HRP940840B1 - 2,4- and 2,5-bis-(tetrazolyl)pyridines, process for their preparation and their use as medicines - Google Patents

2,4- and 2,5-bis-(tetrazolyl)pyridines, process for their preparation and their use as medicines

Info

Publication number: HRP940840B1
Authority: HR; Croatia
Prior art keywords: pyridines; tetrazolyl; bis; medicines; preparation
Prior art date: 1991-02-05

Application number

HR940840A

Other languages

English (en)

Inventor

Gerrit Schubert

Ekkehard Baader

Martin Bickel

Volkmar Guenzler-Pukall

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-05

Filing date

1994-10-26

Publication date

2000-12-31

1994-10-26 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-06-30 Publication of HRP940840A2 publication Critical patent/HRP940840A2/hr

2000-12-31 Publication of HRP940840B1 publication Critical patent/HRP940840B1/xx

Links

BOHMMCZTSDZIBJ-UHFFFAOYSA-N 2,5-bis(2h-tetrazol-5-yl)pyridine Chemical class C1=CC(C=2NN=NN=2)=NC=C1C1=NN=NN1 BOHMMCZTSDZIBJ-UHFFFAOYSA-N 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 abstract 1
108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 abstract 1
102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
230000036570 collagen biosynthesis Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR940840A 1991-02-05 1994-10-26 2,4- and 2,5-bis-(tetrazolyl)pyridines, process for their preparation and their use as medicines HRP940840B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4103372		1991-02-05
YU9492A YU9492A (sh)	1991-02-05	1992-01-30	2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje

Publications (2)

Publication Number	Publication Date
HRP940840A2 HRP940840A2 (en)	1997-06-30
HRP940840B1 true HRP940840B1 (en)	2000-12-31

Family

ID=6424383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR940840A HRP940840B1 (en)	1991-02-05	1994-10-26	2,4- and 2,5-bis-(tetrazolyl)pyridines, process for their preparation and their use as medicines

Country Status (23)

Country	Link
US (2)	US5482953A (cs)
EP (1)	EP0498334B1 (cs)
JP (1)	JPH0559041A (cs)
KR (1)	KR100214797B1 (cs)
AT (1)	ATE193288T1 (cs)
AU (1)	AU650511B2 (cs)
CA (1)	CA2060622A1 (cs)
CZ (1)	CZ283006B6 (cs)
DE (1)	DE59209838D1 (cs)
DK (1)	DK0498334T3 (cs)
ES (1)	ES2146581T3 (cs)
FI (1)	FI103117B (cs)
GR (1)	GR3033536T3 (cs)
HR (1)	HRP940840B1 (cs)
HU (1)	HUT61295A (cs)
IE (1)	IE920368A1 (cs)
IL (1)	IL100860A (cs)
MX (1)	MX9200492A (cs)
NO (1)	NO180446C (cs)
NZ (1)	NZ241505A (cs)
PT (1)	PT498334E (cs)
YU (1)	YU9492A (cs)
ZA (1)	ZA92788B (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ305460B6 (cs) *	2013-05-06	2015-10-07	Contipro Biotech S.R.O.	Způsob přípravy esteru 2-oxoglutarátu, přípravek obsahující ester 2-oxoglutarát a jeho použití

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3432094A1 (de) *	1984-08-31	1986-03-06	Hoechst Ag, 6230 Frankfurt	Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
DE3703959A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703963A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
US5238948A (en) *	1987-02-10	1993-08-24	Hoechst Aktiengesellschaft	Pyridine-2,4- and -2,5-dicarboxylic acid derivatives and medicaments based on these compounds
ATE113036T1 (de) *	1988-08-04	1994-11-15	Hoechst Ag	Verbessertes verfahren zur herstellung von n,n- bis(alkoxyalkyl)-pyridin -2,4- dicarbonsäurediamiden.
JPH02178263A (ja) *	1988-12-27	1990-07-11	Kaken Pharmaceut Co Ltd	アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤
DE3924093A1 (de) *	1989-07-20	1991-02-07	Hoechst Ag	N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
FR2655801B1 (fr) *	1989-12-08	1992-03-13	Charbonnages De France	Procede et dispositif de transmission de signaux video en milieu confine.
ZA91291B (en) *	1990-01-16	1991-09-25	Hoechst Ag	Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof
DE4020570A1 (de) *	1990-06-28	1992-01-02	Hoechst Ag	2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung

1992
- 1992-01-30 YU YU9492A patent/YU9492A/sh unknown
- 1992-02-01 KR KR1019920001589A patent/KR100214797B1/ko not_active Expired - Fee Related
- 1992-02-03 EP EP92101709A patent/EP0498334B1/de not_active Expired - Lifetime
- 1992-02-03 PT PT92101709T patent/PT498334E/pt unknown
- 1992-02-03 AT AT92101709T patent/ATE193288T1/de not_active IP Right Cessation
- 1992-02-03 ES ES92101709T patent/ES2146581T3/es not_active Expired - Lifetime
- 1992-02-03 NZ NZ241505A patent/NZ241505A/en unknown
- 1992-02-03 DE DE59209838T patent/DE59209838D1/de not_active Expired - Fee Related
- 1992-02-03 DK DK92101709T patent/DK0498334T3/da active
- 1992-02-03 IL IL10086092A patent/IL100860A/en not_active IP Right Cessation
- 1992-02-03 FI FI920460A patent/FI103117B/fi active
- 1992-02-04 CZ CS92309A patent/CZ283006B6/cs not_active IP Right Cessation
- 1992-02-04 NO NO920462A patent/NO180446C/no not_active IP Right Cessation
- 1992-02-04 MX MX9200492A patent/MX9200492A/es unknown
- 1992-02-04 IE IE036892A patent/IE920368A1/en not_active Application Discontinuation
- 1992-02-04 ZA ZA92788A patent/ZA92788B/xx unknown
- 1992-02-04 AU AU10724/92A patent/AU650511B2/en not_active Ceased
- 1992-02-04 HU HU9200336A patent/HUT61295A/hu unknown
- 1992-02-04 JP JP4018627A patent/JPH0559041A/ja active Pending
- 1992-02-04 CA CA002060622A patent/CA2060622A1/en not_active Abandoned
1994
- 1994-01-21 US US08/183,786 patent/US5482953A/en not_active Expired - Fee Related
- 1994-10-26 HR HR940840A patent/HRP940840B1/xx not_active IP Right Cessation
1995
- 1995-06-05 US US08/465,326 patent/US5614537A/en not_active Expired - Fee Related
2000
- 2000-05-31 GR GR20000401228T patent/GR3033536T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0498334A1 (de)	1992-08-12
JPH0559041A (ja)	1993-03-09
YU9492A (sh)	1995-03-27
AU1072492A (en)	1992-08-13
FI920460A0 (fi)	1992-02-03
KR920016443A (ko)	1992-09-24
US5614537A (en)	1997-03-25
CS30992A3 (en)	1992-11-18
HU9200336D0 (en)	1992-04-28
NO180446B (no)	1997-01-13
GR3033536T3 (en)	2000-09-29
DK0498334T3 (da)	2000-09-18
NO180446C (no)	1997-04-23
IE920368A1 (en)	1992-08-12
IL100860A (en)	1995-11-27
KR100214797B1 (ko)	1999-08-02
CA2060622A1 (en)	1992-08-06
ZA92788B (en)	1992-10-28
HRP940840A2 (en)	1997-06-30
EP0498334B1 (de)	2000-05-24
ES2146581T3 (es)	2000-08-16
NO920462L (no)	1992-08-06
HUT61295A (en)	1992-12-28
PT498334E (pt)	2000-09-29
MX9200492A (es)	1992-08-01
US5482953A (en)	1996-01-09
FI920460L (fi)	1992-08-06
NO920462D0 (no)	1992-02-04
ATE193288T1 (de)	2000-06-15
IL100860A0 (en)	1992-11-15
CZ283006B6 (cs)	1997-12-17
DE59209838D1 (de)	2000-06-29
AU650511B2 (en)	1994-06-23
NZ241505A (en)	1994-12-22
FI103117B1 (fi)	1999-04-30
FI103117B (fi)	1999-04-30

Legal Events

Date	Code	Title	Description
1997-06-30	A1OB	Publication of a patent application
1997-12-23	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2000-12-31	B1PR	Patent granted
2001-01-30	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20010130 Year of fee payment: 10
2002-07-31	PBON	Lapse due to non-payment of renewal fee	Effective date: 20020131

Publication	Publication Date	Title
AU588826B2 (en)	1989-09-28	Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments for the inhibition of proline hydroxylase and lysine hydroxylase
AU635961B2 (en)	1993-04-08	Novel peptidase and isomerase inhibitors
MY112413A (en)	2001-06-30	Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
US5889009C1 (en)	2002-05-07	Method of inhibiting cell adhesion
IL104154A0 (en)	1993-05-13	Saccharin derivatives,their preparation and pharmaceutical compositions containing them
LTIP1464A (en)	1995-05-25	2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same
AU650511B2 (en)	1994-06-23	2,4- and 2,5-bistetrazolypyridines, a process for the preparation thereof and the use thereof as pharmaceuticals
IL116384A0 (en)	1996-03-31	Ylidene compounds and their preparation
AU4610689A (en)	1990-06-21	Pyridine-3-peroxycarboxylic acid monopersulfate
NO910163L (no)	1991-07-17	Fremgangsmaate for fremstilling og anvendelse av pyridin-2,4- og 2,5-dikarboksylsyredi-(nitroksyalkyl)amid.
AP9400608A0 (en)	1995-07-12	"New nicotinic acid derivative".
NZ225055A (en)	1990-03-27	Composition for introducing hypersensitivity to gram-positive bacteria containing exoantigens of the bacteria, or their homologues
GR3019685T3 (en)	1996-07-31	Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
HU9200891D0 (en)	1992-05-28	Mixed piridine-2,4- and 2,5-docarbonic acid-diamides and medical preparations containing them, and the process for their production