HRP20090086T3 - Phosphoindoles as hiv inhibitors - Google Patents

Phosphoindoles as hiv inhibitors

Info

Publication number
HRP20090086T3
HRP20090086T3 HR20090086T HRP20090086T HRP20090086T3 HR P20090086 T3 HRP20090086 T3 HR P20090086T3 HR 20090086 T HR20090086 T HR 20090086T HR P20090086 T HRP20090086 T HR P20090086T HR P20090086 T3 HRP20090086 T3 HR P20090086T3
Authority
HR
Croatia
Prior art keywords
alkyl
aryl
amino acid
amino
heterocycle
Prior art date
Application number
HR20090086T
Other languages
English (en)
Croatian (hr)
Inventor
Storer Richard
Dousson Cyril
Alexandre Fran�ois-Ren�
Roland Arlene
Original Assignee
Idenix Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20090086(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idenix Pharmaceuticals filed Critical Idenix Pharmaceuticals
Publication of HRP20090086T3 publication Critical patent/HRP20090086T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20090086T 2004-09-17 2005-09-16 Phosphoindoles as hiv inhibitors HRP20090086T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61106104P 2004-09-17 2004-09-17
US71144505P 2005-08-25 2005-08-25
US71156505P 2005-08-26 2005-08-26
PCT/IB2005/004063 WO2006054182A2 (en) 2004-09-16 2005-09-16 Phosphoindoles as hiv inhibitors

Publications (1)

Publication Number Publication Date
HRP20090086T3 true HRP20090086T3 (en) 2009-03-31

Family

ID=36407947

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090086T HRP20090086T3 (en) 2004-09-17 2005-09-16 Phosphoindoles as hiv inhibitors

Country Status (24)

Country Link
US (2) US7534809B2 (de)
EP (3) EP1961757B1 (de)
JP (1) JP5031569B2 (de)
KR (1) KR101242962B1 (de)
CN (1) CN102304150B (de)
AT (2) ATE479693T1 (de)
AU (1) AU2005305609B2 (de)
BR (1) BRPI0515344A (de)
CA (1) CA2583409C (de)
CY (1) CY1109440T1 (de)
DE (2) DE602005011031D1 (de)
DK (1) DK1799696T3 (de)
ES (1) ES2320252T3 (de)
HR (1) HRP20090086T3 (de)
IL (1) IL181909A0 (de)
MX (1) MX2007003040A (de)
NO (1) NO20071871L (de)
NZ (1) NZ554232A (de)
PL (1) PL1799696T3 (de)
PT (1) PT1799696E (de)
RS (1) RS50981B (de)
SG (1) SG155939A1 (de)
SI (1) SI1799696T1 (de)
WO (1) WO2006054182A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005011031D1 (en) 2004-09-17 2008-12-24 Idenix Pharmaceuticals Inc Phosphoindole als hiv-inhibitoren
ES2488922T3 (es) 2006-09-29 2014-09-01 Idenix Pharmaceuticals, Inc. Fosfoindoles enantiómeramente puros como inhibidores del HIV
WO2008054605A2 (en) * 2006-10-06 2008-05-08 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
CA2687747C (en) 2007-05-30 2015-11-17 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
TW200944537A (en) * 2008-04-03 2009-11-01 Idenix Pharmaceuticals Inc Formulations comprising a phosphoindole compound and one or more second active agents
WO2010090976A1 (en) * 2009-02-03 2010-08-12 Idenix Pharmaceuticals, Inc. Phosphinate ruthenium complexes
JP5690286B2 (ja) * 2009-03-04 2015-03-25 イデニク プハルマセウティカルス，インコーポレイテッド ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤
UA105556C2 (uk) 2010-01-27 2014-05-26 Віів Гелскер Компані Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
CN103275126B (zh) * 2013-05-28 2016-03-23 兰州大学 一种立体选择性合成3-位膦酰化吲哚的方法
ITMI20131218A1 (it) * 2013-07-19 2015-01-20 Need Pharma Srl Nuovi ureido derivati di acidi naftalensolfonici
EP3695225A4 (de) * 2017-10-13 2021-06-30 Ursure, Inc. Produkte und verfahren zur überwachung der adhärenz bei einer nukleosid-reverse-transkriptase-inhibitortherapie

Family Cites Families (37)

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Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
US5124327A (en) * 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
US5527819A (en) 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
JPH08507067A (ja) 1993-02-24 1996-07-30 メルク エンド カンパニー インコーポレーテッド Ｈｉｖ逆転写酵素阻害剤
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
US5489586A (en) 1994-03-07 1996-02-06 Warner-Lambert Company Method for treating inflammatory disease in humans
US5612330A (en) 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
US5489685A (en) 1994-05-12 1996-02-06 Merck & Co., Ltd. Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
US5852011A (en) 1994-05-31 1998-12-22 Mitsui Chemicals, Inc. Benzimidazole derivatives
US5734081A (en) 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
WO1996021644A1 (en) 1995-01-10 1996-07-18 Smithkline Beecham S.P.A. Indole derivatives useful in the treatment of osteoporosis
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
US6025344A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US6017903A (en) * 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
GB9614347D0 (en) 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
PL332413A1 (en) 1996-09-27 1999-09-13 Guilford Pharm Inc Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals
US5830894A (en) 1997-02-21 1998-11-03 Viropharma Incorporated Methods for preventing and treating pestivirus infection and associated diseases
US5935982A (en) 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
US6068988A (en) * 1997-02-28 2000-05-30 Biosynth Ag Detection of microbial metabolites with a 3-indoxyl-myo-inositol-1-phosphate compound
EP0994707A4 (de) 1997-05-27 2001-11-14 Guilford Pharm Inc Inhibitoren der naaladase-enzym-aktivität
EP1069111A4 (de) 1998-03-26 2001-06-06 Shionogi & Co Indol derivate mit antiviraler aktivität
IT1299068B1 (it) 1998-04-10 2000-02-07 Chemi Spa Legandi fosforati chirali e loro complessi organometallici, utili come catalizzatori in sintesi stereoselettive
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
EP1390029B1 (de) * 2001-04-11 2009-12-16 Idenix (Cayman) Limited Phenylindole zur behandlung von hiv
US6825201B2 (en) 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
JP3368273B1 (ja) * 2001-12-28 2003-01-20 株式会社トミー 動作玩具の駆動装置及び動作玩具
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
AU2003231765B9 (en) 2002-04-26 2010-01-28 Gilead Sciences, Inc. Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
US6900206B2 (en) * 2002-06-20 2005-05-31 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
US20040063746A1 (en) 2002-07-25 2004-04-01 Alicia Regueiro-Ren Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives
JP2006500355A (ja) * 2002-08-07 2006-01-05 イデニクス（ケイマン）リミテツド Ｈｉｖ治療用の置換フェニルインドール類
DE602005011031D1 (en) 2004-09-17 2008-12-24 Idenix Pharmaceuticals Inc Phosphoindole als hiv-inhibitoren
ES2488922T3 (es) * 2006-09-29 2014-09-01 Idenix Pharmaceuticals, Inc. Fosfoindoles enantiómeramente puros como inhibidores del HIV

Also Published As

Publication number Publication date
BRPI0515344A (pt) 2008-07-15
US7534809B2 (en) 2009-05-19
NZ554232A (en) 2010-09-30
JP5031569B2 (ja) 2012-09-19
ATE414092T1 (de) 2008-11-15
MX2007003040A (es) 2007-08-02
DE602005011031D1 (en) 2008-12-24
WO2006054182A2 (en) 2006-05-26
JP2008515782A (ja) 2008-05-15
DE602005023360D1 (de) 2010-10-14
RS50981B (sr) 2010-10-31
KR20070063545A (ko) 2007-06-19
WO2006054182A3 (en) 2007-03-01
EP1799696A2 (de) 2007-06-27
PL1799696T3 (pl) 2009-04-30
AU2005305609A1 (en) 2006-05-26
EP1799696B1 (de) 2008-11-12
PT1799696E (pt) 2009-02-16
AU2005305609B2 (en) 2011-10-06
CY1109440T1 (el) 2014-08-13
US20090163444A1 (en) 2009-06-25
ATE479693T1 (de) 2010-09-15
ES2320252T3 (es) 2009-05-20
CA2583409A1 (en) 2006-05-26
CN102304150B (zh) 2014-06-18
SG155939A1 (en) 2009-10-29
DK1799696T3 (da) 2009-03-09
US8044091B2 (en) 2011-10-25
SI1799696T1 (sl) 2009-04-30
IL181909A0 (en) 2007-07-04
CA2583409C (en) 2014-06-17
EP1961757A1 (de) 2008-08-27
WO2006054182A9 (en) 2006-08-17
CN102304150A (zh) 2012-01-04
HK1100142A1 (en) 2007-09-07
NO20071871L (no) 2007-05-15
EP1961757B1 (de) 2010-09-01
EP2256124A1 (de) 2010-12-01
US20060074054A1 (en) 2006-04-06
KR101242962B1 (ko) 2013-03-13

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