HRP20010833A2 - Short-chain peptide dye conjugates used as contrast agents for optical diagnostics - Google Patents

Short-chain peptide dye conjugates used as contrast agents for optical diagnostics Download PDF

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Publication number
HRP20010833A2
HRP20010833A2 HR20010833A HRP20010833A HRP20010833A2 HR P20010833 A2 HRP20010833 A2 HR P20010833A2 HR 20010833 A HR20010833 A HR 20010833A HR P20010833 A HRP20010833 A HR P20010833A HR P20010833 A2 HRP20010833 A2 HR P20010833A2
Authority
HR
Croatia
Prior art keywords
image
residue
peptide
compounds according
dye
Prior art date
Application number
HR20010833A
Other languages
English (en)
Croatian (hr)
Inventor
Kai Licha
Andreas Becker
Wolfhard Semmler
Bertram Wiedenmann
Carsten Hessenius
Rudolf Volkmer-Engert
Jens Schneider-Mergener
Sarah Bhargava
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Publication of HRP20010833A2 publication Critical patent/HRP20010833A2/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/083—Neurotensin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Indole Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Testing Of Optical Devices Or Fibers (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
HR20010833A 1999-04-09 2000-03-28 Short-chain peptide dye conjugates used as contrast agents for optical diagnostics HRP20010833A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19917713A DE19917713A1 (de) 1999-04-09 1999-04-09 Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
PCT/EP2000/002697 WO2000061194A2 (fr) 1999-04-09 2000-03-28 Conjugues de colorants ayant des peptides a courte chaine utilises comme agents de contraste pour le diagnostic optique

Publications (1)

Publication Number Publication Date
HRP20010833A2 true HRP20010833A2 (en) 2004-08-31

Family

ID=7905136

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010833A HRP20010833A2 (en) 1999-04-09 2000-03-28 Short-chain peptide dye conjugates used as contrast agents for optical diagnostics

Country Status (28)

Country Link
EP (2) EP1281405B1 (fr)
JP (1) JP2002541219A (fr)
KR (1) KR20020000555A (fr)
CN (1) CN1351505A (fr)
AT (2) ATE259246T1 (fr)
AU (1) AU769392B2 (fr)
BG (1) BG105988A (fr)
BR (1) BR0009658A (fr)
CA (1) CA2368490A1 (fr)
CZ (1) CZ20013562A3 (fr)
DE (3) DE19917713A1 (fr)
DK (1) DK1176987T3 (fr)
EE (1) EE200100521A (fr)
ES (2) ES2215641T3 (fr)
HK (1) HK1046867A1 (fr)
HR (1) HRP20010833A2 (fr)
HU (1) HUP0202990A3 (fr)
IL (1) IL145596A0 (fr)
MX (1) MXPA01010174A (fr)
NO (1) NO20014911L (fr)
NZ (2) NZ514533A (fr)
PL (1) PL351766A1 (fr)
PT (1) PT1176987E (fr)
RU (1) RU2001129707A (fr)
SK (1) SK14152001A3 (fr)
WO (1) WO2000061194A2 (fr)
YU (1) YU70501A (fr)
ZA (1) ZA200109238B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2072002A (en) 2000-11-28 2002-06-11 Mondobiotech Sa Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
KR100406460B1 (ko) * 2001-09-29 2003-11-19 한국과학기술연구원 커플링된 스티릴시아닌 색소 및 그의 제조 방법
IL148921A0 (en) 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
JP4599948B2 (ja) * 2003-09-18 2010-12-15 チッソ株式会社 α−フルオロアクリレート化合物、組成物およびその重合体
GB0328060D0 (en) * 2003-12-04 2004-01-07 Sod Conseils Rech Applic Botulinum toxin treatment
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
NO20035681D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av lungekreft
NO20035682D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av ösofagkreft og Barretts ösofag
RU2393167C2 (ru) * 2004-06-16 2010-06-27 Джи-И Хелткер АС Пептидные соединения
EP1679082A1 (fr) * 2005-01-07 2006-07-12 Schering AG Utilisation de colorants de type cyanine pour le diagnostic de maladies proliférantes
CA2591942A1 (fr) 2005-01-13 2006-07-20 Cinvention Ag Materiaux composites contenant des nanoparticules de carbone
KR100716840B1 (ko) * 2005-08-29 2007-05-09 삼성전기주식회사 노트북 컴퓨터 자동개폐장치
GB0615211D0 (en) * 2006-07-31 2006-09-06 Ge Healthcare Uk Ltd Asymmetric flouro-substituted polymethine dyes
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
CA3162577C (fr) 2008-05-20 2023-09-26 University Health Network Dispositif et procede pour imagerie et surveillance par fluorescence
CZ304948B6 (cs) * 2013-01-02 2015-02-04 Vysoká škola chemicko-technologická v Praze Využití polymethiniových solí jako senzorů pro nádorové markery
WO2016011534A1 (fr) 2014-07-24 2016-01-28 University Health Network Collecte et analyse de données à des fins de diagnostic
JP2020066637A (ja) * 2017-02-27 2020-04-30 富士フイルム株式会社 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素
JP7747660B2 (ja) 2020-06-23 2025-10-01 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 近赤外シアニン色素およびそのコンジュゲート
CN118048050B (zh) * 2024-04-16 2024-06-25 南京诺源医疗器械有限公司 一种七甲川菁近红外荧光染料及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627027A (en) * 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
JPS6488537A (en) * 1987-09-30 1989-04-03 Fuji Photo Film Co Ltd Silver halide photographic sensitive material
JPS6491134A (en) * 1987-10-02 1989-04-10 Fuji Photo Film Co Ltd Silver halide photographic sensitive material
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
JP3137349B2 (ja) * 1991-03-27 2001-02-19 生化学工業株式会社 ペプチド誘導体
EP0591820A1 (fr) * 1992-10-05 1994-04-13 E.I. Du Pont De Nemours And Company Colorants absorbant dans le proche infrarouge préparés à partir de sels de stenhouse
JPH06172212A (ja) * 1992-12-10 1994-06-21 Tsumura & Co 医薬組成物
JPH06202260A (ja) * 1993-01-07 1994-07-22 Konica Corp ハロゲン化銀写真感光材料及びその処理方法
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5824772A (en) * 1995-04-04 1998-10-20 Advanced Bioconcept, Inc. Fluorescent somatostatin
JP2000508709A (ja) * 1996-04-19 2000-07-11 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド スクアラート染料類および蛍光配列決定法におけるそれらの使用
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
GB9712524D0 (en) * 1997-06-16 1997-08-20 Nycomed Imaging As Method
DE19817517A1 (de) * 1998-04-09 1999-10-14 Diagnostikforschung Inst Neue Benzylguanidinderivate für die Therapie, In-vivo- und In-vitro-Diagnostik
US6284223B1 (en) * 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity

Also Published As

Publication number Publication date
AU4291100A (en) 2000-11-14
EP1281405B1 (fr) 2009-01-21
ZA200109238B (en) 2003-02-10
EP1176987A2 (fr) 2002-02-06
DE50015530D1 (de) 2009-03-12
NZ514533A (en) 2003-09-26
IL145596A0 (en) 2002-06-30
HUP0202990A3 (en) 2005-09-28
WO2000061194A3 (fr) 2001-11-08
ATE421341T1 (de) 2009-02-15
ES2321586T3 (es) 2009-06-09
JP2002541219A (ja) 2002-12-03
CZ20013562A3 (cs) 2002-05-15
NZ522136A (en) 2004-05-28
EP1281405A3 (fr) 2003-02-12
PL351766A1 (en) 2003-06-16
YU70501A (sh) 2004-05-12
ES2215641T3 (es) 2004-10-16
EP1281405A2 (fr) 2003-02-05
HUP0202990A2 (hu) 2002-12-28
DK1176987T3 (da) 2004-06-14
NO20014911D0 (no) 2001-10-09
PT1176987E (pt) 2004-06-30
RU2001129707A (ru) 2003-09-27
HK1046867A1 (zh) 2003-01-30
NO20014911L (no) 2001-12-06
DE19917713A1 (de) 2000-10-19
KR20020000555A (ko) 2002-01-05
EP1176987B1 (fr) 2004-02-11
ATE259246T1 (de) 2004-02-15
SK14152001A3 (sk) 2002-04-04
BR0009658A (pt) 2002-01-15
AU769392B2 (en) 2004-01-22
CN1351505A (zh) 2002-05-29
BG105988A (en) 2002-06-28
DE50005261D1 (de) 2004-03-18
MXPA01010174A (es) 2003-08-20
WO2000061194A2 (fr) 2000-10-19
EE200100521A (et) 2002-12-16
CA2368490A1 (fr) 2000-10-19

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A1OB Publication of a patent application
OBST Application withdrawn