GR3030713T3 - Synthesis of 4-alkoxy-n-acetylneuraminic acid - Google Patents

Synthesis of 4-alkoxy-n-acetylneuraminic acid

Info

Publication number: GR3030713T3
Authority: GR; Greece
Prior art keywords: alkoxy; acetylneuraminic acid; synthesis; group; alkyl
Prior art date: 1994-08-05

Application number

GR990401796T

Other languages

English (en)

Inventor

Avraham Liav

Ragen F Hardgrave

Sheri Blystone

Gregory A Turner

Original Assignee

Oklahoma Med Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-05

Filing date

1999-07-07

Publication date

1999-11-30

1999-07-07 Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found

1999-11-30 Publication of GR3030713T3 publication Critical patent/GR3030713T3/el

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR990401796T 1994-08-05 1999-07-07 Synthesis of 4-alkoxy-n-acetylneuraminic acid GR3030713T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/286,573 US5556963A (en)	1994-08-05	1994-08-05	Synthesis of 4-alkoxy-N-acetylneuraminic acid
PCT/US1995/009223 WO1996004291A1 (en)	1994-08-05	1995-07-21	Synthesis of 4-alkoxy-n-acetylneuraminic acid

Publications (1)

Publication Number	Publication Date
GR3030713T3 true GR3030713T3 (en)	1999-11-30

Family

ID=23099220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR990401796T GR3030713T3 (en)	1994-08-05	1999-07-07	Synthesis of 4-alkoxy-n-acetylneuraminic acid

Country Status (12)

Country	Link
US (1)	US5556963A (el)
EP (1)	EP0775152B1 (el)
JP (1)	JP3947218B2 (el)
AT (1)	ATE180488T1 (el)
AU (1)	AU685312B2 (el)
CA (1)	CA2195872A1 (el)
DE (1)	DE69509903T2 (el)
DK (1)	DK0775152T3 (el)
ES (1)	ES2131841T3 (el)
GR (1)	GR3030713T3 (el)
NO (1)	NO305757B1 (el)
WO (1)	WO1996004291A1 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5663055A (en) *	1989-12-29	1997-09-02	Oklahoma Medical Research Foundation	Methods for diagnosing human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrated for use therein
US5958973A (en) *	1993-09-03	1999-09-28	Gilead Sciences, Inc.	Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors
US5866601A (en) *	1995-02-27	1999-02-02	Gilead Sciences, Inc.	Carbocyclic compounds
BR9607098B8 (pt)	1995-02-27	2014-11-18	Gilead Sciences Inc	Composto e composição farmacêutica.
US5763483A (en) *	1995-12-29	1998-06-09	Gilead Sciences, Inc.	Carbocyclic compounds
US5891855A (en)	1996-02-12	1999-04-06	The Scripps Research Institute	Inhibitors of leaderless protein export
US5859284A (en)	1996-08-23	1999-01-12	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
US6518438B2 (en)	1996-08-23	2003-02-11	Gilead Sciences, Inc.	Preparation of cyclohexene carboxylate derivatives
US5719020A (en) *	1996-09-25	1998-02-17	Oklahoma Medical Research Foundation	4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
US5994377A (en) *	1996-10-21	1999-11-30	Gilead Sciences, Inc.	Piperidine compounds
US5886213A (en) *	1997-08-22	1999-03-23	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
US20040053999A1 (en) *	1997-09-17	2004-03-18	Bischofberger Norbert W.	Novel compounds and methods for synthesis and therapy
TW477783B (en) *	1997-12-12	2002-03-01	Gilead Sciences Inc	Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6303764B1 (en)	1998-09-24	2001-10-16	Zymetx, Inc.	Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
JP2002541858A (ja) *	1999-04-16	2002-12-10	ザイメテックスインコーポレイテッド	ウイルス由来の酵素および化学発光基質を用いるウイルス検出法
US6420552B1 (en)	1999-09-10	2002-07-16	Zymetx, Inc.	Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
US9119866B2 (en) *	2008-04-08	2015-09-01	Huiru Wang	Glycan-based drugs, therapies and biomarkers
EP4416163A1 (en) *	2021-10-14	2024-08-21	Owlstone Medical Limited	Method for the synthesis of evoc probes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950322A (en) *	1973-08-27	1976-04-13	Research Corporation	Fluorogenic substrate glycosides
US5239091A (en) *	1988-08-30	1993-08-24	G. D. Searle & Co.	2-deoxy derivatives of N-acetyl neuraminic acid and their preparation
US5191073A (en) *	1989-02-13	1993-03-02	Miles Inc.	Chromogenic merocyanine enzyme substrates
AU656721B2 (en) *	1989-12-29	1995-02-16	Symex Corp.	Methods for diagnosting human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrates for use therein
CZ288492B6 (en) *	1990-04-24	2001-06-13	Biota Scient Management	Derivatives of alpha-D-neuraminic acid, process of their preparation, their use and pharmaceutical preparations based thereon
US5138044A (en) *	1990-08-13	1992-08-11	Glycomed, Inc.	Synthesis of sialosides
WO1992006691A1 (en) *	1990-10-19	1992-04-30	Biota Scientific Management Pty. Ltd.	Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
US5252458A (en) *	1990-12-31	1993-10-12	Symex Corp.	Method for visually detecting the presence of a virus in a clinical specimen
JPH04300890A (ja) *	1991-03-29	1992-10-23	Nisshin Oil Mills Ltd:The	シアル酸部分を変換したガングリオシドｇｍ３類縁体

1994
- 1994-08-05 US US08/286,573 patent/US5556963A/en not_active Expired - Lifetime
1995
- 1995-07-21 DE DE69509903T patent/DE69509903T2/de not_active Expired - Fee Related
- 1995-07-21 EP EP95926764A patent/EP0775152B1/en not_active Expired - Lifetime
- 1995-07-21 WO PCT/US1995/009223 patent/WO1996004291A1/en not_active Ceased
- 1995-07-21 ES ES95926764T patent/ES2131841T3/es not_active Expired - Lifetime
- 1995-07-21 AT AT95926764T patent/ATE180488T1/de not_active IP Right Cessation
- 1995-07-21 JP JP50656596A patent/JP3947218B2/ja not_active Expired - Fee Related
- 1995-07-21 DK DK95926764T patent/DK0775152T3/da active
- 1995-07-21 CA CA002195872A patent/CA2195872A1/en not_active Abandoned
- 1995-07-21 AU AU31033/95A patent/AU685312B2/en not_active Ceased
1997
- 1997-02-03 NO NO970462A patent/NO305757B1/no not_active IP Right Cessation
1999
- 1999-07-07 GR GR990401796T patent/GR3030713T3/el unknown

Also Published As

Publication number	Publication date
JP3947218B2 (ja)	2007-07-18
NO305757B1 (no)	1999-07-19
CA2195872A1 (en)	1996-02-15
AU685312B2 (en)	1998-01-15
DK0775152T3 (da)	1999-11-29
EP0775152A1 (en)	1997-05-28
US5556963A (en)	1996-09-17
NO970462D0 (no)	1997-02-03
ES2131841T3 (es)	1999-08-01
NO970462L (no)	1997-04-07
DE69509903D1 (de)	1999-07-01
AU3103395A (en)	1996-03-04
WO1996004291A1 (en)	1996-02-15
EP0775152B1 (en)	1999-05-26
ATE180488T1 (de)	1999-06-15
JPH10506103A (ja)	1998-06-16
DE69509903T2 (de)	1999-10-28

Publication	Publication Date	Title
GR3030713T3 (en)	1999-11-30	Synthesis of 4-alkoxy-n-acetylneuraminic acid
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