BRPI0608392A2 - compostos de quinolinona como agonistas do receptor 5-ht4 - Google Patents

compostos de quinolinona como agonistas do receptor 5-ht4

Info

Publication number
BRPI0608392A2
BRPI0608392A2 BRPI0608392-7A BRPI0608392A BRPI0608392A2 BR PI0608392 A2 BRPI0608392 A2 BR PI0608392A2 BR PI0608392 A BRPI0608392 A BR PI0608392A BR PI0608392 A2 BRPI0608392 A2 BR PI0608392A2
Authority
BR
Brazil
Prior art keywords
compounds
receptor agonists
quinolinone
quinolinone compounds
receptor
Prior art date
Application number
BRPI0608392-7A
Other languages
English (en)
Inventor
Adam A Goldblum
Seok-Ki Choi
Roland Gendron
Lan Jiang
Daniel D Long
Daniel Marquess
Derek S Turner
Paul Ross Fatheree
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of BRPI0608392A2 publication Critical patent/BRPI0608392A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS DE QUINOLINONA COMO AGONISTAS DO RECEPTOR 5-HT4. A invenção proporciona novos compostos agonistas do receptor 5-HT4 de quinolinona-carboxamida. A invenção também proporciona composições farmacêuticas compreendendo tais compostos, métodos de uso de tais compostos para tratar doenças associada à atividade do receptor 5-HT4 e processos e intermediários úteis para o preparo de tais compostos.
BRPI0608392-7A 2005-03-02 2006-03-01 compostos de quinolinona como agonistas do receptor 5-ht4 BRPI0608392A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65800705P 2005-03-02 2005-03-02
PCT/US2006/007284 WO2006094063A1 (en) 2005-03-02 2006-03-01 Quinolinone compounds as 5-ht4 receptor agonists

Publications (1)

Publication Number Publication Date
BRPI0608392A2 true BRPI0608392A2 (pt) 2009-12-29

Family

ID=36588769

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608392-7A BRPI0608392A2 (pt) 2005-03-02 2006-03-01 compostos de quinolinona como agonistas do receptor 5-ht4

Country Status (16)

Country Link
US (2) US7446114B2 (pt)
EP (1) EP1871772B1 (pt)
JP (1) JP5042043B2 (pt)
KR (1) KR20070107807A (pt)
CN (1) CN101163701A (pt)
AU (1) AU2006218603A1 (pt)
BR (1) BRPI0608392A2 (pt)
CA (1) CA2599404A1 (pt)
EA (1) EA013567B1 (pt)
ES (1) ES2523851T3 (pt)
IL (1) IL185407A0 (pt)
MX (1) MX2007010769A (pt)
NO (1) NO20074884L (pt)
NZ (1) NZ560828A (pt)
WO (1) WO2006094063A1 (pt)
ZA (1) ZA200707142B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
MY143574A (en) * 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
US8338142B2 (en) * 2007-02-19 2012-12-25 Kaneka Corporation Method for producing optically active 3-aminopiperidine or salt thereof
SG178557A1 (en) * 2009-09-14 2012-03-29 Suven Life Sciences Ltd L -dihydro-2-oxoquinoline compounds a 5-ht4 receptor ligands
US20160287573A1 (en) 2015-04-02 2016-10-06 Theravance Biopharma R&D Ip, Llc Combination dosage form of a mu opioid receptor antagonist and an opioid agent
CA3245086A1 (en) 2022-01-11 2023-07-20 Suven Life Sciences Limited PYRROLO[1,2-B]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

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Also Published As

Publication number Publication date
NZ560828A (en) 2011-01-28
EP1871772B1 (en) 2014-09-10
US20090036483A1 (en) 2009-02-05
IL185407A0 (en) 2008-01-06
CA2599404A1 (en) 2006-09-08
US20060199839A1 (en) 2006-09-07
AU2006218603A1 (en) 2006-09-08
NO20074884L (no) 2007-11-29
KR20070107807A (ko) 2007-11-07
JP5042043B2 (ja) 2012-10-03
WO2006094063A1 (en) 2006-09-08
US7875629B2 (en) 2011-01-25
CN101163701A (zh) 2008-04-16
ZA200707142B (en) 2008-10-29
ES2523851T3 (es) 2014-12-02
MX2007010769A (es) 2008-03-07
EA200701867A1 (ru) 2008-02-28
EA013567B1 (ru) 2010-06-30
JP2008531711A (ja) 2008-08-14
US7446114B2 (en) 2008-11-04
EP1871772A1 (en) 2008-01-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2211 DE 21/05/2013.