GR3031973T3 - A process for preparing a hyaluronic acid fraction having a low polydispersion index - Google Patents
A process for preparing a hyaluronic acid fraction having a low polydispersion indexInfo
- Publication number
- GR3031973T3 GR3031973T3 GR990403066T GR990403066T GR3031973T3 GR 3031973 T3 GR3031973 T3 GR 3031973T3 GR 990403066 T GR990403066 T GR 990403066T GR 990403066 T GR990403066 T GR 990403066T GR 3031973 T3 GR3031973 T3 GR 3031973T3
- Authority
- GR
- Greece
- Prior art keywords
- hyaluronic acid
- preparing
- pct
- acid fraction
- polydispersion index
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
- 229920002674 hyaluronan Polymers 0.000 title abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 3
- 239000000061 acid fraction Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000005708 Sodium hypochlorite Substances 0.000 abstract 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95PD000244A IT1282219B1 (it) | 1995-12-20 | 1995-12-20 | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
| PCT/EP1996/005701 WO1997022629A1 (en) | 1995-12-20 | 1996-12-19 | A process for preparing a hyaluronic acid fraction having a low polydispersion index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3031973T3 true GR3031973T3 (en) | 2000-03-31 |
Family
ID=11391198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR990403066T GR3031973T3 (en) | 1995-12-20 | 1999-11-29 | A process for preparing a hyaluronic acid fraction having a low polydispersion index |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6020484A (el) |
| EP (1) | EP0868437B1 (el) |
| JP (1) | JP4094059B2 (el) |
| AT (1) | ATE184024T1 (el) |
| AU (1) | AU703332B2 (el) |
| CZ (1) | CZ291394B6 (el) |
| DE (1) | DE69604087T2 (el) |
| DK (1) | DK0868437T3 (el) |
| ES (1) | ES2139402T3 (el) |
| GR (1) | GR3031973T3 (el) |
| HU (1) | HU226949B1 (el) |
| IL (1) | IL124909A (el) |
| IT (1) | IT1282219B1 (el) |
| WO (1) | WO1997022629A1 (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1282219B1 (it) * | 1995-12-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
| IT1291452B1 (it) | 1997-04-14 | 1999-01-11 | Fidia Advanced Biopolymers Srl | Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni |
| US20020172712A1 (en) * | 2001-03-19 | 2002-11-21 | Alan Drizen | Antiemetic, anti-motion sustained release drug delivery system |
| US20060153893A1 (en) * | 2002-04-08 | 2006-07-13 | Denki Kagaku Kogyo Kabushiki Kaisha | Therapeutic composition for bone infectious disease |
| BR0309890A (pt) * | 2002-05-09 | 2005-05-10 | Medigenes | Composição farmacêutica contendo plasma sanguìneo, ou soro sanguìneo utilizada no tratamento de lesões, bem como seu método e processo de aplicação |
| BR0310087A (pt) * | 2002-05-17 | 2005-08-16 | Wyeth Corp | Veìculos sólidos injetáveis para ácido hialurÈnico para aplicação de proteìnas osteogênicas |
| AU2003247816A1 (en) * | 2002-07-02 | 2004-01-23 | Procyte Corporation | Compositions containing peptide copper complexes and soft tissue fillers |
| US20060183709A1 (en) * | 2005-02-15 | 2006-08-17 | Ahmad Alkayali | Preparation of low molecular weight hyaluronic acid as a food supplement |
| JP4576583B2 (ja) * | 2005-03-22 | 2010-11-10 | キユーピー株式会社 | ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物 |
| US7323184B2 (en) * | 2005-08-22 | 2008-01-29 | Healagenics, Inc. | Compositions and methods for the treatment of wounds and the reduction of scar formation |
| CN101415731B (zh) * | 2006-02-24 | 2011-11-02 | 丘比株式会社 | 新型低分子透明质酸和/或其盐以及使用其的化妆品、医药组合物和食品组合物 |
| CA2654255A1 (en) * | 2006-06-28 | 2008-01-03 | Novozymes Biopolymer A/S | Compositions with several hyaluronic acid fractions for cosmetic and medical uses |
| WO2008003321A2 (en) * | 2006-07-07 | 2008-01-10 | Novozymes Biopolymer A/S | Compositions with several hyaluronic acid fractions for cosmetic use |
| CN101501075B (zh) | 2006-08-04 | 2013-07-10 | 诺维信生物制药丹麦公司 | 支化透明质酸和制造方法 |
| US8529951B1 (en) | 2007-02-21 | 2013-09-10 | Anand Ramamurthi | Elastogenic cues and methods for using same |
| CA2705850C (en) | 2007-11-13 | 2016-07-19 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
| US20130209531A1 (en) * | 2010-06-08 | 2013-08-15 | University Of Utah Research Foundation | Applications of partially and fully sulfated hyaluronan |
| MX395130B (es) * | 2016-03-02 | 2025-03-24 | Merz Pharma Gmbh & Co Kgaa | Composicion que comprende toxina botulinica |
| CN113512134B (zh) | 2021-07-30 | 2022-05-20 | 梅晔生物医药股份有限公司 | 一种全分子量分布的透明质酸钠及其制备方法和应用 |
| JP7503278B1 (ja) | 2024-02-09 | 2024-06-20 | 株式会社ブルー・スターR&D | 低分子ヒアルロン酸の製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| EP0138572B1 (en) * | 1983-10-11 | 1990-07-25 | FIDIA S.p.A. | Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| GB8713747D0 (en) * | 1987-06-12 | 1987-07-15 | Unilever Plc | Skin treatment composition |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| JPH0675512B2 (ja) * | 1989-03-20 | 1994-09-28 | 株式会社紀文食品 | 低重合度ヒアルロン酸アルカリ塩の製造方法 |
| IT1247175B (it) * | 1991-04-19 | 1994-12-12 | Fidia Spa | Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. |
| IT1260148B (it) * | 1992-04-17 | 1996-03-28 | Fidia Spa | Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo |
| IT1268954B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
| ITPD940054A1 (it) * | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| IT1282219B1 (it) * | 1995-12-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
-
1995
- 1995-12-20 IT IT95PD000244A patent/IT1282219B1/it active IP Right Grant
-
1996
- 1996-12-19 DE DE69604087T patent/DE69604087T2/de not_active Expired - Lifetime
- 1996-12-19 IL IL12490996A patent/IL124909A/en not_active IP Right Cessation
- 1996-12-19 AT AT96944007T patent/ATE184024T1/de active
- 1996-12-19 AU AU13749/97A patent/AU703332B2/en not_active Ceased
- 1996-12-19 ES ES96944007T patent/ES2139402T3/es not_active Expired - Lifetime
- 1996-12-19 CZ CZ19981889A patent/CZ291394B6/cs not_active IP Right Cessation
- 1996-12-19 HU HU9903666A patent/HU226949B1/hu not_active IP Right Cessation
- 1996-12-19 JP JP52251197A patent/JP4094059B2/ja not_active Expired - Fee Related
- 1996-12-19 WO PCT/EP1996/005701 patent/WO1997022629A1/en not_active Ceased
- 1996-12-19 DK DK96944007T patent/DK0868437T3/da active
- 1996-12-19 US US09/096,646 patent/US6020484A/en not_active Expired - Lifetime
- 1996-12-19 EP EP96944007A patent/EP0868437B1/en not_active Expired - Lifetime
-
1999
- 1999-10-26 US US09/426,536 patent/US6232303B1/en not_active Expired - Lifetime
- 1999-11-29 GR GR990403066T patent/GR3031973T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1282219B1 (it) | 1998-03-16 |
| HU226949B1 (en) | 2010-03-29 |
| ITPD950244A0 (el) | 1995-12-20 |
| DE69604087T2 (de) | 2000-02-24 |
| ES2139402T3 (es) | 2000-02-01 |
| WO1997022629A1 (en) | 1997-06-26 |
| DE69604087D1 (de) | 1999-10-07 |
| US6232303B1 (en) | 2001-05-15 |
| DK0868437T3 (da) | 2000-03-13 |
| AU703332B2 (en) | 1999-03-25 |
| EP0868437A1 (en) | 1998-10-07 |
| HUP9903666A3 (en) | 2001-03-28 |
| JP4094059B2 (ja) | 2008-06-04 |
| ATE184024T1 (de) | 1999-09-15 |
| HUP9903666A2 (hu) | 2000-03-28 |
| IL124909A0 (en) | 1999-01-26 |
| IL124909A (en) | 2002-09-12 |
| CZ291394B6 (cs) | 2003-02-12 |
| US6020484A (en) | 2000-02-01 |
| AU1374997A (en) | 1997-07-14 |
| ITPD950244A1 (it) | 1997-06-20 |
| EP0868437B1 (en) | 1999-09-01 |
| JP2000502141A (ja) | 2000-02-22 |
| CZ188998A3 (cs) | 1998-09-16 |
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