HRP20190769T1 - Postupak proizvodnje 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina - Google Patents

Postupak proizvodnje 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina Download PDF

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Publication number
HRP20190769T1
HRP20190769T1 HRP20190769TT HRP20190769T HRP20190769T1 HR P20190769 T1 HRP20190769 T1 HR P20190769T1 HR P20190769T T HRP20190769T T HR P20190769TT HR P20190769 T HRP20190769 T HR P20190769T HR P20190769 T1 HRP20190769 T1 HR P20190769T1
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HR
Croatia
Prior art keywords
mol
compound
palladium
equivalents
protecting group
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HRP20190769TT
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English (en)
Croatian (hr)
Inventor
Kim Lasse Christensen
Original Assignee
H. Lundbeck A/S
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48744991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20190769(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20190769T1 publication Critical patent/HRP20190769T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HRP20190769TT 2012-01-03 2012-12-20 Postupak proizvodnje 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina HRP20190769T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261582527P 2012-01-03 2012-01-03
DKPA201200006 2012-01-03
EP12815676.7A EP2800746B1 (fr) 2012-01-03 2012-12-20 Procédé de fabrication de 1- [2- (2,4-diméthyl-phénylsulfanyl)-phényl]-pipérazine
PCT/EP2012/076377 WO2013102573A1 (fr) 2012-01-03 2012-12-20 Procédé de fabrication de 1- [2- (2,4-diméthyl-phénylsulfanyl)-phényl]-pipérazine

Publications (1)

Publication Number Publication Date
HRP20190769T1 true HRP20190769T1 (hr) 2019-06-28

Family

ID=48744991

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20190769TT HRP20190769T1 (hr) 2012-01-03 2012-12-20 Postupak proizvodnje 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina

Country Status (24)

Country Link
US (1) US9133144B2 (fr)
EP (1) EP2800746B1 (fr)
JP (1) JP6018644B2 (fr)
KR (1) KR102008039B1 (fr)
CN (1) CN104011034B (fr)
AU (1) AU2012364402B2 (fr)
BR (1) BR112014016322B8 (fr)
CA (1) CA2860103C (fr)
CL (1) CL2014001765A1 (fr)
CO (1) CO7000771A2 (fr)
CY (1) CY1121629T1 (fr)
DK (1) DK2800746T3 (fr)
HR (1) HRP20190769T1 (fr)
IL (1) IL233093A (fr)
LT (1) LT2800746T (fr)
MX (1) MX344144B (fr)
PL (1) PL2800746T3 (fr)
RS (1) RS58683B1 (fr)
RU (1) RU2608307C2 (fr)
SG (1) SG11201403835UA (fr)
SI (1) SI2800746T1 (fr)
SM (1) SMT201900248T1 (fr)
WO (1) WO2013102573A1 (fr)
ZA (1) ZA201404881B (fr)

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* Cited by examiner, † Cited by third party
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US10414741B2 (en) 2013-09-30 2019-09-17 Cadila Healthcare Limited Amorphous vortioxetine and salts thereof
EP2878596A1 (fr) * 2013-11-29 2015-06-03 LEK Pharmaceuticals d.d. Synthèse de vortioxetine via des intermédiaires de (2-(pipérazine-1-yl)phényl)lithium
EP2894154A1 (fr) 2014-01-14 2015-07-15 LEK Pharmaceuticals d.d. Synthèse de vortioxetine via des intermédiaires de (2-(piperazine-1-yl)phényl)aniline
CN103788020B (zh) * 2014-01-22 2015-11-04 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN103788019B (zh) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN106103418A (zh) 2014-01-31 2016-11-09 埃吉斯药物私人有限公司 沃替西汀盐的制备方法
EP2930171A1 (fr) 2014-04-07 2015-10-14 LEK Pharmaceuticals d.d. Synthèse de vortioxetine via intermédiaire de (2,4-diméthylphényl) (2-iodophényl)sulfane
CN104974110A (zh) * 2014-04-10 2015-10-14 江苏豪森药业股份有限公司 1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪氢溴酸盐的新晶型及其制备方法和用途
CN105254590B (zh) * 2014-05-09 2019-09-03 江苏豪森药业集团有限公司 沃替西汀氢溴酸盐晶型及其制备方法和用途
WO2015169130A1 (fr) * 2014-05-09 2015-11-12 上海科胜药物研发有限公司 Nouvel intermédiaire de vortioxétine et son procédé de synthèse
CN104059030B (zh) * 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
CN104292183B (zh) * 2014-09-29 2016-01-06 杨献美 一种抗抑郁药物沃替西汀的制备方法
WO2016079751A2 (fr) 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. Procédé de préparation de vortioxétine et de polymorphes de cette substance
EP3023417B1 (fr) * 2014-11-21 2017-06-28 Dipharma Francis S.r.l. Procédé pour la préparation d'un antidépresseur et ses intermédiaires
CN104356092B (zh) * 2014-11-27 2017-03-22 合肥创新医药技术有限公司 沃替西汀的制备方法
WO2016125191A2 (fr) 2015-02-04 2016-08-11 Mylan Laboratories Limited Procédés de préparation de bromhydrate de vortioxétine
AU2016224930A1 (en) 2015-02-25 2017-09-07 Lupin Limited Process for the preparation of Vortioxetine
CN104650004B (zh) * 2015-03-06 2017-06-06 中山万汉制药有限公司 一种氢溴酸沃替西汀的制备方法
CN105061364A (zh) * 2015-08-17 2015-11-18 河北国龙制药有限公司 氢溴酸沃替西汀的制备方法
WO2017029377A1 (fr) * 2015-08-19 2017-02-23 Amneal Pharmaceuticals Company Gmbh Procédé de préparation de bromhydrate de vortioxétine
CN106556663B (zh) * 2015-09-30 2018-05-29 成都弘达药业有限公司 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法
WO2018002115A1 (fr) 2016-07-01 2018-01-04 H. Lundbeck A/S Schémas posologiques de la vortioxétine destinés à une apparition rapide de l'effet antidépresseur
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
CN106831652B (zh) * 2017-01-23 2019-01-11 齐鲁天和惠世制药有限公司 一种沃赛汀的制备方法
CN108017595A (zh) * 2017-12-20 2018-05-11 安徽源久源科技有限公司 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法
PT3810582T (pt) 2018-06-20 2024-04-09 Vio Ag Pharmaceuticals S A Uma abordagem de ativação de c-h organo-pseudocatalítica em um só recipiente para a preparação de vortioxetina e intermediário de vortioxetina
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN109438390A (zh) * 2018-11-26 2019-03-08 合肥创新医药技术有限公司 一种氢溴酸沃替西汀杂质的合成方法
US12281088B2 (en) 2020-09-10 2025-04-22 Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd Process for the synthesis of vortioxetine
CN112250642A (zh) * 2020-10-28 2021-01-22 合肥亿帆生物制药有限公司 一种氢溴酸伏硫西汀杂质标准品的制备方法
CN115368318B (zh) * 2022-06-22 2023-11-03 山东辰龙药业有限公司 一种伏硫西汀的合成方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07110050A (ja) 1993-10-13 1995-04-25 Daikin Mfg Co Ltd 捩じり振動減衰装置
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
ATE359276T1 (de) * 2001-12-20 2007-05-15 Lundbeck & Co As H Aryloxyphenyl und arylsulfanylphenylderivate
PL2044043T5 (pl) * 2006-06-16 2022-05-02 H. Lundbeck A/S Bromowodorek 1-[2-(2,4-dimetylofenylosulfanylo)fenylo]piperazyny jako związek o połączonym działaniu wychwytu zwrotnego serotoniny i działaniu na 5-ht3 i 5-ht1a do leczenia upośledzenia funckji poznawczych
TW201033181A (en) 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
WO2013102573A1 (fr) 2013-07-11
RU2608307C2 (ru) 2017-01-17
SI2800746T1 (sl) 2019-06-28
BR112014016322A2 (pt) 2017-06-13
ZA201404881B (en) 2015-12-23
CO7000771A2 (es) 2014-07-21
SG11201403835UA (en) 2014-10-30
CA2860103A1 (fr) 2013-07-11
CY1121629T1 (el) 2020-07-31
AU2012364402B2 (en) 2016-10-06
JP6018644B2 (ja) 2016-11-02
EP2800746B1 (fr) 2019-04-17
RS58683B1 (sr) 2019-06-28
JP2015504062A (ja) 2015-02-05
CN104011034A (zh) 2014-08-27
BR112014016322A8 (pt) 2017-07-04
KR20140107357A (ko) 2014-09-04
CA2860103C (fr) 2020-07-07
MX2014008052A (es) 2014-09-26
IL233093A0 (en) 2014-08-03
EP2800746A1 (fr) 2014-11-12
PL2800746T3 (pl) 2019-07-31
CN104011034B (zh) 2016-08-17
IL233093A (en) 2017-04-30
US20140343287A1 (en) 2014-11-20
DK2800746T3 (da) 2019-05-20
AU2012364402A1 (en) 2014-07-03
BR112014016322B1 (pt) 2020-09-15
BR112014016322B8 (pt) 2020-12-01
SMT201900248T1 (it) 2019-07-11
CL2014001765A1 (es) 2014-10-03
HK1200827A1 (en) 2015-08-14
KR102008039B1 (ko) 2019-08-06
US9133144B2 (en) 2015-09-15
LT2800746T (lt) 2019-06-10
MX344144B (es) 2016-12-07
RU2014131943A (ru) 2016-02-27

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