HRP20060286T3 - Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof - Google Patents

Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof

Info

Publication number
HRP20060286T3
HRP20060286T3 HR20060286T HRP20060286T HRP20060286T3 HR P20060286 T3 HRP20060286 T3 HR P20060286T3 HR 20060286 T HR20060286 T HR 20060286T HR P20060286 T HRP20060286 T HR P20060286T HR P20060286 T3 HRP20060286 T3 HR P20060286T3
Authority
HR
Croatia
Prior art keywords
ring
thioxy
haloalkylsulfinyl
haloalkylsulfonyl
haloalkylthio
Prior art date
Application number
HR20060286T
Other languages
English (en)
Croatian (hr)
Inventor
Semple Graeme
Schrader Thomas
J. Skinner Philip
L. Colletti Steven
E. Imbriglio Jason
Liang Rui
Raghavan Subharekha
Schmidt Darby
R. Tata James
Gharbaoui Tawfik
Jung Jae-Kyu
Original Assignee
Arena Pharmaceuticals Inc
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharmaceuticals Inc, Merck & Co. Inc. filed Critical Arena Pharmaceuticals Inc
Publication of HRP20060286T3 publication Critical patent/HRP20060286T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20060286T 2003-10-31 2004-10-29 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof HRP20060286T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51623803P 2003-10-31 2003-10-31
PCT/US2004/035927 WO2005044816A1 (fr) 2003-10-31 2004-10-29 Derives de tetrazole et methodes de traitement de troubles lies au metabolisme

Publications (1)

Publication Number Publication Date
HRP20060286T3 true HRP20060286T3 (en) 2007-03-31

Family

ID=34572875

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20060286T HRP20060286T3 (en) 2003-10-31 2004-10-29 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof

Country Status (37)

Country Link
US (2) US8637555B2 (fr)
EP (2) EP1683794A1 (fr)
JP (2) JP4533898B2 (fr)
KR (1) KR100850591B1 (fr)
CN (1) CN1867562B (fr)
AR (1) AR046611A1 (fr)
AT (1) ATE328880T1 (fr)
AU (1) AU2004287861B2 (fr)
BR (1) BRPI0415631A (fr)
CA (1) CA2539985C (fr)
CO (1) CO5690551A2 (fr)
CR (1) CR8270A (fr)
CY (1) CY1105479T1 (fr)
DE (1) DE602004001134T2 (fr)
DK (1) DK1599469T3 (fr)
EA (1) EA011484B1 (fr)
EC (1) ECSP066529A (fr)
ES (1) ES2267077T3 (fr)
GE (1) GEP20094801B (fr)
HR (1) HRP20060286T3 (fr)
IL (1) IL174042A0 (fr)
IS (1) IS2372B (fr)
MA (1) MA28171A1 (fr)
MX (1) MXPA06004556A (fr)
MY (1) MY140410A (fr)
NO (1) NO20062509L (fr)
NZ (1) NZ546285A (fr)
PE (1) PE20050483A1 (fr)
PL (1) PL1599469T3 (fr)
PT (1) PT1599469E (fr)
RS (1) RS20060290A (fr)
SI (1) SI1599469T1 (fr)
TN (1) TNSN06150A1 (fr)
TW (1) TWI258478B (fr)
UA (1) UA86783C2 (fr)
WO (1) WO2005044816A1 (fr)
ZA (2) ZA200603419B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094572B2 (en) 2003-03-14 2006-08-22 Bristol-Myers Squibb Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
TWI258478B (en) 2003-10-31 2006-07-21 Arena Pharm Inc Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
US20070093545A1 (en) * 2003-11-21 2007-04-26 Arena Pharmaceuticals, Inc. 4-Oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof
US20070244107A1 (en) * 2004-08-25 2007-10-18 Waters M Gerard Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
JP2008519080A (ja) * 2004-11-05 2008-06-05 アリーナ ファーマシューティカルズ， インコーポレイテッド ナイアシン受容体部分的アゴニストを含む、潮紅および脂質関連障害を処置するための組成物
PE20060949A1 (es) * 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
DK1901731T3 (da) 2005-06-28 2011-06-14 Merck Sharp & Dohme Niacinreceptoragonister, sammensætninger indeholdende sådanne forbindelser og fremgangsmåder til behandling
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102008063992A1 (de) 2008-12-19 2010-09-02 Lerner, Zinoviy, Dipl.-Ing. Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
HK1210825A1 (en) 2012-07-11 2016-05-06 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
AP2015008670A0 (en) 2013-02-21 2015-08-31 Adverio Pharma Gmbh Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-B]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate
EP3026054B1 (fr) 2013-07-23 2019-03-06 Eisai R&D Management Co., Ltd. Composé cyclique hétérocondensé
CN103755637A (zh) * 2013-12-26 2014-04-30 平湖优康药物研发有限公司 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺
CA3096145A1 (fr) * 2019-10-11 2021-04-11 Royal Bank Of Canada Systeme et methode d`apprentissage automatique utilisant des reseaux de plongements

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02178263A (ja) * 1988-12-27 1990-07-11 Kaken Pharmaceut Co Ltd アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤
US5134155A (en) 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
US5948786A (en) 1996-04-12 1999-09-07 Sumitomo Pharmaceuticals Company, Limited Piperidinylpyrimidine derivatives
CN1246847A (zh) 1996-12-23 2000-03-08 杜邦药品公司 作为Xa因子抑制剂的含氮杂芳族化合物
JP4345230B2 (ja) 1998-03-10 2009-10-14 小野薬品工業株式会社 カルボン酸誘導体およびその誘導体を有効成分として含有する薬剤
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US6743793B2 (en) 2000-03-09 2004-06-01 Ono Pharmaceutical Co., Ltd. Indole derivatives, process for preparation of the same and use thereof
US20010047027A1 (en) 2000-04-12 2001-11-29 Marc Labelle Prostaglandin D2 receptor antagonists
IL153688A0 (en) 2000-06-28 2003-07-06 Teva Pharma Carvedilol
BR0111947A (pt) 2000-06-30 2003-05-06 Glaxo Group Ltd Composto, composição farmacêutica, método para o tratamento de um distúrbio em um mamìfero, uso de um composto e processo para preparar, um composto
US6410583B1 (en) 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
DE10057751A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Carbamat-substituierte Pyrazolopyridinderivate
ATE340796T1 (de) 2001-05-23 2006-10-15 Merck Frosst Canada Inc Dihydropyrrolo(1,2-aöindol- und tetrahydropyrido)1,2-aöindolderivate als prostaglandin rezeptor antagonisten
DK1397351T3 (da) 2001-06-01 2010-01-18 Hoffmann La Roche Pyrimidin-, triazin- og pyrazinderivater som glutamatreceptorer
CA2451128A1 (fr) 2001-06-26 2003-01-09 Bristol-Myers Squibb Company Inhibiteurs n-heterocycliques d'expression tnf-alpha
CN1233648C (zh) 2001-06-27 2005-12-28 尔艾斯特公司 Salen催化剂、催化剂的制备和通过使用催化剂制备手性化合物的方法
KR20040044856A (ko) 2001-09-07 2004-05-31 오노 야꾸힝 고교 가부시키가이샤 인돌 유도체 화합물
DE10148617A1 (de) 2001-09-25 2003-04-24 Schering Ag Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
MXPA04009095A (es) 2002-03-19 2004-12-06 Ono Pharmaceutical Co Compuesto de acido carboxilico y agente farmaceutico que comprende el compuesto como ingrediente activo.
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
AU2003282679A1 (en) 2002-10-04 2004-05-04 Arena Pharmaceuticals, Inc. Hydroxypyrazoles for use against metabolic-related disorders
AU2003300014A1 (en) * 2002-10-10 2004-05-04 Arena Pharmaceuticals, Inc. 5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia
DE10261131A1 (de) 2002-12-20 2004-07-01 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
US7232823B2 (en) 2003-06-09 2007-06-19 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
CA2528834A1 (fr) 2003-06-13 2005-02-10 Arena Pharmaceuticals, Inc. Derives d'acide 2h-pyrazol-3- carboxylique substitues en 5 utilises comme agonistes du recepteur de l'acide nicotinique rup25 pour le traitement des dyslipidemies et des pathologies apparentees
GB0319124D0 (en) 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
GB0319126D0 (en) 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
TWI258478B (en) 2003-10-31 2006-07-21 Arena Pharm Inc Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
HRP20130406T1 (hr) 2004-02-14 2013-06-30 Glaxosmithkline Intellectual Property Development Limited Medikamenti s aktivnošä†u prema receptoru hm74a
US20070244107A1 (en) 2004-08-25 2007-10-18 Waters M Gerard Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
JP2008519080A (ja) 2004-11-05 2008-06-05 アリーナ ファーマシューティカルズ， インコーポレイテッド ナイアシン受容体部分的アゴニストを含む、潮紅および脂質関連障害を処置するための組成物
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles

Also Published As

Publication number Publication date
GEP20094801B (en) 2009-10-26
MY140410A (en) 2009-12-31
JP4533898B2 (ja) 2010-09-01
EP1599469B1 (fr) 2006-06-07
TNSN06150A1 (en) 2007-11-15
DE602004001134T2 (de) 2007-04-19
NZ546285A (en) 2010-04-30
CN1867562A (zh) 2006-11-22
ES2267077T3 (es) 2007-03-01
US20060217562A1 (en) 2006-09-28
IS8481A (is) 2006-05-24
IL174042A0 (en) 2006-08-01
JP2007509181A (ja) 2007-04-12
WO2005044816A1 (fr) 2005-05-19
AR046611A1 (es) 2005-12-14
ECSP066529A (es) 2006-10-10
CN1867562B (zh) 2011-07-13
CA2539985C (fr) 2010-02-16
HK1076468A1 (en) 2006-01-20
MXPA06004556A (es) 2006-07-06
US20070072924A1 (en) 2007-03-29
DE602004001134D1 (de) 2006-07-20
BRPI0415631A (pt) 2006-12-12
TWI258478B (en) 2006-07-21
CY1105479T1 (el) 2010-07-28
US8637555B2 (en) 2014-01-28
PT1599469E (pt) 2006-10-31
AU2004287861B2 (en) 2008-08-14
CA2539985A1 (fr) 2005-05-19
CO5690551A2 (es) 2006-10-31
UA86783C2 (ru) 2009-05-25
CR8270A (es) 2006-10-06
EP1599469A1 (fr) 2005-11-30
IS2372B (is) 2008-06-15
EP1683794A1 (fr) 2006-07-26
EA200600879A1 (ru) 2006-10-27
ATE328880T1 (de) 2006-06-15
MA28171A1 (fr) 2006-09-01
PE20050483A1 (es) 2005-08-25
KR20060073974A (ko) 2006-06-29
PL1599469T3 (pl) 2006-10-31
DK1599469T3 (da) 2006-10-09
ZA200603419B (en) 2006-10-25
RS20060290A (sr) 2008-11-28
AU2004287861A1 (en) 2005-05-19
ZA200606203B (en) 2007-04-25
SI1599469T1 (sl) 2006-10-31
JP2010163448A (ja) 2010-07-29
TW200530221A (en) 2005-09-16
NO20062509L (no) 2006-06-26
EA011484B1 (ru) 2009-04-28
KR100850591B1 (ko) 2008-08-05

Similar Documents

Publication Publication Date Title
SE0202463D0 (sv) Novel compounds
DE60210944D1 (de) N-substituierte heterocyclische nichtaryl-nmda/nr2b-antagonisten
TW200745029A (en) Sulfonamide derivatives exhibiting PGD2 receptor antagonism
BR9809451A (pt) Pirazóis substituìdos com 3(5)-heteroarila como inibidores de quinase p38.
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
HRP20090281T1 (hr) 1,2,3,4-tetrasubstituirani indol za liječenje respiratornih bolesti
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
MXPA02003977A (es) Inhibidores de adhesion de celula mediada por al°2.
ATE394383T1 (de) Biphenylkarbonsäureamidderivate als p38 kinase- inhibitoren
DE60322359D1 (de) Imidazopyridinderivate als kinaseinhibitoren
EA200500377A1 (ru) Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
PL378555A1 (pl) Sulfonoamido-podstawione pochodne ksantyny do stosowania jako inhibitory PEPCK
ES2189968T3 (es) Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS.
CO5690551A2 (es) Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo
WO2004100865A3 (fr) Nouveaux derives de benzimidazole
SE0402762D0 (sv) Indazole sulphonamide derivatives
ATE316962T1 (de) Pyrimidin-derivate als selective inhibitoren von cox-2
GB0308201D0 (en) Novel compounds
DE60023008D1 (de) Mittel zur verhinderung der chronischen abstossreaktion infolge einer organtransplantation
ATE402175T1 (de) 4-oxo-1-(3-substituiertesphenyl)-1,4-dihydro-1, - naphthyridin-3-carbonsäureamide alsphoshodiesterase-4-inhibitoren
EA200700848A1 (ru) Ингибиторы pi3-гамма-киназы для лечения анемии
ATE505462T1 (de) Neue biologischaktive molekü le
MXPA05009282A (es) Derivados de anilina sustituidos.
DK1165544T3 (da) Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase
CA2412596A1 (fr) Inhibiteurs de phosphodiesterase specifique de gmp cyclique