HRP950436A2 - 8-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them - Google Patents

8-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them Download PDF

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Publication number
HRP950436A2
HRP950436A2 HRMI94A001696A HRP950436A HRP950436A2 HR P950436 A2 HRP950436 A2 HR P950436A2 HR MI94A001696 A HRMI94A001696 A HR MI94A001696A HR P950436 A HRP950436 A HR P950436A HR P950436 A2 HRP950436 A2 HR P950436A2
Authority
HR
Croatia
Prior art keywords
fluoro
demethoxy
fucosyl
esters
amino
Prior art date
Application number
HRMI94A001696A
Other languages
English (en)
Croatian (hr)
Inventor
Fabio Animati
Federico Arcamone
Giuseppe Giannini
Paolo Lombardi
Edith Monteagdo
Original Assignee
Menarini Ind Farmachetiche Riu
Bristol Myers Squibb Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ind Farmachetiche Riu, Bristol Myers Squibb Spa filed Critical Menarini Ind Farmachetiche Riu
Publication of HRP950436A2 publication Critical patent/HRP950436A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/38—Quinones containing —CHO or non—quinoid keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HRMI94A001696A 1994-08-04 1995-08-03 8-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them HRP950436A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941696A IT1271689B (it) 1994-08-04 1994-08-04 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number Publication Date
HRP950436A2 true HRP950436A2 (en) 1997-10-31

Family

ID=11369446

Family Applications (1)

Application Number Title Priority Date Filing Date
HRMI94A001696A HRP950436A2 (en) 1994-08-04 1995-08-03 8-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US5814608A (da)
EP (1) EP0776328B1 (da)
JP (1) JPH10503509A (da)
AT (1) ATE172980T1 (da)
AU (1) AU700929B2 (da)
BG (1) BG101163A (da)
BR (1) BR9508518A (da)
CA (1) CA2196752A1 (da)
CZ (1) CZ28097A3 (da)
DE (1) DE69505828T2 (da)
DK (1) DK0776328T3 (da)
ES (1) ES2126923T3 (da)
FI (1) FI970455L (da)
HR (1) HRP950436A2 (da)
HU (1) HUT76339A (da)
IL (1) IL114791A0 (da)
IT (1) IT1271689B (da)
NO (1) NO305561B1 (da)
NZ (1) NZ291426A (da)
PL (1) PL319630A1 (da)
RU (1) RU2146261C1 (da)
SK (1) SK13797A3 (da)
TJ (1) TJ245B (da)
WO (1) WO1996004292A1 (da)
ZA (1) ZA956480B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058543A1 (en) * 1998-05-13 1999-11-18 Instytut Farmaceutyczny New n-alkyloxycarbonyl derivatives of monosaccharides l-acosamine and l-daunosamine
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
RU2642068C1 (ru) * 2017-04-26 2018-01-24 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) N-пиперонильные производные даунорубицина, обладающие антипролиферативными свойствами

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159357B1 (en) * 1983-10-19 1992-09-09 The University Of Melbourne Carminomycinone precursors and analogues and derivatives thereof
MA21995A1 (fr) * 1989-11-13 1991-07-01 Menarini Farma Ind Nouvelles fluoronaphthacenediones,leurs derives glycozyles et leurs procedes de fabrication .
IT1241927B (it) * 1990-05-14 1994-02-01 Menarini Farma Ind 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono
FI925611L (fi) * 1990-06-11 1992-12-10 Iaf Biochem Int Heterocykliska antracyklidon- och antracyklinanaloger
IT1262565B (it) * 1993-09-30 1996-07-04 Menarini Farma Ind Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
DK0776328T3 (da) 1999-07-19
FI970455A7 (fi) 1997-02-03
NO970059D0 (no) 1997-01-08
ATE172980T1 (de) 1998-11-15
EP0776328A1 (en) 1997-06-04
FI970455A0 (fi) 1997-02-03
NZ291426A (en) 1998-05-27
HUT76339A (en) 1997-08-28
AU3255395A (en) 1996-03-04
PL319630A1 (en) 1997-08-18
CA2196752A1 (en) 1996-02-15
CZ28097A3 (en) 1997-08-13
FI970455L (fi) 1997-02-03
DE69505828T2 (de) 1999-05-20
EP0776328B1 (en) 1998-11-04
AU700929B2 (en) 1999-01-14
IT1271689B (it) 1997-06-04
DE69505828D1 (de) 1998-12-10
RU2146261C1 (ru) 2000-03-10
ITMI941696A0 (it) 1994-08-04
SK13797A3 (en) 1997-07-09
JPH10503509A (ja) 1998-03-31
NO970059L (no) 1997-01-08
ES2126923T3 (es) 1999-04-01
BG101163A (bg) 1997-09-30
ZA956480B (en) 1996-03-14
US5814608A (en) 1998-09-29
WO1996004292A1 (en) 1996-02-15
NO305561B1 (no) 1999-06-21
BR9508518A (pt) 1997-12-23
ITMI941696A1 (it) 1996-02-04
IL114791A0 (en) 1995-11-27
TJ245B (en) 2001-08-06

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Legal Events

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A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODBC Application rejected