HK24292A - Production of a-21978c derivatives - Google Patents
Production of a-21978c derivatives Download PDFInfo
- Publication number
- HK24292A HK24292A HK242/92A HK24292A HK24292A HK 24292 A HK24292 A HK 24292A HK 242/92 A HK242/92 A HK 242/92A HK 24292 A HK24292 A HK 24292A HK 24292 A HK24292 A HK 24292A
- Authority
- HK
- Hong Kong
- Prior art keywords
- complex
- culture
- producing
- acid
- antibiotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Treating Waste Gases (AREA)
- Pyrane Compounds (AREA)
Claims (13)
- Procedé pour la préparation d'un dérivé de A-21978C répondant à la formule (I) : dans laquelle R représente un groupe alcanoyle en C₂-C₁₄, ce procédé consistant à procurer 1'acide alcanoïque en C₂-C₁₄ correspondant, son ester ou son sel, à une culture productrice de A-21978C.
- Procédé selon la revendication 1, dans lequel on utilise un acide alcanoïque en C₂-C₁₄.
- Procédé selon la revendication 1, dans lequel on utilise un ester alkylique en C₁-C₄ de l'acide alcanoïque en C₂-C₁₄.
- Procédé selon la revendication 1, dans lequel on utilise un sel de l'acide alcanoïque en C₂-C₁₄.
- Procédé selon l'une quelconque des revendications 1 à 4, dans lequel on utilise l'acide caprique, un de ses esters ou un de ses sels.
- Procédé selon la revendication 1, dans lequel l'acide alcanoïque en C₂-C₁₄ utilisé est l'acide caprylique, l'acide nonanoïque, l'acide undécanoïque, 1'acide laurique ou un ester ou un sel de ces derniers.
- Procédé selon l'une quelconque des revendications 1 à 6, dans lequel la culture productrice de A-21978C comprend Streptomyces roseosporus NRRL 11379 ou un mutant, un variant ou encore un recombinant de ce dernier, qui garde la caractéristique de produire l'antibiotique avec un rendement élevé.
- Procédé selon la revendication 7, dans lequel la culture comprend Streptomyces roseosporus NRRL 15998 ou un mutant, un variant ou encore un recombinant de ce dernier, producteur de A-21978C.
- Procédé pour la préparation du complexe antibiotique A-21978C ou de ses facteurs, consistant à cultiver Streptomyces roseosporus NRRL 15998 ou un mutant, un variant ou encore un recombinant de ce dernier, producteur de A-21978C, qui garde la caractéristique de produire l'antibiotique avec un rendement élevé, dans un milieu de culture contenant des sources assimilables de carbone, de l'azote, ainsi que des sels inorganiques, dans des conditions de fermentation aérobie submergée jusqu'à 1'obtention des antibiotiques A-21978C et si on le souhaite, séparer le complexe A-21978C obtenu et encore, si on le souhaite, séparer les facteurs individuels de A-21978C du complexe.
- Procédé pour la préparation du complexe antibiotique A-21978C selon la revendication 9, qui implique l'étape supplémentaire consistant à séparer le complexe A-21978C du milieu de culture.
- Procédé pour la préparation des facteurs individuels de l'antibiotique A-21978C C₀, C₁, C₂, C₃, C₄ ou C₅ selon la revendication 9 ou 10, qui englobe l'étape supplémentaire de séparer les facteurs individuels du complexe antibiotique A-21978C.
- Culture biologiquement pure de Streptomyces roseosporus NRRL 15998 ou d'un de ses mutants, variants ou recombinants, qui garde la caractéristique de produire les antibiotiques A-21978C avec un rendement élevé.
- Streptomyces roseosporus NRRL 15998.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65897984A | 1984-10-09 | 1984-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK24292A true HK24292A (en) | 1992-04-10 |
Family
ID=24643546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK242/92A HK24292A (en) | 1984-10-09 | 1992-04-02 | Production of a-21978c derivatives |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0178152B1 (fr) |
| JP (1) | JPH0787796B2 (fr) |
| KR (1) | KR890000800B1 (fr) |
| CN (2) | CN1013120B (fr) |
| AT (1) | ATE67788T1 (fr) |
| AU (2) | AU4837785A (fr) |
| BG (1) | BG47040A3 (fr) |
| CS (2) | CS276978B6 (fr) |
| CY (1) | CY1633A (fr) |
| DD (2) | DD238068A5 (fr) |
| DE (1) | DE3584218D1 (fr) |
| DK (2) | DK165416C (fr) |
| EG (1) | EG17619A (fr) |
| ES (2) | ES8700862A1 (fr) |
| FI (1) | FI82075C (fr) |
| GR (1) | GR852432B (fr) |
| HK (1) | HK24292A (fr) |
| HU (1) | HU196845B (fr) |
| IE (1) | IE58655B1 (fr) |
| IL (1) | IL76608A (fr) |
| NZ (1) | NZ213731A (fr) |
| PH (1) | PH21217A (fr) |
| PL (1) | PL152359B1 (fr) |
| PT (1) | PT81265B (fr) |
| SG (1) | SG3292G (fr) |
| SU (1) | SU1452484A3 (fr) |
| ZA (1) | ZA857759B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0294990A3 (fr) * | 1987-06-10 | 1990-05-09 | Eli Lilly And Company | Procédé de purification chromatographique |
| US4930494A (en) * | 1988-03-09 | 1990-06-05 | Olympus Optical Co., Ltd. | Apparatus for bending an insertion section of an endoscope using a shape memory alloy |
| US4977083A (en) * | 1988-04-11 | 1990-12-11 | Eli Lilly And Company | Processes for preparing A54145 compounds |
| DE3832362A1 (de) * | 1988-09-23 | 1990-03-29 | Sandoz Ag | Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung |
| IL150223A0 (en) | 1999-12-15 | 2002-12-01 | Cubist Pharm Inc | Lipopeptides and pharmaceutical compositions containing the same |
| CN1423656A (zh) * | 1999-12-15 | 2003-06-11 | 卡比斯特制药公司 | 作为抗菌剂的脂肽 |
| US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
| DK2379580T3 (da) | 2008-12-22 | 2014-01-20 | Cubist Pharm Inc | Hidtil ukendte antibakterielle midler til behandling af gram-positive infektioner |
| PT2504353T (pt) | 2009-11-23 | 2018-10-18 | Cubist Pharmaceuticals Llc | Composições de lipopéptido e métodos relacionados |
| EP2723452A2 (fr) | 2011-06-22 | 2014-04-30 | Vyome Biosciences Pvt Ltd | Promédicaments antifongiques et antibactériens à base d'un conjugué |
| IT201600127655A1 (it) | 2016-12-16 | 2018-06-16 | Gnosis Spa | Processo per la purificazione di antibiotici lipopolipeptidici |
| CN107964557B (zh) * | 2018-01-17 | 2020-11-20 | 自然资源部第三海洋研究所 | 一种提高芽孢杆菌抗菌脂肽产量的发酵方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208403A (en) * | 1978-10-16 | 1980-06-17 | Eli Lilly And Company | A-21978 Antibiotics and process for their production |
| IL68700A0 (en) * | 1982-05-21 | 1983-09-30 | Lilly Co Eli | Improvements relating to a-21978c cyclic peptide derivatives and their production |
-
1985
- 1985-10-08 DD DD85281515A patent/DD238068A5/de not_active IP Right Cessation
- 1985-10-08 CN CN85107552A patent/CN1013120B/zh not_active Expired
- 1985-10-08 CS CS857198A patent/CS276978B6/cs not_active IP Right Cessation
- 1985-10-08 CN CN90109304A patent/CN1051200A/zh active Pending
- 1985-10-08 PH PH32894A patent/PH21217A/en unknown
- 1985-10-08 ES ES547689A patent/ES8700862A1/es not_active Expired
- 1985-10-08 EG EG634/85A patent/EG17619A/xx active
- 1985-10-08 HU HU853912A patent/HU196845B/hu unknown
- 1985-10-08 DE DE8585307185T patent/DE3584218D1/de not_active Expired - Lifetime
- 1985-10-08 KR KR1019850007397A patent/KR890000800B1/ko not_active Expired
- 1985-10-08 IE IE246685A patent/IE58655B1/en not_active IP Right Cessation
- 1985-10-08 AT AT85307185T patent/ATE67788T1/de not_active IP Right Cessation
- 1985-10-08 IL IL76608A patent/IL76608A/xx not_active IP Right Cessation
- 1985-10-08 DK DK457585A patent/DK165416C/da not_active IP Right Cessation
- 1985-10-08 EP EP85307185A patent/EP0178152B1/fr not_active Expired - Lifetime
- 1985-10-08 NZ NZ213731A patent/NZ213731A/en unknown
- 1985-10-08 GR GR852432A patent/GR852432B/el unknown
- 1985-10-08 BG BG071957A patent/BG47040A3/xx unknown
- 1985-10-08 SU SU853964395A patent/SU1452484A3/ru active
- 1985-10-08 JP JP60225925A patent/JPH0787796B2/ja not_active Expired - Lifetime
- 1985-10-08 PL PL1985255683A patent/PL152359B1/pl unknown
- 1985-10-08 PT PT81265A patent/PT81265B/pt unknown
- 1985-10-08 CS CS868192A patent/CS276983B6/cs not_active IP Right Cessation
- 1985-10-08 ZA ZA857759A patent/ZA857759B/xx unknown
- 1985-10-08 FI FI853910A patent/FI82075C/fi not_active IP Right Cessation
- 1985-10-08 AU AU48377/85A patent/AU4837785A/en not_active Abandoned
-
1986
- 1986-03-25 DD DD86288284A patent/DD247023A5/de unknown
- 1986-04-01 ES ES553603A patent/ES8800362A1/es not_active Expired
-
1990
- 1990-04-20 AU AU53752/90A patent/AU634766B2/en not_active Expired
-
1991
- 1991-08-21 DK DK148791A patent/DK165757C/da not_active IP Right Cessation
-
1992
- 1992-01-11 SG SG32/92A patent/SG3292G/en unknown
- 1992-04-02 HK HK242/92A patent/HK24292A/en not_active IP Right Cessation
- 1992-11-06 CY CY1633A patent/CY1633A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PE | Patent expired |
Effective date: 20051007 |