HRP970098B1 - Oxa- and thia-diazole muscarinic receptor antagonists - Google Patents

Oxa- and thia-diazole muscarinic receptor antagonists

Info

Publication number: HRP970098B1
Authority: HR; Croatia
Prior art keywords: diazole; thia; oxa; receptor antagonists; muscarinic receptor
Prior art date: 1996-02-22

Application number

HR970098A

Other languages

English (en)

Inventor

Alexander Roderick Mackenzie

Anthony Wood

Robert John Bass

Original Assignee

Pfizer Res And Dev Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-22

Filing date

1997-02-20

Publication date

2001-12-31

1997-02-20 Application filed by Pfizer Res And Dev Company filed Critical Pfizer Res And Dev Company

1999-04-30 Publication of HRP970098A2 publication Critical patent/HRP970098A2/hr

2001-12-31 Publication of HRP970098B1 publication Critical patent/HRP970098B1/xx

Links

229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 title 1
VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HR970098A 1996-02-22 1997-02-20 Oxa- and thia-diazole muscarinic receptor antagonists HRP970098B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9603755.1A GB9603755D0 (en)	1996-02-22	1996-02-22	Therapeutic agents

Publications (2)

Publication Number	Publication Date
HRP970098A2 HRP970098A2 (en)	1999-04-30
HRP970098B1 true HRP970098B1 (en)	2001-12-31

Family

ID=10789217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR970098A HRP970098B1 (en)	1996-02-22	1997-02-20	Oxa- and thia-diazole muscarinic receptor antagonists

Country Status (42)

Country	Link
US (1)	US5977142A (fr)
EP (1)	EP0885218B1 (fr)
JP (1)	JP3148252B2 (fr)
KR (1)	KR100315934B1 (fr)
CN (1)	CN1089340C (fr)
AP (1)	AP751A (fr)
AR (1)	AR005916A1 (fr)
AT (1)	ATE200899T1 (fr)
AU (1)	AU712230B2 (fr)
BG (2)	BG102699A (fr)
BR (1)	BR9707733A (fr)
CA (1)	CA2247164C (fr)
CO (1)	CO4650040A1 (fr)
CZ (1)	CZ292650B6 (fr)
DE (1)	DE69704701T2 (fr)
DK (1)	DK0885218T3 (fr)
DZ (1)	DZ2181A1 (fr)
ES (1)	ES2156357T3 (fr)
GB (1)	GB9603755D0 (fr)
GR (1)	GR3036032T3 (fr)
HN (1)	HN1997000020A (fr)
HR (1)	HRP970098B1 (fr)
HU (1)	HUP9900501A3 (fr)
ID (1)	ID16642A (fr)
IL (1)	IL125413A (fr)
IS (1)	IS4803A (fr)
MY (1)	MY129729A (fr)
NO (1)	NO313414B1 (fr)
NZ (1)	NZ331039A (fr)
OA (1)	OA10838A (fr)
PE (1)	PE42798A1 (fr)
PL (1)	PL186879B1 (fr)
PT (1)	PT885218E (fr)
RU (1)	RU2162848C2 (fr)
SK (1)	SK283461B6 (fr)
TN (1)	TNSN97039A1 (fr)
TR (1)	TR199801644T2 (fr)
TW (1)	TW492961B (fr)
UA (1)	UA61068C2 (fr)
WO (1)	WO1997030994A1 (fr)
YU (1)	YU35698A (fr)
ZA (1)	ZA971513B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107313A (en) *	1998-10-02	2000-08-22	Combichem, Inc.	Dopamine receptor antagonists
CA2438991C (fr) *	2001-02-21	2010-08-17	Nps Pharmaceuticals, Inc.	Composes heteropolycycliques et leur utilisations en tant qu'antagonistes des recepteurs metabotropiques du glutamate
GB0510141D0 (en) *	2005-05-18	2005-06-22	Addex Pharmaceuticals Sa	Novel compounds B3
GB0510139D0 (en) *	2005-05-18	2005-06-22	Addex Pharmaceuticals Sa	Novel compounds B1
GB0516313D0 (en)	2005-08-08	2005-09-14	Argenta Discovery Ltd	Azole derivatives and their uses
WO2008017827A2 (fr) *	2006-08-08	2008-02-14	Argenta Discovery Limited	Composés chimiques
JP2010501533A (ja) *	2006-08-21	2010-01-21	アージェンタディスカバリーリミテッド	Ｍ３レセプター調節物質として有用な窒素含有複素環化合物
WO2008096093A1 (fr) *	2007-02-06	2008-08-14	Argenta Discovery Ltd.	Dérivés d'oxazole et de thiazole et leurs utilisations
GB0702414D0 (en) *	2007-02-07	2007-03-21	Argenta Discovery Ltd	Oxazole and thiazole derivatives and their uses 2
GB0702385D0 (en) *	2007-02-07	2007-03-21	Argenta Discovery Ltd	New combination
BRPI0807004A2 (pt) *	2007-02-07	2014-04-15	Argenta Discovery Ltd	Sal
GB0702382D0 (en) *	2007-02-07	2007-03-21	Argenta Discovery Ltd	New salt
GB0702416D0 (en) *	2007-02-07	2007-03-21	Argenta Discovery Ltd	New combination
TW200843759A (en) *	2007-02-15	2008-11-16	Argenta Discovery Ltd	Compounds and their use II
WO2009098453A1 (fr) *	2008-02-06	2009-08-13	Astrazeneca Ab	Azonia bicycloalcanes comme antagonistes du récepteur d'acétylcholine muscarinique m3
US8263623B2 (en)	2008-07-11	2012-09-11	Pfizer Inc.	Triazol derivatives useful for the treatment of diseases
WO2010018352A1 (fr) *	2008-08-12	2010-02-18	Argenta Discovery Limited	Composés hétérocycliques utilisés dans le traitement de maladies impliquant l’activation améliorée du récepteur m3
JP2014065387A (ja) *	2012-09-25	2014-04-17	Showa Corp	自動二輪車の車高調整装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
IL88846A0 (en) *	1988-01-08	1989-07-31	Merck Sharp & Dohme	Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
US5043345A (en) *	1989-02-22	1991-08-27	Novo Nordisk A/S	Piperidine compounds and their preparation and use
EP0619814A1 (fr) *	1991-12-31	1994-10-19	Fujisawa Pharmaceutical Co., Ltd.	Derives d'oxadiazole a effet inhibiteur de l'acetylcholinesterase et agoniste muscarinique
TW360653B (en) *	1995-03-01	1999-06-11	Janssen Pharmaceutica Nv	A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition

1996
- 1996-02-22 GB GBGB9603755.1A patent/GB9603755D0/en active Pending
1997
- 1997-01-21 TW TW086100642A patent/TW492961B/zh not_active IP Right Cessation
- 1997-02-03 HN HN1997000020A patent/HN1997000020A/es unknown
- 1997-02-04 AU AU16014/97A patent/AU712230B2/en not_active Ceased
- 1997-02-04 KR KR1019980706534A patent/KR100315934B1/ko not_active Expired - Fee Related
- 1997-02-04 SK SK1123-98A patent/SK283461B6/sk unknown
- 1997-02-04 PT PT97902337T patent/PT885218E/pt unknown
- 1997-02-04 WO PCT/EP1997/000525 patent/WO1997030994A1/fr not_active Ceased
- 1997-02-04 NZ NZ331039A patent/NZ331039A/en unknown
- 1997-02-04 AT AT97902337T patent/ATE200899T1/de not_active IP Right Cessation
- 1997-02-04 CA CA002247164A patent/CA2247164C/fr not_active Expired - Fee Related
- 1997-02-04 HU HU9900501A patent/HUP9900501A3/hu unknown
- 1997-02-04 ES ES97902337T patent/ES2156357T3/es not_active Expired - Lifetime
- 1997-02-04 DK DK97902337T patent/DK0885218T3/da active
- 1997-02-04 PL PL97328633A patent/PL186879B1/pl not_active IP Right Cessation
- 1997-02-04 IL IL12541397A patent/IL125413A/en not_active IP Right Cessation
- 1997-02-04 US US09/117,556 patent/US5977142A/en not_active Expired - Fee Related
- 1997-02-04 RU RU98117457/04A patent/RU2162848C2/ru not_active IP Right Cessation
- 1997-02-04 JP JP52974197A patent/JP3148252B2/ja not_active Expired - Fee Related
- 1997-02-04 DE DE69704701T patent/DE69704701T2/de not_active Expired - Fee Related
- 1997-02-04 EP EP97902337A patent/EP0885218B1/fr not_active Expired - Lifetime
- 1997-02-04 CN CN97192486A patent/CN1089340C/zh not_active Expired - Fee Related
- 1997-02-04 BR BR9707733A patent/BR9707733A/pt not_active Application Discontinuation
- 1997-02-04 TR TR1998/01644T patent/TR199801644T2/xx unknown
- 1997-02-04 CZ CZ19982678A patent/CZ292650B6/cs not_active IP Right Cessation
- 1997-02-13 CO CO97007550A patent/CO4650040A1/es unknown
- 1997-02-14 PE PE1997000104A patent/PE42798A1/es not_active Application Discontinuation
- 1997-02-19 DZ DZ970027A patent/DZ2181A1/fr active
- 1997-02-19 TN TNTNSN97039A patent/TNSN97039A1/fr unknown
- 1997-02-20 AP APAP/P/1997/000930A patent/AP751A/en active
- 1997-02-20 AR ARP970100667A patent/AR005916A1/es unknown
- 1997-02-20 HR HR970098A patent/HRP970098B1/xx not_active IP Right Cessation
- 1997-02-21 ZA ZA971513A patent/ZA971513B/xx unknown
- 1997-02-21 ID IDP970521A patent/ID16642A/id unknown
- 1997-02-21 MY MYPI97000654A patent/MY129729A/en unknown
- 1997-04-02 UA UA98094939A patent/UA61068C2/uk unknown
1998
- 1998-07-21 IS IS4803A patent/IS4803A/is unknown
- 1998-08-14 OA OA9800143A patent/OA10838A/en unknown
- 1998-08-19 BG BG102699A patent/BG102699A/xx unknown
- 1998-08-19 BG BG102699A patent/BG63971B1/bg unknown
- 1998-08-21 NO NO19983871A patent/NO313414B1/no not_active IP Right Cessation
- 1998-08-21 YU YU35698A patent/YU35698A/sh unknown
2001
- 2001-06-13 GR GR20010400885T patent/GR3036032T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1211981A (zh)	1999-03-24
BG63971B1 (bg)	2003-08-29
CN1089340C (zh)	2002-08-21
GR3036032T3 (en)	2001-09-28
CO4650040A1 (es)	1998-09-03
HRP970098A2 (en)	1999-04-30
WO1997030994A1 (fr)	1997-08-28
DZ2181A1 (fr)	2002-12-01
IS4803A (is)	1998-07-21
ID16642A (id)	1997-10-23
SK283461B6 (sk)	2003-08-05
KR19990087143A (ko)	1999-12-15
TR199801644T2 (xx)	1998-11-23
BG102699A (en)	1999-09-30
PE42798A1 (es)	1998-08-18
TW492961B (en)	2002-07-01
SK112398A3 (en)	2000-04-10
DE69704701T2 (de)	2001-08-16
HN1997000020A (es)	1997-06-05
AR005916A1 (es)	1999-07-21
NO313414B1 (no)	2002-09-30
US5977142A (en)	1999-11-02
AU712230B2 (en)	1999-11-04
JPH11504051A (ja)	1999-04-06
AP751A (en)	1999-07-12
AP9700930A0 (en)	1997-04-30
NO983871D0 (no)	1998-08-21
RU2162848C2 (ru)	2001-02-10
UA61068C2 (en)	2003-11-17
CA2247164C (fr)	2004-11-16
KR100315934B1 (ko)	2002-03-21
CZ267898A3 (cs)	1999-08-11
MY129729A (en)	2007-04-30
OA10838A (en)	2001-08-13
CA2247164A1 (fr)	1997-08-28
IL125413A0 (en)	1999-03-12
EP0885218B1 (fr)	2001-05-02
ES2156357T3 (es)	2001-06-16
EP0885218A1 (fr)	1998-12-23
PT885218E (pt)	2001-08-30
TNSN97039A1 (fr)	2005-03-15
HK1018274A1 (en)	1999-12-17
ZA971513B (en)	1998-08-21
JP3148252B2 (ja)	2001-03-19
AU1601497A (en)	1997-09-10
BR9707733A (pt)	1999-07-27
DE69704701D1 (de)	2001-06-07
PL186879B1 (pl)	2004-03-31
IL125413A (en)	2002-09-12
HUP9900501A2 (hu)	1999-06-28
HUP9900501A3 (en)	2001-02-28
YU35698A (sh)	1999-07-28
NZ331039A (en)	1999-10-28
NO983871L (no)	1998-08-21
GB9603755D0 (en)	1996-04-24
DK0885218T3 (da)	2001-05-28
CZ292650B6 (cs)	2003-11-12
PL328633A1 (en)	1999-02-15
ATE200899T1 (de)	2001-05-15

Legal Events

Date	Code	Title	Description
1997-02-20	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1999-04-30	A1OB	Publication of a patent application
2001-12-31	B1PR	Patent granted
2004-01-19	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20040119 Year of fee payment: 8
2005-08-21	PBON	Lapse due to non-payment of renewal fee	Effective date: 20050221

Publication	Publication Date	Title
PL331534A1 (en)	1999-07-19	Muscarinic antagonists
CY2576B1 (en)	2008-07-02	Vitronectin receptor antagonists
HU9603525D0 (en)	1997-02-28	Vironectin receptor antagonists
EP0912175A4 (fr)	1999-09-08	Antagonistes du recepteur de fibrinogene
GB9020051D0 (en)	1990-10-24	Muscarinic receptor antagonists
HU9601529D0 (en)	1996-07-29	Pyrimidinedion-, pyrimidinetrion-, triazinedion-, tetrahydro-quinazolinedion- derivatives as alpha-adrenerg receptor antagonists
SG80041A1 (en)	2001-04-17	Muscarinic receptor antagonists
EP0915651A4 (fr)	2001-10-24	Antagonistes des recepteurs d'il-8
IL130760A0 (en)	2001-01-28	Vitronectin receptor antagonists
GR3036032T3 (en)	2001-09-28	Oxa- and thia-diazole muscarinic receptor antagonists
EP0885213A4 (fr)	1999-04-28	Antagonistes du recepteur du fibrinogene
EP0885205A4 (fr)	2002-11-27	Antagonistes des recepteurs de fibrinogenes
EP0907362A4 (fr)	1999-12-01	Antagonistes des recepteurs d'il-8
IL140249A0 (en)	2002-02-10	Muscarinic antagonists
IL135028A0 (en)	2001-05-20	Vitronectin receptor antagonists
GB9600344D0 (en)	1996-03-13	Benzimidzolyl neuropeptide y receptor antagonists
EP0920253A4 (fr)	2001-10-17	Antagonistes du recepteur il-8
ZA200003475B (en)	2001-10-11	Muscarinic receptor antagonists.
SI0957917T1 (sl)	2006-04-30	Antagonisti receptorja vitronektina
ZA961293B (en)	1996-08-19	Muscarinic antagonists
EP0957908A4 (fr)	2003-03-12	Antagonistes de recepteurs du fibrinogene
GB9603371D0 (en)	1996-04-17	Fibrinogen receptor antagonists
GB9606489D0 (en)	1996-06-05	Fibrinogen receptor antagonists
GB9613688D0 (en)	1996-08-28	Fibrinogen receptor antagonists
GB9603373D0 (en)	1996-04-17	Integrin receptor antagonists