PL2788374T3 - Mutant GDF-5 do indukowania tworzenia chrząstki - Google Patents

Mutant GDF-5 do indukowania tworzenia chrząstki

Info

Publication number
PL2788374T3
PL2788374T3 PL12795011T PL12795011T PL2788374T3 PL 2788374 T3 PL2788374 T3 PL 2788374T3 PL 12795011 T PL12795011 T PL 12795011T PL 12795011 T PL12795011 T PL 12795011T PL 2788374 T3 PL2788374 T3 PL 2788374T3
Authority
PL
Poland
Prior art keywords
gdf
mutant
cartilage formation
inducing cartilage
inducing
Prior art date
Application number
PL12795011T
Other languages
English (en)
Inventor
Frank Plöger
Florian Wagner
Original Assignee
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh filed Critical Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh
Publication of PL2788374T3 publication Critical patent/PL2788374T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL12795011T 2011-12-05 2012-12-05 Mutant GDF-5 do indukowania tworzenia chrząstki PL2788374T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11191973.4A EP2602264A1 (en) 2011-12-05 2011-12-05 GDF-5 mutant for inducing cartilage formation
EP12795011.1A EP2788374B1 (en) 2011-12-05 2012-12-05 Gdf-5 mutant for inducing cartilage formation

Publications (1)

Publication Number Publication Date
PL2788374T3 true PL2788374T3 (pl) 2017-08-31

Family

ID=47278877

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12795011T PL2788374T3 (pl) 2011-12-05 2012-12-05 Mutant GDF-5 do indukowania tworzenia chrząstki
PL16203435T PL3168230T3 (pl) 2011-12-05 2012-12-05 Mutant gdf-5 do indukowania tworzenia chrząstki

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL16203435T PL3168230T3 (pl) 2011-12-05 2012-12-05 Mutant gdf-5 do indukowania tworzenia chrząstki

Country Status (22)

Country Link
US (1) US9718867B2 (pl)
EP (3) EP2602264A1 (pl)
JP (1) JP6185926B2 (pl)
KR (1) KR102067724B1 (pl)
CN (1) CN104039820B (pl)
AU (1) AU2012347305B2 (pl)
BR (1) BR112014013122A2 (pl)
CA (1) CA2856458C (pl)
DK (2) DK2788374T3 (pl)
EA (1) EA028554B1 (pl)
ES (2) ES2708675T3 (pl)
HR (2) HRP20170205T1 (pl)
HU (2) HUE033025T2 (pl)
IN (1) IN2014KN01026A (pl)
LT (2) LT3168230T (pl)
MX (1) MX351809B (pl)
PL (2) PL2788374T3 (pl)
PT (2) PT2788374T (pl)
RS (2) RS55686B1 (pl)
SI (2) SI3168230T1 (pl)
TR (1) TR201901263T4 (pl)
WO (1) WO2013083649A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101639269B1 (ko) 2015-12-02 2016-07-13 주식회사 셀루메드 알칼라인 포스파타아제 어세이를 개선하기 위한 방법
CN114786707A (zh) * 2019-12-18 2022-07-22 默克专利股份公司 Gdf-5突变体用于治疗疼痛和软骨破坏的用途
CN111701075A (zh) * 2020-06-24 2020-09-25 亘元(天津)生物医药科技有限公司 一种软骨修复材料、软骨重建生物支架及制备方法
EP4599842A1 (en) * 2024-02-09 2025-08-13 Association Institut de Myologie Pegylated gdf5 protein

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2153654A1 (en) 1993-01-12 1994-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
IL110589A0 (en) 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
EP0733109B9 (en) 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 and tendon-inducing compositions thereof
AU1120295A (en) 1994-11-07 1996-05-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cartilage-derived morphogenetic proteins
PL186518B1 (pl) 1995-04-19 2004-01-30 Bioph Biotech Entw Pharm Gmbh Białko, kompozycja farmaceutyczna i sposób wytwarzania białka
JPH0931098A (ja) 1995-07-24 1997-02-04 Hoechst Japan Ltd 新規なタンパク質ｈｍｗヒトｍｐ５２
ZA966489B (en) 1995-08-03 1997-02-26 Bioph Biotech Entw Pharm Gmbh New protein human MP52 Arg.
DE19647853A1 (de) 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität
EP1074620A1 (en) 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
JPH11335398A (ja) 1998-05-22 1999-12-07 Hoechst Marion Roussel Kk 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬
JP2000119192A (ja) 1998-10-09 2000-04-25 Aventis Pharma Ltd 骨誘導因子アンタゴニスト活性を有する成熟型蛋白質
DE10026713A1 (de) 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
KR100530299B1 (ko) 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
EP1571159A1 (en) 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
EP1698691A1 (en) * 2005-03-04 2006-09-06 Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH Growth factor mutants with improved biological activity
EP1721909A1 (en) 2005-05-10 2006-11-15 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Growth factor mutants with altered biological attributes
JP2007054013A (ja) 2005-08-26 2007-03-08 Research Institute Of Innovative Technology For The Earth 耐熱性ｌ−スレオニンアルドラ−ゼおよびそれをコードする遺伝子
DK1948689T3 (da) * 2005-11-18 2012-07-23 Bioph Biotech Entw Pharm Gmbh Højaktivitetsvækstfaktormutanter
PT2423230E (pt) 2006-03-27 2013-08-26 Medimmune Ltd Membro de ligação para o recetor de gm-csf
EP1915986A1 (en) 2006-10-23 2008-04-30 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Lipid growth factor formulations
EP2949338B1 (en) 2010-08-20 2017-10-25 Wyeth LLC Designer osteogenic proteins

Also Published As

Publication number Publication date
AU2012347305A1 (en) 2014-06-26
HUE033025T2 (en) 2017-11-28
MX2014006465A (es) 2015-03-20
KR102067724B1 (ko) 2020-01-17
HUE042191T2 (hu) 2019-06-28
ES2708675T3 (es) 2019-04-10
EP2788374B1 (en) 2017-01-04
HRP20170205T1 (hr) 2017-06-16
US20140369978A1 (en) 2014-12-18
CA2856458A1 (en) 2013-06-13
EA201491119A1 (ru) 2014-12-30
ES2630853T3 (es) 2017-08-24
MX351809B (es) 2017-10-30
EA028554B1 (ru) 2017-11-30
DK3168230T3 (en) 2019-01-14
AU2012347305B2 (en) 2016-11-03
CN104039820A (zh) 2014-09-10
HRP20190160T8 (hr) 2020-02-07
PT3168230T (pt) 2019-01-30
CA2856458C (en) 2024-03-12
IN2014KN01026A (pl) 2015-10-09
HRP20190160T1 (hr) 2019-03-22
SI2788374T1 (sl) 2017-04-26
US9718867B2 (en) 2017-08-01
KR20140100969A (ko) 2014-08-18
EP2788374A1 (en) 2014-10-15
JP2015504649A (ja) 2015-02-16
RS55686B1 (sr) 2017-07-31
HK1198768A1 (en) 2015-06-05
RS58253B1 (sr) 2019-03-29
LT3168230T (lt) 2019-03-12
WO2013083649A1 (en) 2013-06-13
BR112014013122A2 (pt) 2020-10-27
TR201901263T4 (tr) 2019-02-21
EP2602264A1 (en) 2013-06-12
JP6185926B2 (ja) 2017-08-23
SI3168230T1 (sl) 2019-03-29
PL3168230T3 (pl) 2019-06-28
PT2788374T (pt) 2017-02-15
EP3168230A1 (en) 2017-05-17
LT2788374T (lt) 2017-02-10
DK2788374T3 (en) 2017-04-10
EP3168230B1 (en) 2018-12-05
CN104039820B (zh) 2018-01-09

Similar Documents

Publication Publication Date Title
AP3907A (en) 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
GB201121426D0 (en) Controller
GB201121428D0 (en) Controller
GB201105145D0 (en) Controller
TWI560388B (en) Dampferzeugerheizrohrreparaturmittel und reparaturverfahren
AU341795S (en) Paver
SG2014012280A (en) Bracket
PL2760315T3 (pl) Okucie
IL232230A0 (en) Derivation of aminoalkyl substituted n-thianylbenzamide
GB201110973D0 (en) Bracket
EP2799759A4 (en) LIGHTING APPARATUS
EP2780631A4 (en) CONNECTABLE LIGHTING DEVICE
AU337816S (en) Bracket
PL2479398T3 (pl) Wykańczarka albo zasilacz
SG11201403280PA (en) Bioreactor
EP2710865A4 (en) CONTROL UNIT
ZA201401983B (en) Phenyl derivative
HRP20190160T8 (hr) Mutant gdf-5 za indukciju formiranja hrskavice
PL2599920T3 (pl) Wykańczarka
GB2496130B (en) Bracket
GB201103407D0 (en) Genetic association
GB2490658B (en) Lighting apparatus
GB2497747B (en) Improved hanger
GB201112384D0 (en) Sanitising apparatus
PL120332U1 (pl) Agregat uprawowo-sadzeniowy