SK57399A3 - Conjugates useful in the treatment of prostate cancer - Google Patents

Conjugates useful in the treatment of prostate cancer Download PDF

Info

Publication number: SK57399A3
Authority: SK; Slovakia
Prior art keywords: seq; conjugate; hyp; dox; amino acid
Prior art date: 1996-10-30

Application number

SK573-99A

Other languages

English (en)

Slovak (sk)

Inventor

Victor M Garsky

Dong-Mei Feng

Deborah Defeo-Jones

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-30

Filing date

1997-10-27

Publication date

2000-01-18

1996-12-18 Priority claimed from GBGB9626309.0A external-priority patent/GB9626309D0/en

1997-08-28 Priority claimed from GBGB9718160.6A external-priority patent/GB9718160D0/en

1997-10-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2000-01-18 Publication of SK57399A3 publication Critical patent/SK57399A3/sk

Links

206010060862 Prostate cancer Diseases 0.000 title claims abstract description 18
208000000236 Prostatic Neoplasms Diseases 0.000 title claims abstract description 18
108010072866 Prostate-Specific Antigen Proteins 0.000 claims abstract description 104
108010038807 Oligopeptides Proteins 0.000 claims abstract description 94
102000015636 Oligopeptides Human genes 0.000 claims abstract description 94
229940127089 cytotoxic agent Drugs 0.000 claims abstract description 58
239000002254 cytotoxic agent Substances 0.000 claims abstract description 58
231100000599 cytotoxic agent Toxicity 0.000 claims abstract description 49
239000000126 substance Substances 0.000 claims abstract description 14
206010004446 Benign prostatic hyperplasia Diseases 0.000 claims abstract description 9
208000004403 Prostatic Hyperplasia Diseases 0.000 claims abstract description 9
235000001014 amino acid Nutrition 0.000 claims description 277
229940024606 amino acid Drugs 0.000 claims description 276
150000001413 amino acids Chemical group 0.000 claims description 235
102100038358 Prostate-specific antigen Human genes 0.000 claims description 102
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 84
-1 cyclic amino acid Chemical class 0.000 claims description 72
WAMWSIDTKSNDCU-ZETCQYMHSA-N (2s)-2-azaniumyl-2-cyclohexylacetate Chemical compound OC(=O)[C@@H](N)C1CCCCC1 WAMWSIDTKSNDCU-ZETCQYMHSA-N 0.000 claims description 54
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125000002686 geranylgeranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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239000000367 immunologic factor Substances 0.000 description 1
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230000003211 malignant effect Effects 0.000 description 1
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238000005259 measurement Methods 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
239000002609 medium Substances 0.000 description 1
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230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
125000002757 morpholinyl group Chemical group 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
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230000007935 neutral effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
125000001715 oxadiazolyl group Chemical group 0.000 description 1
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125000000466 oxiranyl group Chemical group 0.000 description 1
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125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
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UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
239000003600 podophyllotoxin derivative Substances 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
239000008057 potassium phosphate buffer Substances 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
150000003147 proline derivatives Chemical class 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
201000005825 prostate adenocarcinoma Diseases 0.000 description 1
208000023958 prostate neoplasm Diseases 0.000 description 1
235000019833 protease Nutrition 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
238000000746 purification Methods 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
239000011535 reaction buffer Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
210000000582 semen Anatomy 0.000 description 1
238000000926 separation method Methods 0.000 description 1
108010026333 seryl-proline Proteins 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
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239000007929 subcutaneous injection Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
125000006089 thiamorpholinyl sulfoxide group Chemical group 0.000 description 1
125000002769 thiazolinyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000004589 thienofuryl group Chemical group O1C(=CC2=C1C=CS2)* 0.000 description 1
125000004587 thienothienyl group Chemical group S1C(=CC2=C1C=CS2)* 0.000 description 1
125000004568 thiomorpholinyl group Chemical group 0.000 description 1
229960000187 tissue plasminogen activator Drugs 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 description 1
XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Natural products NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
108010077037 tyrosyl-tyrosyl-phenylalanine Proteins 0.000 description 1
230000035899 viability Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Plant Substances (AREA)

SK573-99A 1996-10-30 1997-10-27 Conjugates useful in the treatment of prostate cancer SK57399A3 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US2922496P	1996-10-30	1996-10-30
GBGB9626309.0A GB9626309D0 (en)	1996-12-18	1996-12-18	Conjugates useful in the treatment of prostate cancer
US4292197P	1997-04-04	1997-04-04
GBGB9718160.6A GB9718160D0 (en)	1997-08-28	1997-08-28	Conjugates useful in the treatment of prostate cancer
PCT/US1997/019225 WO1998018493A2 (en)	1996-10-30	1997-10-27	Conjugates useful in the treatment of prostate cancer

Publications (1)

Publication Number	Publication Date
SK57399A3 true SK57399A3 (en)	2000-01-18

Family

ID=27451580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK573-99A SK57399A3 (en)	1996-10-30	1997-10-27	Conjugates useful in the treatment of prostate cancer

Country Status (31)

Country	Link
EP (1)	EP0942754B1 (de)
JP (1)	JP2000509407A (de)
KR (1)	KR100508199B1 (de)
AR (1)	AR008907A1 (de)
AT (1)	ATE239509T1 (de)
AU (1)	AU726434B2 (de)
BG (1)	BG64768B1 (de)
BR (1)	BR9712589A (de)
CA (1)	CA2268738A1 (de)
CO (1)	CO4930281A1 (de)
CZ (1)	CZ155599A3 (de)
DE (1)	DE69721810T2 (de)
DK (1)	DK0942754T3 (de)
DZ (1)	DZ2333A1 (de)
EA (1)	EA002066B1 (de)
EE (1)	EE03858B1 (de)
ES (1)	ES2196374T3 (de)
HR (1)	HRP970566A2 (de)
HU (1)	HUP0000651A3 (de)
ID (1)	ID21358A (de)
IL (1)	IL129356A0 (de)
IS (1)	IS5025A (de)
NO (1)	NO992069L (de)
PE (1)	PE17399A1 (de)
PL (1)	PL333004A1 (de)
PT (1)	PT942754E (de)
SK (1)	SK57399A3 (de)
TR (1)	TR199901485T2 (de)
TW (1)	TW425286B (de)
WO (1)	WO1998018493A2 (de)
YU (1)	YU21399A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20000367A2 (en) *	1997-12-02	2000-12-31	Merck & Co Inc	Conjugates useful in the treatment of prostate cancer
CA2238257A1 (en) *	1998-05-22	1999-11-22	Universite De Montreal	Endocytosis of amf-r and uses thereof in cancer therapy
WO2000003737A2 (en) *	1998-07-17	2000-01-27	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Water-soluble drugs and methods for their production
US6174858B1 (en)	1998-11-17	2001-01-16	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
PT1144011E (pt) *	1998-12-11	2010-06-16	Coulter Pharm Inc	Compostos pró-fármacos e processo para a sua preparação
GB9924759D0 (en)	1999-10-19	1999-12-22	Merck Sharp & Dohme	Process for preparing peptide intermediates
WO2001028593A2 (en) *	1999-10-19	2001-04-26	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
JP2003512475A (ja) *	1999-10-27	2003-04-02	メルクエンドカムパニーインコーポレーテッド	前立腺癌の治療に有用な複合体の塩形態
HUP0300590A2 (hu) *	2000-03-15	2003-07-28	Bristol-Myers Squibb Pharma Company	Peptidázzal hasítható, célzott antineoplasztikus szerek és terápiás alkalmazásuk
EP2316468A1 (de) *	2002-02-22	2011-05-04	Shire LLC	Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
US20050187147A1 (en) *	2003-09-22	2005-08-25	Newman Michael J.	Compositions and methods for increasing drug efficiency
CN100372862C (zh) *	2003-11-05	2008-03-05	天津和美生物技术有限公司	具有抗癌活性的阿霉素衍生物及其制备方法和应用
WO2008067495A2 (en) *	2006-11-29	2008-06-05	Rutgers, The State University Of New Jersey	Chemotherapeutic conjugates and methods of use
CN101225094A (zh) *	2007-01-18	2008-07-23	天津和美生物技术有限公司	具有抗癌活性的蒽醌四环类化合物
AU2010223565B2 (en) *	2009-03-09	2016-06-23	Ktb Tumorforschungsgesellschaft Mbh	Prodrugs
JP6130307B2 (ja)	2011-03-17	2017-05-17	ザユニバーシティオブバーミンガム	再指向性免疫療法
CA2861066C (en)	2012-01-12	2024-01-02	Yale University	Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
GB201203442D0 (en)	2012-02-28	2012-04-11	Univ Birmingham	Immunotherapeutic molecules and uses
GB201311888D0 (en)	2013-07-03	2013-08-14	Glaxosmithkline Ip Dev Ltd	Novel compounds
GB201311891D0 (en)	2013-07-03	2013-08-14	Glaxosmithkline Ip Dev Ltd	Novel compound
US20180228907A1 (en)	2014-04-14	2018-08-16	Arvinas, Inc.	Cereblon ligands and bifunctional compounds comprising the same
US10441649B2 (en)	2015-02-02	2019-10-15	The University Of Birmingham	Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes
ES2873846T5 (en)	2015-11-19	2025-06-23	Revitope Ltd	Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells
CA3203072A1 (en)	2020-12-22	2022-06-30	Andrea CASAZZA	Compounds comprising a tetrapeptidic moiety
WO2022167664A1 (en)	2021-02-07	2022-08-11	Cobiores Nv	Compounds comprising a tetrapeptidic moiety

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6143864A (en) *	1994-06-28	2000-11-07	Merck & Co., Inc.	Peptides
US5866679A (en) *	1994-06-28	1999-02-02	Merck & Co., Inc.	Peptides
AU708475B2 (en) *	1995-10-18	1999-08-05	Merck & Co., Inc.	Conjugates useful in the treatment of benign prostatic hyperplasia

1997
- 1997-10-24 HR HR9718160.6A patent/HRP970566A2/hr not_active Application Discontinuation
- 1997-10-27 HU HU0000651A patent/HUP0000651A3/hu unknown
- 1997-10-27 CA CA002268738A patent/CA2268738A1/en not_active Abandoned
- 1997-10-27 AU AU51497/98A patent/AU726434B2/en not_active Ceased
- 1997-10-27 ES ES97946296T patent/ES2196374T3/es not_active Expired - Lifetime
- 1997-10-27 WO PCT/US1997/019225 patent/WO1998018493A2/en not_active Ceased
- 1997-10-27 IL IL12935697A patent/IL129356A0/xx not_active IP Right Cessation
- 1997-10-27 AT AT97946296T patent/ATE239509T1/de not_active IP Right Cessation
- 1997-10-27 EP EP97946296A patent/EP0942754B1/de not_active Expired - Lifetime
- 1997-10-27 PT PT97946296T patent/PT942754E/pt unknown
- 1997-10-27 YU YU21399A patent/YU21399A/sh unknown
- 1997-10-27 JP JP10520593A patent/JP2000509407A/ja not_active Ceased
- 1997-10-27 BR BR9712589-0A patent/BR9712589A/pt not_active Application Discontinuation
- 1997-10-27 ID IDW990259A patent/ID21358A/id unknown
- 1997-10-27 DK DK97946296T patent/DK0942754T3/da active
- 1997-10-27 EE EEP199900179A patent/EE03858B1/xx not_active IP Right Cessation
- 1997-10-27 EA EA199900428A patent/EA002066B1/ru not_active IP Right Cessation
- 1997-10-27 DE DE69721810T patent/DE69721810T2/de not_active Expired - Fee Related
- 1997-10-27 KR KR10-1999-7003846A patent/KR100508199B1/ko not_active Expired - Fee Related
- 1997-10-27 PL PL97333004A patent/PL333004A1/xx unknown
- 1997-10-27 TR TR1999/01485T patent/TR199901485T2/xx unknown
- 1997-10-27 CZ CZ991555A patent/CZ155599A3/cs unknown
- 1997-10-27 SK SK573-99A patent/SK57399A3/sk unknown
- 1997-10-28 CO CO97063170A patent/CO4930281A1/es unknown
- 1997-10-28 TW TW086115986A patent/TW425286B/zh not_active IP Right Cessation
- 1997-10-29 AR ARP970105032A patent/AR008907A1/es not_active Application Discontinuation
- 1997-10-29 DZ DZ970183A patent/DZ2333A1/xx active
- 1997-10-29 PE PE1997000970A patent/PE17399A1/es not_active Application Discontinuation
1999
- 1999-04-13 IS IS5025A patent/IS5025A/is unknown
- 1999-04-29 NO NO992069A patent/NO992069L/no not_active Application Discontinuation
- 1999-05-26 BG BG103436A patent/BG64768B1/bg unknown

Also Published As

Publication number	Publication date
PT942754E (pt)	2003-08-29
EA002066B1 (ru)	2001-12-24
NO992069D0 (no)	1999-04-29
IS5025A (is)	1999-04-13
CO4930281A1 (es)	2000-06-27
KR20000052970A (ko)	2000-08-25
ATE239509T1 (de)	2003-05-15
EE03858B1 (et)	2002-10-15
BG103436A (en)	2000-04-28
EP0942754B1 (de)	2003-05-07
AU5149798A (en)	1998-05-22
NO992069L (no)	1999-06-30
YU21399A (sh)	2000-03-21
AU726434B2 (en)	2000-11-09
DZ2333A1 (fr)	2002-12-28
IL129356A0 (en)	2000-02-17
EA199900428A1 (ru)	2000-02-28
WO1998018493A2 (en)	1998-05-07
HK1024876A1 (en)	2000-10-27
HUP0000651A2 (hu)	2000-06-28
DE69721810D1 (de)	2003-06-12
HRP970566A2 (en)	1998-08-31
ID21358A (id)	1999-05-27
TW425286B (en)	2001-03-11
KR100508199B1 (ko)	2005-08-17
CZ155599A3 (cs)	1999-10-13
WO1998018493A3 (en)	1998-07-23
EP0942754A2 (de)	1999-09-22
ES2196374T3 (es)	2003-12-16
TR199901485T2 (xx)	1999-08-23
CA2268738A1 (en)	1998-05-07
DK0942754T3 (da)	2003-08-04
EE9900179A (et)	1999-12-15
HUP0000651A3 (en)	2001-12-28
PL333004A1 (en)	1999-11-08
PE17399A1 (es)	1999-02-20
AR008907A1 (es)	2000-02-23
BG64768B1 (bg)	2006-03-31
DE69721810T2 (de)	2004-03-11
JP2000509407A (ja)	2000-07-25
BR9712589A (pt)	1999-10-26

Publication	Publication Date	Title
US5948750A (en)	1999-09-07	Conjugates useful in the treatment of prostate cancer
US6391305B1 (en)	2002-05-21	Conjugates useful in the treatment of prostate cancer
AU715632B2 (en)	2000-02-03	Conjugates useful in the treatment of prostate cancer
SK57399A3 (en)	2000-01-18	Conjugates useful in the treatment of prostate cancer
JP3481948B2 (ja)	2003-12-22	新規ペプチド
RU2162855C2 (ru)	2001-02-10	Новые пептиды
US5998362A (en)	1999-12-07	Conjugates useful in the treatment of prostate cancer
AU740597B2 (en)	2001-11-08	Conjugates useful in the treatment of prostate cancer
US20030232760A1 (en)	2003-12-18	Conjugates useful in the treatment of prostate cancer
US20070129309A1 (en)	2007-06-07	Conjugates useful in the treatment of prostate cancer
KR100580137B1 (ko)	2006-05-16	전립선 암 치료에 유용한 접합체 및 이를 포함하는 약제학적 조성물
US20020115596A1 (en)	2002-08-22	Conjugates useful in the treatment of prostate cancer
AU7432196A (en)	1997-05-07	Conjugates useful in the treatment of benign prostatic hyperplasia
US6127333A (en)	2000-10-03	Conjugates useful in the treatment of prostate cancer
US20050119166A1 (en)	2005-06-02	Conjugates useful in the treatment of prostate cancer
AU714288B2 (en)	1999-12-23	Novel peptides
CA2321171A1 (en)	1999-09-10	Conjugates useful in the treatment of prostate cancer
CA2234763A1 (en)	1997-04-24	Conjugates useful in the treatment of benign prostatic hyperplasia