HRP20100209T1 - Makrociklički inhibitori virusa hepatitisa c - Google Patents

Makrociklički inhibitori virusa hepatitisa c Download PDF

Info

Publication number: HRP20100209T1
Authority: HR; Croatia
Prior art keywords: compound according; c6alkyl; image; hydrogen; alkyl
Prior art date: 2005-07-29

Application number

HR20100209T

Other languages

English (en)

Croatian (hr)

Inventor

Jean-Marie Bernard Raboisson Pierre

Augustinus De Kock Herman

Hu Lili

Alan Simmen Kenneth

Charlotta Lindquist Karin

Stefan Lindstr�m Mats

Karin Gertrud Linnea Belfrage Anna

J�rgen W�hling Horst

Magnus Nilsson Karl

Bertil Samuelsson Bengt

Annica Kristina Rosenquist Asa

Crister Sahlberg Sven

Kristian Wallberg Hans

Cecilia Kahnberg Pia

Olof Classon Bj�rn

Original Assignee

Medivir Ab

Tibotec Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-29

Filing date

2006-07-28

Publication date

2010-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37708968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100209(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-07-28 Application filed by Medivir Ab, Tibotec Pharmaceuticals filed Critical Medivir Ab

2010-05-31 Publication of HRP20100209T1 publication Critical patent/HRP20100209T1/hr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

HR20100209T 2005-07-29 2006-07-28 Makrociklički inhibitori virusa hepatitisa c HRP20100209T1 (hr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05107057		2005-07-29
EP06113097		2006-04-25
PCT/EP2006/064822 WO2007014927A2 (fr)	2005-07-29	2006-07-28	Inhibiteurs macrocycliques du virus de l'hepatite c

Publications (1)

Publication Number	Publication Date
HRP20100209T1 true HRP20100209T1 (hr)	2010-05-31

Family

ID=37708968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20100209T HRP20100209T1 (hr)	2005-07-29	2006-07-28	Makrociklički inhibitori virusa hepatitisa c

Country Status (31)

Country	Link
US (1)	US7659245B2 (fr)
EP (1)	EP1912981B1 (fr)
JP (1)	JP5230418B2 (fr)
KR (1)	KR101083631B1 (fr)
AP (1)	AP2585A (fr)
AR (1)	AR057702A1 (fr)
AT (1)	ATE455775T1 (fr)
AU (1)	AU2006274866B2 (fr)
BR (1)	BRPI0614153A2 (fr)
CA (1)	CA2617103C (fr)
CY (1)	CY1110008T1 (fr)
DE (1)	DE602006011905D1 (fr)
DK (1)	DK1912981T3 (fr)
EA (1)	EA014188B1 (fr)
ES (1)	ES2339702T3 (fr)
GT (1)	GT200600343A (fr)
HR (1)	HRP20100209T1 (fr)
IL (1)	IL188320A (fr)
ME (1)	ME01454B (fr)
MY (1)	MY151026A (fr)
NO (1)	NO20081075L (fr)
NZ (1)	NZ564540A (fr)
PE (1)	PE20070343A1 (fr)
PL (1)	PL1912981T3 (fr)
PT (1)	PT1912981E (fr)
RS (1)	RS51227B (fr)
SI (1)	SI1912981T1 (fr)
SV (1)	SV2008002641A (fr)
TW (1)	TWI387597B (fr)
UY (1)	UY29704A1 (fr)
WO (1)	WO2007014927A2 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
KR20120090077A (ko)	2004-01-30	2012-08-16	얀센 알 앤드 디 아일랜드	Ｈｃｖｎｓ?３ 세린 프로테아제 저해제
PE20070211A1 (es)	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
TWI412535B (zh)	2005-07-29	2013-10-21	Tibotec Pharm Ltd	Ｃ型肝炎病毒之大環抑制劑（五）
JO2768B1 (en) *	2005-07-29	2014-03-15	تيبوتيك فارماسيوتيكالز ليمتد	Large cyclic inhibitors of hepatitis C virus
ES2373685T3 (es)	2005-07-29	2012-02-07	Tibotec Pharmaceuticals	Inhibidores macrocíclicos del virus de la hepatitis c.
GEP20104956B (en)	2005-10-11	2010-04-12	Array Biopharma Inc	Compounds for inhibiting hepatitis c viral replication and use thereof
US7741281B2 (en)	2005-11-03	2010-06-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
KR20090024834A (ko)	2006-07-05	2009-03-09	인터뮨, 인크.	Ｃ형 간염 바이러스 복제의 신규 억제제
EP2049474B1 (fr)	2006-07-11	2015-11-04	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
CA2657618C (fr)	2006-07-13	2016-10-11	Achillion Pharmaceuticals, Inc.	4-amino-4-oxobutanoyl peptides en tant qu'inhibiteurs de la replication virale
US8343477B2 (en)	2006-11-01	2013-01-01	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
US7772180B2 (en)	2006-11-09	2010-08-10	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7888464B2 (en)	2006-11-16	2011-02-15	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7763584B2 (en)	2006-11-16	2010-07-27	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8003604B2 (en)	2006-11-16	2011-08-23	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CA2661338C (fr) *	2006-11-17	2015-05-12	Tibotec Pharmaceuticals Ltd.	Inhibiteurs macrocycliques du virus de l'hepatite c
PL2121674T3 (pl) *	2007-02-01	2010-10-29	Janssen Sciences Ireland Uc	Sposoby i związki pośrednie do wytwarzania makrocyklicznego inhibitora proteazy HCV
US8937080B2 (en) *	2007-02-08	2015-01-20	Medivir Ab	Pyrimidine substituted macrocyclic HCV inhibitors
ITMI20071616A1 (it)	2007-08-03	2009-02-04	Cosmo Spa	Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
EP2190858A4 (fr) *	2007-09-24	2013-02-13	Achillion Pharmaceuticals Inc	Peptides contenant de l'urée en tant qu'inhibiteurs de la réplication virale
US8383583B2 (en)	2007-10-26	2013-02-26	Enanta Pharmaceuticals, Inc.	Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
US8426360B2 (en) *	2007-11-13	2013-04-23	Enanta Pharmaceuticals, Inc.	Carbocyclic oxime hepatitis C virus serine protease inhibitors
WO2009070692A1 (fr)	2007-11-29	2009-06-04	Enanta Pharmaceuticals, Inc.	Inhibiteurs de sérine protéase de l'hépatite c macrocycliques, dérivés de la proline, substitués en c5
US8202996B2 (en)	2007-12-21	2012-06-19	Bristol-Myers Squibb Company	Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
EP2226315A4 (fr)	2007-12-28	2012-01-25	Carna Biosciences Inc	Dérivé de 2-aminoquinazoline
CA2719008A1 (fr)	2008-03-20	2009-09-24	Enanta Pharmaceuticals, Inc.	Composes macrocycliques fluores en tant qu'inhibiteurs du virus de l'hepatite c
US8163921B2 (en)	2008-04-16	2012-04-24	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7964560B2 (en)	2008-05-29	2011-06-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8044023B2 (en)	2008-05-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8563505B2 (en)	2008-09-29	2013-10-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8044087B2 (en)	2008-09-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
ES2527166T3 (es)	2008-12-10	2015-01-21	Achillion Pharmaceuticals, Inc.	Nuevos péptidos de 4-amino-4-oxobutanoílo como inhibidores de la replicación viral
US8283310B2 (en)	2008-12-15	2012-10-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
MX340792B (es)	2009-02-27	2016-07-25	Ortho-Mcneil-Janssen Pharmaceuticals Inc *	Sal amorfa de un inhibidor macrociclico de virus de hepatitis c.
US8377962B2 (en)	2009-04-08	2013-02-19	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors
WO2010136475A1 (fr) *	2009-05-29	2010-12-02	Syngenta Participations Ag	Quinazolines substituées, utilisées en tant que fongicides
US9284307B2 (en)	2009-08-05	2016-03-15	Idenix Pharmaceuticals Llc	Macrocyclic serine protease inhibitors
WO2012092411A2 (fr)	2010-12-30	2012-07-05	Enanta Pharmaceuticals, Inc.	Inhibiteurs macrocycliques de phénanthridine de sérine protéase d'hépatite c
CN103534256B (zh)	2010-12-30	2016-08-10	益安药业	大环丙型肝炎丝氨酸蛋白酶抑制剂
US9353100B2 (en)	2011-02-10	2016-05-31	Idenix Pharmaceuticals Llc	Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
BR112014016157A8 (pt)	2011-12-28	2017-07-04	Janssen R&D Ireland	derivados heterobicíclicos como inibidores de vhc
CA2886973C (fr) *	2012-10-15	2017-08-15	Albemarle Corporation	Procedes de synthese de 2-amino-4,6-dimethoxybenzamide et d'autres composes de benzamide
SI2909205T1 (sl)	2012-10-19	2017-02-28	Bristol-Myers Squibb Company	9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
EP2914598B1 (fr)	2012-11-02	2017-10-18	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
EP2914613B1 (fr)	2012-11-02	2017-11-22	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
US9409943B2 (en)	2012-11-05	2016-08-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9580463B2 (en)	2013-03-07	2017-02-28	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9006423B2 (en)	2013-03-15	2015-04-14	Achillion Pharmaceuticals Inc.	Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
WO2014145600A1 (fr)	2013-03-15	2014-09-18	Achillion Pharmaceuticals, Inc.	Polymorphes de sel de sodium d'ach-0142684, composition les comprenant, et leur procédé de fabrication
WO2015103490A1 (fr)	2014-01-03	2015-07-09	Abbvie, Inc.	Formes galéniques antivirales solides
EP3108879A1 (fr)	2015-06-25	2016-12-28	Cassiopea S.p.A.	Formulation à concentration élevée

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6323180B1 (en)	1998-08-10	2001-11-27	Boehringer Ingelheim (Canada) Ltd	Hepatitis C inhibitor tri-peptides
UA74546C2 (en) *	1999-04-06	2006-01-16	Boehringer Ingelheim Ca Ltd	Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6867185B2 (en) *	2001-12-20	2005-03-15	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
JP2005535574A (ja)	2002-04-11	2005-11-24	バーテックス　ファーマシューティカルズ　インコーポレイテッド	セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター
MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
US20050075279A1 (en) *	2002-10-25	2005-04-07	Boehringer Ingelheim International Gmbh	Macrocyclic peptides active against the hepatitis C virus
US20040180815A1 (en) *	2003-03-07	2004-09-16	Suanne Nakajima	Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
AU2004211637C1 (en) *	2003-02-07	2010-08-19	Enanta Pharmaceuticals, Inc.	Macrocyclic hepatitis C serine protease inhibitors
EP1629000B1 (fr) *	2003-04-16	2009-02-18	Bristol-Myers Squibb Company	Peptide d'isoquinoleine macrocyclique inhibiteurs du virus de l'hepatite c
US7125845B2 (en) *	2003-07-03	2006-10-24	Enanta Pharmaceuticals, Inc.	Aza-peptide macrocyclic hepatitis C serine protease inhibitors
RS20060197A (sr)	2003-09-22	2008-09-29	Boehringer Ingelheim International Gmbh.,	Makrociklični peptidi koji su aktivni protiv hepatitisa c virusa
KR20120090077A (ko) *	2004-01-30	2012-08-16	얀센 알 앤드 디 아일랜드	Ｈｃｖｎｓ?３ 세린 프로테아제 저해제
US7700552B2 (en) *	2005-07-29	2010-04-20	Medivir Ab	Macrocyclic inhibitors of hepatitis C virus
DK1919904T3 (da) *	2005-07-29	2014-04-07	Janssen R & D Ireland	Makrocykliske inhibitorer af hepatitis-c-virus
US20100120855A1 (en) *	2005-07-29	2010-05-13	Tibotec Pharmaceuticals Ltd.	Macrocylic inhibitors of hepatitis c virus
PE20070211A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c

2006
- 2006-07-26 PE PE2006000903A patent/PE20070343A1/es not_active Application Discontinuation
- 2006-07-28 JP JP2008523383A patent/JP5230418B2/ja not_active Expired - Fee Related
- 2006-07-28 DE DE602006011905T patent/DE602006011905D1/de active Active
- 2006-07-28 MY MYPI20063670 patent/MY151026A/en unknown
- 2006-07-28 WO PCT/EP2006/064822 patent/WO2007014927A2/fr not_active Ceased
- 2006-07-28 UY UY29704A patent/UY29704A1/es unknown
- 2006-07-28 BR BRPI0614153-6A patent/BRPI0614153A2/pt not_active Application Discontinuation
- 2006-07-28 EP EP06764268A patent/EP1912981B1/fr active Active
- 2006-07-28 ME MEP-2012-119A patent/ME01454B/me unknown
- 2006-07-28 SI SI200630627T patent/SI1912981T1/sl unknown
- 2006-07-28 RS RSP-2010/0183A patent/RS51227B/sr unknown
- 2006-07-28 KR KR1020087004894A patent/KR101083631B1/ko not_active Expired - Fee Related
- 2006-07-28 PT PT06764268T patent/PT1912981E/pt unknown
- 2006-07-28 DK DK06764268.6T patent/DK1912981T3/da active
- 2006-07-28 ES ES06764268T patent/ES2339702T3/es active Active
- 2006-07-28 TW TW095127585A patent/TWI387597B/zh not_active IP Right Cessation
- 2006-07-28 US US11/995,900 patent/US7659245B2/en not_active Expired - Fee Related
- 2006-07-28 HR HR20100209T patent/HRP20100209T1/hr unknown
- 2006-07-28 GT GT200600343A patent/GT200600343A/es unknown
- 2006-07-28 AR ARP060103303A patent/AR057702A1/es not_active Application Discontinuation
- 2006-07-28 CA CA2617103A patent/CA2617103C/fr not_active Expired - Fee Related
- 2006-07-28 AP AP2008004306A patent/AP2585A/xx active
- 2006-07-28 PL PL06764268T patent/PL1912981T3/pl unknown
- 2006-07-28 AU AU2006274866A patent/AU2006274866B2/en not_active Ceased
- 2006-07-28 EA EA200800482A patent/EA014188B1/ru not_active IP Right Cessation
- 2006-07-28 AT AT06764268T patent/ATE455775T1/de active
- 2006-07-28 NZ NZ564540A patent/NZ564540A/en not_active IP Right Cessation
- 2006-07-29 SV SV2006002641A patent/SV2008002641A/es unknown
2007
- 2007-12-20 IL IL188320A patent/IL188320A/en not_active IP Right Cessation
2008
- 2008-02-29 NO NO20081075A patent/NO20081075L/no not_active Application Discontinuation
2010
- 2010-04-20 CY CY20101100355T patent/CY1110008T1/el unknown

Also Published As

Publication number	Publication date
AP2585A (en)	2013-02-04
MY151026A (en)	2014-03-31
IL188320A (en)	2014-07-31
CA2617103A1 (fr)	2007-02-08
US20090118312A1 (en)	2009-05-07
AR057702A1 (es)	2007-12-12
HK1116488A1 (en)	2008-12-24
ES2339702T3 (es)	2010-05-24
WO2007014927A3 (fr)	2007-11-29
BRPI0614153A2 (pt)	2011-03-15
ME01454B (me)	2014-04-20
SI1912981T1 (sl)	2010-05-31
DE602006011905D1 (de)	2010-03-11
AU2006274866A1 (en)	2007-02-08
RS51227B (sr)	2010-12-31
IL188320A0 (en)	2008-04-13
JP5230418B2 (ja)	2013-07-10
KR20080033475A (ko)	2008-04-16
EA014188B1 (ru)	2010-10-29
AU2006274866B2 (en)	2012-04-12
UY29704A1 (es)	2007-05-31
NZ564540A (en)	2010-03-26
PE20070343A1 (es)	2007-05-12
SV2008002641A (es)	2008-07-23
NO20081075L (no)	2008-04-25
EP1912981B1 (fr)	2010-01-20
DK1912981T3 (da)	2010-05-25
CY1110008T1 (el)	2015-01-14
GT200600343A (es)	2007-08-06
ATE455775T1 (de)	2010-02-15
EP1912981A2 (fr)	2008-04-23
PL1912981T3 (pl)	2010-07-30
JP2009502890A (ja)	2009-01-29
WO2007014927A2 (fr)	2007-02-08
TW200745116A (en)	2007-12-16
CA2617103C (fr)	2015-01-06
KR101083631B1 (ko)	2011-11-16
PT1912981E (pt)	2010-04-16
EA200800482A1 (ru)	2008-06-30
US7659245B2 (en)	2010-02-09
TWI387597B (zh)	2013-03-01

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HRP20100048T1 (hr)	2010-04-30	Inhibitori hcv ns-3 serin proteaze
AR057702A1 (es)	2007-12-12	Inhibidores macrociclicos del virus de la hepatitis c, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para la profilaxis o el tratamiento de infecciones por flavivirus
JP2013514359A5 (fr)	2014-01-09
EP2041159B8 (fr)	2012-02-22	Composes macrocycliques en tant qu'agents antiviraux
HRP20181075T1 (hr)	2018-09-07	Makrociklični inhibitori hepatitisa c serin proteaze
SG161315A1 (en)	2010-05-27	Compounds and methods for the treatment or prevention of flavivirus infections
CU23787B7 (es)	2012-03-15	Compuestos macrocíclicos como inhibidores de la replicación viral
MY146123A (en)	2012-06-29	Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatment using the same
GEP20247600B (en)	2024-02-26	B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
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IN2012DN00999A (fr)	2015-04-10
HRP20110169T1 (hr)	2011-04-30	Upotreba [d-meala]3-[etval]4-ciklosporina za liječenje infekcija hepatitisom c
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SG164376A1 (en)	2010-09-29	Hcv ns3 protease inhibitors
BR112014000563A2 (pt)	2019-12-10	composto, composição farmacêutica, e, uso do composto
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UA91255C2 (uk)	2010-07-12	Антивірусні нуклеозиди
IL195025A (en)	2013-09-30	History of compressed indolubenzazepine with cyclopropyl and pharmaceuticals containing them as an anti-hcv drug
MX2010004623A (es)	2010-06-07	Compuestos heterociclicos antiviricos.
MX2009008872A (es)	2009-10-30	Compuestos macrociclicos como inhibidores de proteasa ns3 del virus de hepatitis c.