HRP20120077T1 - Benzimidazolonski spojevi s aktivnošću agonista 5-ht4 receptora - Google Patents

Benzimidazolonski spojevi s aktivnošću agonista 5-ht4 receptora Download PDF

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Publication number
HRP20120077T1
HRP20120077T1 HR20120077T HRP20120077T HRP20120077T1 HR P20120077 T1 HRP20120077 T1 HR P20120077T1 HR 20120077 T HR20120077 T HR 20120077T HR P20120077 T HRP20120077 T HR P20120077T HR P20120077 T1 HRP20120077 T1 HR P20120077T1
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HR
Croatia
Prior art keywords
group
substituents
carbon atoms
substituted
independently selected
Prior art date
Application number
HR20120077T
Other languages
English (en)
Croatian (hr)
Inventor
Iguchi Satoru
Katsu Yasuhiro
Sone Hiroki
Uchida Chikara
Kojima Takashi
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20120077T1 publication Critical patent/HRP20120077T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Structural Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20120077T 2003-09-03 2004-08-20 Benzimidazolonski spojevi s aktivnošću agonista 5-ht4 receptora HRP20120077T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50014403P 2003-09-03 2003-09-03
PCT/IB2004/002741 WO2005021539A1 (fr) 2003-09-03 2004-08-20 Composes de benzimidazolone a activite d'agonistes du recepteur 5-ht4

Publications (1)

Publication Number Publication Date
HRP20120077T1 true HRP20120077T1 (hr) 2012-02-29

Family

ID=34272920

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20120077T HRP20120077T1 (hr) 2003-09-03 2004-08-20 Benzimidazolonski spojevi s aktivnošću agonista 5-ht4 receptora

Country Status (39)

Country Link
US (2) US7776885B2 (fr)
EP (1) EP1664036B1 (fr)
JP (1) JP3983269B1 (fr)
KR (1) KR100738784B1 (fr)
CN (1) CN100482659C (fr)
AP (1) AP2184A (fr)
AR (1) AR045552A1 (fr)
AT (1) ATE539077T1 (fr)
AU (1) AU2004268840B9 (fr)
BR (1) BRPI0414105B8 (fr)
CA (1) CA2537127C (fr)
CR (1) CR8267A (fr)
CY (1) CY1112321T1 (fr)
DK (1) DK1664036T3 (fr)
EA (1) EA009457B1 (fr)
EC (1) ECSP066407A (fr)
ES (1) ES2377484T3 (fr)
GE (1) GEP20084527B (fr)
GT (1) GT200400174A (fr)
HR (1) HRP20120077T1 (fr)
IL (3) IL173705A (fr)
IS (1) IS8289A (fr)
MA (1) MA28021A1 (fr)
MX (1) MXPA06002550A (fr)
NL (1) NL1026959C2 (fr)
NO (1) NO20061519L (fr)
OA (1) OA13248A (fr)
PA (1) PA8610601A1 (fr)
PE (1) PE20050874A1 (fr)
PL (1) PL1664036T3 (fr)
PT (1) PT1664036E (fr)
RS (1) RS20060145A (fr)
SI (1) SI1664036T1 (fr)
TN (1) TNSN06073A1 (fr)
TW (1) TW200510332A (fr)
UA (1) UA86204C2 (fr)
UY (1) UY28496A1 (fr)
WO (1) WO2005021539A1 (fr)
ZA (1) ZA200601324B (fr)

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Publication number Publication date
RS20060145A (sr) 2008-06-05
BRPI0414105B8 (pt) 2021-05-25
EA009457B1 (ru) 2007-12-28
ECSP066407A (es) 2006-09-18
TNSN06073A1 (en) 2007-10-03
AU2004268840B2 (en) 2010-09-23
GEP20084527B (en) 2008-11-10
NO20061519L (no) 2006-06-01
AU2004268840A1 (en) 2005-03-10
PT1664036E (pt) 2012-02-16
CN1845922A (zh) 2006-10-11
NL1026959C2 (nl) 2006-01-23
KR100738784B1 (ko) 2007-07-12
CA2537127A1 (fr) 2005-03-10
OA13248A (en) 2007-01-31
JP2007533613A (ja) 2007-11-22
US20100273794A1 (en) 2010-10-28
UA86204C2 (uk) 2009-04-10
MXPA06002550A (es) 2006-06-20
CR8267A (es) 2006-11-21
WO2005021539A1 (fr) 2005-03-10
EP1664036B1 (fr) 2011-12-28
ZA200601324B (en) 2007-05-30
IL205600A0 (en) 2010-11-30
NL1026959A1 (nl) 2005-03-07
GT200400174A (es) 2005-05-02
ES2377484T3 (es) 2012-03-28
CY1112321T1 (el) 2015-12-09
PA8610601A1 (es) 2005-03-28
AR045552A1 (es) 2005-11-02
BRPI0414105B1 (pt) 2018-08-14
KR20060087540A (ko) 2006-08-02
MA28021A1 (fr) 2006-07-03
PL1664036T3 (pl) 2012-04-30
TW200510332A (en) 2005-03-16
US7776885B2 (en) 2010-08-17
AU2004268840B9 (en) 2011-02-03
PE20050874A1 (es) 2005-10-26
UY28496A1 (es) 2005-04-29
HK1093338A1 (zh) 2007-03-02
EA200600327A1 (ru) 2006-08-25
EP1664036A1 (fr) 2006-06-07
SI1664036T1 (sl) 2012-03-30
ATE539077T1 (de) 2012-01-15
AP2006003536A0 (en) 2006-04-30
BRPI0414105A (pt) 2006-11-21
IL173705A0 (en) 2006-07-05
IL173705A (en) 2013-04-30
IS8289A (is) 2006-02-09
DK1664036T3 (da) 2012-02-13
CA2537127C (fr) 2011-04-05
AP2184A (en) 2010-12-02
US20050148573A1 (en) 2005-07-07
JP3983269B1 (ja) 2007-09-26
CN100482659C (zh) 2009-04-29
IL205599A0 (en) 2010-11-30

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