DK27885A - Fremstilling af peptider - Google Patents

Fremstilling af peptider Download PDF

Info

Publication number: DK27885A
Authority: DK; Denmark
Prior art keywords: derivatives; glucagon; expression; yeast; fragments
Prior art date: 1985-01-22

Application number

DK27885A

Other languages

English (en)

Other versions

DK27885D0 (da

Inventor

Kjeld Norris

Mogens Trier Hansen

Lars Thim

Alister James Moody

Fanny Norris

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-22

Filing date

1985-01-22

Publication date

1986-07-23

1985-01-22 Application filed by Novo Industri As filed Critical Novo Industri As

1985-01-22 Priority to DK27885A priority Critical patent/DK27885A/da

1985-01-22 Publication of DK27885D0 publication Critical patent/DK27885D0/da

1986-01-20 Priority to FI860251A priority patent/FI87800C/fi

1986-01-20 Priority to AU52472/86A priority patent/AU587218B2/en

1986-01-20 Priority to NO860178A priority patent/NO172185C/no

1986-01-20 Priority to ZA86393A priority patent/ZA86393B/xx

1986-01-20 Priority to PT81872A priority patent/PT81872B/pt

1986-01-20 Priority to AT86300384T priority patent/ATE48643T1/de

1986-01-20 Priority to GR860149A priority patent/GR860149B/el

1986-01-20 Priority to DE8686300384T priority patent/DE3667488D1/de

1986-01-20 Priority to EP86300384A priority patent/EP0189998B1/en

1986-01-20 Priority to CA000499911A priority patent/CA1294232C/en

1986-01-20 Priority to IE16286A priority patent/IE58726B1/en

1986-01-20 Priority to ES551042A priority patent/ES8708250A1/es

1986-01-20 Priority to JP61009822A priority patent/JPH0720435B2/ja

1986-01-20 Priority to MX1277A priority patent/MX163776B/es

1986-01-21 Priority to US06/820,144 priority patent/US4826763A/en

1986-01-21 Priority to NZ214883A priority patent/NZ214883A/en

1986-01-21 Priority to DK28386A priority patent/DK156008C/da

1986-07-23 Publication of DK27885A publication Critical patent/DK27885A/da

1993-10-13 Priority to JP5255433A priority patent/JPH0746986B2/ja

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
102000051325 Glucagon Human genes 0.000 abstract 3
108060003199 Glucagon Proteins 0.000 abstract 3
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 3
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 3
229960004666 glucagon Drugs 0.000 abstract 3
239000012634 fragment Substances 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108700005078 Synthetic Genes Proteins 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK27885A 1985-01-22 1985-01-22 Fremstilling af peptider DK27885A (da)

Priority Applications (19)

Application Number	Priority Date	Filing Date	Title
DK27885A DK27885A (da)	1985-01-22	1985-01-22	Fremstilling af peptider
MX1277A MX163776B (es)	1985-01-22	1986-01-20	Procedimiento para preparar glucamon o sus derivados en una cepa de levadura transformada
DE8686300384T DE3667488D1 (de)	1985-01-22	1986-01-20	Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm.
CA000499911A CA1294232C (en)	1985-01-22	1986-01-20	Process for preparing glucagon or derivatives or fragments thereof in yeast
NO860178A NO172185C (no)	1985-01-22	1986-01-20	Fremgangsmaate for fremstilling av glukagon
ZA86393A ZA86393B (en)	1985-01-22	1986-01-20	Process for preparing glucagon or derivatives of fragments thereof in yeast
PT81872A PT81872B (pt)	1985-01-22	1986-01-20	Processo para a preparacao de glucagon ou dos seus derivados em uma estirpe de levedura transformada
AT86300384T ATE48643T1 (de)	1985-01-22	1986-01-20	Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm.
GR860149A GR860149B (en)	1985-01-22	1986-01-20	Process of preparing glucagon or derivatives thereof in a transformed yeast strain
FI860251A FI87800C (fi)	1985-01-22	1986-01-20	Foerfarande foer framstaellning av glukagon i jaest
EP86300384A EP0189998B1 (en)	1985-01-22	1986-01-20	A process for preparing glucagon or derivatives thereof in a transformed yeast strain
AU52472/86A AU587218B2 (en)	1985-01-22	1986-01-20	Process for preparing glucagon or glucagon (1-21) in yeast
IE16286A IE58726B1 (en)	1985-01-22	1986-01-20	A process for preparing glucagon or derivatives thereof in a transformed yeast strain
ES551042A ES8708250A1 (es)	1985-01-22	1986-01-20	Un procedimiento para producir glucagon o fragmentos o derivados del mismo en levadura
JP61009822A JPH0720435B2 (ja)	1985-01-22	1986-01-20	形質転換酵母におけるグルカゴンの製造方法
DK28386A DK156008C (da)	1985-01-22	1986-01-21	Fremgangsmaade til fremstilling a glucagon i en transformeret gaerstamme
US06/820,144 US4826763A (en)	1985-01-22	1986-01-21	Process for preparing glucagon or fragments or derivatives thereof in yeast
NZ214883A NZ214883A (en)	1985-01-22	1986-01-21	Preparation of glucagon by transformant yeast strain
JP5255433A JPH0746986B2 (ja)	1985-01-22	1993-10-13	グルカゴンを生産する形質転換酵母

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK27885A DK27885A (da)	1985-01-22	1985-01-22	Fremstilling af peptider

Publications (2)

Publication Number	Publication Date
DK27885D0 DK27885D0 (da)	1985-01-22
DK27885A true DK27885A (da)	1986-07-23

Family

ID=8091749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK27885A DK27885A (da)	1985-01-22	1985-01-22	Fremstilling af peptider

Country Status (17)

Country	Link
US (1)	US4826763A (da)
EP (1)	EP0189998B1 (da)
JP (2)	JPH0720435B2 (da)
AT (1)	ATE48643T1 (da)
AU (1)	AU587218B2 (da)
CA (1)	CA1294232C (da)
DE (1)	DE3667488D1 (da)
DK (1)	DK27885A (da)
ES (1)	ES8708250A1 (da)
FI (1)	FI87800C (da)
GR (1)	GR860149B (da)
IE (1)	IE58726B1 (da)
MX (1)	MX163776B (da)
NO (1)	NO172185C (da)
NZ (1)	NZ214883A (da)
PT (1)	PT81872B (da)
ZA (1)	ZA86393B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5151354A (en) *	1986-08-21	1992-09-29	Cornelius Hollenberg	Fermentation processes using amylolytic enzyme producing microorganisms
DK175919B1 (da) *	1986-09-19	2005-06-27	Univ Washington	Ekspression af biologisk aktiv faktor XIII
JPH01187499A (ja) *	1988-01-21	1989-07-26	Science & Tech Agency	原子炉解体用ロボット
IL93173A0 (en) *	1989-02-01	1990-11-05	Shionogi & Co	Production of glucagon
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5234906A (en) *	1991-01-10	1993-08-10	Amylin Pharmaceuticals, Inc.	Hyperglycemic compositions
US5510459A (en) *	1991-01-17	1996-04-23	Zymogenetics, Inc.	Glucagon antagonists
US5408037A (en) *	1991-01-17	1995-04-18	Zymogenetics, Inc.	Methods for detecting glucagon antagonists
WO1994001215A1 (en) *	1992-07-06	1994-01-20	Beckman Instruments, Inc.	Fluid delivery system utilizing multiple port valve
DK144093D0 (da) *	1993-12-23	1993-12-23	Novo Nordisk As
US5652216A (en) *	1994-05-26	1997-07-29	Novo Nordisk A/S	Pharmaceutical preparation
ATE253375T1 (de) *	1997-05-16	2003-11-15	Ontario Inc 1149336	Verwendung von glp-2 agonisten zur verbesserung der wirkung des oberen gastrointestinaltraktes
NZ541365A (en) *	2002-12-27	2009-09-25	Diobex Inc	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en) *	2002-12-27	2010-02-02	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
DK3178835T3 (da)	2009-02-03	2019-06-24	Amunix Pharmaceuticals Inc	Forlængede rekombinante polypeptider og sammensætninger omfattende samme
WO2010144508A1 (en)	2009-06-08	2010-12-16	Amunix Operating Inc.	Glucose-regulating polypeptides and methods of making and using same
CN104302408B (zh)	2012-02-27	2016-12-14	阿穆尼克斯运营公司	Xten缀合组合物和制造其的方法
ES2938734T3 (es)	2018-10-09	2023-04-14	Fresenius Kabi Ipsum S R L	Procedimiento para la fabricación de análogos de GLP-1
EP3753946A1 (en)	2019-06-18	2020-12-23	Fresenius Kabi iPSUM S.r.l.	Improved process for the preparation of high purity glucagon
WO2020254479A1 (en)	2019-06-18	2020-12-24	Fresenius Kabi Ipsum S.R.L.	Process for the manufacture of glucagon
EP4058466A1 (en)	2019-11-13	2022-09-21	Amunix Pharmaceuticals, Inc.	Barcoded xten polypeptides and compositions thereof, and methods for making and using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4401759A (en) *	1980-05-01	1983-08-30	Harvey Rubin	Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
DK283180A (da) *	1980-07-01	1982-01-02	Novo Industri As	Polypeptider og derivater deraf
US4546082A (en) *	1982-06-17	1985-10-08	Regents Of The Univ. Of California	E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

1985
- 1985-01-22 DK DK27885A patent/DK27885A/da unknown
1986
- 1986-01-20 JP JP61009822A patent/JPH0720435B2/ja not_active Expired - Lifetime
- 1986-01-20 ZA ZA86393A patent/ZA86393B/xx unknown
- 1986-01-20 AT AT86300384T patent/ATE48643T1/de not_active IP Right Cessation
- 1986-01-20 FI FI860251A patent/FI87800C/fi not_active IP Right Cessation
- 1986-01-20 EP EP86300384A patent/EP0189998B1/en not_active Expired
- 1986-01-20 NO NO860178A patent/NO172185C/no not_active IP Right Cessation
- 1986-01-20 GR GR860149A patent/GR860149B/el active IP Right Revival
- 1986-01-20 MX MX1277A patent/MX163776B/es unknown
- 1986-01-20 DE DE8686300384T patent/DE3667488D1/de not_active Expired - Lifetime
- 1986-01-20 IE IE16286A patent/IE58726B1/en not_active IP Right Cessation
- 1986-01-20 PT PT81872A patent/PT81872B/pt active IP Right Revival
- 1986-01-20 ES ES551042A patent/ES8708250A1/es not_active Expired
- 1986-01-20 CA CA000499911A patent/CA1294232C/en not_active Expired - Lifetime
- 1986-01-20 AU AU52472/86A patent/AU587218B2/en not_active Expired
- 1986-01-21 US US06/820,144 patent/US4826763A/en not_active Expired - Lifetime
- 1986-01-21 NZ NZ214883A patent/NZ214883A/en unknown
1993
- 1993-10-13 JP JP5255433A patent/JPH0746986B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0189998A1 (en)	1986-08-06
MX163776B (es)	1992-06-22
FI87800B (fi)	1992-11-13
NO172185C (no)	1993-06-16
IE860162L (en)	1986-07-22
ES8708250A1 (es)	1987-10-01
EP0189998B1 (en)	1989-12-13
AU587218B2 (en)	1989-08-10
IE58726B1 (en)	1993-11-03
GR860149B (en)	1986-05-21
ZA86393B (en)	1987-03-25
PT81872A (en)	1986-02-01
FI860251L (fi)	1986-07-23
JPS61181398A (ja)	1986-08-14
NZ214883A (en)	1988-04-29
AU5247286A (en)	1986-07-31
FI87800C (fi)	1993-02-25
DE3667488D1 (de)	1990-01-18
FI860251A0 (fi)	1986-01-20
NO860178L (no)	1986-07-23
ATE48643T1 (de)	1989-12-15
NO172185B (no)	1993-03-08
PT81872B (pt)	1988-05-27
DK27885D0 (da)	1985-01-22
US4826763A (en)	1989-05-02
ES551042A0 (es)	1987-10-01
JPH06292594A (ja)	1994-10-21
CA1294232C (en)	1992-01-14
JPH0720435B2 (ja)	1995-03-08
JPH0746986B2 (ja)	1995-05-24

Publication	Publication Date	Title
DK27885D0 (da)	1985-01-22	Fremstilling af peptider
AU2790292A (en)	1993-04-27	Viral recombinant vectors for expression in muscle cells
HU9201712D0 (en)	1992-09-28	A mammalian cytokine, il-11
AU6733487A (en)	1987-06-02	Mammalian interleukin-4
AU4833897A (en)	1998-04-23	Glial mitogenic factors, their preparation and use
AU6569386A (en)	1987-06-04	Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process
NZ221119A (en)	1990-08-28	Proteins with factor viii activity produced by microorganisms produced by genetic engineering
AU2212088A (en)	1989-05-25	Method for culturing recombinant cells
NO871785D0 (no)	1987-04-29	Fremgangsmaate for fremstilling av et proteinprodukt, samt vektorsystem for fremgangsmaatens utfoerelse.
AU3192889A (en)	1989-09-06	T cell activation markers
BR8203507A (pt)	1983-06-07	Polipeptideo sequencia de dna veiculo de expressao microbiana replicavel plasmideo microorganismo cultura microbiana uso de um polipeptideo vacina e processo para producao de um polipeptideo
IL75963A0 (en)	1985-12-31	Interferon derivatives,their preparation and pharmaceutical compositions containing them
FI896261A7 (fi)	1989-12-22	Menetelmä proteiinin tai polypeptidin valmistamiseksi, polypeptidiä ko odaava DNA-sekvenssi, DNA-sekvenssin sisältämä mikro-organismi sekä po lypeptidi ja sen käyttö farmaseuttisena valmisteena
ES2078243T3 (es)	1995-12-16	Mejoras en o relativas a la expresion eucariotica.
EP0276778A3 (en)	1990-01-10	High level expression in e. coli of soluble mature hil-1beta and derivatives with altered biological activity
IL88381A0 (en)	1989-06-30	Peptide structures,immunogens containing them and their uses in the control of fertility
ES2045004T3 (es)	1994-01-16	Procedimiento para la preparacion de proteinas extra\as en estreptomicetos.
EP0165759A3 (en)	1987-08-19	Mammalian promotors useful in yeast expression
WU	1981	SYNTHESIS AND SECRETION OF HUMAN IFN-? B IN SACCHAROMYCE CEREVISIAE
DK28386A (da)	1986-07-23	Fremstilling af peptider
AU3434789A (en)	1989-10-16	The gene encoding phosphoribosylaminoimidazolecarboxylase of schwanniomyces occidentalis