HRP20030647A2 - Isoxazoline derivatives as anti-depressants - Google Patents

Isoxazoline derivatives as anti-depressants Download PDF

Info

Publication number
HRP20030647A2
HRP20030647A2 HR20030647A HRP20030647A HRP20030647A2 HR P20030647 A2 HRP20030647 A2 HR P20030647A2 HR 20030647 A HR20030647 A HR 20030647A HR P20030647 A HRP20030647 A HR P20030647A HR P20030647 A2 HRP20030647 A2 HR P20030647A2
Authority
HR
Croatia
Prior art keywords
compound according
group
image
mol
formula
Prior art date
Application number
HR20030647A
Other languages
English (en)
Croatian (hr)
Inventor
Jose
Francisco
Manuel
Pastor-Fernandez Joaquin
Antonius
Godelieve
Xavier
Margaretha
Thomas
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20030647A2 publication Critical patent/HRP20030647A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HR20030647A 2001-02-21 2002-02-13 Isoxazoline derivatives as anti-depressants HRP20030647A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01200611 2001-02-21
EP01201264 2001-04-05
PCT/EP2002/001567 WO2002066484A1 (en) 2001-02-21 2002-02-13 Isoxazoline derivatives as anti-depressants

Publications (1)

Publication Number Publication Date
HRP20030647A2 true HRP20030647A2 (en) 2005-06-30

Family

ID=26076836

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030647A HRP20030647A2 (en) 2001-02-21 2002-02-13 Isoxazoline derivatives as anti-depressants

Country Status (32)

Country Link
US (1) US7169786B2 (de)
EP (1) EP1368358B1 (de)
JP (1) JP3953424B2 (de)
KR (1) KR100848898B1 (de)
CN (1) CN100400540C (de)
AR (1) AR035685A1 (de)
AT (1) ATE337322T1 (de)
AU (1) AU2002244717B2 (de)
BG (1) BG107984A (de)
BR (1) BR0207433A (de)
CA (1) CA2437505C (de)
CY (1) CY1106448T1 (de)
CZ (1) CZ20032515A3 (de)
DE (1) DE60214138T2 (de)
DK (1) DK1368358T3 (de)
EA (1) EA006747B1 (de)
EE (1) EE200300398A (de)
EG (1) EG23929A (de)
ES (1) ES2271230T3 (de)
HR (1) HRP20030647A2 (de)
HU (1) HUP0303270A3 (de)
IL (2) IL157470A0 (de)
MX (1) MXPA03007432A (de)
MY (1) MY137836A (de)
NO (1) NO20033700L (de)
NZ (1) NZ526741A (de)
PL (1) PL208593B1 (de)
PT (1) PT1368358E (de)
SI (1) SI1368358T1 (de)
SK (1) SK11612003A3 (de)
TW (1) TWI257392B (de)
WO (1) WO2002066484A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
ATE372342T1 (de) * 2002-04-02 2007-09-15 Janssen Pharmaceutica Nv Substituierte aminoisoxazolinderivate und ihre verwendung als antidepressiva
TW200409777A (en) * 2002-08-12 2004-06-16 Janssen Pharmaceutica Nv C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants
CN100522972C (zh) * 2002-08-15 2009-08-05 詹森药业有限公司 稠合杂环异噁唑啉衍生物和它们作为抗抑郁剂的用途
JP4478570B2 (ja) * 2002-08-21 2010-06-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ６−およびｃ９−置換’４，３−ｃ！イソキサゾリン誘導体およびそれらの抗鬱薬としての使用
CA2517081A1 (en) * 2003-03-07 2004-09-16 Astellas Pharma Inc. Nitrogen-containing heterocyclic derivatives having 2-6, disubtituted styryl
EP1944306A1 (de) * 2003-09-17 2008-07-16 Janssen Pharmaceutica, N.V. Fusionierte heterocyclische Verbindungen
SI1668014T1 (sl) * 2003-09-17 2009-06-30 Janssen Pharmaceutica Nv Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
ES2331144T3 (es) * 2004-11-26 2009-12-22 Janssen Pharmaceutica Nv Derivados de isoxazolina-indol con actividad antipsicotica y ansiolitica mejorada.
NZ579431A (en) 2007-03-09 2012-04-27 Sanofi Aventis Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof
WO2008154442A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
AR078171A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055011T3 (es) * 1988-09-19 1994-08-16 Akzo Nv Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano.
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
EP0892804B1 (de) * 1996-04-12 2002-08-28 Janssen Pharmaceutica N.V. Isoxazolidine derivate
HUP9602763A3 (en) * 1996-10-09 1999-05-28 Egyt Gyogyszervegyeszeti Gyar 3-phenyl isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
JP2002527438A (ja) * 1998-10-09 2002-08-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ４，５−ジヒドロ−イソオキサゾール誘導体及びそれらの製薬学的使用

Also Published As

Publication number Publication date
CA2437505C (en) 2010-02-09
CY1106448T1 (el) 2011-10-12
HUP0303270A2 (hu) 2004-01-28
HK1065537A1 (zh) 2005-02-25
ATE337322T1 (de) 2006-09-15
US7169786B2 (en) 2007-01-30
US20040122037A1 (en) 2004-06-24
MXPA03007432A (es) 2003-11-18
JP2004518748A (ja) 2004-06-24
NO20033700L (no) 2003-10-21
EP1368358A1 (de) 2003-12-10
BR0207433A (pt) 2004-06-01
AU2002244717B2 (en) 2007-07-19
PT1368358E (pt) 2007-01-31
EA200300915A1 (ru) 2004-06-24
PL208593B1 (pl) 2011-05-31
DE60214138D1 (de) 2006-10-05
IL157470A (en) 2008-07-08
PL363264A1 (en) 2004-11-15
KR20030076590A (ko) 2003-09-26
SK11612003A3 (sk) 2004-04-06
CZ20032515A3 (cs) 2003-12-17
EG23929A (en) 2008-01-14
KR100848898B1 (ko) 2008-07-29
IL157470A0 (en) 2004-03-28
NO20033700D0 (no) 2003-08-20
EE200300398A (et) 2003-12-15
EA006747B1 (ru) 2006-04-28
JP3953424B2 (ja) 2007-08-08
DE60214138T2 (de) 2007-03-29
DK1368358T3 (da) 2007-01-02
WO2002066484A1 (en) 2002-08-29
HUP0303270A3 (en) 2007-03-28
EP1368358B1 (de) 2006-08-23
BG107984A (bg) 2004-09-30
SI1368358T1 (sl) 2007-02-28
TWI257392B (en) 2006-07-01
AR035685A1 (es) 2004-06-23
CA2437505A1 (en) 2002-08-29
ES2271230T3 (es) 2007-04-16
CN100400540C (zh) 2008-07-09
MY137836A (en) 2009-03-31
CN1492871A (zh) 2004-04-28
NZ526741A (en) 2004-04-30

Similar Documents

Publication Publication Date Title
RU2282619C2 (ru) Способы получения замещенных арилконденсированных азаполициклических соединений, промежуточные продукты и способы их получения
HRP20030647A2 (en) Isoxazoline derivatives as anti-depressants
JP2008525524A (ja) アリールスルホンアミドモジュレーター
EP1682549B1 (de) Imidazo[1,2-a]pyridin-anxiolytika
AU2008235528B2 (en) Heterocycles as orexin antagonists
AU2002244717A1 (en) Isoxazoline derivatives as anti-depressants
JP4580653B2 (ja) 置換されたアミノイソオキサゾリン誘導体および抗鬱薬としてのそれらの使用
JP5274258B2 (ja) β−セクレターゼ調節物質及び使用方法
JP4478571B2 (ja) 縮合複素環式イソオキサゾリン誘導体及び抗うつ薬としてのそれらの使用
JP4681295B2 (ja) Ｃ−置換三環式イソオキサゾリン誘導体及び抗−うつ薬としてのそれらの使用
JP4478570B2 (ja) Ｃ６−およびｃ９−置換’４，３−ｃ！イソキサゾリン誘導体およびそれらの抗鬱薬としての使用
AU2015255181A1 (en) Spiro-cyclic amine derivatives as s1p modulators
HK1065537B (en) Isoxazoline derivatives as anti-depressants
WO2026075101A1 (ja) オピオイド受容体拮抗剤及び医薬組成物
UA77405C2 (en) Isoxazolines derivatives as antidepressants

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20090210

Year of fee payment: 8

ODBC Application rejected