HRP940271B1 - Intermediate for azithromycin - Google Patents

Intermediate for azithromycin

Info

Publication number: HRP940271B1
Authority: HR; Croatia
Prior art keywords: pct; date nov; sec; iii; compound
Prior art date: 1993-05-19

Application number

HR08/064,610A

Other languages

English (en)

Inventor

V Yang Bingwei

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-19

Filing date

1994-04-27

Publication date

2000-02-29

1994-04-27 Application filed by Pfizer filed Critical Pfizer

1996-12-31 Publication of HRP940271A2 publication Critical patent/HRP940271A2/xx

2000-02-29 Publication of HRP940271B1 publication Critical patent/HRP940271B1/xx

Links

MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
229960004099 azithromycin Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HR08/064,610A 1993-05-19 1994-04-27 Intermediate for azithromycin HRP940271B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6461093A	1993-05-19	1993-05-19

Publications (2)

Publication Number	Publication Date
HRP940271A2 HRP940271A2 (en)	1996-12-31
HRP940271B1 true HRP940271B1 (en)	2000-02-29

Family

ID=22057118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR08/064,610A HRP940271B1 (en)	1993-05-19	1994-04-27	Intermediate for azithromycin

Country Status (12)

Country	Link
US (1)	US5686587A (de)
EP (1)	EP0699207B1 (de)
JP (1)	JP2696608B2 (de)
AT (1)	ATE154806T1 (de)
CA (1)	CA2162401C (de)
DE (1)	DE69403963T2 (de)
DK (1)	DK0699207T3 (de)
ES (1)	ES2104386T3 (de)
FI (1)	FI110781B (de)
GR (1)	GR3024297T3 (de)
HR (1)	HRP940271B1 (de)
WO (1)	WO1994026758A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ES2122905B1 (es) *	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
GB9705323D0 (en) *	1997-03-14	1997-04-30	Biochemie Sa	Organic compounds
PT102006B (pt) *	1997-05-19	2000-06-30	Hovione Sociedade Quimica S A	Novo processo de preparacao de azitromicina
HRP980189B1 (en) *	1998-04-06	2004-04-30	Pliva Pharm & Chem Works	Novel 15-membered lactams ketolides
GB9824580D0 (en) *	1998-11-10	1999-01-06	Biochemie Sa	Organic compounds
US6764996B1 (en)	1999-08-24	2004-07-20	Abbott Laboratories	9a-azalides with antibacterial activity
ATE315042T1 (de) *	1999-08-24	2006-02-15	Abbott Lab	9a-azalide mit antibakterieller wirkung
ES2177373B1 (es)	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
ATE320441T1 (de) *	2000-07-25	2006-04-15	Silanes Sa De Cv Lab	Einstufiges verfahren zur herstellung von 7,16-
DE60114028T2 (de)	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
ES2179756B1 (es) *	2000-11-30	2004-10-01	Ercros Industrial, S.A.	Procedimiento de obtencion de azaeritromicina.
EP1671979B1 (de)	2001-05-22	2008-08-13	Pfizer Products Inc.	Neue Kristallforme von Azithromycin
HRP20040163A2 (en) *	2001-08-21	2005-02-28	Pfizer Products Inc.	Single dose azithromycin for treating respiratory infections
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US6645941B1 (en) *	2003-03-26	2003-11-11	Enanta Pharmaceuticals, Inc.	6,11-3C-bicyclic 9a-azalide derivatives
WO2005030227A1 (en) *	2003-09-23	2005-04-07	Enanta Pharmaceuticals, Inc.	9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
US7265094B2 (en) *	2004-01-09	2007-09-04	Enanta Pharmaceuticals, Inc.	9N-substituted 6-11 bicyclic erythromycin derivatives
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US7235646B2 (en)	2004-06-28	2007-06-26	Alembic Limited	Process for the preparation of azithromycin monohydrate isopropanol clathrate
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
WO2007015265A2 (en) *	2005-05-24	2007-02-08	Kopran Research Laboratories Ltd	A process for preparing 6,9-imino ether
US7407942B2 (en) *	2006-03-29	2008-08-05	Emata Pharmaceuticals, Inc	3,6-bridged 9,12-oxolides
CN102863486A (zh) *	2012-09-18	2013-01-09	太仓市运通化工厂	一种9-脱氧-9a-氮杂-9a-高红霉素的合成方法
CN104262429A (zh) *	2014-10-03	2015-01-07	菏泽市方明制药有限公司	一种阿奇霉素的纯化方法
CN108530494B (zh) *	2018-06-29	2021-03-30	宜昌东阳光生化制药有限公司	一种阿奇霉素重排杂质r的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI7910768A8 (en) *	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4464527A (en) *	1983-06-30	1984-08-07	Pfizer Inc.	Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
SI8311553A8 (en) *	1983-07-18	1995-06-30	Pliva Pharm & Chem Works	Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones
US4518590A (en) *	1984-04-13	1985-05-21	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2062932A1 (en) *	1991-03-15	1992-09-16	Robert R. Wilkening	9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
CA2064634C (en) *	1991-04-04	1998-08-04	James V. Heck	9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5202434A (en) *	1991-04-05	1993-04-13	Merck & Co., Inc.	8a-aza-8a-homoerythromycin lactams
CA2065222A1 (en) *	1991-04-09	1992-10-10	Robert R. Wilkening	Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065674A1 (en) *	1991-04-10	1992-10-11	Robert R. Wilkening	8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) *	1992-04-02	1993-02-23	Merck & Co., Inc.	8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) *	1991-04-11	1992-10-12	Robert R. Wilkening	Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives

1994
- 1994-03-14 ES ES94914706T patent/ES2104386T3/es not_active Expired - Lifetime
- 1994-03-14 CA CA002162401A patent/CA2162401C/en not_active Expired - Fee Related
- 1994-03-14 WO PCT/US1994/002547 patent/WO1994026758A1/en not_active Ceased
- 1994-03-14 EP EP94914706A patent/EP0699207B1/de not_active Expired - Lifetime
- 1994-03-14 JP JP6525396A patent/JP2696608B2/ja not_active Expired - Fee Related
- 1994-03-14 AT AT94914706T patent/ATE154806T1/de not_active IP Right Cessation
- 1994-03-14 US US08/537,741 patent/US5686587A/en not_active Expired - Fee Related
- 1994-03-14 DK DK94914706.0T patent/DK0699207T3/da active
- 1994-03-14 DE DE69403963T patent/DE69403963T2/de not_active Expired - Fee Related
- 1994-04-27 HR HR08/064,610A patent/HRP940271B1/xx not_active IP Right Cessation
- 1994-05-18 FI FI942313A patent/FI110781B/fi not_active IP Right Cessation
1997
- 1997-07-30 GR GR970401946T patent/GR3024297T3/el unknown

Also Published As

Publication number	Publication date
CA2162401A1 (en)	1994-11-24
EP0699207A1 (de)	1996-03-06
FI942313A0 (fi)	1994-05-18
EP0699207B1 (de)	1997-06-25
CA2162401C (en)	1998-11-03
ATE154806T1 (de)	1997-07-15
GR3024297T3 (en)	1997-10-31
JP2696608B2 (ja)	1998-01-14
DE69403963T2 (de)	1997-11-20
WO1994026758A1 (en)	1994-11-24
DK0699207T3 (da)	1997-12-08
US5686587A (en)	1997-11-11
HRP940271A2 (en)	1996-12-31
JPH08506596A (ja)	1996-07-16
FI942313L (fi)	1994-11-20
ES2104386T3 (es)	1997-10-01
DE69403963D1 (de)	1997-07-31
FI110781B (fi)	2003-03-31

Legal Events

Date	Code	Title	Description
1996-12-31	A1OB	Publication of a patent application
1997-06-30	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2000-02-29	B1PR	Patent granted
2004-01-02	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20040102 Year of fee payment: 11
2005-10-28	PBON	Lapse due to non-payment of renewal fee	Effective date: 20050428

Publication	Publication Date	Title
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