Use of nitrophenyl groups for stimulating the capability of incorporation of a drug into the sensitive cells of a host
IT1243343B (it)	1994-06-10	Composizione farmaceutica liquida per la somministrazione nasale contenente un polipeptide come sostanza attiva