HRP20020220A2 - Thienoisoxazolyl- and thienilpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists - Google Patents

Thienoisoxazolyl- and thienilpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists Download PDF

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Publication number
HRP20020220A2
HRP20020220A2 HR20020220A HRP20020220A HRP20020220A2 HR P20020220 A2 HRP20020220 A2 HR P20020220A2 HR 20020220 A HR20020220 A HR 20020220A HR P20020220 A HRP20020220 A HR P20020220A HR P20020220 A2 HRP20020220 A2 HR P20020220A2
Authority
HR
Croatia
Prior art keywords
thieno
compound according
phenoxy
isoxazol
propan
Prior art date
Application number
HR20020220A
Other languages
English (en)
Croatian (hr)
Inventor
David M Fink
Brian S Freed
Nicholas J Hrib
Raymond W Kosley Jr
Georg E Lee
Gregory H Merriman
Barbara S Rauckman
Original Assignee
Aventis Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals filed Critical Aventis Pharmaceuticals
Publication of HRP20020220A2 publication Critical patent/HRP20020220A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HR20020220A 1999-09-14 2000-09-13 Thienoisoxazolyl- and thienilpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists HRP20020220A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39608199A 1999-09-14 1999-09-14
PCT/US2000/024962 WO2001019833A1 (fr) 1999-09-14 2000-09-13 Derives thienoisoxazolyle et thienylpyrrazolyle du propyle a substitution phenoxy, antagonistes du d¿4?

Publications (1)

Publication Number Publication Date
HRP20020220A2 true HRP20020220A2 (en) 2004-02-29

Family

ID=23565772

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020220A HRP20020220A2 (en) 1999-09-14 2000-09-13 Thienoisoxazolyl- and thienilpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists

Country Status (26)

Country Link
EP (1) EP1216250B1 (fr)
JP (1) JP4847662B2 (fr)
KR (1) KR20020027647A (fr)
AR (1) AR032134A1 (fr)
AT (1) ATE254621T1 (fr)
AU (1) AU7577400A (fr)
BR (1) BR0014515A (fr)
CA (1) CA2383340C (fr)
CY (1) CY1101692T1 (fr)
CZ (1) CZ2002897A3 (fr)
DE (1) DE60006699T2 (fr)
DK (1) DK1216250T3 (fr)
EA (1) EA200200355A1 (fr)
EE (1) EE200200135A (fr)
ES (1) ES2209995T3 (fr)
HR (1) HRP20020220A2 (fr)
HU (1) HUP0203526A3 (fr)
IL (1) IL148623A0 (fr)
MX (1) MXPA02002695A (fr)
NO (1) NO20021251L (fr)
PL (1) PL354515A1 (fr)
PT (1) PT1216250E (fr)
SK (1) SK3512002A3 (fr)
TW (1) TW530060B (fr)
WO (1) WO2001019833A1 (fr)
ZA (1) ZA200201762B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
EP1688412A3 (fr) * 2001-02-16 2006-08-16 Aventis Pharmaceuticals, Inc. Nouveaux derives heterocycliques d'amides et leur utilisation comme ligands du recepteur de la dopamine D3
WO2002083648A1 (fr) * 2001-04-16 2002-10-24 Eisai Co., Ltd. Nouveau compose a base de 1h-indazole
KR20040020457A (ko) * 2002-08-30 2004-03-09 주식회사 대웅 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
AU2004209522A1 (en) * 2003-01-17 2004-08-19 Gilead Palo Alto, Inc. Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases
JP2007297321A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd アリール２−メチルグリシジルエーテル類の製造法
JP2007297330A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd ２−メチルグリシジル誘導体の製造法
JP2016505597A (ja) 2012-12-21 2016-02-25 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
US9908887B2 (en) 2012-12-21 2018-03-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US8993555B2 (en) 2012-12-21 2015-03-31 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2014100716A1 (fr) 2012-12-21 2014-06-26 Epizyme, Inc. Inhibiteurs de prmt5 et leurs utilisations
WO2015200680A2 (fr) * 2014-06-25 2015-12-30 Epizyme, Inc. Inhibiteurs de prmt5 et leurs utilisations
US10653693B2 (en) 2014-08-04 2020-05-19 Epizyme, Inc. PRMT5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
ATE367389T1 (de) * 1998-02-09 2007-08-15 Duphar Int Res Benzisoxazolderivate mit d4-antagonistischer wirkung

Also Published As

Publication number Publication date
DK1216250T3 (da) 2004-02-23
CA2383340C (fr) 2010-06-15
JP4847662B2 (ja) 2011-12-28
AR032134A1 (es) 2003-10-29
EE200200135A (et) 2003-04-15
ATE254621T1 (de) 2003-12-15
NO20021251D0 (no) 2002-03-13
MXPA02002695A (es) 2002-07-30
ES2209995T3 (es) 2004-07-01
IL148623A0 (en) 2002-09-12
JP2003509432A (ja) 2003-03-11
KR20020027647A (ko) 2002-04-13
DE60006699T2 (de) 2004-09-30
EP1216250A1 (fr) 2002-06-26
DE60006699D1 (en) 2003-12-24
HUP0203526A2 (hu) 2003-01-28
PT1216250E (pt) 2004-04-30
BR0014515A (pt) 2002-06-25
TW530060B (en) 2003-05-01
WO2001019833A1 (fr) 2001-03-22
CA2383340A1 (fr) 2001-03-22
NO20021251L (no) 2002-05-10
EA200200355A1 (ru) 2002-10-31
PL354515A1 (en) 2004-01-26
CZ2002897A3 (cs) 2002-07-17
ZA200201762B (en) 2003-08-27
HUP0203526A3 (en) 2004-12-28
AU7577400A (en) 2001-04-17
EP1216250B1 (fr) 2003-11-19
CY1101692T1 (el) 2010-07-28
SK3512002A3 (en) 2003-03-04

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