HRP20050308A2 - Chirale oxazole-arylpropionic acid derivatives and their use as ppar agonists - Google Patents

Chirale oxazole-arylpropionic acid derivatives and their use as ppar agonists

Info

Publication number
HRP20050308A2
HRP20050308A2 HR20050308A HRP20050308A HRP20050308A2 HR P20050308 A2 HRP20050308 A2 HR P20050308A2 HR 20050308 A HR20050308 A HR 20050308A HR P20050308 A HRP20050308 A HR P20050308A HR P20050308 A2 HRP20050308 A2 HR P20050308A2
Authority
HR
Croatia
Prior art keywords
chirale
oxazole
acid derivatives
ppar agonists
arylpropionic acid
Prior art date
Application number
HR20050308A
Other languages
English (en)
Croatian (hr)
Inventor
Binggeli Alfred
Boehringer Markus
Grether Uwe
Hilpert Hans
Hirth Georges
Maerki Hans-Peter
Meyer Markus
Mohr Peter
Ricklin Fabienne
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20050308A2 publication Critical patent/HRP20050308A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20050308A 2002-10-07 2003-10-06 Chirale oxazole-arylpropionic acid derivatives and their use as ppar agonists HRP20050308A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02022286 2002-10-07
PCT/EP2003/011030 WO2004031162A1 (en) 2002-10-07 2003-10-06 Chirale oxazole-arylpropionic acid derivatives and their use as ppar agonists

Publications (1)

Publication Number Publication Date
HRP20050308A2 true HRP20050308A2 (en) 2006-07-31

Family

ID=32049977

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050308A HRP20050308A2 (en) 2002-10-07 2003-10-06 Chirale oxazole-arylpropionic acid derivatives and their use as ppar agonists

Country Status (31)

Country Link
US (2) US6969725B2 (de)
EP (1) EP1551814B1 (de)
JP (1) JP4414886B2 (de)
KR (1) KR100623819B1 (de)
CN (1) CN100415727C (de)
AR (1) AR041481A1 (de)
AT (1) ATE402153T1 (de)
AU (1) AU2003273949B2 (de)
BR (1) BR0315114A (de)
CA (1) CA2499721C (de)
CO (1) CO5540385A2 (de)
DE (1) DE60322408D1 (de)
DK (1) DK1551814T3 (de)
ES (1) ES2311110T3 (de)
GT (1) GT200300218A (de)
HR (1) HRP20050308A2 (de)
IL (1) IL167250A (de)
MX (1) MXPA05003392A (de)
MY (1) MY143576A (de)
NO (1) NO330171B1 (de)
NZ (1) NZ538465A (de)
PA (1) PA8584501A1 (de)
PE (1) PE20040591A1 (de)
PL (1) PL208743B1 (de)
PT (1) PT1551814E (de)
RU (1) RU2303593C2 (de)
SI (1) SI1551814T1 (de)
TW (1) TWI343915B (de)
UY (1) UY28006A1 (de)
WO (1) WO2004031162A1 (de)
ZA (1) ZA200502664B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105551B2 (en) * 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
JP2006514976A (ja) * 2002-11-15 2006-05-18 カディラ ヘルスケア リミティド 置換されているアラルキル誘導体
US7262303B2 (en) * 2003-09-29 2007-08-28 Hoffman-La Roche Inc. Process for the production of chiral propionic acid derivatives
US20100063041A1 (en) * 2007-03-07 2010-03-11 Ho-Sang Moon Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
RU2361581C2 (ru) 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
EA022417B1 (ru) * 2008-10-21 2015-12-30 Саймабэй Терапевтикс, Инк. Арильные агонисты рецептора gpr120 и их применение
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
CN101805336B (zh) * 2009-02-13 2012-05-30 天津药物研究院 一类含色氨酸和异恶唑骨架的化合物、其制备方法和用途
CN101805337B (zh) * 2009-02-13 2012-05-23 天津药物研究院 一类含脯氨酸和异恶唑骨架的化合物、其制备方法和用途
US8637096B2 (en) 2009-12-04 2014-01-28 Curtis C. Stojan Compositions and method for enhancing insulin activity
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
CN102285933B (zh) * 2010-06-18 2016-03-09 浙江海正药业股份有限公司 一种对亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用
EP2758041B1 (de) 2011-09-20 2021-01-13 Basf Se Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
RU2174121C2 (ru) * 1996-08-19 2001-09-27 Джапан Тобакко Инк. Производные пропионовой кислоты и фармацевтическая композиция на их основе
CN1781915A (zh) * 1998-03-30 2006-06-07 日本烟草产业株式会社 噁唑基乙醇衍生物的制备方法
ES2226377T3 (es) * 1998-05-11 2005-03-16 Takeda Chemical Industries, Ltd. Derivados de acido oxiimino-alcalino con actividad hipoglucemica e hipolipidemica.
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
PL351898A1 (en) * 1999-04-06 2003-06-30 Sankyo Co O-substituted derivatives of carboxylic acids
TWI302149B (en) 1999-09-22 2008-10-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
DE10031657A1 (de) 2000-06-29 2002-01-24 Siemens Ag Hochfrequenz-Bauelement
DK1313716T3 (da) * 2000-08-23 2007-08-27 Lilly Co Eli Oxazolyl-arylpropionsyrederivater og anvendelse deraf som PPAR-agonister
RU2278859C2 (ru) * 2001-05-15 2006-06-27 Ф.Хоффманн-Ля Рош Аг Замещенные карбоновыми кислотами оксазоловые производные в качестве ppar-альфа и гамма-активаторов при лечении диабета
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar

Also Published As

Publication number Publication date
US20050267180A1 (en) 2005-12-01
MXPA05003392A (es) 2005-06-22
PL376363A1 (en) 2005-12-27
BR0315114A (pt) 2005-08-16
AU2003273949B2 (en) 2007-04-05
DK1551814T3 (da) 2008-10-27
HK1083339A1 (en) 2006-06-30
NZ538465A (en) 2007-08-31
PA8584501A1 (es) 2004-05-21
CN100415727C (zh) 2008-09-03
EP1551814B1 (de) 2008-07-23
TWI343915B (en) 2011-06-21
ES2311110T3 (es) 2009-02-01
US7348349B2 (en) 2008-03-25
AR041481A1 (es) 2005-05-18
NO20051011L (no) 2005-05-02
PL208743B1 (pl) 2011-06-30
GT200300218A (es) 2004-05-24
PE20040591A1 (es) 2004-08-30
US20040116487A1 (en) 2004-06-17
ZA200502664B (en) 2006-02-22
DE60322408D1 (de) 2008-09-04
RU2303593C2 (ru) 2007-07-27
EP1551814A1 (de) 2005-07-13
RU2005114373A (ru) 2006-05-10
CN1703406A (zh) 2005-11-30
JP2006504709A (ja) 2006-02-09
WO2004031162A1 (en) 2004-04-15
CA2499721C (en) 2011-03-15
ATE402153T1 (de) 2008-08-15
NO330171B1 (no) 2011-02-28
KR100623819B1 (ko) 2006-09-13
SI1551814T1 (sl) 2008-10-31
JP4414886B2 (ja) 2010-02-10
IL167250A (en) 2010-12-30
UY28006A1 (es) 2004-04-30
CO5540385A2 (es) 2005-07-29
AU2003273949A1 (en) 2004-04-23
MY143576A (en) 2011-05-31
TW200409761A (en) 2004-06-16
US6969725B2 (en) 2005-11-29
KR20050055750A (ko) 2005-06-13
CA2499721A1 (en) 2004-04-15
PT1551814E (pt) 2008-09-22

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