HRP20041070A2 - Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one - Google Patents

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one Download PDF

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Publication number
HRP20041070A2
HRP20041070A2 HR20041070A HRP20041070A HRP20041070A2 HR P20041070 A2 HRP20041070 A2 HR P20041070A2 HR 20041070 A HR20041070 A HR 20041070A HR P20041070 A HRP20041070 A HR P20041070A HR P20041070 A2 HRP20041070 A2 HR P20041070A2
Authority
HR
Croatia
Prior art keywords
methyl
tetrahydro
carbazol
imidazol
solvent system
Prior art date
Application number
HR20041070A
Other languages
English (en)
Croatian (hr)
Inventor
Szabo Csaba
Molnar Szandor
Meszaros-Sos Erzsebet
Salvi Szabolcs
Tamas Tivadar
Original Assignee
Biogal Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt. filed Critical Biogal Gyogyszergyar Rt.
Publication of HRP20041070A2 publication Critical patent/HRP20041070A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HR20041070A 2002-04-29 2003-04-29 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one HRP20041070A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37632302P 2002-04-29 2002-04-29
PCT/US2003/013221 WO2003093281A1 (en) 2002-04-29 2003-04-29 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one

Publications (1)

Publication Number Publication Date
HRP20041070A2 true HRP20041070A2 (en) 2005-02-28

Family

ID=29401332

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20041070A HRP20041070A2 (en) 2002-04-29 2003-04-29 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one

Country Status (19)

Country Link
US (2) US7098345B2 (de)
EP (1) EP1499623B1 (de)
JP (1) JP2005529142A (de)
KR (1) KR20040104654A (de)
CN (1) CN1665823A (de)
AT (1) ATE364611T1 (de)
AU (1) AU2003223764A1 (de)
CA (1) CA2483566A1 (de)
DE (1) DE60314400T2 (de)
DK (1) DK1499623T3 (de)
ES (1) ES2288606T3 (de)
HR (1) HRP20041070A2 (de)
IL (1) IL164904A0 (de)
MX (1) MXPA04010846A (de)
NO (1) NO20045192L (de)
PL (1) PL373191A1 (de)
PT (1) PT1499623E (de)
WO (1) WO2003093281A1 (de)
ZA (1) ZA200408934B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK6182003A3 (en) * 2000-10-30 2004-03-02 Teva Pharma Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
HRP20041136A2 (en) * 2002-04-30 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) * 2004-10-26 2006-05-04 Ipca Laboratories Limited A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
PH22672A (en) 1984-01-25 1988-11-14 Glaxo Group Ltd Imidazolylmethyltetrahydrocarbazolone derivatives, composition and method of use thereof
EP0385517B1 (de) 1985-03-14 1993-04-14 BEECHAM GROUP plc Arzneimittel zur Behandlung von Erbrechen
GB8518742D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518741D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US4859662A (en) 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en) 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8816187D0 (en) * 1988-07-07 1988-08-10 Glaxo Group Ltd Medicaments
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5344658A (en) 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
WO1993000074A1 (en) 1991-06-26 1993-01-07 Sepracor, Inc. Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
CA2106642C (en) 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
GB9423588D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1045437C (zh) 1994-12-29 1999-10-06 中国科学院上海有机化学研究所 恩丹西酮及其生理盐的合成
SK6182003A3 (en) 2000-10-30 2004-03-02 Teva Pharma Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
EP1207160A1 (de) 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Verfahren zur Herstellung von 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
ES2219201T1 (es) 2001-01-11 2004-12-01 Teva Pharmaceutical Industries Ltd. Procedimiento mejorado para la preparacion de ondansetron clorhidrato dihidrato puro.
AU2002251329A1 (en) 2002-04-25 2003-11-10 Generics (Uk) Limited Novel crystalline forms of celecoxib and other compounds
HRP20041136A2 (en) 2002-04-30 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them

Also Published As

Publication number Publication date
AU2003223764A1 (en) 2003-11-17
KR20040104654A (ko) 2004-12-10
ES2288606T3 (es) 2008-01-16
IL164904A0 (en) 2005-12-18
NO20045192L (no) 2005-01-28
CN1665823A (zh) 2005-09-07
PL373191A1 (en) 2005-08-22
ZA200408934B (en) 2006-07-26
US20060252942A1 (en) 2006-11-09
EP1499623B1 (de) 2007-06-13
WO2003093281A1 (en) 2003-11-13
DK1499623T3 (da) 2007-10-08
DE60314400T2 (de) 2008-02-07
CA2483566A1 (en) 2003-11-13
US20050020655A1 (en) 2005-01-27
PT1499623E (pt) 2007-08-10
DE60314400D1 (de) 2007-07-26
JP2005529142A (ja) 2005-09-29
US7098345B2 (en) 2006-08-29
ATE364611T1 (de) 2007-07-15
MXPA04010846A (es) 2005-01-25
EP1499623A1 (de) 2005-01-26

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