ATE184024T1 - Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex - Google Patents

Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex

Info

Publication number: ATE184024T1
Authority: AT; Austria
Prior art keywords: hyaluronic acid; pct; producing; acid fraction; polydispersion index
Prior art date: 1995-12-20

Application number

AT96944007T

Other languages

English (en)

Inventor

Lanfranco Callegaro

Davide Renier

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-20

Filing date

1996-12-19

Publication date

1999-09-15

1996-12-19 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE184024T1 publication Critical patent/ATE184024T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
229920002674 hyaluronan Polymers 0.000 title abstract 3
229960003160 hyaluronic acid Drugs 0.000 title abstract 3
239000000061 acid fraction Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000005708 Sodium hypochlorite Substances 0.000 abstract 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract 1
238000002604 ultrasonography Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT96944007T 1995-12-20 1996-12-19 Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex ATE184024T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT95PD000244A IT1282219B1 (it)	1995-12-20	1995-12-20	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Publications (1)

Publication Number	Publication Date
ATE184024T1 true ATE184024T1 (de)	1999-09-15

Family

ID=11391198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96944007T ATE184024T1 (de)	1995-12-20	1996-12-19	Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex

Country Status (14)

Country	Link
US (2)	US6020484A (de)
EP (1)	EP0868437B1 (de)
JP (1)	JP4094059B2 (de)
AT (1)	ATE184024T1 (de)
AU (1)	AU703332B2 (de)
CZ (1)	CZ291394B6 (de)
DE (1)	DE69604087T2 (de)
DK (1)	DK0868437T3 (de)
ES (1)	ES2139402T3 (de)
GR (1)	GR3031973T3 (de)
HU (1)	HU226949B1 (de)
IL (1)	IL124909A (de)
IT (1)	IT1282219B1 (de)
WO (1)	WO1997022629A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1282219B1 (it) *	1995-12-20	1998-03-16	Fidia Advanced Biopolymers Srl	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1291452B1 (it)	1997-04-14	1999-01-11	Fidia Advanced Biopolymers Srl	Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20020172712A1 (en) *	2001-03-19	2002-11-21	Alan Drizen	Antiemetic, anti-motion sustained release drug delivery system
JPWO2003084571A1 (ja) *	2002-04-08	2005-08-11	電気化学工業株式会社	骨感染症治療用組成物
EP1507543A4 (de) *	2002-05-09	2006-07-26	Cambridgemed Inc	Pharmazeutische zusammensetzung zur behandlung von wunden mit blutplasma oder serum
TWI282283B (en) *	2002-05-17	2007-06-11	Wyeth Corp	Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
KR20050059003A (ko) *	2002-07-02	2005-06-17	프로사이트 코포레이션	펩티드 구리 착화합물 및 연조직 충전제를 함유하는조성물
US20060183709A1 (en) *	2005-02-15	2006-08-17	Ahmad Alkayali	Preparation of low molecular weight hyaluronic acid as a food supplement
JP4576583B2 (ja) *	2005-03-22	2010-11-10	キユーピー株式会社	ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US7323184B2 (en) *	2005-08-22	2008-01-29	Healagenics, Inc.	Compositions and methods for the treatment of wounds and the reduction of scar formation
KR101482800B1 (ko)	2006-02-24	2015-01-14	큐피가부시키가이샤	신규한 저분자량 히알루론산 및/또는 이의 염, 및 이를 이용한 화장료, 의약 조성물 및 식품 조성물
CA2654255A1 (en) *	2006-06-28	2008-01-03	Novozymes Biopolymer A/S	Compositions with several hyaluronic acid fractions for cosmetic and medical uses
WO2008003321A2 (en) *	2006-07-07	2008-01-10	Novozymes Biopolymer A/S	Compositions with several hyaluronic acid fractions for cosmetic use
WO2008014787A1 (en)	2006-08-04	2008-02-07	Novozymes Biopolymer A/S	Branched hyaluronic acid and method of manufacture
US8529951B1 (en)	2007-02-21	2013-09-10	Anand Ramamurthi	Elastogenic cues and methods for using same
CN101855248B (zh) *	2007-11-13	2012-08-22	生物技术通用（以色列）有限公司	用于粘弹性生物聚合物的稀释过滤灭菌方法
US20130209531A1 (en) *	2010-06-08	2013-08-15	University Of Utah Research Foundation	Applications of partially and fully sulfated hyaluronan
CN108463242A (zh) *	2016-03-02	2018-08-28	梅尔兹制药公司	包含肉毒杆菌毒素的组合物
CN113512134B (zh) *	2021-07-30	2022-05-20	梅晔生物医药股份有限公司	一种全分子量分布的透明质酸钠及其制备方法和应用
JP7503278B1 (ja)	2024-02-09	2024-06-20	株式会社ブルー・スターR&D	低分子ヒアルロン酸の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5166331A (en) *	1983-10-10	1992-11-24	Fidia, S.P.A.	Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
FR2553099B1 (fr) *	1983-10-11	1989-09-08	Fidia Spa	Fractions d'acide hyaluronique ayant une activite pharmaceutique, procedes pour leur preparation et compositions pharmaceutiques les contenant
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
GB8713747D0 (en) *	1987-06-12	1987-07-15	Unilever Plc	Skin treatment composition
IT1219587B (it) *	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
JPH0675512B2 (ja) *	1989-03-20	1994-09-28	株式会社紀文食品	低重合度ヒアルロン酸アルカリ塩の製造方法
IT1247175B (it) *	1991-04-19	1994-12-12	Fidia Spa	Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
IT1260148B (it) *	1992-04-17	1996-03-28	Fidia Spa	Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
IT1268954B1 (it) *	1994-03-11	1997-03-18	Fidia Advanced Biopolymers Srl	Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) *	1994-03-23	1995-09-23	Fidia Advanced Biopolymers Srl	Polisaccaridi solfatati
IT1282219B1 (it) *	1995-12-20	1998-03-16	Fidia Advanced Biopolymers Srl	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

1995
- 1995-12-20 IT IT95PD000244A patent/IT1282219B1/it active IP Right Grant
1996
- 1996-12-19 CZ CZ19981889A patent/CZ291394B6/cs not_active IP Right Cessation
- 1996-12-19 DE DE69604087T patent/DE69604087T2/de not_active Expired - Lifetime
- 1996-12-19 ES ES96944007T patent/ES2139402T3/es not_active Expired - Lifetime
- 1996-12-19 JP JP52251197A patent/JP4094059B2/ja not_active Expired - Fee Related
- 1996-12-19 DK DK96944007T patent/DK0868437T3/da active
- 1996-12-19 AT AT96944007T patent/ATE184024T1/de active
- 1996-12-19 AU AU13749/97A patent/AU703332B2/en not_active Ceased
- 1996-12-19 EP EP96944007A patent/EP0868437B1/de not_active Expired - Lifetime
- 1996-12-19 HU HU9903666A patent/HU226949B1/hu not_active IP Right Cessation
- 1996-12-19 WO PCT/EP1996/005701 patent/WO1997022629A1/en not_active Ceased
- 1996-12-19 IL IL12490996A patent/IL124909A/en not_active IP Right Cessation
- 1996-12-19 US US09/096,646 patent/US6020484A/en not_active Expired - Lifetime
1999
- 1999-10-26 US US09/426,536 patent/US6232303B1/en not_active Expired - Lifetime
- 1999-11-29 GR GR990403066T patent/GR3031973T3/el unknown

Also Published As

Publication number	Publication date
HUP9903666A3 (en)	2001-03-28
HU226949B1 (en)	2010-03-29
GR3031973T3 (en)	2000-03-31
JP2000502141A (ja)	2000-02-22
DK0868437T3 (da)	2000-03-13
EP0868437B1 (de)	1999-09-01
HUP9903666A2 (hu)	2000-03-28
IL124909A0 (en)	1999-01-26
ITPD950244A1 (it)	1997-06-20
IT1282219B1 (it)	1998-03-16
DE69604087T2 (de)	2000-02-24
CZ188998A3 (cs)	1998-09-16
JP4094059B2 (ja)	2008-06-04
IL124909A (en)	2002-09-12
CZ291394B6 (cs)	2003-02-12
US6020484A (en)	2000-02-01
ES2139402T3 (es)	2000-02-01
DE69604087D1 (de)	1999-10-07
US6232303B1 (en)	2001-05-15
EP0868437A1 (de)	1998-10-07
ITPD950244A0 (de)	1995-12-20
AU1374997A (en)	1997-07-14
WO1997022629A1 (en)	1997-06-26
AU703332B2 (en)	1999-03-25

Legal Events

Date	Code	Title	Description
2000-02-15	UEP	Publication of translation of european patent specification
2010-03-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
DE69604087D1 (de)	1999-10-07	Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex
ATE204162T1 (de)	2001-09-15	Verfahren zur herstellung von wirkstoffzubereitungen in form einer festen lösung des wirkstoffs in einer polymermatrix
ATE160352T1 (de)	1997-12-15	Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren
DE69521653D1 (de)	2001-08-16	Verfahren zur Kontrolle der Strukturstabilität von Kollagenfasern hergestellt aus Lösungen und Dispersionen, behandelt mit Natriumhydroxid für die Deaktivierung von infektiösen Wirkstoffen
DE69019640D1 (de)	1995-06-29	Verfahren zur herstellung von beta-1,3-glucan in algen.
DE59503194D1 (de)	1998-09-17	Verfahren zur herstellung von stärkeabbauprodukten
ATE204905T1 (de)	2001-09-15	Verfahren zur herstellung von äthylalkohol
DE69018440D1 (de)	1995-05-11	Verfahren zur herstellung von hyaluronsäure mit niedrigem molekulargewicht.
DE58905117D1 (de)	1993-09-09	Verfahren zur herstellung von 4-chlor-2,5-dimethoxyanilin.
DE69403087D1 (de)	1997-06-12	Verfahren zur herstellung von 9-(2-hydroxy)-ethoxy-guanin
DE59608718D1 (de)	2002-03-21	Verfahren zur herstellung von substituierten 4,4'-diaminostilben-2,2'-disulfonsäuresalzen
DE59001106D1 (de)	1993-05-06	Verfahren zur herstellung von 1,1,1-trifluor-2-chlorethan.
DE69514122D1 (de)	2000-01-27	Lösungsmittelfreies verfahren zur herstellung von 2,6 difluorbenzonitril
DE69606041D1 (de)	2000-02-10	Verfahren zur herstellung einer zelluloseformiatelösung durch imprägnierung und kneten von zelluloseplatten
ATE248807T1 (de)	2003-09-15	Verfahren zur herstellung von n-hydrocarbyl- substituierten amiden
ATE176280T1 (de)	1999-02-15	Enzymatisches verfahren zur herstellung von morphin-6-glucuroniden oder substituierten morphin-6-glucuroniden
DE69018261D1 (de)	1995-05-04	Verbessertes verfahren zur herstellung von 1,2,4-triazol-5-on mit niedrigem chlorgehalt.
DE69022830D1 (de)	1995-11-09	Verfahren zur herstellung von stahlblechen zur emaillierung mit verbesserter emailhaftung.
DE59002140D1 (de)	1993-09-09	Verfahren zur herstellung von 2,3,5-trimethyl-p-benzochinon.
ATE192437T1 (de)	2000-05-15	Verfahren zur herstellung von 3-amino-2-chlor-4- alkyl- bzw. 4-cycloalkyl-pyridine
DE69012103D1 (de)	1994-10-06	Verfahren zur herstellung von 4,4'-diisopropylbiphenyl.
DE59106058D1 (de)	1995-08-24	Verfahren zur herstellung von 2,3-difluor-6-nitrophenol.
ATE169912T1 (de)	1998-09-15	Verfahren zur herstellung von 5-amino-1,3- dioxanen
ATE215552T1 (de)	2002-04-15	Verfahren zur herstellung von ivermectin
CA2240682A1 (en)	1997-06-26	A process for preparing a hyaluronic acid fraction having a low polydispersion index