HRP20200039T1 - Formulacija fosfomicina za parenteralnu primjenu - Google Patents
Formulacija fosfomicina za parenteralnu primjenu Download PDFInfo
- Publication number
- HRP20200039T1 HRP20200039T1 HRP20200039TT HRP20200039T HRP20200039T1 HR P20200039 T1 HRP20200039 T1 HR P20200039T1 HR P20200039T T HRP20200039T T HR P20200039TT HR P20200039 T HRP20200039 T HR P20200039T HR P20200039 T1 HRP20200039 T1 HR P20200039T1
- Authority
- HR
- Croatia
- Prior art keywords
- fosfomycin
- closed container
- solution
- primarily
- container
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (13)
1. Zatvoreni spremnik koji sadrži vodenu otopinu pripremljenu za parenteralnu primjenu, naznačen time, da su najmanje jedna farmaceutski prihvatljiva sol fosfomicina i farmaceutski prihvatljiva kiselina rastopljene u otopini, pri čemu je kiselina sukcinska kiselina, dok pritom otopina sadrži ukupnu dozu fosfomicina koja odgovara za 1 do 15 grama fosfomicina, gdje omjer mase sukcinske kiseline prema fosfomicinu u otopini, iznosi između 30:1 i 50:1, pri čemu volumen otopine iznosi od 1 ml do 100 ml / g fosfomicina.
2. Zatvoreni spremnik prema patentnom zahtjevu 1, naznačen time, da je otopina spremna za intravenoznu primjenu.
3. Zatvoreni spremnik prema patentnom zahtjevu 1 ili zahtjevu 2, naznačen time, da je zatvoreni spremnik zabrtvljen, poželjno je pritom spremnik zatvoren na takav način, da je otvaranje spremnika uglavnom neponovljivo.
4. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 3, naznačen time, da je spremnik odabran od sljedećih:
- ampula, prvenstveno načinjena od plastičnog materijala ili stakla, poželjno je to ampula na otkidanje, prvenstveno načinjena od plastičnog materijala ili stakla;
- fijala koja se može probušiti, poželjno je zabrtvljena uporabom zaštitne kapice;
- infuzijska vrećica; i
- šprica, prvenstveno prethodno napunjena štrcaljka.
5. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 4, naznačen time, da spremnik koji je poželjno fijala na otkidanje ili infuzijska vrećica, ima nedodirljivu pregradu, primjerice načinjenu od gume.
6. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 5 naznačen time, da spremnik omogućava otopini zaštitu od svjetlosti, i prvenstveno je neproziran.
7. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 6, naznačen time, da je farmaceutski prihvatljiva sol fosfomicina odabrana od sljedećih: dinatrijeva sol fosfomicina, mononatrijeva sol fosfomicina, kalijeva sol fosfomicina, litijeva sol fosfomicina, magnezijeva sol fosfomicina i kalcijeva sol fosfomicina.
8. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 7, naznačen time, da otopina ima pH-vrijednost od 6,4 do 8,4, poželjno veću od 6,5 i manju od 8,0, još poželjnije od 6,9 do 7,9, posebno poželjno od 7,0 do 7,8, čak najviše poželjno od 7,1 do 7,7, ili čak od 7,3 do 7,5;
ili time, da otopina ima pH-vrijednost manju od 10,0, poželjno manju od 9,0, još poželjnije manju od 8,5, čak još poželjnije manju od 8,0, prvenstveno manju od 7,75 ili dapače najveću do 7,5.
9. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 8, naznačen time, da je maseni omjer sukcinske kiseline prema fosfomicinu uglavnom 40:1.
10. Zatvoreni spremnik prema bilo kojem patentnom zahtjevu od 1 do 9, naznačen time, da je zatvoreni spremnik u skladu s Europskim pravilnikom za dobro postupanje u proizvodnji medicinskih proizvoda za ljudsku i životinjsku uporabu - "EU Guidelines for Good Manufacturing Practice for Medicinal Products for Human and Veterinary Use", koji je na snazi od 15. veljače 2016. godine, posebno prema Aneksu 1 u verziji od "25. studenog 2008. (revidiran)"; i/ili
time, da je spremnik napunjen s otopinom i zatvoren u skladu s Aneksom 1 od spomenutog pravilnika "EU Guidelines for Good Manufacturing Practice for Medicinal Products for Human and Veterinary Use", u verziji od "25. studenog 2008. (revidiran)".
11. Pakiranje, naznačeno time, da obuhvaća najmanje jedan zatvoreni spremnik u skladu s bilo kojim od patentnih zahtjeva 1 do 10 i poželjno informacijski letak za pacijenta;
pri čemu pakiranje omogućava otopini i zatvorenom spremniku zaštitu od svjetlosti, prvenstveno je ono pritom uglavnom neprozirno, i/ili time, da spremnik omogućava otopini zaštitu od svjetlosti, s time da je on prvenstveno uglavnom neproziran.
12. Postupak, naznačen time, da obuhvaća skladištenje zatvorenog spremnika prema bilo kojem od patentnih zahtjeva 1 do 10, ili pakiranja prema patentnom zahtjevu 11, na temperaturi između 0°C i 60°C, prvenstveno na temperaturi od 15°C do 35°C ili na sobnoj temperaturi, u trajanju od najmanje jednog tjedna, poželjno u trajanju od najmanje jednog mjeseca, prvenstveno poželjno u trajanju od najmanje tri mjeseca, gdje je pritom skladištenje ostvareno pod zaštitom od svjetlosti.
13. Postupak za proizvodnju zatvorenog spremnika u skladu s bilo kojim od patentnih zahtjeva 1 do 10, naznačen time, da obuhvaća punjenje spremnika s otopinom u sterilnim uvjetima, i zatvaranje spremnika, prema potrebi dalje obuhvaća brtvljenje zatvorenog spremnika; dok poželjno pritom otopina nije proizvedena od praškaste smjese farmaceutski prihvatljive soli fosfomicina i farmaceutski prihvatljive kiseline, koji su pomiješani u na sterilni način u skladu sa spomenutim pravilnikom "EU Guidelines for Good Manufacturing Practice for Medicinal Products for Human and Veterinary Use", koji je na snazi od 15. veljače 2016. godine, posebno prema Aneksu 1 u verziji od "25. studenog 2008. (revidiran)".
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16160698.3A EP3219305A1 (de) | 2016-03-16 | 2016-03-16 | Fosfomycin-formulierung zur parenteralen verabreichung |
| EP17710315.7A EP3419598B1 (de) | 2016-03-16 | 2017-03-16 | Fosfomycin-formulierung zur parenteralen verabreichung |
| PCT/EP2017/056252 WO2017158099A1 (de) | 2016-03-16 | 2017-03-16 | Fosfomycin-formulierung zur parenteralen verabreichung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200039T1 true HRP20200039T1 (hr) | 2020-05-29 |
Family
ID=55637175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200039TT HRP20200039T1 (hr) | 2016-03-16 | 2017-03-16 | Formulacija fosfomicina za parenteralnu primjenu |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10675291B2 (hr) |
| EP (3) | EP3219305A1 (hr) |
| JP (1) | JP2019511573A (hr) |
| KR (1) | KR20180122346A (hr) |
| CN (1) | CN108883062A (hr) |
| AU (1) | AU2017235463A1 (hr) |
| BR (1) | BR112018068510A2 (hr) |
| CA (1) | CA3014503A1 (hr) |
| CY (1) | CY1123109T1 (hr) |
| DK (1) | DK3419598T3 (hr) |
| ES (1) | ES2771486T3 (hr) |
| HR (1) | HRP20200039T1 (hr) |
| HU (1) | HUE047900T2 (hr) |
| LT (1) | LT3419598T (hr) |
| MX (1) | MX2018011217A (hr) |
| PL (1) | PL3419598T3 (hr) |
| PT (1) | PT3419598T (hr) |
| RS (1) | RS59873B1 (hr) |
| RU (1) | RU2018134749A (hr) |
| SI (1) | SI3419598T1 (hr) |
| SM (1) | SMT202000062T1 (hr) |
| WO (1) | WO2017158099A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3219305A1 (de) * | 2016-03-16 | 2017-09-20 | Apostolos Georgopoulos | Fosfomycin-formulierung zur parenteralen verabreichung |
| KR20210148496A (ko) * | 2020-05-28 | 2021-12-08 | 제주대학교 산학협력단 | 포스포마이신을 이용한 멜라닌 저색소증 개선제 조성물 |
| TWI796597B (zh) * | 2020-09-21 | 2023-03-21 | 長庚大學 | 使用紫蘇之經水萃取的產物來對抗冠狀病毒感染的方法 |
| EP4268805A1 (de) * | 2022-04-29 | 2023-11-01 | Apostolos Georgopoulos | Fosfomycin-formulierung zur parenteralen verabreichung und herstellungsverfahren |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3602145C1 (de) | 1986-01-24 | 1993-04-15 | Buender Glas Gmbh | Ampulle auf Glas |
| DE3823428A1 (de) | 1988-07-11 | 1990-01-18 | Hansen Bernd | Ampulle aus kunststoff |
| BRPI0406668A (pt) | 2003-01-09 | 2005-12-20 | Baxter Healthcare Sa | Recipiente de segurança, processo para a produção do mesmo, e, uso de um meio que contém pelo menos um polìmero |
| WO2005000786A1 (en) * | 2003-05-23 | 2005-01-06 | Transform Pharmaceuticals, Inc. | Sertraline compositions |
| BRPI0509026A (pt) * | 2004-05-17 | 2007-09-18 | Corus Pharma Inc | formulação de aerossol, método para a prevenção e tratamento de infecção causada por bactéria do trato respiratório, e, solução |
| DE102004063764A1 (de) | 2004-12-29 | 2006-07-13 | Hexal Ag | Kunststoff-Flasche für Oxaliplatin |
| WO2008071197A1 (en) | 2006-12-11 | 2008-06-19 | Drugrecure Aps | Methods for treating cystic fibrosis or pneumonia with bacterial infection via pulmonary administration of fosfomycin |
| CH697917B1 (de) | 2007-09-21 | 2012-03-30 | Franz Dr Marschall | Verpackungseinheit zur Bereitstellung einer parenteral verabreichbaren, pharmakologisch akzeptablen pharmazeutischen Formulierung. |
| DE102007056462B4 (de) | 2007-11-23 | 2011-10-27 | Pari Pharma Gmbh | Einwegampulle für eine Vorrichtung zur Erzeugung von Aerosolen |
| AU2009307875A1 (en) | 2008-10-21 | 2010-04-29 | Gilead Sciences, Inc. | Fosfomycin/tobramycin combinations for the treatment and prevention of ophthalmic, otological and dermatological infections |
| WO2012030513A2 (en) | 2010-08-30 | 2012-03-08 | Cempra Pharmaceuticals Inc. | Methods of treating bacterial infections through pulmonary delivery of fusidic acid |
| EA021876B1 (ru) | 2010-09-20 | 2015-09-30 | ЛИМОНОВ, Виктор Львович | Фармацевтическая композиция антимикробного и противовоспалительного действия для парентерального введения, способ ее получения |
| EP2708219A1 (en) | 2012-09-12 | 2014-03-19 | PARI Pharma GmbH | Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element |
| TWI571259B (zh) * | 2013-03-15 | 2017-02-21 | 卡帝俄斯製藥公司 | 胺基糖苷及磷黴素組合之改良調配物及用於治療呼吸器相關性肺炎（ｖａｐ）與呼吸器相關性氣管（ｖａｔ）支氣管炎之方法及系統 |
| CN103251634A (zh) * | 2013-05-27 | 2013-08-21 | 关卫 | 磷霉素钠/舒巴坦钠注射剂 |
| CN103356663A (zh) * | 2013-06-28 | 2013-10-23 | 浙江省农业科学院 | 兽用磺胺间甲氧嘧啶-环丙沙星-磷霉素联合注射液及其制备方法 |
| CN105705138A (zh) | 2013-08-26 | 2016-06-22 | 卡迪斯制药公司 | 具有改进的化学性质的氨基糖苷类物质和磷霉素的组合制剂 |
| WO2015070131A1 (en) * | 2013-11-11 | 2015-05-14 | Forest Laboratories Holdings Limited | Compositions and methods of treatment comprising fosfomycin disodium |
| JP2017509599A (ja) * | 2014-02-05 | 2017-04-06 | レポネックス・ファーマシューティカルズ・エーピーエス | 皮膚潰瘍及び創傷の治癒を促進するための組成物 |
| EP3219305A1 (de) * | 2016-03-16 | 2017-09-20 | Apostolos Georgopoulos | Fosfomycin-formulierung zur parenteralen verabreichung |
-
2016
- 2016-03-16 EP EP16160698.3A patent/EP3219305A1/de not_active Withdrawn
-
2017
- 2017-03-16 HU HUE17710315A patent/HUE047900T2/hu unknown
- 2017-03-16 AU AU2017235463A patent/AU2017235463A1/en not_active Abandoned
- 2017-03-16 SI SI201730181T patent/SI3419598T1/sl unknown
- 2017-03-16 LT LTEP17710315.7T patent/LT3419598T/lt unknown
- 2017-03-16 ES ES17710315T patent/ES2771486T3/es active Active
- 2017-03-16 RU RU2018134749A patent/RU2018134749A/ru not_active Application Discontinuation
- 2017-03-16 DK DK17710315.7T patent/DK3419598T3/da active
- 2017-03-16 JP JP2019500015A patent/JP2019511573A/ja active Pending
- 2017-03-16 PL PL17710315T patent/PL3419598T3/pl unknown
- 2017-03-16 SM SM20200062T patent/SMT202000062T1/it unknown
- 2017-03-16 EP EP19197649.7A patent/EP3603618A1/de not_active Withdrawn
- 2017-03-16 MX MX2018011217A patent/MX2018011217A/es unknown
- 2017-03-16 CA CA3014503A patent/CA3014503A1/en not_active Abandoned
- 2017-03-16 PT PT177103157T patent/PT3419598T/pt unknown
- 2017-03-16 WO PCT/EP2017/056252 patent/WO2017158099A1/de not_active Ceased
- 2017-03-16 EP EP17710315.7A patent/EP3419598B1/de active Active
- 2017-03-16 RS RS20200103A patent/RS59873B1/sr unknown
- 2017-03-16 BR BR112018068510-0A patent/BR112018068510A2/pt active Search and Examination
- 2017-03-16 US US16/082,590 patent/US10675291B2/en not_active Expired - Fee Related
- 2017-03-16 HR HRP20200039TT patent/HRP20200039T1/hr unknown
- 2017-03-16 CN CN201780016929.5A patent/CN108883062A/zh active Pending
- 2017-03-16 KR KR1020187026081A patent/KR20180122346A/ko not_active Ceased
-
2020
- 2020-02-05 CY CY20201100110T patent/CY1123109T1/el unknown
- 2020-05-08 US US16/869,646 patent/US10993951B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018068510A2 (pt) | 2021-04-13 |
| ES2771486T3 (es) | 2020-07-06 |
| CY1123109T1 (el) | 2021-10-29 |
| EP3219305A1 (de) | 2017-09-20 |
| HUE047900T2 (hu) | 2020-05-28 |
| SMT202000062T1 (it) | 2020-03-13 |
| US10675291B2 (en) | 2020-06-09 |
| EP3603618A1 (de) | 2020-02-05 |
| US10993951B2 (en) | 2021-05-04 |
| US20200261478A1 (en) | 2020-08-20 |
| CN108883062A (zh) | 2018-11-23 |
| KR20180122346A (ko) | 2018-11-12 |
| RU2018134749A3 (hr) | 2020-05-21 |
| AU2017235463A1 (en) | 2018-09-27 |
| WO2017158099A1 (de) | 2017-09-21 |
| PL3419598T3 (pl) | 2020-05-18 |
| RS59873B1 (sr) | 2020-03-31 |
| EP3419598A1 (de) | 2019-01-02 |
| RU2018134749A (ru) | 2020-04-16 |
| JP2019511573A (ja) | 2019-04-25 |
| SI3419598T1 (sl) | 2020-03-31 |
| US20190070202A1 (en) | 2019-03-07 |
| MX2018011217A (es) | 2019-03-28 |
| PT3419598T (pt) | 2020-02-18 |
| DK3419598T3 (da) | 2020-02-10 |
| LT3419598T (lt) | 2020-02-10 |
| EP3419598B1 (de) | 2019-11-06 |
| CA3014503A1 (en) | 2017-09-21 |
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