HRP20190160T8 - Mutant gdf-5 za indukciju formiranja hrskavice - Google Patents

Mutant gdf-5 za indukciju formiranja hrskavice

Info

Publication number: HRP20190160T8
Authority: HR; Croatia
Prior art keywords: gdf; mutant; cartilage formation; inducing cartilage; inducing
Prior art date: 2011-12-05

Application number

HRP20190160TT

Other languages

English (en)

Inventor

Frank PLÖGER

Florian Wagner

Original Assignee

Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-05

Filing date

2019-01-23

Publication date

2020-02-07

2019-01-23 Application filed by Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh filed Critical Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh

2019-03-22 Publication of HRP20190160T1 publication Critical patent/HRP20190160T1/hr

2020-02-07 Publication of HRP20190160T8 publication Critical patent/HRP20190160T8/hr

Links

101100175316 Mus musculus Gdf5 gene Proteins 0.000 title 1
230000022159 cartilage development Effects 0.000 title 1
230000001939 inductive effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

HRP20190160TT 2011-12-05 2019-01-23 Mutant gdf-5 za indukciju formiranja hrskavice HRP20190160T8 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP11191973.4A EP2602264A1 (en)	2011-12-05	2011-12-05	GDF-5 mutant for inducing cartilage formation
EP16203435.9A EP3168230B1 (en)	2011-12-05	2012-12-05	Gdf-5 mutant for inducing cartilage formation

Publications (2)

Publication Number	Publication Date
HRP20190160T1 HRP20190160T1 (hr)	2019-03-22
HRP20190160T8 true HRP20190160T8 (hr)	2020-02-07

Family

ID=47278877

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HRP20170205TT HRP20170205T1 (hr)	2011-12-05	2012-12-05	Mutant gdf-5 za indukciju formiranja hrskavice
HRP20190160TT HRP20190160T8 (hr)	2011-12-05	2019-01-23	Mutant gdf-5 za indukciju formiranja hrskavice

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
HRP20170205TT HRP20170205T1 (hr)	2011-12-05	2012-12-05	Mutant gdf-5 za indukciju formiranja hrskavice

Country Status (22)

Country	Link
US (1)	US9718867B2 (hr)
EP (3)	EP2602264A1 (hr)
JP (1)	JP6185926B2 (hr)
KR (1)	KR102067724B1 (hr)
CN (1)	CN104039820B (hr)
AU (1)	AU2012347305B2 (hr)
BR (1)	BR112014013122A2 (hr)
CA (1)	CA2856458C (hr)
DK (2)	DK2788374T3 (hr)
EA (1)	EA028554B1 (hr)
ES (2)	ES2708675T3 (hr)
HR (2)	HRP20170205T1 (hr)
HU (2)	HUE033025T2 (hr)
IN (1)	IN2014KN01026A (hr)
LT (2)	LT3168230T (hr)
MX (1)	MX351809B (hr)
PL (2)	PL2788374T3 (hr)
PT (2)	PT3168230T (hr)
RS (2)	RS55686B1 (hr)
SI (2)	SI3168230T1 (hr)
TR (1)	TR201901263T4 (hr)
WO (1)	WO2013083649A1 (hr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101639269B1 (ko)	2015-12-02	2016-07-13	주식회사 셀루메드	알칼라인 포스파타아제 어세이를 개선하기 위한 방법
IL293988A (en) *	2019-12-18	2022-08-01	Merck Patent Gmbh	Use of a gdf-5 mutant in the treatment of pain and cartilage destruction
CN111701075A (zh) *	2020-06-24	2020-09-25	亘元(天津)生物医药科技有限公司	一种软骨修复材料、软骨重建生物支架及制备方法
EP4599842A1 (en) *	2024-02-09	2025-08-13	Association Institut de Myologie	Pegylated gdf5 protein

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0690871A4 (en)	1993-01-12	1999-10-20	Univ Johns Hopkins Med	GROWTH DIFFERENTIATION FACTOR-5
IL110589A0 (en)	1993-08-10	1994-11-11	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF- beta family
AU689184B2 (en)	1993-12-07	1998-03-26	Genetics Institute, Llc	BMP-12, BMP-13 and tendon-inducing compositions thereof
AU1120295A (en)	1994-11-07	1996-05-31	Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The	Cartilage-derived morphogenetic proteins
WO1996033215A1 (en)	1995-04-19	1996-10-24	Hoechst Pharmaceuticals & Chemicals K.K.	Novel protein and process for producing the same
JPH0931098A (ja)	1995-07-24	1997-02-04	Hoechst Japan Ltd	新規なタンパク質ｈｍｗヒトｍｐ５２
ZA966489B (en)	1995-08-03	1997-02-26	Bioph Biotech Entw Pharm Gmbh	New protein human MP52 Arg.
DE19647853A1 (de)	1996-11-19	1998-05-20	Bioph Biotech Entw Pharm Gmbh	Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität
EP1074620A1 (en)	1999-08-06	2001-02-07	HyGene AG	Monomeric protein of the TGF-beta family
JPH11335398A (ja)	1998-05-22	1999-12-07	Hoechst Marion Roussel Kk	新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬
JP2000119192A (ja)	1998-10-09	2000-04-25	Aventis Pharma Ltd	骨誘導因子アンタゴニスト活性を有する成熟型蛋白質
DE10026713A1 (de)	2000-05-30	2001-12-06	Walter Sebald	Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
KR100530299B1 (ko) *	2003-08-11	2005-11-22	산도즈 게엠베하	변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
EP1571159A1 (en)	2004-03-04	2005-09-07	Bayerische Julius-Maximilians-Universität Würzburg	Mutein of a bone morphogenetic protein and use thereof
EP1698691A1 (en) *	2005-03-04	2006-09-06	Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH	Growth factor mutants with improved biological activity
EP1721909A1 (en)	2005-05-10	2006-11-15	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Growth factor mutants with altered biological attributes
JP2007054013A (ja) *	2005-08-26	2007-03-08	Research Institute Of Innovative Technology For The Earth	耐熱性ｌ−スレオニンアルドラ−ゼおよびそれをコードする遺伝子
WO2007057212A1 (en) *	2005-11-18	2007-05-24	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	High activity growth factor mutants
MX2008012291A (es) *	2006-03-27	2009-01-12	Medimmune Ltd	Miembro que enlaza al receptor gm-csf.
EP1915986A1 (en)	2006-10-23	2008-04-30	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Lipid growth factor formulations
CN105198981B (zh)	2010-08-20	2019-07-16	惠氏有限责任公司	经设计的成骨蛋白

2011
- 2011-12-05 EP EP11191973.4A patent/EP2602264A1/en not_active Ceased
2012
- 2012-12-05 RS RS20170146A patent/RS55686B1/sr unknown
- 2012-12-05 EA EA201491119A patent/EA028554B1/ru not_active IP Right Cessation
- 2012-12-05 SI SI201231517T patent/SI3168230T1/sl unknown
- 2012-12-05 LT LTEP16203435.9T patent/LT3168230T/lt unknown
- 2012-12-05 AU AU2012347305A patent/AU2012347305B2/en not_active Ceased
- 2012-12-05 PL PL12795011T patent/PL2788374T3/pl unknown
- 2012-12-05 RS RS20190038A patent/RS58253B1/sr unknown
- 2012-12-05 ES ES16203435T patent/ES2708675T3/es active Active
- 2012-12-05 IN IN1026KON2014 patent/IN2014KN01026A/en unknown
- 2012-12-05 MX MX2014006465A patent/MX351809B/es active IP Right Grant
- 2012-12-05 PT PT16203435T patent/PT3168230T/pt unknown
- 2012-12-05 PL PL16203435T patent/PL3168230T3/pl unknown
- 2012-12-05 US US14/362,691 patent/US9718867B2/en active Active
- 2012-12-05 HR HRP20170205TT patent/HRP20170205T1/hr unknown
- 2012-12-05 HU HUE12795011A patent/HUE033025T2/en unknown
- 2012-12-05 BR BR112014013122-8A patent/BR112014013122A2/pt not_active Application Discontinuation
- 2012-12-05 CA CA2856458A patent/CA2856458C/en active Active
- 2012-12-05 LT LTEP12795011.1T patent/LT2788374T/lt unknown
- 2012-12-05 EP EP16203435.9A patent/EP3168230B1/en active Active
- 2012-12-05 PT PT127950111T patent/PT2788374T/pt unknown
- 2012-12-05 DK DK12795011.1T patent/DK2788374T3/en active
- 2012-12-05 TR TR2019/01263T patent/TR201901263T4/tr unknown
- 2012-12-05 WO PCT/EP2012/074549 patent/WO2013083649A1/en not_active Ceased
- 2012-12-05 EP EP12795011.1A patent/EP2788374B1/en active Active
- 2012-12-05 SI SI201230892A patent/SI2788374T1/sl unknown
- 2012-12-05 HU HUE16203435A patent/HUE042191T2/hu unknown
- 2012-12-05 ES ES12795011.1T patent/ES2630853T3/es active Active
- 2012-12-05 KR KR1020147017053A patent/KR102067724B1/ko not_active Expired - Fee Related
- 2012-12-05 JP JP2014543942A patent/JP6185926B2/ja active Active
- 2012-12-05 DK DK16203435.9T patent/DK3168230T3/en active
- 2012-12-05 CN CN201280058254.8A patent/CN104039820B/zh not_active Expired - Fee Related
2019
- 2019-01-23 HR HRP20190160TT patent/HRP20190160T8/hr unknown

Also Published As

Publication number	Publication date
SI2788374T1 (sl)	2017-04-26
DK3168230T3 (en)	2019-01-14
US20140369978A1 (en)	2014-12-18
AU2012347305B2 (en)	2016-11-03
HUE033025T2 (en)	2017-11-28
AU2012347305A1 (en)	2014-06-26
RS55686B1 (sr)	2017-07-31
KR20140100969A (ko)	2014-08-18
US9718867B2 (en)	2017-08-01
PL3168230T3 (pl)	2019-06-28
EA201491119A1 (ru)	2014-12-30
TR201901263T4 (tr)	2019-02-21
WO2013083649A1 (en)	2013-06-13
PT3168230T (pt)	2019-01-30
HRP20190160T1 (hr)	2019-03-22
MX2014006465A (es)	2015-03-20
EP2602264A1 (en)	2013-06-12
HUE042191T2 (hu)	2019-06-28
EP3168230A1 (en)	2017-05-17
ES2708675T3 (es)	2019-04-10
KR102067724B1 (ko)	2020-01-17
ES2630853T3 (es)	2017-08-24
EP3168230B1 (en)	2018-12-05
PT2788374T (pt)	2017-02-15
CN104039820A (zh)	2014-09-10
HK1198768A1 (en)	2015-06-05
LT2788374T (lt)	2017-02-10
JP2015504649A (ja)	2015-02-16
BR112014013122A2 (pt)	2020-10-27
DK2788374T3 (en)	2017-04-10
HRP20170205T1 (hr)	2017-06-16
RS58253B1 (sr)	2019-03-29
EP2788374B1 (en)	2017-01-04
JP6185926B2 (ja)	2017-08-23
PL2788374T3 (pl)	2017-08-31
EP2788374A1 (en)	2014-10-15
EA028554B1 (ru)	2017-11-30
CA2856458C (en)	2024-03-12
SI3168230T1 (sl)	2019-03-29
IN2014KN01026A (hr)	2015-10-09
MX351809B (es)	2017-10-30
CN104039820B (zh)	2018-01-09
CA2856458A1 (en)	2013-06-13
LT3168230T (lt)	2019-03-12

Publication	Publication Date	Title
AP3907A (en)	2016-11-23	3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
TWI560388B (en)	2016-12-01	Dampferzeugerheizrohrreparaturmittel und reparaturverfahren
GB201121428D0 (en)	2012-01-25	Controller
GB201121426D0 (en)	2012-01-25	Controller
GB201105145D0 (en)	2011-05-11	Controller
AU341795S (en)	2012-04-05	Paver
SG2014012280A (en)	2014-07-30	Bracket
PT2760315T (pt)	2016-11-02	Ferragem
IL232230A0 (en)	2014-06-30	Derivation of aminoalkyl substituted n-thianylbenzamide
GB201110973D0 (en)	2011-08-10	Bracket
EP2799759A4 (en)	2015-09-02	LIGHTING APPARATUS
EP2780631A4 (en)	2015-07-15	CONNECTABLE LIGHTING DEVICE
AU337816S (en)	2011-07-26	Bracket
PL2479398T3 (pl)	2017-10-31	Wykańczarka albo zasilacz
SG11201403280PA (en)	2014-07-30	Bioreactor
EP2710865A4 (en)	2016-05-04	CONTROL UNIT
ZA201401983B (en)	2015-09-30	Phenyl derivative
HRP20190160T1 (hr)	2019-03-22	Mutant gdf-5 za indukciju formiranja hrskavice
PL2599920T3 (pl)	2015-07-31	Wykańczarka
GB2496130B (en)	2017-03-01	Bracket
GB201103407D0 (en)	2011-04-13	Genetic association
GB2490658B (en)	2013-03-27	Lighting apparatus
GB2497747B (en)	2017-07-12	Improved hanger
GB201112384D0 (en)	2011-08-31	Sanitising apparatus
PL120332U1 (pl)	2013-03-18	Agregat uprawowo-sadzeniowy