HRP20100604T1 - Derivati 4h-1,2,4-triazin-5-ona, njihova priprava i njihova uporaba kao alfa 7 nikotinskih acetilkolinskih receptora - Google Patents

Derivati 4h-1,2,4-triazin-5-ona, njihova priprava i njihova uporaba kao alfa 7 nikotinskih acetilkolinskih receptora Download PDF

Info

Publication number
HRP20100604T1
HRP20100604T1 HR20100604T HRP20100604T HRP20100604T1 HR P20100604 T1 HRP20100604 T1 HR P20100604T1 HR 20100604 T HR20100604 T HR 20100604T HR P20100604 T HRP20100604 T HR P20100604T HR P20100604 T1 HRP20100604 T1 HR P20100604T1
Authority
HR
Croatia
Prior art keywords
triazin
group
compound
formula
indol
Prior art date
Application number
HR20100604T
Other languages
English (en)
Croatian (hr)
Inventor
Benedetti Yannick
Bohme Andrees
Genevois-Borella Arielle
Touyer Gaetan
Zhang Jidong
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of HRP20100604T1 publication Critical patent/HRP20100604T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20100604T 2005-04-22 2006-04-21 Derivati 4h-1,2,4-triazin-5-ona, njihova priprava i njihova uporaba kao alfa 7 nikotinskih acetilkolinskih receptora HRP20100604T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0504042A FR2884822B1 (fr) 2005-04-22 2005-04-22 Derives de triazines, leur preparation et leur application en therapeutique
PCT/FR2006/000887 WO2006111662A2 (fr) 2005-04-22 2006-04-21 Derives de 4h-1 , 2 , 4-triazin-5-0nes , leur preparation et leur utilisation comme des recepteurs a l'acetylcholine de type nicotiniques alpha7

Publications (1)

Publication Number Publication Date
HRP20100604T1 true HRP20100604T1 (hr) 2010-12-31

Family

ID=35219499

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100604T HRP20100604T1 (hr) 2005-04-22 2006-04-21 Derivati 4h-1,2,4-triazin-5-ona, njihova priprava i njihova uporaba kao alfa 7 nikotinskih acetilkolinskih receptora

Country Status (17)

Country Link
US (1) US7517881B2 (de)
EP (1) EP1874761B1 (de)
JP (1) JP4966295B2 (de)
AR (1) AR054033A1 (de)
AT (1) ATE478068T1 (de)
CY (1) CY1111288T1 (de)
DE (1) DE602006016258D1 (de)
DK (1) DK1874761T3 (de)
ES (1) ES2350950T3 (de)
FR (1) FR2884822B1 (de)
HR (1) HRP20100604T1 (de)
PL (1) PL1874761T3 (de)
PT (1) PT1874761E (de)
RS (1) RS51557B (de)
SI (1) SI1874761T1 (de)
TW (1) TW200708506A (de)
WO (1) WO2006111662A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
CA3024067C (en) * 2016-05-12 2024-04-09 Buck Institute For Research On Aging Compounds to promote normal processing of app

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4774604B2 (ja) * 2000-02-14 2011-09-14 和光純薬工業株式会社 第４級アンモニウム塩の製造方法
JP4616971B2 (ja) * 2000-07-18 2011-01-19 田辺三菱製薬株式会社 １−アザビシクロアルカン化合物およびその医薬用途
EP1432707B1 (de) * 2001-10-02 2012-03-28 Pharmacia & Upjohn Company LLC Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten
SE0301320D0 (sv) * 2003-05-06 2003-05-06 Astrazeneca Ab Positive modulators of nicotinic acetylcholine receptors

Also Published As

Publication number Publication date
CY1111288T1 (el) 2015-08-05
AR054033A1 (es) 2007-05-30
TW200708506A (en) 2007-03-01
JP4966295B2 (ja) 2012-07-04
WO2006111662A3 (fr) 2006-11-30
PL1874761T3 (pl) 2011-02-28
EP1874761A2 (de) 2008-01-09
ATE478068T1 (de) 2010-09-15
DE602006016258D1 (de) 2010-09-30
WO2006111662A2 (fr) 2006-10-26
EP1874761B1 (de) 2010-08-18
PT1874761E (pt) 2010-11-18
DK1874761T3 (da) 2010-12-13
FR2884822B1 (fr) 2007-06-29
JP2008536902A (ja) 2008-09-11
RS51557B (sr) 2011-06-30
US7517881B2 (en) 2009-04-14
SI1874761T1 (sl) 2010-12-31
FR2884822A1 (fr) 2006-10-27
US20080096891A1 (en) 2008-04-24
ES2350950T3 (es) 2011-01-28

Similar Documents

Publication Publication Date Title
JP7398391B2 (ja) Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物
KR101129933B1 (ko) 인다졸, 벤조티아졸 및 벤조이소티아졸 및 그의 제조 및용도
AU2005261866B8 (en) 3-(heteroaryl-oxy)-2-alkyl-1-aza-bicycloalkyl derivatives as alpha.7-NACHR ligands for the treatment of CNS diseases
ES2815373T3 (es) Procedimiento de compuesto antifúngico
AU2005254689B2 (en) 1-aza-bicyclo[3.3.1]nonanes
JP2019530726A (ja) 二環式ピリドンラクタム及びその使用方法。
US11851433B2 (en) Compounds, compositions and methods
TW200718692A (en) Dihydrobenzofuran derivatives and uses thereof
ATE280170T1 (de) Cyclopenta(b)(1,4) diazepino(6,7,1-hi)indole als 5ht2c antagonisten
EP3552017B1 (de) Verbindungen zur verwendung als ripk1-hemmer
JP2007500168A5 (de)
CN104203943A (zh) 取代的嘧啶化合物及其作为syk抑制剂的用途
WO2017096045A1 (en) Multivalent ras binding compounds
JP4995203B2 (ja) 精神病および神経変性障害の処置のための、ｎ−ＡＣｈＲのコリン作動性リガンドとしての（１−アザ−ビシクロ［３．３．１］ノン−４−イル）−［５−（１Ｈ−インドール−５−イル）−ヘテロアリール］−アミン
ES2742078T3 (es) Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
AR065333A1 (es) Antagonistas del receptor de dopamina 2 de rapida disociacion
WO2006136837A3 (en) Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
WO2011071996A1 (en) Faah inhibitors
TW200740806A (en) Bridged N-cyclic sulfonamido inhibitors of gamma secretase
BR9509353A (pt) Utilzação de diazepino-indolas as respectivas diazepino- indolas e medicamen to
EA201001459A1 (ru) 2-амино-3-сульфонил-тетрагидропиразоло[1,5-а]пиридопиримидины - антагонисты серотониновых 5-нтрецепторов, способы их получения и применения
WO2008044144A3 (en) Chiral tetra-hydro beta-carbolic derivatives and applications thereof as antiparasitic compounds
ES2442293T3 (es) Derivados de dihidro-oxazolobenzodiazepinona, procedimientos para su preparación y composiciones farmacéuticas que contienen estos compuestos
WO2009093206A3 (ru) 3-CУЛЬФOHИЛ-ПИPAЗOЛO[1,5-a]ПИPИMИДИHЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
JP2003513072A5 (de)