ATE210826T1 - Verfahren zur bestimmung von cyclooxygenase-1- aktivität - Google Patents

Verfahren zur bestimmung von cyclooxygenase-1- aktivität

Info

Publication number
ATE210826T1
ATE210826T1 AT96201845T AT96201845T ATE210826T1 AT E210826 T1 ATE210826 T1 AT E210826T1 AT 96201845 T AT96201845 T AT 96201845T AT 96201845 T AT96201845 T AT 96201845T AT E210826 T1 ATE210826 T1 AT E210826T1
Authority
AT
Austria
Prior art keywords
activity
determining
cyclooxygenase
sample
determining cyclooxygenase
Prior art date
Application number
AT96201845T
Other languages
English (en)
Inventor
Wanda A Cromlish
Brian P Kennedy
Gary O'neill
Philip J Vickers
Elizabeth Wong
Joseph A Mancini
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26744337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE210826(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE210826T1 publication Critical patent/ATE210826T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/61—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving triglycerides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99001—Prostaglandin-endoperoxide synthase (1.14.99.1), i.e. cyclooxygenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
AT96201845T 1992-12-22 1993-12-17 Verfahren zur bestimmung von cyclooxygenase-1- aktivität ATE210826T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99476092A 1992-12-22 1992-12-22
US08/064,271 US5543297A (en) 1992-12-22 1993-05-06 Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity

Publications (1)

Publication Number Publication Date
ATE210826T1 true ATE210826T1 (de) 2001-12-15

Family

ID=26744337

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94902571T ATE155811T1 (de) 1992-12-22 1993-12-17 Menschliche cyclooxygenase-2cdna und bestimmung von menschliche cyclooxygenase-2-inhibierung
AT96201845T ATE210826T1 (de) 1992-12-22 1993-12-17 Verfahren zur bestimmung von cyclooxygenase-1- aktivität

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94902571T ATE155811T1 (de) 1992-12-22 1993-12-17 Menschliche cyclooxygenase-2cdna und bestimmung von menschliche cyclooxygenase-2-inhibierung

Country Status (11)

Country Link
US (2) US5543297A (de)
EP (3) EP0675964B1 (de)
JP (2) JP3608622B2 (de)
AT (2) ATE155811T1 (de)
AU (1) AU5690694A (de)
CA (1) CA2151231C (de)
DE (2) DE69312513T2 (de)
DK (1) DK0675964T3 (de)
ES (2) ES2168436T3 (de)
GR (1) GR3025111T3 (de)
WO (1) WO1994014977A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
JPH09502880A (ja) * 1993-09-27 1997-03-25 メルク フロスト カナダ インコーポレーテツド ヒトシクロオキシゲナーゼ−2の高レベル発現
EP0796109A1 (de) * 1993-12-17 1997-09-24 The Ohio State University Antisense oligonukleotide zur unterdrückung der eicosanoidbildung
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
AT401061B (de) * 1995-01-26 1996-06-25 Hafslund Nycomed Pharma Benutzung einer menschlichen monozytenartigen zellinie zur identifikation und bestimmung von substanzen zur hemmung des menschlichen enzyms cyclooxygenase-2
WO1996040720A1 (en) * 1995-06-07 1996-12-19 University Of Rochester Mammalian prostaglandin h synthase-2
JPH0977664A (ja) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd シクロオキシゲナーゼ−2特異的阻害剤及び抗炎症剤
WO1997031631A1 (en) * 1996-02-27 1997-09-04 Rpms Technology Limited Cox-2 selective inhibitors for managing labour and uterine contractions
AT402936B (de) * 1996-05-29 1997-09-25 Nycomed Austria Gmbh Benutzung einer menschlichen zellinie zur identifikation und bestimmung von substanzen zur hemmung der induktion der expression des cyclooxygenase-2-genes
GB2319032A (en) * 1996-10-04 1998-05-13 Merck & Co Inc Crystals of human cyclooxygenase-2 (hCOX-2)
SI0956009T1 (en) * 1996-11-21 2002-08-31 Mount Sinai School Of Medicine Treatment of neurodegenerative conditions with nimesulide
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
US6200760B1 (en) * 1997-02-24 2001-03-13 Cornell Research Foundation, Inc. Method of screening agents as candidates for drugs or sources of drugs
JP2001514663A (ja) * 1997-03-12 2001-09-11 エスモンド,ロバート ダブリュー. アルツハイマー病を処置または予防するための方法
ES2221717T3 (es) 1997-12-08 2005-01-01 Emd Lexigen Research Center Corp. Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general.
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
CN1318092C (zh) * 1998-04-15 2007-05-30 利思进药品公司 含有抗体-细胞因子融合蛋白和血管生成抑制剂的免疫治疗用组合物
EP1109918B1 (de) 1998-06-24 2006-10-04 University of Dundee Mitogen- und stress-aktivierte proteinkinasen, die zwei kinase domänen enthalten, und deren verwendungen
AU764872B2 (en) * 1998-10-23 2003-09-04 Merck Frosst Canada & Co. Combination product comprising an E-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
GB9827430D0 (en) * 1998-12-11 1999-02-03 Ludwig Inst Cancer Res Differential expression in primary breast cancer
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
EP1187934A4 (de) * 1999-06-16 2002-07-31 Univ Temple Auf zellen basierter assay zum screening von cox-2-inhibitoren
US6933128B1 (en) 1999-06-16 2005-08-23 Temple University-Of The Commonwealth System Of Higher Education Cell-based assay for screening cox-2 inhibitors
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
WO2001011026A1 (en) * 1999-08-06 2001-02-15 G.D. Searle & Co. Canine cyclooxygenase-1 (cox-1) and cyclooxygenase-2 (cox-2)
WO2001010912A1 (en) * 1999-08-09 2001-02-15 Lexigen Pharmaceuticals Corp. Multiple cytokine-antibody complexes
CA2391080A1 (en) 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties
CO5261556A1 (es) * 1999-12-08 2003-03-31 Pharmacia Corp Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
DE60138535D1 (de) * 2000-02-04 2009-06-10 Children S Hospital Res Founda Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten
JP5179689B2 (ja) * 2000-02-11 2013-04-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗体ベース融合タンパク質の循環系内半減期の増強
CZ2003214A3 (cs) * 2000-06-29 2003-08-13 Merck Patent Gmbh Zesílení odpovědi mediovaných fúzním proteinem protilátka-cytokin kombinovanou léčbou pomocí činidel zvyšujících uptake imunocytokinu
EP1299123A2 (de) * 2000-07-13 2003-04-09 Pharmacia Corporation Verwendung von cox-2 hemmern zur behandlung und vorbeugung von cox-2-abhängigen augenkrankheiten
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
NZ524252A (en) * 2000-07-20 2004-03-26 Lauras As Cox-2 inhibitors for treating HIV and AIDS
AU8474701A (en) * 2000-08-07 2002-02-18 Univ Vanderbilt Compositions and methods for detecting and quantifying cox-2 activity and 2-arachidonylglycerol metabolites
US6783943B2 (en) * 2000-12-20 2004-08-31 The Regents Of The University Of California Rolling circle amplification detection of RNA and DNA
JP2005506039A (ja) * 2000-12-29 2005-03-03 ネオジェネシス ファーマシューティカルズ インコーポレイテッド アフィニティ選択に基づいた疎水性タンパク質のスクリーニング
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
DK1366067T3 (da) * 2001-03-07 2012-10-22 Merck Patent Gmbh Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
PE20021017A1 (es) 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible
BR0209177A (pt) 2001-05-03 2004-10-05 Merck Patent Gmbh Anticorpo especìfico a tumor recombinante e uso do mesmo
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AU2002340063B2 (en) * 2001-09-28 2007-05-10 Brigham Young University Novel cyclooxygenase variants and methods of use
EP1454138B1 (de) * 2001-12-04 2012-01-18 Merck Patent GmbH Immunocytokine mit modulierter selektivität
ES2375181T3 (es) 2002-05-09 2012-02-27 The Brigham And Women's Hospital, Inc. 1l 1rl-1 como un marcador de enfermedades cardiovasculares.
US7314709B2 (en) * 2002-08-06 2008-01-01 Vanderbilt University Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
ATE471946T1 (de) * 2002-12-17 2010-07-15 Merck Patent Gmbh Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2
AU2004315596B2 (en) 2003-08-29 2011-11-24 President And Fellows Of Harvard College Inhibitors of cellular necrosis
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
ES2439229T3 (es) 2004-10-06 2014-01-22 The Brigham And Women's Hospital, Inc. Relevancia de niveles logrados de marcadores de inflamación sistémica tras el tratamiento
NZ560386A (en) * 2005-01-31 2009-12-24 Mylan Lab Inc Pharmaceutical composition comprising hydroxylated nebivolol
US7358237B2 (en) * 2005-04-28 2008-04-15 The Johns Hopkins University Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
NZ563759A (en) 2005-05-31 2010-06-25 Mylan Lab Inc Compositions comprising nebivolol, a hydralazine compound and an isosorbide nitrate
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
US8119358B2 (en) * 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
US8198094B2 (en) 2006-03-15 2012-06-12 The Brigham And Women's Hospital, Inc. Methods of using gelsolin levels to characterize a subject's risk of developing rheumatoid arthritis
WO2007127965A1 (en) 2006-04-28 2007-11-08 Mayo Foundation For Medical Education And Research Treating glaucoma, cardiovascular diseases, and renal diseases
CA2659082A1 (en) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
TW200849035A (en) 2007-04-18 2008-12-16 Tethys Bioscience Inc Diabetes-related biomarkers and methods of use thereof
KR20120139723A (ko) 2010-02-01 2012-12-27 더 호스피탈 포 식 칠드런 재발협착증의 치료 및 예방을 위한 원격 허혈 처치
SG184353A1 (en) 2010-03-31 2012-11-29 Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
WO2014145022A1 (en) 2013-03-15 2014-09-18 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
RU2706366C2 (ru) * 2017-11-01 2019-11-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) Способ отбора противовоспалительных средств с использованием рассчитанных энергий взаимодействия с ферментами циклооксигеназ 1 и 2
CN112996854B (zh) 2018-09-19 2024-08-30 摩登纳特斯有限公司 高纯度peg脂质和其用途
US12151029B2 (en) 2018-09-19 2024-11-26 Modernatx, Inc. PEG lipids and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562155A (en) * 1983-05-19 1985-12-31 The Wistar Institute Of Anatomy And Biology Hybrid viral plasmid and microorganisms containing same
JPS63157980A (ja) 1986-12-22 1988-06-30 Chisso Corp プロスタグランジン合成酵素の安定化方法
JPH01228479A (ja) * 1988-03-10 1989-09-12 Meiji Milk Prod Co Ltd プロスタグランジンエンドペルオキシドシンテターゼをコードするdna
US6048850A (en) 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
AU688282B2 (en) * 1992-09-22 1998-03-12 University Of Rochester Stably-transformed mammalian cells expressing a regulated, inflammatory cyclooxygenase
US5837479A (en) 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
JPH06315798A (ja) * 1993-05-07 1994-11-15 Kobe Steel Ltd 高エネルギービーム溶接用裏当材

Also Published As

Publication number Publication date
USRE39696E1 (en) 2007-06-19
EP1130110A3 (de) 2005-02-23
DE69312513T2 (de) 1998-01-15
JP2004081211A (ja) 2004-03-18
CA2151231C (en) 2004-11-09
GR3025111T3 (en) 1998-01-30
EP1130110A2 (de) 2001-09-05
DK0675964T3 (da) 1997-09-15
WO1994014977A1 (en) 1994-07-07
AU5690694A (en) 1994-07-19
EP0675964B1 (de) 1997-07-23
JPH08504584A (ja) 1996-05-21
ATE155811T1 (de) 1997-08-15
JP3608622B2 (ja) 2005-01-12
EP0675964A1 (de) 1995-10-11
DE69312513D1 (de) 1997-08-28
DE69331340D1 (de) 2002-01-24
CA2151231A1 (en) 1994-07-07
ES2168436T3 (es) 2002-06-16
JP3573743B2 (ja) 2004-10-06
US5543297A (en) 1996-08-06
EP0736769B1 (de) 2001-12-12
HK1027471A1 (en) 2001-01-12
DE69331340T2 (de) 2002-08-22
EP0736769A1 (de) 1996-10-09
ES2105611T3 (es) 1997-10-16

Similar Documents

Publication Publication Date Title
DE69331340D1 (de) Verfahren zur Bestimmung von Cyclooxygenase-1-Aktivität
DE3381979D1 (de) Verfahren zur photometrischen bestimmung biologischer agglutinaten.
ATE81722T1 (de) Verfahren zur bestimmung von mimotopen.
AR230954A1 (es) Un metodo mejorado de separacion y concentracion de la proteina de actividad pro-coagulante viii:c a partir de un complejo de factor viii que contiene viii:c y viii:rp y un inmunoabsorbente empleado
DE69022786D1 (de) Verfahren zur Bestimmung der Konzentration von Glucose.
DE3876273D1 (de) Isoelektrisches fokussierverfahren sowie einrichtung zur durchfuehrung dieses verfahrens.
DK149475C (da) Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma
DE3788762D1 (de) Verfahren zur Bestimmung von physiologisch wirksamen Substanzen.
DE3777417D1 (de) Verfahren zur kryokonservierung von herzklappen.
DE3689218D1 (de) Verfahren zur differenzierten Bestimmung weisser Blutkörperchen.
AT362532B (de) Verfahren zur quantitativen enzymatischen bestimmung von adp
DE3863285D1 (de) Verfahren und reagenz zur bestimmung von persaeuren.
ATE10013T1 (de) Verfahren und reagens zur bestimmung von glycerin.
DE3682149D1 (de) Verfahren zur quantitativen bestimmung von 1,5-anhydroglucitol.
DK164973C (da) Undersoegelsesmetode til bestemmelse af 1,25-dihydroxy vitamin d og saet til brug ved denne metode
DE68906650D1 (de) Verfahren zur zementierung von plattformbeinen.
DE3583875D1 (de) Verfahren zur herstellung von kugelfoermigen vollblut-erythrocyten und fixierung derselben.
NO874453D0 (no) Fremgangsmaate til bestemmelse av anti-hiv, middel dertil og dets anvendelse i fremgangsmaaten.
FI895215A7 (fi) Menetelmä antitrombiini III:n biologisen aktiivisuuden määrittämiseksi ja reagenssi sitä varten
FI882265A7 (fi) Menetelmä fruktosamiinin määrittämiseksi.
FI854627A7 (fi) Menetelmä ja reagenssi plasmassa, seerumissa tai kokoveressä olevan vapaan tyroksiinin kvantitatiiviseksi määrittämiseksi.
DE3585238D1 (de) Verfahren zur bestimmung des reduzierten zustands von nicotinamid-adenin-dinukleotid.
DE68914252D1 (de) Verfahren zur Bestimmung eines Antigens.
DE69026611D1 (de) Verfahren zur Bestimmung von Fruktosaminen
ATE4328T1 (de) Verfahren und reagens zur bestimmung von glycerin.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties