HK34896A - Novel polypeptide and production thereof - Google Patents

Novel polypeptide and production thereof Download PDF

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Publication number
HK34896A
HK34896A HK34896A HK34896A HK34896A HK 34896 A HK34896 A HK 34896A HK 34896 A HK34896 A HK 34896A HK 34896 A HK34896 A HK 34896A HK 34896 A HK34896 A HK 34896A
Authority
HK
Hong Kong
Prior art keywords
polypeptide
dna
cells
amino acid
fragment
Prior art date
Application number
HK34896A
Other languages
German (de)
English (en)
Inventor
Nakahama Kazuo
Kaisho Yoshihiko
Yoshimura Koji
Sasada Reiko
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27463714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK34896(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of HK34896A publication Critical patent/HK34896A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (10)

  1. Procédé de préparation d'un polypeptide (I) comportant, dans sa molécule, la séquence d'acides aminés suivante (II): ce procédé comprenant la culture, dans un milieu de culture, de transformants transformés par un vecteur comportant une séquence d'ADN codant pour le polypeptide, l'accumulation du polypeptide et le recueillement du polypeptide.
  2. Procédé conforme à la revendication 1 dans lequel le polypeptide (I) préparé possède la séquence d'acides aminés suivante (II') :
  3. Procédé de préparation d'une séquence d'ADN codant pour un polypeptide (I) comportant, dans sa molécule, la séquence d'acide aminés suivante (II) : lequel procédé comprend l'isolation du mARN à partir de cellules produisant le polypeptide (I).
  4. Procédé de préparation d'un vecteur comportant une séquence d'ADN codant pour un polypeptide (I) qui comporte, dans sa molécule, la séquence d'acides aminés (II) suivante: lequel procédé comprend l'insertion d'une séquence d'ADN préparée selon la revendication 3, dans un vecteur en aval d'un promoteur.
  5. Procédé de préparation d'un transformant transformé par un vecteur comportant une séquence d'ADN codant pour le polypeptide (I) comportant, dans sa molécule, la séquence d'acide aminé (II) suivante: lequel procédé comprend la transformation d'une cellule hôte par le vecteur préparé selon la revendication 4.
  6. Procédé conforme à la revendication 5 dans lequel le transformant préparé est Escherichia coli BL21 (DE3)/pENGFT102 (FERM BP-2420).
  7. Procédé conforme à la revendication 5 dans lequel le transformant préparé est Saccharomyces cerevisiae TB39⁻/pANT341T (FERM BP-2530).
  8. Procédé conforme à la revendication 5 dans lequel le transformant préparé est Escherichia coli BL21 (DE3)/pENGFT102 (FERM BP-2529).
  9. Procédé conforme à la revendication 5 dans lequel le transformant préparé est L-H14-1 (FERM BP-2754).
HK34896A 1989-03-10 1996-02-29 Novel polypeptide and production thereof HK34896A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5898389 1989-03-10
JP12771089 1989-05-19
JP19365489 1989-07-26
JP26361389 1989-10-09

Publications (1)

Publication Number Publication Date
HK34896A true HK34896A (en) 1996-03-08

Family

ID=27463714

Family Applications (1)

Application Number Title Priority Date Filing Date
HK34896A HK34896A (en) 1989-03-10 1996-02-29 Novel polypeptide and production thereof

Country Status (11)

Country Link
US (1) US6709837B1 (fr)
EP (1) EP0386752B1 (fr)
JP (1) JPH0780904B2 (fr)
KR (1) KR0132425B1 (fr)
AT (1) ATE111521T1 (fr)
CA (1) CA2011833C (fr)
DE (1) DE69012377T2 (fr)
DK (1) DK0386752T3 (fr)
ES (1) ES2059854T3 (fr)
HK (1) HK34896A (fr)
IE (1) IE65361B1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656435A (en) * 1989-08-28 1997-08-12 Takeda Chemical Industries, Ltd. Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof
IL95511A (en) * 1989-08-30 2000-10-31 Max Planck Gesellschaft Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US6933276B1 (en) 1989-08-30 2005-08-23 Regeneron Pharmaceuticals, Inc. Methods of treating peripheral neuropathies using neurotrophin-3
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence
EP0499993B1 (fr) * 1991-02-18 1997-06-11 Takeda Chemical Industries, Ltd. Méthode pour la production du NGF-2 humain
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
ATE206056T1 (de) * 1992-06-08 2001-10-15 Takeda Chemical Industries Ltd Therapeutisches agens für neutropenie
IL107831A0 (en) * 1992-12-02 1994-05-30 Zymogenetics Inc Novel human amyloid protein precursor homolog and kunitz-type inhibitor
JP2732005B2 (ja) * 1992-12-14 1998-03-25 眞一 富永 ヒトｓｔ２をコードするｄｎａ、該ｄｎａの発現産物、該ｄｎａを発現させることによる発現産物の製造方法
JPH07246040A (ja) * 1993-07-06 1995-09-26 Takeda Chem Ind Ltd ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物
US5877016A (en) * 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5681931A (en) * 1995-03-15 1997-10-28 Becton, Dickinson And Company Human restrictin
US5864018A (en) * 1996-04-16 1999-01-26 Schering Aktiengesellschaft Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor
EP0942964A2 (fr) * 1996-11-22 1999-09-22 Human Genome Sciences, Inc. Polymerases thermostables a fidelite modifiee

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor

Also Published As

Publication number Publication date
DE69012377T2 (de) 1995-05-04
ES2059854T3 (es) 1994-11-16
JPH0780904B2 (ja) 1995-08-30
ATE111521T1 (de) 1994-09-15
EP0386752B1 (fr) 1994-09-14
US6709837B1 (en) 2004-03-23
EP0386752A1 (fr) 1990-09-12
IE65361B1 (en) 1995-10-18
CA2011833C (fr) 2002-11-05
DE69012377D1 (de) 1994-10-20
IE900785L (en) 1990-09-10
CA2011833A1 (fr) 1990-09-10
DK0386752T3 (da) 1994-12-05
KR0132425B1 (ko) 1998-04-14
JPH03204897A (ja) 1991-09-06
KR900014428A (ko) 1990-10-23

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