HRP940251B1 - Process for the preparation of azithromycin dihydrochloride - Google Patents

Process for the preparation of azithromycin dihydrochloride

Info

Publication number: HRP940251B1
Authority: HR; Croatia
Prior art keywords: preparation; azithromycin; dihydrochloride; azithromycin dihydrochloride; broad
Prior art date: 1994-04-15

Application number

HR940251A

Other languages

English (en)

Inventor

Stjepan Mutak

Original Assignee

Stjepan Mutak

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-15

Filing date

1994-04-15

Publication date

1998-12-31

1994-04-15 Application filed by Stjepan Mutak filed Critical Stjepan Mutak

1994-04-15 Priority to HR940251A priority Critical patent/HRP940251B1/xx

1995-04-06 Priority to CA002146475A priority patent/CA2146475C/fr

1995-04-07 Priority to AT95105285T priority patent/ATE154028T1/de

1995-04-07 Priority to ES95105285T priority patent/ES2104441T3/es

1995-04-07 Priority to EP95105285A priority patent/EP0677530B1/fr

1995-04-07 Priority to DE69500327T priority patent/DE69500327T2/de

1995-04-11 Priority to RO95-00700A priority patent/RO113737B1/ro

1995-04-11 Priority to UA95048323A priority patent/UA41902C2/uk

1995-04-12 Priority to PL95308095A priority patent/PL177292B1/pl

1995-04-13 Priority to JP07088166A priority patent/JP3075681B2/ja

1995-04-13 Priority to CN95104228A priority patent/CN1042033C/zh

1995-04-13 Priority to SK491-95A priority patent/SK281178B6/sk

1995-04-13 Priority to SI9500124A priority patent/SI9500124A/sl

1995-04-14 Priority to BG99580A priority patent/BG61769B1/bg

1995-04-14 Priority to RU95105596A priority patent/RU2134271C1/ru

1995-04-14 Priority to HU9501084A priority patent/HU217553B/hu

1997-06-30 Publication of HRP940251A2 publication Critical patent/HRP940251A2/hr

1998-12-31 Publication of HRP940251B1 publication Critical patent/HRP940251B1/xx

Links

WUTMHODASJRZBL-KUJJYQHYSA-N Cl.Cl.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 Chemical compound Cl.Cl.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WUTMHODASJRZBL-KUJJYQHYSA-N 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 abstract 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 1
229960004099 azithromycin Drugs 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HR940251A 1994-04-15 1994-04-15 Process for the preparation of azithromycin dihydrochloride HRP940251B1 (en)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
HR940251A HRP940251B1 (en)	1994-04-15	1994-04-15	Process for the preparation of azithromycin dihydrochloride
CA002146475A CA2146475C (fr)	1994-04-15	1995-04-06	Methode de preparation de dichlorhydrate d'azithromycine
AT95105285T ATE154028T1 (de)	1994-04-15	1995-04-07	Verfahren zur herstellung von azithromycin dihydrochloriden
ES95105285T ES2104441T3 (es)	1994-04-15	1995-04-07	Procedimiento para la preparacion de diclorhidrato de azitromicina.
EP95105285A EP0677530B1 (fr)	1994-04-15	1995-04-07	Procédé pour la préparation d'azithromycin dihydrochloride
DE69500327T DE69500327T2 (de)	1994-04-15	1995-04-07	Verfahren zur Herstellung von azithromycin Dihydrochloriden
RO95-00700A RO113737B1 (ro)	1994-04-15	1995-04-11	Procedeu de obtinere a diclorhidratului de azitromicina
UA95048323A UA41902C2 (uk)	1994-04-15	1995-04-11	Спосіб одержання дигідрохлориду азитроміцину
PL95308095A PL177292B1 (pl)	1994-04-15	1995-04-12	Sposób wytwarzania dwuchlorowodorku azytromycyny
JP07088166A JP3075681B2 (ja)	1994-04-15	1995-04-13	アジスロマイシン二塩酸塩の製造方法
CN95104228A CN1042033C (zh)	1994-04-15	1995-04-13	阿齐霉素二盐酸盐的制备方法
SK491-95A SK281178B6 (sk)	1994-04-15	1995-04-13	Spôsob prípravy dihydrochloridu azitromycínu
SI9500124A SI9500124A (en)	1994-04-15	1995-04-13	Process for the preparation of Azithromycin Dihydrochloride
BG99580A BG61769B1 (bg)	1994-04-15	1995-04-14	Метод за получаване на азитромицин дихидрохлорид
RU95105596A RU2134271C1 (ru)	1994-04-15	1995-04-14	Способ получения дигидрохлорида азитромицина
HU9501084A HU217553B (hu)	1994-04-15	1995-04-14	Eljárás azitromicin-dihidroklorid előállítására

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR940251A HRP940251B1 (en)	1994-04-15	1994-04-15	Process for the preparation of azithromycin dihydrochloride

Publications (2)

Publication Number	Publication Date
HRP940251A2 HRP940251A2 (en)	1997-06-30
HRP940251B1 true HRP940251B1 (en)	1998-12-31

Family

ID=10946105

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR940251A HRP940251B1 (en)	1994-04-15	1994-04-15	Process for the preparation of azithromycin dihydrochloride

Country Status (16)

Country	Link
EP (1)	EP0677530B1 (fr)
JP (1)	JP3075681B2 (fr)
CN (1)	CN1042033C (fr)
AT (1)	ATE154028T1 (fr)
BG (1)	BG61769B1 (fr)
CA (1)	CA2146475C (fr)
DE (1)	DE69500327T2 (fr)
ES (1)	ES2104441T3 (fr)
HR (1)	HRP940251B1 (fr)
HU (1)	HU217553B (fr)
PL (1)	PL177292B1 (fr)
RO (1)	RO113737B1 (fr)
RU (1)	RU2134271C1 (fr)
SI (1)	SI9500124A (fr)
SK (1)	SK281178B6 (fr)
UA (1)	UA41902C2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
KR100431431B1 (ko) *	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
ATE421882T1 (de)	2003-07-24	2009-02-15	Pliva Hrvatska D O O	Schnellösliches azithromycin in einzeldosisform
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
CN100343267C (zh) *	2005-08-05	2007-10-17	新昌国邦化学工业有限公司	阿奇霉素酒石酸盐的制备方法
CN100427499C (zh) *	2005-12-20	2008-10-22	山东诚创医药技术开发有限公司	一种阿奇霉素的可溶性盐及其制备方法
CN101092440B (zh) *	2007-07-19	2010-05-26	浙江尖峰药业有限公司	硫酸阿奇霉素的制备方法
CN102746350A (zh) *	2011-04-21	2012-10-24	常州泰康制药有限公司	盐酸阿奇霉素的制备方法
CN104045674B (zh) *	2014-05-21	2017-01-04	丽珠医药集团股份有限公司	一种阿奇霉素的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en)	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
YU43658B (en) *	1983-07-18	1989-10-31	Pliva Pharm & Chem Works	Process for preparing 7,16-dioxa-2-aza-10-0-cladinosyl-12,0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)hexadeca-1(2)-ene-8
CA2064634C (fr) *	1991-04-04	1998-08-04	James V. Heck	Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a

1994
- 1994-04-15 HR HR940251A patent/HRP940251B1/xx not_active IP Right Cessation
1995
- 1995-04-06 CA CA002146475A patent/CA2146475C/fr not_active Expired - Fee Related
- 1995-04-07 EP EP95105285A patent/EP0677530B1/fr not_active Expired - Lifetime
- 1995-04-07 DE DE69500327T patent/DE69500327T2/de not_active Expired - Fee Related
- 1995-04-07 ES ES95105285T patent/ES2104441T3/es not_active Expired - Lifetime
- 1995-04-07 AT AT95105285T patent/ATE154028T1/de not_active IP Right Cessation
- 1995-04-11 UA UA95048323A patent/UA41902C2/uk unknown
- 1995-04-11 RO RO95-00700A patent/RO113737B1/ro unknown
- 1995-04-12 PL PL95308095A patent/PL177292B1/pl not_active IP Right Cessation
- 1995-04-13 SK SK491-95A patent/SK281178B6/sk unknown
- 1995-04-13 SI SI9500124A patent/SI9500124A/sl not_active IP Right Cessation
- 1995-04-13 JP JP07088166A patent/JP3075681B2/ja not_active Expired - Fee Related
- 1995-04-13 CN CN95104228A patent/CN1042033C/zh not_active Expired - Fee Related
- 1995-04-14 BG BG99580A patent/BG61769B1/bg unknown
- 1995-04-14 RU RU95105596A patent/RU2134271C1/ru not_active IP Right Cessation
- 1995-04-14 HU HU9501084A patent/HU217553B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69500327D1 (de)	1997-07-10
DE69500327T2 (de)	1998-01-08
JP3075681B2 (ja)	2000-08-14
ATE154028T1 (de)	1997-06-15
PL308095A1 (en)	1995-10-16
BG99580A (bg)	1995-12-29
RU2134271C1 (ru)	1999-08-10
BG61769B1 (bg)	1998-05-29
HRP940251A2 (en)	1997-06-30
CA2146475C (fr)	1999-06-29
HU9501084D0 (en)	1995-06-28
PL177292B1 (pl)	1999-10-29
CA2146475A1 (fr)	1995-10-16
HU217553B (hu)	2000-02-28
EP0677530A1 (fr)	1995-10-18
CN1112566A (zh)	1995-11-29
HUT71840A (en)	1996-02-28
EP0677530B1 (fr)	1997-06-04
SK281178B6 (sk)	2000-12-11
CN1042033C (zh)	1999-02-10
JPH0841058A (ja)	1996-02-13
SK49195A3 (en)	1995-11-08
RO113737B1 (ro)	1998-10-30
RU95105596A (ru)	1997-01-10
ES2104441T3 (es)	1997-10-01
SI9500124A (en)	1995-10-31
UA41902C2 (uk)	2001-10-15

Legal Events

Date	Code	Title	Description
1997-06-30	A1OB	Publication of a patent application
1997-08-08	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1998-12-31	B1PR	Patent granted
2004-01-30	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20040130 Year of fee payment: 11
2005-10-16	PBON	Lapse due to non-payment of renewal fee	Effective date: 20050416

Publication	Publication Date	Title
SG47520A1 (en)	1998-04-17	New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
HUT71840A (en)	1996-02-28	Process for the preparation of azithromycin dihydrochloride
CA2349338A1 (fr)	2000-05-11	Nouveaux antibiotiques macrolide
MX9708696A (es)	1998-08-30	Cefalosporinas antibacterianas.
MX9804046A (es)	1998-09-30	6-0-metil eritromicina d y proceso para hacerla.
EP0136830A3 (fr)	1986-03-19	Dérivés d'azahomoerythromycine D et produits intermédiaires
ZA953975B (en)	1996-11-18	Glucopyranoside benzothiophenes
RU2091378C1 (en)	1997-09-27	7-acyl-3-substituted carbamoylhydroxycephems, methods of their synthesis, substituted carbamoylhydroxy-3-cephems, methods of their synthesis and antibacterial composition
EP0472826A3 (en)	1992-04-29	Novel quinolinecarboxylic acid derivatives, use thereof, antibacterial agent containing the same, process for preparing said compounds and intermediate compound
AU627895B2 (en)	1992-09-03	Novel penam derivatives and salts thereof, processes for producing the same and antibacterial agent comprising the same
GR3025607T3 (en)	1998-03-31	A novel antibiotic, Deoxymulundocandin, a process for its production and its use as medicament
GR3015422T3 (en)	1995-06-30	Thiadiazolylacetamide cephem derivatives.
YU147385A (en)	1988-06-30	Process for obtaining new antibiotics
EP0937718A4 (fr)	2002-02-27	Antibiotique tkr2648 et son procede de production
DE3461806D1 (en)	1987-02-05	2-desoxyoxanosine, a process for the preparation thereof and its use as a medicament
MX9605773A (es)	1998-02-28	Compuestos de cefalosporina y procesos para la preparacion de los mismos.