ATE180488T1 - Synthese von 4-alkoxy-n-acetylneuraminsäure - Google Patents

Synthese von 4-alkoxy-n-acetylneuraminsäure

Info

Publication number: ATE180488T1
Authority: AT; Austria
Prior art keywords: alkoxy; synthesis; group; alkyl; alkylated
Prior art date: 1994-08-05

Application number

AT95926764T

Other languages

English (en)

Inventor

Avraham Liav

Ragen F Hardgrave

Sheri Blystone

Gregory A Turner

Original Assignee

Oklahoma Med Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-05

Filing date

1995-07-21

Publication date

1999-06-15

1995-07-21 Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found

1999-06-15 Application granted granted Critical

1999-06-15 Publication of ATE180488T1 publication Critical patent/ATE180488T1/de

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
239000002253 acid Substances 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT95926764T 1994-08-05 1995-07-21 Synthese von 4-alkoxy-n-acetylneuraminsäure ATE180488T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/286,573 US5556963A (en)	1994-08-05	1994-08-05	Synthesis of 4-alkoxy-N-acetylneuraminic acid

Publications (1)

Publication Number	Publication Date
ATE180488T1 true ATE180488T1 (de)	1999-06-15

Family

ID=23099220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95926764T ATE180488T1 (de)	1994-08-05	1995-07-21	Synthese von 4-alkoxy-n-acetylneuraminsäure

Country Status (12)

Country	Link
US (1)	US5556963A (de)
EP (1)	EP0775152B1 (de)
JP (1)	JP3947218B2 (de)
AT (1)	ATE180488T1 (de)
AU (1)	AU685312B2 (de)
CA (1)	CA2195872A1 (de)
DE (1)	DE69509903T2 (de)
DK (1)	DK0775152T3 (de)
ES (1)	ES2131841T3 (de)
GR (1)	GR3030713T3 (de)
NO (1)	NO305757B1 (de)
WO (1)	WO1996004291A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5663055A (en) *	1989-12-29	1997-09-02	Oklahoma Medical Research Foundation	Methods for diagnosing human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrated for use therein
US5958973A (en) *	1993-09-03	1999-09-28	Gilead Sciences, Inc.	Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors
ES2249863T3 (es)	1995-02-27	2006-04-01	Gilead Sciences, Inc.	Inhibidores selectivos de neuraminidasa viral o bacteriana.
US5866601A (en) *	1995-02-27	1999-02-02	Gilead Sciences, Inc.	Carbocyclic compounds
US5763483A (en) *	1995-12-29	1998-06-09	Gilead Sciences, Inc.	Carbocyclic compounds
US5891855A (en)	1996-02-12	1999-04-06	The Scripps Research Institute	Inhibitors of leaderless protein export
US6518438B2 (en)	1996-08-23	2003-02-11	Gilead Sciences, Inc.	Preparation of cyclohexene carboxylate derivatives
US5859284A (en)	1996-08-23	1999-01-12	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
US5719020A (en) *	1996-09-25	1998-02-17	Oklahoma Medical Research Foundation	4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
US5994377A (en) *	1996-10-21	1999-11-30	Gilead Sciences, Inc.	Piperidine compounds
US5886213A (en) *	1997-08-22	1999-03-23	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
US20040053999A1 (en) *	1997-09-17	2004-03-18	Bischofberger Norbert W.	Novel compounds and methods for synthesis and therapy
TW480247B (en) *	1997-12-12	2002-03-21	Gilead Sciences Inc	Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6303764B1 (en)	1998-09-24	2001-10-16	Zymetx, Inc.	Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
EP1185710A2 (de) *	1999-04-16	2002-03-13	Zymetx, Inc.	Verfahren zum nachweis von viren, das viralisch-codierte enzymen und chemilumineszentsubstraten verwendet
US6420552B1 (en)	1999-09-10	2002-07-16	Zymetx, Inc.	Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
US9119866B2 (en)	2008-04-08	2015-09-01	Huiru Wang	Glycan-based drugs, therapies and biomarkers
WO2023062386A1 (en) *	2021-10-14	2023-04-20	Owlstone Medical Limited	Method for the synthesis of evoc probes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950322A (en) *	1973-08-27	1976-04-13	Research Corporation	Fluorogenic substrate glycosides
US5239091A (en) *	1988-08-30	1993-08-24	G. D. Searle & Co.	2-deoxy derivatives of N-acetyl neuraminic acid and their preparation
US5191073A (en) *	1989-02-13	1993-03-02	Miles Inc.	Chromogenic merocyanine enzyme substrates
ES2097804T3 (es) *	1989-12-29	1997-04-16	Oklahoma Med Res Found	Metodos para diagnosticar la gripe humana y sustratos cromogenos de acido n-acetilneuraminico para usar en estos metodos.
AP249A (en) *	1990-04-24	1993-03-17	Biota Scient Management Pty Ltd	Anti-viral compounds.
US5138044A (en) *	1990-08-13	1992-08-11	Glycomed, Inc.	Synthesis of sialosides
WO1992006691A1 (en) *	1990-10-19	1992-04-30	Biota Scientific Management Pty. Ltd.	Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
US5252458A (en) *	1990-12-31	1993-10-12	Symex Corp.	Method for visually detecting the presence of a virus in a clinical specimen
JPH04300890A (ja) *	1991-03-29	1992-10-23	Nisshin Oil Mills Ltd:The	シアル酸部分を変換したガングリオシドｇｍ３類縁体

1994
- 1994-08-05 US US08/286,573 patent/US5556963A/en not_active Expired - Lifetime
1995
- 1995-07-21 DK DK95926764T patent/DK0775152T3/da active
- 1995-07-21 ES ES95926764T patent/ES2131841T3/es not_active Expired - Lifetime
- 1995-07-21 JP JP50656596A patent/JP3947218B2/ja not_active Expired - Fee Related
- 1995-07-21 AU AU31033/95A patent/AU685312B2/en not_active Ceased
- 1995-07-21 CA CA002195872A patent/CA2195872A1/en not_active Abandoned
- 1995-07-21 AT AT95926764T patent/ATE180488T1/de not_active IP Right Cessation
- 1995-07-21 DE DE69509903T patent/DE69509903T2/de not_active Expired - Fee Related
- 1995-07-21 WO PCT/US1995/009223 patent/WO1996004291A1/en not_active Ceased
- 1995-07-21 EP EP95926764A patent/EP0775152B1/de not_active Expired - Lifetime
1997
- 1997-02-03 NO NO970462A patent/NO305757B1/no not_active IP Right Cessation
1999
- 1999-07-07 GR GR990401796T patent/GR3030713T3/el unknown

Also Published As

Publication number	Publication date
EP0775152A1 (de)	1997-05-28
CA2195872A1 (en)	1996-02-15
EP0775152B1 (de)	1999-05-26
WO1996004291A1 (en)	1996-02-15
ES2131841T3 (es)	1999-08-01
NO305757B1 (no)	1999-07-19
DE69509903T2 (de)	1999-10-28
NO970462L (no)	1997-04-07
NO970462D0 (no)	1997-02-03
JPH10506103A (ja)	1998-06-16
US5556963A (en)	1996-09-17
GR3030713T3 (en)	1999-11-30
DE69509903D1 (de)	1999-07-01
AU685312B2 (en)	1998-01-15
AU3103395A (en)	1996-03-04
DK0775152T3 (da)	1999-11-29
JP3947218B2 (ja)	2007-07-18

Legal Events

Date	Code	Title	Description
2000-01-15	UEP	Publication of translation of european patent specification
2001-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69509903D1 (de)	1999-07-01	Synthese von 4-alkoxy-n-acetylneuraminsäure
ID21654A (id)	1999-07-08	Proses derivatisasi selektif taksana
FI941632A7 (fi)	1994-04-08	Parannettu menetelmä (5R)-1,1-dimetyylietyyli-6-syano-5-hydroksi-3-oksoheksanoaatin valmistamiseksi
FI103279B1 (fi)	1999-05-31	Menetelmä terapeuttisesti käyttökelpoisten fosfolipidi- tai lipidiliitteisten glykosaminoglykaaniyhdisteiden valmistamiseksi
KR850008657A (ko)	1985-12-21	포름산의 제조방법
ES8705871A1 (es)	1987-05-16	Un procedimiento para preparar un derivado de benzofurano
BR0109048A (pt)	2003-06-03	Processo para a sìntese de citalopram
KR830007550A (ko)	1983-10-21	시클릭아민의 제조방법
BR0009735A (pt)	2002-01-02	Produção de butanodiol
ATE248156T1 (de)	2003-09-15	Verwendung von 7-acyltaxolen zur behandlung von multidrugresistenten zellen
PL342511A1 (en)	2001-06-18	Process for obtaining simvastatin and its derivatives
CA2545052A1 (en)	2005-05-26	Method for the catalytic production of hydrocodone and hydromorphone
KR950032164A (ko)	1995-12-20	사이클로프로판 유도체 및 이의 제조방법
KR900009651A (ko)	1990-07-05	디카르복실산의 모노에스테르 및 그의 제조방법
ATE310040T1 (de)	2005-12-15	Verfahren zur herstellung von polyetheralkoholen
GB1498919A (en)	1978-01-25	Furanose-o-pyridylcarboxylic acid esters
KR840002855A (ko)	1984-07-21	Omt에스테르 유도체의 제조방법
KR910009720A (ko)	1991-06-28	알콕시메틸리덴 에피포도필로톡신 배당체
CA2314514A1 (en)	1999-06-24	Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
KR910006199A (ko)	1991-04-27	카르보닐화합물의 제조 방법
KR910006315A (ko)	1991-04-29	에피포도필로톡신 알트로사이드 유도체
ES2167946T3 (es)	2002-05-16	Esteres de acidos policarboxilicos aromaticos con 2-alquilalcan-1-oles.
JPS55131000A (en)	1980-10-11	Production of 24,25-dihydroxycholesterol derivative
KR910008144A (ko)	1991-05-30	폴리에틸렌 글라이콜 첨가에 의한 세팔렉신 제조 방법
JPS55151549A (en)	1980-11-26	Production of guanidinocaproic ester