HRP970566A2 - Conjugates useful in the treatment of prostate canser - Google Patents

Conjugates useful in the treatment of prostate canser

Info

Publication number: HRP970566A2
Authority: HR; Croatia
Prior art keywords: seq; image; oligopeptide; alkyl; hipxaasertirgln
Prior art date: 1996-10-30

Application number

HR9718160.6A

Other languages

English (en)

Croatian (hr)

Inventor

Jones Deborah Defeo

Original Assignee

Jones Deborah Defeo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-30

Filing date

1997-10-24

Publication date

1998-08-31

1996-12-18 Priority claimed from GBGB9626309.0A external-priority patent/GB9626309D0/en

1997-08-28 Priority claimed from GBGB9718160.6A external-priority patent/GB9718160D0/en

1997-10-24 Application filed by Jones Deborah Defeo filed Critical Jones Deborah Defeo

1998-08-31 Publication of HRP970566A2 publication Critical patent/HRP970566A2/hr

Links

210000002307 prostate Anatomy 0.000 title description 5
108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 103
108010038807 Oligopeptides Proteins 0.000 claims description 95
102000015636 Oligopeptides Human genes 0.000 claims description 95
229940127089 cytotoxic agent Drugs 0.000 claims description 68
239000002254 cytotoxic agent Substances 0.000 claims description 68
-1 cyclic amino acid Chemical class 0.000 claims description 65
231100000599 cytotoxic agent Toxicity 0.000 claims description 63
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 54
229940024606 amino acid Drugs 0.000 claims description 51
235000001014 amino acid Nutrition 0.000 claims description 51
229910052739 hydrogen Inorganic materials 0.000 claims description 33
239000001257 hydrogen Substances 0.000 claims description 33
150000003839 salts Chemical class 0.000 claims description 32
229960004679 doxorubicin Drugs 0.000 claims description 29
150000001413 amino acids Chemical class 0.000 claims description 28
125000003118 aryl group Chemical group 0.000 claims description 28
150000001875 compounds Chemical class 0.000 claims description 28
239000000203 mixture Substances 0.000 claims description 28
NFDYGNFETJVMSE-BQBZGAKWSA-N Ser-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CO NFDYGNFETJVMSE-BQBZGAKWSA-N 0.000 claims description 26
238000000034 method Methods 0.000 claims description 23
XQJCEKXQUJQNNK-ZLUOBGJFSA-N Ser-Ser-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O XQJCEKXQUJQNNK-ZLUOBGJFSA-N 0.000 claims description 20
150000002431 hydrogen Chemical class 0.000 claims description 19
XZKQVQKUZMAADP-IMJSIDKUSA-N Ser-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(O)=O XZKQVQKUZMAADP-IMJSIDKUSA-N 0.000 claims description 16
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims description 16
230000003287 optical effect Effects 0.000 claims description 15
229960003048 vinblastine Drugs 0.000 claims description 15
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims description 15
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
206010060862 Prostate cancer Diseases 0.000 claims description 14
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125000001424 substituent group Chemical group 0.000 claims description 14
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 12
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BMKNXTJLHFIAAH-CIUDSAMLSA-N Ser-Ser-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O BMKNXTJLHFIAAH-CIUDSAMLSA-N 0.000 claims description 8
ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 7
206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 7
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BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims description 6
QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims description 6
QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 claims description 6
150000001412 amines Chemical class 0.000 claims description 6
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PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 5
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125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
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YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims description 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 2
NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims description 2
TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 claims description 2
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UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 2
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LPGWZGMPDKDHEP-HLTPFJCJSA-N Leurosine Chemical compound C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC LPGWZGMPDKDHEP-HLTPFJCJSA-N 0.000 claims description 2
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HRHKSTOGXBBQCB-UHFFFAOYSA-N Mitomycin E Natural products O=C1C(N)=C(C)C(=O)C2=C1C(COC(N)=O)C1(OC)C3N(C)C3CN12 HRHKSTOGXBBQCB-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Plant Substances (AREA)

HR9718160.6A 1996-10-30 1997-10-24 Conjugates useful in the treatment of prostate canser HRP970566A2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US2922496P	1996-10-30	1996-10-30
GBGB9626309.0A GB9626309D0 (en)	1996-12-18	1996-12-18	Conjugates useful in the treatment of prostate cancer
US4292197P	1997-04-04	1997-04-04
GBGB9718160.6A GB9718160D0 (en)	1997-08-28	1997-08-28	Conjugates useful in the treatment of prostate cancer

Publications (1)

Publication Number	Publication Date
HRP970566A2 true HRP970566A2 (en)	1998-08-31

Family

ID=27451580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR9718160.6A HRP970566A2 (en)	1996-10-30	1997-10-24	Conjugates useful in the treatment of prostate canser

Country Status (31)

Country	Link
EP (1)	EP0942754B1 (de)
JP (1)	JP2000509407A (de)
KR (1)	KR100508199B1 (de)
AR (1)	AR008907A1 (de)
AT (1)	ATE239509T1 (de)
AU (1)	AU726434B2 (de)
BG (1)	BG64768B1 (de)
BR (1)	BR9712589A (de)
CA (1)	CA2268738A1 (de)
CO (1)	CO4930281A1 (de)
CZ (1)	CZ155599A3 (de)
DE (1)	DE69721810T2 (de)
DK (1)	DK0942754T3 (de)
DZ (1)	DZ2333A1 (de)
EA (1)	EA002066B1 (de)
EE (1)	EE03858B1 (de)
ES (1)	ES2196374T3 (de)
HR (1)	HRP970566A2 (de)
HU (1)	HUP0000651A3 (de)
ID (1)	ID21358A (de)
IL (1)	IL129356A0 (de)
IS (1)	IS5025A (de)
NO (1)	NO992069L (de)
PE (1)	PE17399A1 (de)
PL (1)	PL333004A1 (de)
PT (1)	PT942754E (de)
SK (1)	SK57399A3 (de)
TR (1)	TR199901485T2 (de)
TW (1)	TW425286B (de)
WO (1)	WO1998018493A2 (de)
YU (1)	YU21399A (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1036093A1 (de) *	1997-12-02	2000-09-20	Merck & Co., Inc.	Konjugate zur verwendung in der behandlung von prostatakrebs
CA2238257A1 (en) *	1998-05-22	1999-11-22	Universite De Montreal	Endocytosis of amf-r and uses thereof in cancer therapy
EP1098666B1 (de) *	1998-07-17	2013-01-16	The United States of America, represented by the Secretary, Department of Health and Human Services	Wasserlösliche arzneimittel und deren herstellungsmethode
US6174858B1 (en)	1998-11-17	2001-01-16	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
JP2003518000A (ja) *	1998-12-11	2003-06-03	コールターファーマシューティカル，インコーポレイティド	プロドラッグ化合物およびその調製方法
GB9924759D0 (en)	1999-10-19	1999-12-22	Merck Sharp & Dohme	Process for preparing peptide intermediates
CA2388700A1 (en)	1999-10-19	2001-04-26	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
EP1228089A2 (de) *	1999-10-27	2002-08-07	Merck & Co., Inc.	Salzform eines konjugates zur behandlung von prostatakrebs
AU4583601A (en) *	2000-03-15	2001-09-24	Du Pont Pharm Co	Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use
EP2316468A1 (de) *	2002-02-22	2011-05-04	Shire LLC	Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
US20050187147A1 (en) *	2003-09-22	2005-08-25	Newman Michael J.	Compositions and methods for increasing drug efficiency
CN100372862C (zh) *	2003-11-05	2008-03-05	天津和美生物技术有限公司	具有抗癌活性的阿霉素衍生物及其制备方法和应用
US8518891B2 (en) *	2006-11-29	2013-08-27	Longqin Hu	Chemotherapeutic conjugates and methods of use
CN101225094A (zh) *	2007-01-18	2008-07-23	天津和美生物技术有限公司	具有抗癌活性的蒽醌四环类化合物
CA2754846C (en) *	2009-03-09	2015-05-12	Ktb Tumorforschungsgesellschaft Mbh	Prostate-specific antigen cleavable prodrugs
WO2012123755A1 (en)	2011-03-17	2012-09-20	The University Of Birmingham	Re-directed immunotherapy
KR102438072B1 (ko)	2012-01-12	2022-08-31	예일 유니버시티	E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법
GB201203442D0 (en)	2012-02-28	2012-04-11	Univ Birmingham	Immunotherapeutic molecules and uses
GB201311891D0 (en)	2013-07-03	2013-08-14	Glaxosmithkline Ip Dev Ltd	Novel compound
GB201311888D0 (en)	2013-07-03	2013-08-14	Glaxosmithkline Ip Dev Ltd	Novel compounds
US20180228907A1 (en)	2014-04-14	2018-08-16	Arvinas, Inc.	Cereblon ligands and bifunctional compounds comprising the same
AU2016215604B2 (en)	2015-02-02	2020-08-13	The University Of Birmingham	Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes
HUE054131T2 (hu)	2015-11-19	2021-08-30	Revitope Ltd	Funkcionális ellenanyag-fragmens-komplementáció nemkívánatos sejtek elpusztítására szolgáló kétkomponensû rendszerben
AU2021405744A1 (en)	2020-12-22	2023-08-03	Cobiores Nv	Compounds comprising a tetrapeptidic moiety
WO2022167664A1 (en)	2021-02-07	2022-08-11	Cobiores Nv	Compounds comprising a tetrapeptidic moiety

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6143864A (en) *	1994-06-28	2000-11-07	Merck & Co., Inc.	Peptides
US5866679A (en) *	1994-06-28	1999-02-02	Merck & Co., Inc.	Peptides
EP0855910A4 (de) *	1995-10-18	2000-07-05	Merck & Co Inc	Verwendbare konjugate zur behandlung der gutartigen prostatehyperplasie

1997
- 1997-10-24 HR HR9718160.6A patent/HRP970566A2/hr not_active Application Discontinuation
- 1997-10-27 EE EEP199900179A patent/EE03858B1/xx not_active IP Right Cessation
- 1997-10-27 PT PT97946296T patent/PT942754E/pt unknown
- 1997-10-27 AU AU51497/98A patent/AU726434B2/en not_active Ceased
- 1997-10-27 CA CA002268738A patent/CA2268738A1/en not_active Abandoned
- 1997-10-27 DE DE69721810T patent/DE69721810T2/de not_active Expired - Fee Related
- 1997-10-27 KR KR10-1999-7003846A patent/KR100508199B1/ko not_active Expired - Fee Related
- 1997-10-27 ID IDW990259A patent/ID21358A/id unknown
- 1997-10-27 WO PCT/US1997/019225 patent/WO1998018493A2/en not_active Ceased
- 1997-10-27 SK SK573-99A patent/SK57399A3/sk unknown
- 1997-10-27 YU YU21399A patent/YU21399A/sh unknown
- 1997-10-27 AT AT97946296T patent/ATE239509T1/de not_active IP Right Cessation
- 1997-10-27 JP JP10520593A patent/JP2000509407A/ja not_active Ceased
- 1997-10-27 BR BR9712589-0A patent/BR9712589A/pt not_active Application Discontinuation
- 1997-10-27 ES ES97946296T patent/ES2196374T3/es not_active Expired - Lifetime
- 1997-10-27 DK DK97946296T patent/DK0942754T3/da active
- 1997-10-27 TR TR1999/01485T patent/TR199901485T2/xx unknown
- 1997-10-27 EA EA199900428A patent/EA002066B1/ru not_active IP Right Cessation
- 1997-10-27 PL PL97333004A patent/PL333004A1/xx unknown
- 1997-10-27 IL IL12935697A patent/IL129356A0/xx not_active IP Right Cessation
- 1997-10-27 HU HU0000651A patent/HUP0000651A3/hu unknown
- 1997-10-27 EP EP97946296A patent/EP0942754B1/de not_active Expired - Lifetime
- 1997-10-27 CZ CZ991555A patent/CZ155599A3/cs unknown
- 1997-10-28 CO CO97063170A patent/CO4930281A1/es unknown
- 1997-10-28 TW TW086115986A patent/TW425286B/zh not_active IP Right Cessation
- 1997-10-29 AR ARP970105032A patent/AR008907A1/es not_active Application Discontinuation
- 1997-10-29 PE PE1997000970A patent/PE17399A1/es not_active Application Discontinuation
- 1997-10-29 DZ DZ970183A patent/DZ2333A1/xx active
1999
- 1999-04-13 IS IS5025A patent/IS5025A/is unknown
- 1999-04-29 NO NO992069A patent/NO992069L/no not_active Application Discontinuation
- 1999-05-26 BG BG103436A patent/BG64768B1/bg unknown

Also Published As

Publication number	Publication date
TW425286B (en)	2001-03-11
EP0942754B1 (de)	2003-05-07
PT942754E (pt)	2003-08-29
DE69721810T2 (de)	2004-03-11
HK1024876A1 (en)	2000-10-27
CO4930281A1 (es)	2000-06-27
KR20000052970A (ko)	2000-08-25
HUP0000651A2 (hu)	2000-06-28
BR9712589A (pt)	1999-10-26
NO992069D0 (no)	1999-04-29
EE03858B1 (et)	2002-10-15
IL129356A0 (en)	2000-02-17
SK57399A3 (en)	2000-01-18
WO1998018493A2 (en)	1998-05-07
ID21358A (id)	1999-05-27
EE9900179A (et)	1999-12-15
EA199900428A1 (ru)	2000-02-28
YU21399A (sh)	2000-03-21
ATE239509T1 (de)	2003-05-15
HUP0000651A3 (en)	2001-12-28
DZ2333A1 (fr)	2002-12-28
JP2000509407A (ja)	2000-07-25
AR008907A1 (es)	2000-02-23
EA002066B1 (ru)	2001-12-24
CZ155599A3 (cs)	1999-10-13
AU5149798A (en)	1998-05-22
ES2196374T3 (es)	2003-12-16
DE69721810D1 (de)	2003-06-12
AU726434B2 (en)	2000-11-09
EP0942754A2 (de)	1999-09-22
KR100508199B1 (ko)	2005-08-17
IS5025A (is)	1999-04-13
PL333004A1 (en)	1999-11-08
BG103436A (en)	2000-04-28
PE17399A1 (es)	1999-02-20
DK0942754T3 (da)	2003-08-04
NO992069L (no)	1999-06-30
WO1998018493A3 (en)	1998-07-23
BG64768B1 (bg)	2006-03-31
TR199901485T2 (xx)	1999-08-23
CA2268738A1 (en)	1998-05-07

Legal Events

Date	Code	Title
1998-08-31	A1OB	Publication of a patent application
1999-01-12	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2005-02-16	OBST	Application withdrawn

Publication	Publication Date	Title
US5948750A (en)	1999-09-07	Conjugates useful in the treatment of prostate cancer
US6391305B1 (en)	2002-05-21	Conjugates useful in the treatment of prostate cancer
AU715632B2 (en)	2000-02-03	Conjugates useful in the treatment of prostate cancer
AU726434B2 (en)	2000-11-09	Conjugates useful in the treatment of prostate cancer
US5998362A (en)	1999-12-07	Conjugates useful in the treatment of prostate cancer
US20020103136A1 (en)	2002-08-01	Conjugates useful in the treatment of prostate cancer
EP0853483A1 (de)	1998-07-22	Neue peptide
EP1009420B1 (de)	2003-12-17	Konjugate welche bei der behandlung von prostatakrebs nützlich sind
US20030232760A1 (en)	2003-12-18	Conjugates useful in the treatment of prostate cancer
US20070244055A1 (en)	2007-10-18	Conjugates useful in the treatment of prostate cancer
US6174858B1 (en)	2001-01-16	Conjugates useful in the treatment of prostate cancer
AU744652B2 (en)	2002-02-28	Conjugates useful in the treatment of prostate cancer
US20020115596A1 (en)	2002-08-22	Conjugates useful in the treatment of prostate cancer
US6127333A (en)	2000-10-03	Conjugates useful in the treatment of prostate cancer
US20050119166A1 (en)	2005-06-02	Conjugates useful in the treatment of prostate cancer
WO1999044628A1 (en)	1999-09-10	Conjugates useful in the treatment of prostate cancer
MXPA00005434A (en)	2002-02-26	Conjugates useful in the treatment of prostate cancer