HRP20030125B1 - Prodrugs to nmda receptor ligands - Google Patents

Prodrugs to nmda receptor ligands

Info

Publication number: HRP20030125B1
Authority: HR; Croatia
Prior art keywords: lower alkyl; prodrugs; nmda receptor; receptor ligands; ylid
Prior art date: 2000-08-21

Application number

HR20030125A

Other languages

English (en)

Croatian (hr)

Inventor

Alanine Alexander

Buettelmann Bernd

Fisher Holger

Heitz Neidhart Marie-Paule

Huwyler Joerg

Jaeschke Georg

Pinard Emmanuel

Wyler Rene

Original Assignee

F. Hoffmann - La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-21

Filing date

2001-08-20

Publication date

2011-07-31

2001-08-20 Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag

2005-02-28 Publication of HRP20030125A2 publication Critical patent/HRP20030125A2/hr

2011-07-31 Publication of HRP20030125B1 publication Critical patent/HRP20030125B1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

HR20030125A 2000-08-21 2001-08-20 Prodrugs to nmda receptor ligands HRP20030125B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00117918		2000-08-21
PCT/EP2001/009561 WO2002016321A1 (de)	2000-08-21	2001-08-20	Prodrugs to nmda receptor ligands

Publications (2)

Publication Number	Publication Date
HRP20030125A2 HRP20030125A2 (en)	2005-02-28
HRP20030125B1 true HRP20030125B1 (en)	2011-07-31

Family

ID=8169594

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20030125A HRP20030125B1 (en)	2000-08-21	2001-08-20	Prodrugs to nmda receptor ligands

Country Status (35)

Country	Link
US (1)	US6407235B1 (de)
EP (1)	EP1313703B1 (de)
JP (1)	JP4162991B2 (de)
KR (1)	KR100589991B1 (de)
CN (1)	CN1227230C (de)
AR (1)	AR030373A1 (de)
AT (1)	ATE386022T1 (de)
AU (2)	AU2001285894B2 (de)
BR (1)	BR0113348A (de)
CA (1)	CA2419279C (de)
CY (1)	CY1107937T1 (de)
CZ (1)	CZ303319B6 (de)
DE (1)	DE60132782T2 (de)
DK (1)	DK1313703T3 (de)
EC (1)	ECSP034489A (de)
EG (1)	EG24293A (de)
ES (1)	ES2299508T3 (de)
HR (1)	HRP20030125B1 (de)
HU (1)	HU229802B1 (de)
IL (1)	IL154254A0 (de)
JO (1)	JO2289B1 (de)
MA (1)	MA26947A1 (de)
MX (1)	MXPA03001311A (de)
MY (1)	MY136065A (de)
NO (1)	NO324941B1 (de)
NZ (1)	NZ523990A (de)
PA (1)	PA8525601A1 (de)
PE (1)	PE20020291A1 (de)
PL (1)	PL204215B1 (de)
PT (1)	PT1313703E (de)
RS (1)	RS51467B (de)
RU (1)	RU2272027C2 (de)
SI (1)	SI1313703T1 (de)
WO (1)	WO2002016321A1 (de)
ZA (1)	ZA200300894B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2245876C2 (ru) *	2000-03-21	2005-02-10	Дзе Проктер Энд Гэмбл Компани	Производные сульфонамидов и фармацевтическая композиция на их основе
US6713490B2 (en)	2002-04-26	2004-03-30	Pfizer, Inc.	3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
CN101374801B (zh) *	2005-12-19	2014-07-02	梅特希尔基因公司	用于增强抗真菌剂活性的组蛋白脱乙酰酶抑制剂
JP2010513326A (ja)	2006-12-19	2010-04-30	メシルジーンインコーポレイテッド	ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ
US8796330B2 (en) *	2006-12-19	2014-08-05	Methylgene Inc.	Inhibitors of histone deacetylase and prodrugs thereof
KR102336426B1 (ko)	2013-11-05	2021-12-08	아스트라제네카 아베	Nmda 길항제 전구약물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0824098A1 (de) *	1996-07-19	1998-02-18	F. Hoffmann-La Roche Ag	4-Hydroxypiperidinderivate
WO2000075109A1 (en) *	1999-06-08	2000-12-14	F. Hoffmann-La Roche Ag	Ethanesulfonyl-piperidine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9408506A (pt) *	1994-01-31	1997-08-05	Pfizer	Compostos neuroprotetores
DE4410822A1 (de)	1994-03-24	1995-09-28	Schering Ag	Neue Piperidin-Derivate
TW340842B (en) *	1995-08-24	1998-09-21	Pfizer	Substituted benzylaminopiperidine compounds

2001
- 2001-08-16 PA PA20018525601A patent/PA8525601A1/es unknown
- 2001-08-16 US US09/931,431 patent/US6407235B1/en not_active Expired - Lifetime
- 2001-08-16 PE PE2001000820A patent/PE20020291A1/es not_active Application Discontinuation
- 2001-08-17 AR ARP010103939A patent/AR030373A1/es active IP Right Grant
- 2001-08-17 MY MYPI20013876A patent/MY136065A/en unknown
- 2001-08-19 JO JO2001136A patent/JO2289B1/en active
- 2001-08-20 WO PCT/EP2001/009561 patent/WO2002016321A1/de not_active Ceased
- 2001-08-20 CA CA002419279A patent/CA2419279C/en not_active Expired - Fee Related
- 2001-08-20 HR HR20030125A patent/HRP20030125B1/xx not_active IP Right Cessation
- 2001-08-20 EG EG20010906A patent/EG24293A/xx active
- 2001-08-20 BR BR0113348-9A patent/BR0113348A/pt not_active Application Discontinuation
- 2001-08-20 PT PT01965201T patent/PT1313703E/pt unknown
- 2001-08-20 AU AU2001285894A patent/AU2001285894B2/en not_active Ceased
- 2001-08-20 PL PL361387A patent/PL204215B1/pl unknown
- 2001-08-20 RS YUP-130/03A patent/RS51467B/sr unknown
- 2001-08-20 DE DE60132782T patent/DE60132782T2/de not_active Expired - Lifetime
- 2001-08-20 EP EP01965201A patent/EP1313703B1/de not_active Expired - Lifetime
- 2001-08-20 CN CNB01814361XA patent/CN1227230C/zh not_active Expired - Fee Related
- 2001-08-20 RU RU2003107572/04A patent/RU2272027C2/ru not_active IP Right Cessation
- 2001-08-20 IL IL15425401A patent/IL154254A0/xx not_active IP Right Cessation
- 2001-08-20 KR KR1020037002485A patent/KR100589991B1/ko not_active Expired - Fee Related
- 2001-08-20 MX MXPA03001311A patent/MXPA03001311A/es active IP Right Grant
- 2001-08-20 AT AT01965201T patent/ATE386022T1/de active
- 2001-08-20 SI SI200130812T patent/SI1313703T1/sl unknown
- 2001-08-20 DK DK01965201T patent/DK1313703T3/da active
- 2001-08-20 NZ NZ523990A patent/NZ523990A/en not_active IP Right Cessation
- 2001-08-20 JP JP2002521197A patent/JP4162991B2/ja not_active Expired - Fee Related
- 2001-08-20 ES ES01965201T patent/ES2299508T3/es not_active Expired - Lifetime
- 2001-08-20 AU AU8589401A patent/AU8589401A/xx active Pending
- 2001-08-20 CZ CZ20030492A patent/CZ303319B6/cs not_active IP Right Cessation
- 2001-08-20 HU HU0301548A patent/HU229802B1/hu not_active IP Right Cessation
2003
- 2003-01-31 ZA ZA200300894A patent/ZA200300894B/en unknown
- 2003-02-19 NO NO20030781A patent/NO324941B1/no not_active IP Right Cessation
- 2003-02-20 EC EC2003004489A patent/ECSP034489A/es unknown
- 2003-02-21 MA MA27052A patent/MA26947A1/fr unknown
2008
- 2008-05-08 CY CY20081100485T patent/CY1107937T1/el unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0824098A1 (de) *	1996-07-19	1998-02-18	F. Hoffmann-La Roche Ag	4-Hydroxypiperidinderivate
WO2000075109A1 (en) *	1999-06-08	2000-12-14	F. Hoffmann-La Roche Ag	Ethanesulfonyl-piperidine derivatives

Also Published As

Publication number	Publication date
CA2419279C (en)	2008-10-14
HUP0301548A3 (en)	2010-03-29
EP1313703A1 (de)	2003-05-28
JO2289B1 (en)	2005-09-12
NO324941B1 (no)	2008-01-07
KR20030022417A (ko)	2003-03-15
CA2419279A1 (en)	2002-02-28
SI1313703T1 (sl)	2008-06-30
RU2272027C2 (ru)	2006-03-20
DE60132782T2 (de)	2009-02-05
PE20020291A1 (es)	2002-04-17
KR100589991B1 (ko)	2006-06-15
EP1313703B1 (de)	2008-02-13
CZ303319B6 (cs)	2012-08-01
YU13003A (sh)	2006-05-25
JP4162991B2 (ja)	2008-10-08
NZ523990A (en)	2004-09-24
PL361387A1 (en)	2004-10-04
CN1447793A (zh)	2003-10-08
AU2001285894B2 (en)	2006-06-15
HRP20030125A2 (en)	2005-02-28
BR0113348A (pt)	2003-07-08
US6407235B1 (en)	2002-06-18
ZA200300894B (en)	2004-04-30
JP2004506715A (ja)	2004-03-04
CN1227230C (zh)	2005-11-16
PT1313703E (pt)	2008-03-25
AR030373A1 (es)	2003-08-20
MA26947A1 (fr)	2004-12-20
AU8589401A (en)	2002-03-04
HK1059083A1 (en)	2004-06-18
DK1313703T3 (da)	2008-05-19
PL204215B1 (pl)	2009-12-31
EG24293A (en)	2009-01-08
RS51467B (sr)	2011-04-30
NO20030781D0 (no)	2003-02-19
CZ2003492A3 (cs)	2004-01-14
ES2299508T3 (es)	2008-06-01
MXPA03001311A (es)	2003-06-30
WO2002016321A1 (de)	2002-02-28
PA8525601A1 (es)	2002-04-25
HUP0301548A2 (hu)	2003-08-28
NO20030781L (no)	2003-02-19
DE60132782D1 (de)	2008-03-27
CY1107937T1 (el)	2013-09-04
US20020040037A1 (en)	2002-04-04
ATE386022T1 (de)	2008-03-15
MY136065A (en)	2008-08-29
HU229802B1 (hu)	2014-07-28
IL154254A0 (en)	2003-09-17
ECSP034489A (es)	2003-03-31

Legal Events

Date	Code	Title	Description
2005-02-28	A1OB	Publication of a patent application
2005-08-02	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2011-07-31	B1PR	Patent granted
2013-07-25	PPPP	Transfer of rights	Owner name: EVOTEC INTERNATIONAL GMBH, DE
2014-07-28	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20140728 Year of fee payment: 14
2016-03-01	PBON	Lapse due to non-payment of renewal fee	Effective date: 20150820

Publication	Publication Date	Title
ID17851A (id)	1998-01-29	Persenyawaan heterosiklis, produksi dan pemakaiannya
ATE209645T1 (de)	2001-12-15	Neue verbindung, verfahren zu ihrer herstellung und antitumormittel
CO4750662A1 (es)	1999-03-31	DERIVADOS DE BENZO (g) QUINOLINA
AR049401A1 (es)	2006-07-26	Aza-biciclononanos
MXPA02012569A (es)	2004-05-17	Ftalidas substituidas novedosas, un procedimiento para su preparacion y las composiciones farmaceuticas que contienen a las mismas.
IL180428A0 (en)	2007-06-03	Novel flame-retardant polystyrenes
TW200745153A (en)	2007-12-16	Trehalose compound and pharmaceutical comprising the compound
MXPA03000547A (es)	2004-04-05	Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares.
TNSN07395A1 (en)	2009-03-17	Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives
IS2472B (is)	2008-12-15	Ný tetrahýdrópýridín, framleiðsluaðferð og lyfjasamsetningar sem innihalda þau
EA200100969A1 (ru)	2002-04-25	Новые соединения циклобутендиона, способ их получения и содержащие их фармацевтические композиции
CY1107937T1 (el)	2013-09-04	Προφαρμακα σε συνδετες υποδοχεα nmda
HRP20031055B1 (hr)	2008-01-31	Novi imunomodulirajući spojevi
BG105123A (en)	2001-11-30	Tetrahydroquinaline derivatives as glycine antagonists
ATE148128T1 (de)	1997-02-15	Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
CA2364199A1 (fr)	2002-06-14	Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MEP12408A (en)	2010-06-10	Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors
EA200000598A1 (ru)	2001-02-26	Новые ингибиторы металлопротеазы, способ их получения и содержащие их фармацевтические композиции
EP1403250A4 (de)	2005-04-13	Bis(5-aryl-2-pyridyl)derivate
FR2826005B1 (fr)	2004-07-16	Synthese totale de la galanthamine, de ses analogues et de ses derives
BR0113907A (pt)	2003-07-22	Derivados bifenilas substituìdos, o respectivo processo de preparação e as composições farmacêuticas que os contêm
TR199901394T2 (xx)	1999-08-23	NMDA antagonistleri haz�rlanmas� i�in i�lem
MY132324A (en)	2007-10-31	New piperazine derivatives and methods for the preperation thereof and compositions containing the same
BR0115809A (pt)	2003-09-16	Processo de ciclização para sìntese de compostos derivados de pirolidina
DK480389A (da)	1990-03-31	Antitumor-aktivt derivat af sf2587, fremgangsmaade til det fremstilling og anticancermiddel indeholdende stoffet