GR3025111T3 - HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2. - Google Patents

HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2.

Info

Publication number
GR3025111T3
GR3025111T3 GR970402753T GR970402753T GR3025111T3 GR 3025111 T3 GR3025111 T3 GR 3025111T3 GR 970402753 T GR970402753 T GR 970402753T GR 970402753 T GR970402753 T GR 970402753T GR 3025111 T3 GR3025111 T3 GR 3025111T3
Authority
GR
Greece
Prior art keywords
cyclooxygenase
assay
2cdna
human
evaluating inhibition
Prior art date
Application number
GR970402753T
Other languages
English (en)
Inventor
Wanda A Cromlish
Brian P Kennedy
Gary O'neill
Philip J Vickers
Elizabeth Wong
Joseph A Mancini
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26744337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3025111(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of GR3025111T3 publication Critical patent/GR3025111T3/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083Miscellaneous (1.14.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/61Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving triglycerides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99Miscellaneous (1.14.99)
    • C12Y114/99001Prostaglandin-endoperoxide synthase (1.14.99.1), i.e. cyclooxygenase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/90241Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
GR970402753T 1992-12-22 1997-10-21 HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2. GR3025111T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99476092A 1992-12-22 1992-12-22
US08/064,271 US5543297A (en) 1992-12-22 1993-05-06 Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
PCT/CA1993/000547 WO1994014977A1 (en) 1992-12-22 1993-12-17 HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2

Publications (1)

Publication Number Publication Date
GR3025111T3 true GR3025111T3 (en) 1998-01-30

Family

ID=26744337

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970402753T GR3025111T3 (en) 1992-12-22 1997-10-21 HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2.

Country Status (11)

Country Link
US (2) US5543297A (el)
EP (3) EP0736769B1 (el)
JP (2) JP3608622B2 (el)
AT (2) ATE155811T1 (el)
AU (1) AU5690694A (el)
CA (1) CA2151231C (el)
DE (2) DE69312513T2 (el)
DK (1) DK0675964T3 (el)
ES (2) ES2105611T3 (el)
GR (1) GR3025111T3 (el)
WO (1) WO1994014977A1 (el)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
WO1995009238A1 (en) * 1993-09-27 1995-04-06 Merck Frosst Canada Inc. High level expression of human cyclooxygenase-2
KR960706358A (ko) * 1993-12-17 1996-12-09 폴지. 라피아티스 아이코사노이드 형성을 억제하는 안티센스 올리고뉴클레오타이드(Antisense Oligonucleotides to Suppress Elcosanoid Formation)
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
AT401061B (de) * 1995-01-26 1996-06-25 Hafslund Nycomed Pharma Benutzung einer menschlichen monozytenartigen zellinie zur identifikation und bestimmung von substanzen zur hemmung des menschlichen enzyms cyclooxygenase-2
AU6029396A (en) * 1995-06-07 1996-12-30 University Of Rochester Mammalian prostaglandin h synthase-2
JPH0977664A (ja) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd シクロオキシゲナーゼ−2特異的阻害剤及び抗炎症剤
WO1997031631A1 (en) * 1996-02-27 1997-09-04 Rpms Technology Limited Cox-2 selective inhibitors for managing labour and uterine contractions
AT402936B (de) * 1996-05-29 1997-09-25 Nycomed Austria Gmbh Benutzung einer menschlichen zellinie zur identifikation und bestimmung von substanzen zur hemmung der induktion der expression des cyclooxygenase-2-genes
GB2319032A (en) * 1996-10-04 1998-05-13 Merck & Co Inc Crystals of human cyclooxygenase-2 (hCOX-2)
SI0956009T1 (en) * 1996-11-21 2002-08-31 Mount Sinai School Of Medicine Treatment of neurodegenerative conditions with nimesulide
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
AU6015098A (en) * 1997-02-24 1998-09-09 Cornell Research Foundation Inc. Method of screening agents as candidates for drugs or sources of drugs
EP1006794B1 (en) * 1997-03-12 2007-11-28 Robert W. Esmond A method for treating or preventing alzheimer's disease
EP1489100B1 (en) 1997-12-08 2016-06-15 Merck Patent GmbH Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
RU2229305C2 (ru) * 1998-04-15 2004-05-27 Лексиген Фармасьютикэлс Корпорейшн Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора ангиогенеза
EP1109918B1 (en) 1998-06-24 2006-10-04 University of Dundee Mitogen- and stress-activated protein kinases that contain two kinase domains and uses thereof
AU764872B2 (en) * 1998-10-23 2003-09-04 Merck Frosst Canada & Co. Combination product comprising an E-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
GB9827430D0 (en) * 1998-12-11 1999-02-03 Ludwig Inst Cancer Res Differential expression in primary breast cancer
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US6933128B1 (en) 1999-06-16 2005-08-23 Temple University-Of The Commonwealth System Of Higher Education Cell-based assay for screening cox-2 inhibitors
WO2000077245A1 (en) * 1999-06-16 2000-12-21 Temple University - Of The Commonwealth System Of Higher Education Cell-based assay for screening cox-2 inhibitors
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
AR025049A1 (es) * 1999-08-06 2002-11-06 Searle & Co Ciclooxigenasa-1 (cox-1) y ciclooxigenasa-2 (cox-2) caninas.
JP4793971B2 (ja) 1999-08-09 2011-10-12 メルク パテント ゲーエムベーハー 複合サイトカイン−抗体複合体
EP1228214A2 (en) 1999-11-12 2002-08-07 MERCK PATENT GmbH Erythropoietin forms with improved properties
ATE283048T1 (de) * 1999-12-08 2004-12-15 Pharmacia Corp Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt
ES2328446T5 (es) 2000-02-04 2014-02-27 Children's Hospital Research Foundation Uso de lipasa ácida lisosomal para tratar la aterosclerosis y enfermedades asociadas
HUP0204475A2 (en) 2000-02-11 2003-04-28 Merck Patent Gmbh Enhancing the circulating half-life of antibody-based fusion proteins
DE60129695T2 (de) * 2000-06-29 2008-06-05 Merck Patent Gmbh Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
WO2002005848A2 (en) * 2000-07-13 2002-01-24 Pharmacia Corporation Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
HUP0302068A3 (en) * 2000-07-20 2005-05-30 Lauras As Use of cox-2 inhibitors for treating or preventing immunodeficiency and pharmaceutical compositions containing them
ATE420201T1 (de) * 2000-08-07 2009-01-15 Univ Vanderbilt Nachweis der cox-2 aktivität und von anandamid- metaboliten
US6783943B2 (en) * 2000-12-20 2004-08-31 The Regents Of The University Of California Rolling circle amplification detection of RNA and DNA
US20020164617A1 (en) * 2000-12-29 2002-11-07 Neogenesis Pharmaceuticals, Inc. Affinity selection-based screening of hydrophobic proteins
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
AU2002248571B2 (en) * 2001-03-07 2007-01-18 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
WO2002079415A2 (en) * 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
PT1383785E (pt) * 2001-05-03 2011-06-28 Merck Patent Gmbh Anticorpo recombinante específico de tumores e utilização deste
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
WO2003029411A2 (en) * 2001-09-28 2003-04-10 Brigham Young University Novel cyclooxygenase variants and methods of use
PT1454138E (pt) 2001-12-04 2012-03-28 Merck Patent Gmbh Imunocitoquinas com seletividade modulada
DK3072978T3 (en) 2002-05-09 2018-09-17 Brigham & Womens Hospital Inc : 1L1RL-1 AS A CARDIOVASCULAR DISEASE MARKER
US7314709B2 (en) * 2002-08-06 2008-01-01 Vanderbilt University Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
CN100432105C (zh) * 2002-12-17 2008-11-12 默克专利有限公司 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
SI2384753T1 (sl) 2003-08-29 2016-06-30 The Brigham And Women's Hospital, Inc. Hidantoinski derivati kot inhibitorji celične nekroze
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US9164104B2 (en) 2004-10-06 2015-10-20 The Brigham And Women's Hospital, Inc. Relevance of achieved levels of markers of systemic inflammation following treatment
WO2006083779A2 (en) * 2005-01-31 2006-08-10 Mylan Laboratories, Inc. Pharmaceutical composition comprising hydroxylated nebivolol
WO2006116702A2 (en) * 2005-04-28 2006-11-02 The Johns Hopkins University Inducible nitric oxide synthase binds, s-nitrosylates, and activates cyclooxygenase-2
AP2896A (en) 2005-05-31 2014-05-31 Mylan Lab Inc Compositions comprising nebivolol
WO2007030375A2 (en) * 2005-09-08 2007-03-15 Children's Hospital Medical Center Lysosomal acid lipase therapy for nafld and related diseases
US8119358B2 (en) * 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
KR101556790B1 (ko) 2006-03-15 2015-10-01 더 브리검 앤드 우먼즈 하스피털, 인크. 염증성 질환의 진단 및 치료를 위한 겔솔린의 용도
WO2007127965A1 (en) 2006-04-28 2007-11-08 Mayo Foundation For Medical Education And Research Treating glaucoma, cardiovascular diseases, and renal diseases
EP2302395B1 (en) 2006-06-07 2015-04-15 Health Diagnostic Laboratory, Inc. Markers associated with arteriovascular events and methods of use thereof
TW200849035A (en) 2007-04-18 2008-12-16 Tethys Bioscience Inc Diabetes-related biomarkers and methods of use thereof
TW201201764A (en) 2010-02-01 2012-01-16 Hospital For Sick Children Remote ischemic conditioning for treatment and prevention of restenosis
KR20130040851A (ko) 2010-03-31 2013-04-24 더 호스피탈 포 식 칠드런 심근 경색 후 결과를 개선시키기 위한 원격 허혈 처치의 사용
US9725452B2 (en) 2013-03-15 2017-08-08 Presidents And Fellows Of Harvard College Substituted indoles and pyrroles as RIP kinase inhibitors
RU2706366C2 (ru) * 2017-11-01 2019-11-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) Способ отбора противовоспалительных средств с использованием рассчитанных энергий взаимодействия с ферментами циклооксигеназ 1 и 2
AU2019345067A1 (en) 2018-09-19 2021-04-08 Modernatx, Inc. High-purity peg lipids and uses thereof
MA53650A (fr) 2018-09-19 2021-07-28 Modernatx Inc Lipides peg et leurs utilisations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562155A (en) * 1983-05-19 1985-12-31 The Wistar Institute Of Anatomy And Biology Hybrid viral plasmid and microorganisms containing same
JPS63157980A (ja) 1986-12-22 1988-06-30 Chisso Corp プロスタグランジン合成酵素の安定化方法
JPH01228479A (ja) * 1988-03-10 1989-09-12 Meiji Milk Prod Co Ltd プロスタグランジンエンドペルオキシドシンテターゼをコードするdna
US5837479A (en) 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
US6048850A (en) 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
WO1994006919A2 (en) * 1992-09-22 1994-03-31 University Of Rochester Stably-transformed mammalian cells expressing a regulated, inflammatory cyclooxygenase
JPH06315798A (ja) * 1993-05-07 1994-11-15 Kobe Steel Ltd 高エネルギービーム溶接用裏当材

Also Published As

Publication number Publication date
ES2105611T3 (es) 1997-10-16
EP0675964A1 (en) 1995-10-11
DK0675964T3 (da) 1997-09-15
EP0736769B1 (en) 2001-12-12
DE69312513T2 (de) 1998-01-15
WO1994014977A1 (en) 1994-07-07
US5543297A (en) 1996-08-06
DE69331340D1 (de) 2002-01-24
CA2151231C (en) 2004-11-09
JPH08504584A (ja) 1996-05-21
CA2151231A1 (en) 1994-07-07
DE69312513D1 (de) 1997-08-28
USRE39696E1 (en) 2007-06-19
EP1130110A3 (en) 2005-02-23
EP1130110A2 (en) 2001-09-05
EP0675964B1 (en) 1997-07-23
EP0736769A1 (en) 1996-10-09
ES2168436T3 (es) 2002-06-16
JP3573743B2 (ja) 2004-10-06
HK1027471A1 (en) 2001-01-12
AU5690694A (en) 1994-07-19
JP3608622B2 (ja) 2005-01-12
ATE155811T1 (de) 1997-08-15
ATE210826T1 (de) 2001-12-15
JP2004081211A (ja) 2004-03-18
DE69331340T2 (de) 2002-08-22

Similar Documents

Publication Publication Date Title
GR3025111T3 (en) HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2.
NO862063L (no) Undervannsventil for bruk ved broenn-testing.
EP0314402A3 (en) Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
FI895959A7 (fi) Koostumus, diagnostinen käyttöpakkaus ja menetelmä vasta-aineiden nope aksi toteamiseksi
EP0645630A3 (en) Method for determining the presence of a pivka and reagent therefor.
IT8148780A0 (it) Composti inibitori dell'enzima aromatasi e procedimento per la loro preparazione
DK164973C (da) Undersoegelsesmetode til bestemmelse af 1,25-dihydroxy vitamin d og saet til brug ved denne metode
ES512894A0 (es) "un procedimiento para obtener de orina una fraccion que contiene un ingrediente antineoplastico de naturaleza peptidica".
IT8567372A1 (it) Assorbente igienico e procedimento per la sua fabbricazione.
EP0307149A3 (en) Solid phase immunoassay for an antibody and biological constructions for use therein
DK161860C (da) Fremgangsmaade til paavisning af det vigtigste ydre membranprotein af chlamydia trachomatis
FR2546302B1 (fr) Methodes immunologiques pour la determination de l'activite cellulaire metastasique
CA2041896A1 (en) Stabilized uric acid reagent
FI882265A7 (fi) Menetelmä fruktosamiinin määrittämiseksi.
FI895215A7 (fi) Menetelmä antitrombiini III:n biologisen aktiivisuuden määrittämiseksi ja reagenssi sitä varten
AU5297390A (en) Method of immunologically assaying human thrombin- antithrombin iii complex, assay reagent and kit therefor
FI854627A7 (fi) Menetelmä ja reagenssi plasmassa, seerumissa tai kokoveressä olevan vapaan tyroksiinin kvantitatiiviseksi määrittämiseksi.
PT90364A (pt) Anticorpos monoclonais para o activador de plaminogenio de tecidos (t-pa) que prolongam a sua semi-vida funcional
CA2202913A1 (en) Antibody reagent for detecting dissecting aortic aneurysm and uses thereof
ATE295886T1 (de) Photometrischer test zur bestimmung von pyrophosphat nach dessen enzymatischer umsetzung
AU590746B2 (en) Method for determining human prolyl 4-hydroxylase by immunoassay
IT8124634A0 (it) Cromogeno per la determinazione colorimetrica dei perossidi emetodo impiegante lo stesso.
FR2496694B1 (fr) Procede de determination de l'activite de l'enzyme transformant l'angiotensine
NO891830D0 (no) Analysator for kontinuerlig elektrokjemisk analyse.
IT1230150B (it) Reattivo per la determinazione analitica dell'enzima gamma glutamiltransferasi.