HK24292A - Production of a-21978c derivatives - Google Patents

Production of a-21978c derivatives Download PDF

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Publication number
HK24292A
HK24292A HK242/92A HK24292A HK24292A HK 24292 A HK24292 A HK 24292A HK 242/92 A HK242/92 A HK 242/92A HK 24292 A HK24292 A HK 24292A HK 24292 A HK24292 A HK 24292A
Authority
HK
Hong Kong
Prior art keywords
complex
culture
producing
acid
antibiotic
Prior art date
Application number
HK242/92A
Other languages
English (en)
French (fr)
Inventor
Floyd Milton Huber
Richard Louis Pieper
Anthony Joseph Tietz
Tom Edward Eaton
Lynda Maxine Ford
Otis Webster Godfrey, Jr.
Mary Louise Braun Huber
Milton Joseph Zmijewski, Jr.
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HK24292A publication Critical patent/HK24292A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treating Waste Gases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)

Claims (13)

  1. Verfahren zur Herstellung eines A-21978C-Derivats der Formel (I): worin R eine C₂-C₁₄-Alkanoylgruppe ist, umfassend, daß man die entsprechende C₂-C₁₄-Alkansäure, einen Ester oder ein Salz davon einer A-21978C-produzierenden Kultur zuführt.
  2. Verfahren nach Anspruch 1, worin eine C₂-C₁₄-Alkansäure verwendet wird.
  3. Verfahren nach Anspruch 1, worin ein C₁-C₄-Alkylester der c₂-C₁₄-Alkansäure verwendet wird.
  4. Verfahren nach Anspruch 1, worin ein Salz der C₂-C₁₄-Alkansäure verwendet wird.
  5. Verfahren nach einem der Ansprüche 1 bis 4, worin Caprinsäure, ein Ester oder ein Salz davon verwendet wird.
  6. Verfahren nach Anspruch 1, worin die verwendete C₂-C₁₄-Alkansäure Caprylsäure, Nonansäure, Undecansäure, Laurinsäure oder ein Ester oder Salz davon ist.
  7. Verfahren nach einem der Ansprüche 1 bis 6, worin die A-21978C-produzierende Kultur Streptomyces roseosporus NRRL 11379 oder eine Mutante, Variante oder Rekombinante davon, die die Eigenschaft der Herstellung dieses Antibiotikums in hoher Ausbeute aufweist, umfaßt.
  8. Verfahren nach Anspruch 7, worin die Kultur Streptomyces roseosporus NRRL 15998 oder eine A-21978C-produzierende Mutante, Variante oder Rekombinante davon umfaßt.
  9. Verfahren zur Herstellung des antibiotischen A-21978C-Komplexes oder dessen Faktoren, umfassend, daß man Streptomyces roseosporus NRRL 15998 oder eine A-21978C-produzierende Mutante, Variante oder Rekombinante davon, die die Eigenschaft der Herstellung dieses Antibiotikums in hoher Ausbeute aufweist, in einem Kulturmedium, das assimilierbare Quellen für Kohlenstoff, Stickstoff und anorganische Salze enthält, unter aeroben Submersfermentationsbedingungen züchtet, bis A-21978C-Antibiotika produziert werden und, falls erwünscht, den hergestellten A-21978C-Komplex abtrennt und weiterhin, falls erwünscht, die einzelnen A-21978C-Faktoren von dem Komplex trennt.
  10. Verfahren zur Herstellung des antibiotischen A-21978C-Komplexes nach Anspruch 9, das die zusätzliche Stufe einschließt, daß man den A-21978C-Komplex von dem Kulturmedium abtrennt.
  11. Verfahren zur Herstellung der einzelnen antibiotischen A-21978C-Faktoren C₀, C₁, C₂, C₃, C₄ oder C₅ wie in Anspruch 9 oder 10 beansprucht, das die zusätzliche Stufe einschließt, daß man die einzelnen Faktoren von dem A-21978C-antibiotischen Komplex abtrennt.
  12. Biologisch reine Kultur von Streptomyces roseosporus NRRL 15998 oder eine Mutante, Variante oder Rekombinante davon, die die Eigenschaft der Produktion von A-21978C-Antibiotika in hoher Ausbeute aufweist.
  13. Streptomyces roseosporus NRRL 15998.
HK242/92A 1984-10-09 1992-04-02 Production of a-21978c derivatives HK24292A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65897984A 1984-10-09 1984-10-09

Publications (1)

Publication Number Publication Date
HK24292A true HK24292A (en) 1992-04-10

Family

ID=24643546

Family Applications (1)

Application Number Title Priority Date Filing Date
HK242/92A HK24292A (en) 1984-10-09 1992-04-02 Production of a-21978c derivatives

Country Status (27)

Country Link
EP (1) EP0178152B1 (de)
JP (1) JPH0787796B2 (de)
KR (1) KR890000800B1 (de)
CN (2) CN1051200A (de)
AT (1) ATE67788T1 (de)
AU (2) AU4837785A (de)
BG (1) BG47040A3 (de)
CS (2) CS276983B6 (de)
CY (1) CY1633A (de)
DD (2) DD238068A5 (de)
DE (1) DE3584218D1 (de)
DK (2) DK165416C (de)
EG (1) EG17619A (de)
ES (2) ES8700862A1 (de)
FI (1) FI82075C (de)
GR (1) GR852432B (de)
HK (1) HK24292A (de)
HU (1) HU196845B (de)
IE (1) IE58655B1 (de)
IL (1) IL76608A (de)
NZ (1) NZ213731A (de)
PH (1) PH21217A (de)
PL (1) PL152359B1 (de)
PT (1) PT81265B (de)
SG (1) SG3292G (de)
SU (1) SU1452484A3 (de)
ZA (1) ZA857759B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0294990A3 (de) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographisches Reinigungsverfahren
US4930494A (en) * 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung
CN1425025A (zh) 1999-12-15 2003-06-18 卡比斯特制药公司 作为抗菌剂的新颖的脂肽
WO2001044274A1 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
BRPI0923567A2 (pt) 2008-12-22 2016-09-27 Cubist Pharm Inc agentes antibactericidas novos para o tratamento de infecções gram positivas
RU2607526C2 (ru) 2009-11-23 2017-01-10 Кьюбист Фармасьютикалз ЭлЭлСи Липопептидные композиции и родственные способы
CN103857440B (zh) * 2011-06-22 2018-09-25 维奥姆生物科学有限公司 基于缀合物的抗真菌和抗细菌前药
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN107964557B (zh) * 2018-01-17 2020-11-20 自然资源部第三海洋研究所 一种提高芽孢杆菌抗菌脂肽产量的发酵方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208403A (en) * 1978-10-16 1980-06-17 Eli Lilly And Company A-21978 Antibiotics and process for their production
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production

Also Published As

Publication number Publication date
EP0178152B1 (de) 1991-09-25
DK148791A (da) 1991-08-21
SG3292G (en) 1992-03-20
DD247023A5 (de) 1987-06-24
CS276983B6 (en) 1992-11-18
EG17619A (en) 1991-03-30
PL255683A1 (en) 1986-07-29
ZA857759B (en) 1987-05-27
FI82075B (fi) 1990-09-28
DK165757B (da) 1993-01-11
ES547689A0 (es) 1986-11-16
BG47040A3 (en) 1990-04-16
FI82075C (fi) 1991-01-10
DK165416C (da) 1993-04-05
AU634766B2 (en) 1993-03-04
PT81265A (en) 1985-11-01
DK148791D0 (da) 1991-08-21
NZ213731A (en) 1988-04-29
AU5375290A (en) 1990-11-01
FI853910A0 (fi) 1985-10-08
IL76608A (en) 1991-03-10
ES553603A0 (es) 1987-11-01
FI853910L (fi) 1986-04-10
SU1452484A3 (ru) 1989-01-15
ATE67788T1 (de) 1991-10-15
HUT39782A (en) 1986-10-29
KR860003335A (ko) 1986-05-23
PT81265B (pt) 1988-02-17
DK165757C (da) 1993-06-07
JPS6192588A (ja) 1986-05-10
DK457585A (da) 1986-04-10
CS719885A3 (en) 1992-03-18
CN1051200A (zh) 1991-05-08
IE852466L (en) 1986-04-09
DK457585D0 (da) 1985-10-08
DD238068A5 (de) 1986-08-06
EP0178152A2 (de) 1986-04-16
DE3584218D1 (de) 1991-10-31
ES8800362A1 (es) 1987-11-01
CN1013120B (zh) 1991-07-10
JPH0787796B2 (ja) 1995-09-27
IE58655B1 (en) 1993-11-03
PH21217A (en) 1987-08-21
HU196845B (en) 1989-01-30
CS819286A3 (en) 1992-03-18
DK165416B (da) 1992-11-23
AU4837785A (en) 1986-04-17
ES8700862A1 (es) 1986-11-16
CY1633A (en) 1992-11-06
GR852432B (de) 1986-02-10
IL76608A0 (en) 1986-02-28
EP0178152A3 (en) 1988-11-02
CN85107552A (zh) 1987-05-20
PL152359B1 (en) 1990-12-31
CS276978B6 (en) 1992-11-18
KR890000800B1 (ko) 1989-04-07

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Effective date: 20051007