HRP980097B1 - Combinatory compositions for the treatment of dementia - Google Patents

Combinatory compositions for the treatment of dementia

Info

Publication number
HRP980097B1
HRP980097B1 HR980097A HRP980097A HRP980097B1 HR P980097 B1 HRP980097 B1 HR P980097B1 HR 980097 A HR980097 A HR 980097A HR P980097 A HRP980097 A HR P980097A HR P980097 B1 HRP980097 B1 HR P980097B1
Authority
HR
Croatia
Prior art keywords
carbon atoms
branched
straight
carbon chain
alkyl
Prior art date
Application number
HR980097A
Other languages
English (en)
Croatian (hr)
Inventor
Schubert Hans-Peter
Nimmesgern Hildegard
Rudolphi Karlo
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of HRP980097A2 publication Critical patent/HRP980097A2/xx
Publication of HRP980097B1 publication Critical patent/HRP980097B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
HR980097A 1997-02-26 1998-02-25 Combinatory compositions for the treatment of dementia HRP980097B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19707655A DE19707655A1 (de) 1997-02-26 1997-02-26 Kombinationspräparat zur Anwendung bei Demenz

Publications (2)

Publication Number Publication Date
HRP980097A2 HRP980097A2 (en) 1998-12-31
HRP980097B1 true HRP980097B1 (en) 2006-09-30

Family

ID=7821517

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980097A HRP980097B1 (en) 1997-02-26 1998-02-25 Combinatory compositions for the treatment of dementia

Country Status (30)

Country Link
US (1) US6037347A (da)
EP (1) EP0867192B1 (da)
JP (1) JP4374440B2 (da)
KR (1) KR100517186B1 (da)
CN (1) CN100363005C (da)
AR (1) AR011860A1 (da)
AT (1) ATE295738T1 (da)
AU (1) AU749278C (da)
BR (1) BR9800766A (da)
CA (1) CA2230350C (da)
CZ (1) CZ298367B6 (da)
DE (2) DE19707655A1 (da)
DK (1) DK0867192T3 (da)
EE (1) EE03387B1 (da)
ES (1) ES2242243T3 (da)
HR (1) HRP980097B1 (da)
HU (1) HUP9800396A3 (da)
ID (1) ID19941A (da)
IL (1) IL123453A (da)
MY (1) MY120530A (da)
NO (1) NO327200B1 (da)
NZ (1) NZ329839A (da)
PL (1) PL191576B1 (da)
PT (1) PT867192E (da)
RU (1) RU2194508C2 (da)
SI (1) SI0867192T1 (da)
SK (1) SK284925B6 (da)
TR (1) TR199800302A3 (da)
TW (1) TW590772B (da)
ZA (1) ZA981561B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1406126A (zh) * 1998-10-01 2003-03-26 诺瓦提斯公司 新型缓释口服制剂
US20040110776A1 (en) * 2002-02-22 2004-06-10 Iok-Hou Pang Use of propentofylline to control intraocular pressure
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
WO2004028634A1 (en) * 2002-09-25 2004-04-08 The Board Of Trustees Of The University Of Illinois Method and composition for treating alzheimer's disease and dementias of vascular origin
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
JP5597343B2 (ja) * 2005-04-28 2014-10-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬を含有する組成物
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
RU2616247C1 (ru) * 2016-03-28 2017-04-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" (СОГУ) Твердая лекарственная форма, обладающая холинопозитивным действием, на основе 9-бутиламино-3,3-диметил-1,2,4-тригидроакридина

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737433A (en) * 1964-09-05 1973-06-05 Albert Ag Chem Werke Certain oxoalkyldimethylxanthines
US3621096A (en) * 1969-04-03 1971-11-16 Univ North Carolina Antidepressant method and composition for same comprising a tricyclic antidepressant and a thyroid hormone
DE2330742C2 (de) * 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2856393C2 (de) * 1978-12-27 1983-04-28 Merz + Co GmbH & Co, 6000 Frankfurt Arzneimittel zur Behandlung von Morbus Parkinson
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
JPH062675B2 (ja) * 1985-04-05 1994-01-12 ヘキストジヤパン株式会社 記憶障害治療剤
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
GB8621870D0 (en) * 1986-09-11 1986-10-15 Beecham Group Plc Active compounds
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
WO1989002739A1 (en) * 1987-10-05 1989-04-06 Pfizer Inc. 4-aminopyridine derivatives
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
RU2039058C1 (ru) * 1988-03-30 1995-07-09 Пфайзер Инк. Производные 4-аминопиридина
DE3817955A1 (de) * 1988-05-27 1989-11-30 Hoechst Ag Tnf-inhibitor enthaltendes arzneimittel
AU643235B2 (en) * 1989-09-15 1993-11-11 Gensia Pharmaceuticals, Inc. Methods of treating neurodegenerative conditions
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
GB9612710D0 (en) * 1996-06-18 1996-08-21 Pfizer Ltd Method of treatment

Also Published As

Publication number Publication date
CN100363005C (zh) 2008-01-23
KR100517186B1 (ko) 2005-12-05
SK284925B6 (sk) 2006-02-02
EE9800075A (et) 1998-10-15
TR199800302A2 (xx) 1998-09-21
SK24098A3 (en) 1998-09-09
US6037347A (en) 2000-03-14
HRP980097A2 (en) 1998-12-31
TR199800302A3 (tr) 1998-09-21
TW590772B (en) 2004-06-11
IL123453A (en) 2004-06-20
DE59812801D1 (de) 2005-06-23
AU749278C (en) 2003-07-31
AU749278B2 (en) 2002-06-20
AU5627398A (en) 1998-09-03
ID19941A (id) 1998-08-27
EP0867192A2 (de) 1998-09-30
ES2242243T3 (es) 2005-11-01
DK0867192T3 (da) 2005-09-05
EE03387B1 (et) 2001-04-16
NZ329839A (en) 2000-05-26
PL191576B1 (pl) 2006-06-30
NO980786L (no) 1998-08-27
HUP9800396A3 (en) 2001-05-28
MY120530A (en) 2005-11-30
CN1192904A (zh) 1998-09-16
EP0867192A3 (de) 2000-12-06
CA2230350A1 (en) 1998-08-26
KR19980071717A (ko) 1998-10-26
DE19707655A1 (de) 1998-08-27
EP0867192B1 (de) 2005-05-18
SI0867192T1 (en) 2005-10-31
RU2194508C2 (ru) 2002-12-20
ZA981561B (en) 1998-08-26
PL325074A1 (en) 1998-08-31
MX9801515A (es) 1998-08-30
PT867192E (pt) 2005-08-31
BR9800766A (pt) 1999-12-07
IL123453A0 (en) 1998-09-24
JP4374440B2 (ja) 2009-12-02
NO327200B1 (no) 2009-05-11
JPH10236979A (ja) 1998-09-08
CZ54098A3 (cs) 1998-09-16
CA2230350C (en) 2007-07-24
ATE295738T1 (de) 2005-06-15
AR011860A1 (es) 2000-09-13
HU9800396D0 (en) 1998-04-28
CZ298367B6 (cs) 2007-09-12
HUP9800396A1 (hu) 1999-07-28
NO980786D0 (no) 1998-02-25

Similar Documents

Publication Publication Date Title
MX9305930A (es) Derivados de piperidina, su preparacion y su aplicacion en terapeutica.
DE69622031D1 (de) INDOLDERIVATE ALS cGMP-PDE INHIBITOREN
AU2721402A (en) Anilinopyrimidine derivatives as jnk pathway inhibitors and compositions and methods related thereto
DK0828728T3 (da) Phenyldihydrobenzofuraner
MA26861A1 (fr) Inhibiteurs non peptidiques de la liaison cellulaire sous la dependance de vla-4 utiles dans le traitement des maladies inflammatoires, auto-immunes et respiratoires
PL315636A1 (en) Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives
HUP0400314A2 (hu) Gyógyszer-kombinációk rák kezelésére
ES8205554A1 (es) Procedimiento de producir agentes orales de inhibicion de placas dentales
FI954609A0 (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
DK1000035T3 (da) Substituerede 6-phenylphenanthridiner
ES2083359T3 (es) Piperidinas 1,4-substituidas como inhibidores de la acetilcolinesterasa y su utilizacion en el tratamiento de la enfermedad de alzheimer.
TR200000022T2 (tr) 3-ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin tek halkalı gastrokinetik benzamidleri.
BG104138A (en) 2-aminopyridines containing substituents with condensed rings as nos inhibitors
ATE459361T1 (de) Therapeutische azidverbindungen
ATE239012T1 (de) Triazin angiogenese-inhibitoren
DK0828727T3 (da) Cyclohexyldihydrobenzofuraner
BR9811589A (pt) Derivados de hidroxicumaranona o-substituìda como agentes antitumores e antimetastáticos
FR2613365B1 (fr) Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
TR200000153T2 (tr) İl-5 inhibite eden 6-azaurasil türevleri.
DK0547545T3 (da) Farmaceutisk præparat til inhibering af knogleresorption
NZ329839A (en) Combination of a compound which inhibits acetylcholinesterase or exhibits muscarinergic action and a compound which increases the endogenous extracellular adenosine level for treating dementia
HUP0004900A2 (hu) Mozgászavarok kezelésére szolgáló, hatóanyagként NMDA-receptor antagonista hatású piperidinszármazékokat tartalmazó gyógyszerkészítmények
MY159418A (en) New derivatives of flavones, their preparation process, their use as medicaments, pharmaceutical compositions and new use
BR9604907B1 (pt) derivados de nucleosidios homocarbociclico de pirimidinodiona substituìda antiviral e composição contendo derivados de nucleosidios homocarbociclico de pirimidinodiona substituìda antiviral com princìpios ativos.
ES8707495A1 (es) Un procedimiento para preparar derivados de azetidinona

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20090223

Year of fee payment: 12

PBON Lapse due to non-payment of renewal fee

Effective date: 20100226