GR860149B - Process of preparing glucagon or derivatives thereof in a transformed yeast strain - Google Patents

Process of preparing glucagon or derivatives thereof in a transformed yeast strain

Info

Publication number: GR860149B
Authority: GR; Greece
Prior art keywords: derivatives; glucagon; yeast strain; transformed yeast; expression
Prior art date: 1985-01-22

Application number

GR860149A

Other languages

English (en)

Inventor

Norris Kjeld

Thim Lars

Hansen Trier Mogens

Norris Fanny

Moody James Alister

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-22

Filing date

1986-01-20

Publication date

1986-05-21

1986-01-20 Application filed by Novo Industri As filed Critical Novo Industri As

1986-05-21 Publication of GR860149B publication Critical patent/GR860149B/el

Links

102000051325 Glucagon Human genes 0.000 title abstract 4
108060003199 Glucagon Proteins 0.000 title abstract 4
240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 4
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 4
229960004666 glucagon Drugs 0.000 title abstract 4
239000012634 fragment Substances 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108700005078 Synthetic Genes Proteins 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Diabetes (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GR860149A 1985-01-22 1986-01-20 Process of preparing glucagon or derivatives thereof in a transformed yeast strain GR860149B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK27885A DK27885A (da)	1985-01-22	1985-01-22	Fremstilling af peptider

Publications (1)

Publication Number	Publication Date
GR860149B true GR860149B (en)	1986-05-21

Family

ID=8091749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR860149A GR860149B (en)	1985-01-22	1986-01-20	Process of preparing glucagon or derivatives thereof in a transformed yeast strain

Country Status (17)

Country	Link
US (1)	US4826763A (el)
EP (1)	EP0189998B1 (el)
JP (2)	JPH0720435B2 (el)
AT (1)	ATE48643T1 (el)
AU (1)	AU587218B2 (el)
CA (1)	CA1294232C (el)
DE (1)	DE3667488D1 (el)
DK (1)	DK27885A (el)
ES (1)	ES8708250A1 (el)
FI (1)	FI87800C (el)
GR (1)	GR860149B (el)
IE (1)	IE58726B1 (el)
MX (1)	MX163776B (el)
NO (1)	NO172185C (el)
NZ (1)	NZ214883A (el)
PT (1)	PT81872B (el)
ZA (1)	ZA86393B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5151354A (en) *	1986-08-21	1992-09-29	Cornelius Hollenberg	Fermentation processes using amylolytic enzyme producing microorganisms
DK175919B1 (da) *	1986-09-19	2005-06-27	Univ Washington	Ekspression af biologisk aktiv faktor XIII
JPH01187499A (ja) *	1988-01-21	1989-07-26	Science & Tech Agency	原子炉解体用ロボット
ZA90533B (en) *	1989-02-01	1990-10-31	Shionogi & Co	A method for the production of glucagon
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5234906A (en) *	1991-01-10	1993-08-10	Amylin Pharmaceuticals, Inc.	Hyperglycemic compositions
US5510459A (en) *	1991-01-17	1996-04-23	Zymogenetics, Inc.	Glucagon antagonists
US5408037A (en) *	1991-01-17	1995-04-18	Zymogenetics, Inc.	Methods for detecting glucagon antagonists
EP0653965B1 (en) *	1992-07-06	1996-05-15	Beckman Instruments, Inc.	Fluid delivery system uitlizing multiple port valve
DK144093D0 (el) *	1993-12-23	1993-12-23	Novo Nordisk As
US5652216A (en) *	1994-05-26	1997-07-29	Novo Nordisk A/S	Pharmaceutical preparation
DK0981362T3 (da) *	1997-05-16	2004-03-15	Ontario Inc 1149336	Anvendelse af GLP-2-agonister, der forbedrer funktionen af den øvre mavetarmkanal
CA2509755A1 (en) *	2002-12-27	2004-07-22	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en)	2002-12-27	2010-02-02	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
CA2748314C (en)	2009-02-03	2018-10-02	Amunix Operating Inc.	Extended recombinant polypeptides and compositions comprising same
JP5839597B2 (ja)	2009-06-08	2016-01-06	アムニクスオペレーティングインコーポレイテッド	グルコース調節ポリペプチド並びにその作成及び使用方法
CN117462693A (zh)	2012-02-27	2024-01-30	阿穆尼克斯运营公司	Xten缀合组合物和制造其的方法
CN112912390B (zh)	2018-10-09	2023-12-15	北京费森尤斯卡比医药有限公司	Glp-1类似物的制备方法
WO2020254479A1 (en)	2019-06-18	2020-12-24	Fresenius Kabi Ipsum S.R.L.	Process for the manufacture of glucagon
EP3753946A1 (en)	2019-06-18	2020-12-23	Fresenius Kabi iPSUM S.r.l.	Improved process for the preparation of high purity glucagon
CN115175920B (zh)	2019-11-13	2025-10-31	阿穆尼克斯制药公司	加条形码的xten多肽及其组合物以及其制备和使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4401759A (en) *	1980-05-01	1983-08-30	Harvey Rubin	Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
DK283180A (da) *	1980-07-01	1982-01-02	Novo Industri As	Polypeptider og derivater deraf
US4546082A (en) *	1982-06-17	1985-10-08	Regents Of The Univ. Of California	E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

1985
- 1985-01-22 DK DK27885A patent/DK27885A/da unknown
1986
- 1986-01-20 FI FI860251A patent/FI87800C/fi not_active IP Right Cessation
- 1986-01-20 NO NO860178A patent/NO172185C/no not_active IP Right Cessation
- 1986-01-20 ZA ZA86393A patent/ZA86393B/xx unknown
- 1986-01-20 DE DE8686300384T patent/DE3667488D1/de not_active Expired - Lifetime
- 1986-01-20 ES ES551042A patent/ES8708250A1/es not_active Expired
- 1986-01-20 AT AT86300384T patent/ATE48643T1/de not_active IP Right Cessation
- 1986-01-20 AU AU52472/86A patent/AU587218B2/en not_active Expired
- 1986-01-20 MX MX1277A patent/MX163776B/es unknown
- 1986-01-20 PT PT81872A patent/PT81872B/pt active IP Right Revival
- 1986-01-20 JP JP61009822A patent/JPH0720435B2/ja not_active Expired - Lifetime
- 1986-01-20 CA CA000499911A patent/CA1294232C/en not_active Expired - Lifetime
- 1986-01-20 IE IE16286A patent/IE58726B1/en not_active IP Right Cessation
- 1986-01-20 EP EP86300384A patent/EP0189998B1/en not_active Expired
- 1986-01-20 GR GR860149A patent/GR860149B/el active IP Right Revival
- 1986-01-21 US US06/820,144 patent/US4826763A/en not_active Expired - Lifetime
- 1986-01-21 NZ NZ214883A patent/NZ214883A/en unknown
1993
- 1993-10-13 JP JP5255433A patent/JPH0746986B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK27885D0 (da)	1985-01-22
NO860178L (no)	1986-07-23
ZA86393B (en)	1987-03-25
DE3667488D1 (de)	1990-01-18
JPH06292594A (ja)	1994-10-21
ES8708250A1 (es)	1987-10-01
JPH0720435B2 (ja)	1995-03-08
JPH0746986B2 (ja)	1995-05-24
FI87800B (fi)	1992-11-13
DK27885A (da)	1986-07-23
NO172185B (no)	1993-03-08
US4826763A (en)	1989-05-02
NO172185C (no)	1993-06-16
CA1294232C (en)	1992-01-14
FI860251A0 (fi)	1986-01-20
IE860162L (en)	1986-07-22
NZ214883A (en)	1988-04-29
IE58726B1 (en)	1993-11-03
ES551042A0 (es)	1987-10-01
PT81872B (pt)	1988-05-27
PT81872A (en)	1986-02-01
FI87800C (fi)	1993-02-25
FI860251L (fi)	1986-07-23
ATE48643T1 (de)	1989-12-15
AU5247286A (en)	1986-07-31
AU587218B2 (en)	1989-08-10
JPS61181398A (ja)	1986-08-14
EP0189998B1 (en)	1989-12-13
EP0189998A1 (en)	1986-08-06
MX163776B (es)	1992-06-22

Legal Events

Date	Code	Title	Description
2002-08-12	ML	Lapse due to non-payment of fees
2003-02-10	MF	Right revoked (revocation)
2006-01-20	MA	Right expired
2022-04-19	NF	Restoration of lapsed right	Effective date: 20030328

Publication	Publication Date	Title
GR860149B (en)	1986-05-21	Process of preparing glucagon or derivatives thereof in a transformed yeast strain
AU2790292A (en)	1993-04-27	Viral recombinant vectors for expression in muscle cells
AU573768B2 (en)	1988-06-23	Hyaluronic acid from streptococci
HUT64595A (en)	1994-01-28	Method for producing mammalian cytokine, il-11
AU6986887A (en)	1987-09-17	Method for preparing carbon fuel for smoking articles and product produced thereby
EP0028033A3 (en)	1981-08-19	Novel dna, cloned dna, recombinant plasmid containing the dna, microorganism containing the recombinant plasmid and process for their production
IL86693A0 (en)	1988-11-30	Novel proteins with factor viii activity,process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
IL68366A (en)	1990-08-31	Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
EP0316738A3 (en)	1989-11-02	Process for the preparation of polyisocyanates containing methane groups, and their use
EP0187991A3 (en)	1988-03-16	Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
ZA887773B (en)	1989-07-26	Interleukin-7
EP0139878A3 (en)	1985-10-02	Production of immune interferon and its mrna
DE3888459D1 (de)	1994-04-21	Zellzüchtung in kontinuierlicher Dispersionskultur mit einem System zur Gewinnung von Zellprodukten.
ZA909122B (en)	1991-09-25	Process for the preparation of genetic vectors for the nerve growth factor expression in eukaryotic cells
AU2179688A (en)	1989-03-02	Recombinant eukaryotic cells production interleukin-2, process and vectors for their preparation and process for the preparation of interleukin-2
AU1987088A (en)	1989-01-19	A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation
EP0292808A3 (en)	1990-09-19	Substituted vinyl cephalosporins, process for their preparation and their use as medicines
AU7265087A (en)	1987-11-12	Animal cell transformant, method for obtaining the transformant and method for producing desired foreign gene product by using the transformant
EP0300425A3 (de)	1991-08-07	Verfahren zur Herstellung von Proteinen in löslicher Form
EP0343388A3 (en)	1990-09-12	Expression of interferon-gamma in methylotrophic yeasts
WO1994011518A3 (en)	1994-11-10	Methods for converting a, ab, and b blood types to o blood type
EP0165759A3 (en)	1987-08-19	Mammalian promotors useful in yeast expression
WU	1981	SYNTHESIS AND SECRETION OF HUMAN IFN-? B IN SACCHAROMYCE CEREVISIAE
ZA874955B (en)	1988-04-27	Functional dna block and plasmid coding for hirudin,transformed yeast,method for preparing hirudin,hirudin obtained and its pharmaceutical use