HRP970235B1 - Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl-6-chloro-1,3-dihydro-2h-indol-2-one - Google Patents

Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl-6-chloro-1,3-dihydro-2h-indol-2-one

Info

Publication number
HRP970235B1
HRP970235B1 HR970235A HRP970235A HRP970235B1 HR P970235 B1 HRP970235 B1 HR P970235B1 HR 970235 A HR970235 A HR 970235A HR P970235 A HRP970235 A HR P970235A HR P970235 B1 HRP970235 B1 HR P970235B1
Authority
HR
Croatia
Prior art keywords
benzisothiazol
indol
piperazinyl
dihydro
chloro
Prior art date
Application number
HR970235A
Other languages
English (en)
Inventor
Frank R Busch
Carol A Rose
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HRP970235A2 publication Critical patent/HRP970235A2/xx
Publication of HRP970235B1 publication Critical patent/HRP970235B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR970235A 1996-05-07 1997-05-07 Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl-6-chloro-1,3-dihydro-2h-indol-2-one HRP970235B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1653796P 1996-05-07 1996-05-07

Publications (2)

Publication Number Publication Date
HRP970235A2 HRP970235A2 (en) 1998-06-30
HRP970235B1 true HRP970235B1 (en) 2002-08-31

Family

ID=21777622

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970235A HRP970235B1 (en) 1996-05-07 1997-05-07 Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl-6-chloro-1,3-dihydro-2h-indol-2-one

Country Status (45)

Country Link
US (1) US6110918A (fr)
EP (1) EP0904273B1 (fr)
JP (1) JP3102896B2 (fr)
KR (1) KR100333214B1 (fr)
CN (1) CN1092658C (fr)
AP (1) AP838A (fr)
AR (1) AR007003A1 (fr)
AT (1) ATE236902T1 (fr)
AU (1) AU730856C (fr)
BG (1) BG63601B1 (fr)
BR (1) BR9708932A (fr)
CA (1) CA2252895C (fr)
CO (1) CO4940465A1 (fr)
CZ (1) CZ289216B6 (fr)
DE (1) DE69720719T2 (fr)
DK (1) DK0904273T3 (fr)
DZ (1) DZ2221A1 (fr)
EA (1) EA001180B1 (fr)
EG (1) EG24401A (fr)
ES (1) ES2192264T3 (fr)
GT (1) GT199700042A (fr)
HN (1) HN1997000040A (fr)
HR (1) HRP970235B1 (fr)
HU (1) HU229057B1 (fr)
ID (1) ID17504A (fr)
IL (1) IL126590A (fr)
IS (1) IS2301B (fr)
MA (1) MA26427A1 (fr)
ME (1) ME00901B (fr)
MY (1) MY128051A (fr)
NO (1) NO312513B1 (fr)
NZ (2) NZ332219A (fr)
OA (1) OA10908A (fr)
PL (1) PL188164B1 (fr)
PT (1) PT904273E (fr)
SI (1) SI0904273T1 (fr)
SK (1) SK282674B6 (fr)
TN (1) TNSN97073A1 (fr)
TR (1) TR199802241T2 (fr)
TW (1) TW427989B (fr)
UA (1) UA47467C2 (fr)
UY (1) UY24543A1 (fr)
WO (1) WO1997042190A1 (fr)
YU (1) YU49398B (fr)
ZA (1) ZA973875B (fr)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
TW491847B (en) 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
ES2204067T3 (es) * 1998-05-26 2004-04-16 Pfizer Products Inc. Medicamento para el tratamiento del glaucoma y de la retinopatia isquemica.
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
DZ3227A1 (fr) 1999-12-23 2001-07-05 Pfizer Prod Inc Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees
AU2001258690A1 (en) * 2000-06-02 2001-12-11 Pfizer Products Inc. S-methyl-dihydro-ziprasidone for treatment of psychiatric and ocular disorders
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
UY27668A1 (es) * 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
WO2004050655A1 (fr) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Formes polymorphes de ziprasidone et son chlorhydrate
CA2525868A1 (fr) * 2003-05-16 2004-11-25 Pfizer Products Inc. Traitements de l'angoisse avec la ziprasidone
MXPA05012325A (es) * 2003-05-16 2006-01-30 Pfizer Prod Inc Procedimiento para potenciar la cognicion usando zipirasidona.
JP2007502856A (ja) * 2003-05-16 2007-02-15 ファイザー・プロダクツ・インク 精神病性障害および抑うつ性障害の治療
EP1546146A1 (fr) * 2003-06-03 2005-06-29 Teva Pharmaceutical Industries Limited Formes polymorphes de ziprasidone chlorhydrate et procedes pour leur elaboration
KR20090080143A (ko) * 2003-09-02 2009-07-23 화이자 프로덕츠 인크. 지프라시돈의 지속 방출형 투여 형태
CA2543805A1 (fr) * 2003-10-24 2005-05-06 Gideon Pilarsky Procedes de preparation de ziprasidone
CA2550485A1 (fr) * 2003-12-18 2005-07-07 Teva Pharmaceutical Industries Ltd. Forme polymorphe b2 de base de ziprasidone
EP1703898A2 (fr) * 2003-12-31 2006-09-27 Alpharma, Inc. Formulations de ziprasidone
ES2334800T3 (es) * 2004-02-27 2010-03-16 Ranbaxy Laboratories Limited Proceso para la preparacion de ziprasidona.
WO2006026426A2 (fr) * 2004-08-27 2006-03-09 University Of Kentucky Research Foundation Enzyme d'inactivation de peptide amyloide pour traiter la maladie d'alzheimer de façon peripherique
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
AU2005307797B2 (en) * 2004-11-16 2011-06-02 Alkermes Pharma Ireland Limited Injectable nanoparticulate olanzapine formulations
CA2593497A1 (fr) * 2005-02-11 2006-08-17 Judith Aronhime Ziprasidone mesylate amorphe
US20080254114A1 (en) * 2005-03-03 2008-10-16 Elan Corporation Plc Controlled Release Compositions Comprising Heterocyclic Amide Derivative Nanoparticles
ITMI20050346A1 (it) 2005-03-07 2006-09-08 Dipharma Spa Forma solida di ziprasidone cloridrato
EP1858892A1 (fr) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd Mesylate de ziprasidone anhydre et son procede de preparation
EP1858891A2 (fr) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd. Formes cristallines de mesylate de ziprasidone
CN101677568A (zh) * 2007-05-18 2010-03-24 赛多斯有限责任公司 齐拉西酮制剂
KR100948126B1 (ko) * 2007-12-10 2010-03-18 씨제이제일제당 (주) 결정형의 지프라시돈 술폰산염, 그 제조방법, 및 그것를포함하는 약제학적 조성물
CN102234273B (zh) * 2010-04-21 2015-08-05 上海医药工业研究院 甲磺酸齐拉西酮半水合物及其制备方法
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji
WO2014078568A1 (fr) 2012-11-14 2014-05-22 The Johns Hopkins University Méthodes et compositions pour le traitement de la schizophrénie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Also Published As

Publication number Publication date
HN1997000040A (es) 1997-06-05
PL329880A1 (en) 1999-04-12
PL188164B1 (pl) 2004-12-31
IS4878A (is) 1998-10-23
DE69720719T2 (de) 2003-11-06
WO1997042190A1 (fr) 1997-11-13
TW427989B (en) 2001-04-01
BG102893A (en) 1999-09-30
EA199800909A1 (ru) 1999-04-29
SK282674B6 (sk) 2002-11-06
EP0904273B1 (fr) 2003-04-09
YU17397A (sh) 2000-10-30
ME00901B (me) 2005-11-28
DE69720719D1 (de) 2003-05-15
BR9708932A (pt) 1999-08-03
MY128051A (en) 2007-01-31
KR100333214B1 (ko) 2002-06-20
AR007003A1 (es) 1999-10-13
ATE236902T1 (de) 2003-04-15
AP9700978A0 (en) 1997-07-31
DZ2221A1 (fr) 2002-12-03
NZ332219A (en) 2005-02-25
KR20000010822A (ko) 2000-02-25
IL126590A0 (en) 1999-08-17
GT199700042A (es) 1998-10-02
JPH11509865A (ja) 1999-08-31
AU730856B2 (en) 2001-03-15
HK1017893A1 (en) 1999-12-03
SK150598A3 (en) 2000-03-13
HRP970235A2 (en) 1998-06-30
HUP9902808A3 (en) 2000-04-28
MA26427A1 (fr) 2004-12-20
TNSN97073A1 (fr) 2005-03-15
CO4940465A1 (es) 2000-07-24
ES2192264T3 (es) 2003-10-01
IL126590A (en) 2001-11-25
NO985193L (no) 1998-11-06
NO312513B1 (no) 2002-05-21
CZ289216B6 (cs) 2001-12-12
YU49398B (sh) 2005-11-28
SI0904273T1 (en) 2003-08-31
PT904273E (pt) 2003-06-30
CN1092658C (zh) 2002-10-16
EG24401A (en) 2009-04-29
CA2252895C (fr) 2002-08-20
CA2252895A1 (fr) 1997-11-13
AP838A (en) 2000-05-03
EA001180B1 (ru) 2000-10-30
BG63601B1 (bg) 2002-06-28
HUP9902808A2 (hu) 2000-03-28
CZ349498A3 (cs) 1999-09-15
UY24543A1 (es) 2000-09-29
IS2301B (is) 2007-10-15
CN1216990A (zh) 1999-05-19
ID17504A (id) 1998-01-08
EP0904273A1 (fr) 1999-03-31
AU730856C (en) 2001-11-15
NO985193D0 (no) 1998-11-06
OA10908A (en) 2001-10-26
DK0904273T3 (da) 2003-07-07
JP3102896B2 (ja) 2000-10-23
TR199802241T2 (fr) 1999-02-22
UA47467C2 (uk) 2002-07-15
ZA973875B (en) 1998-11-06
NZ508303A (en) 2001-07-27
HU229057B1 (en) 2013-07-29
AU1936897A (en) 1997-11-26
US6110918A (en) 2000-08-29

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