HRP990077B1 - Pyrazolopyrimidines and pyrazolotriazines - Google Patents

Pyrazolopyrimidines and pyrazolotriazines

Info

Publication number
HRP990077B1
HRP990077B1 HR990077A HRP990077A HRP990077B1 HR P990077 B1 HRP990077 B1 HR P990077B1 HR 990077 A HR990077 A HR 990077A HR P990077 A HRP990077 A HR P990077A HR P990077 B1 HRP990077 B1 HR P990077B1
Authority
HR
Croatia
Prior art keywords
pyrazolotriazines
pyrazolopyrimidines
Prior art date
Application number
HR990077A
Other languages
English (en)
Inventor
Michael Boes
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HRP990077A2 publication Critical patent/HRP990077A2/hr
Publication of HRP990077B1 publication Critical patent/HRP990077B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HR990077A 1998-03-11 1999-03-11 Pyrazolopyrimidines and pyrazolotriazines HRP990077B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (2)

Publication Number Publication Date
HRP990077A2 HRP990077A2 (en) 2000-02-29
HRP990077B1 true HRP990077B1 (en) 2003-08-31

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
HR990077A HRP990077B1 (en) 1998-03-11 1999-03-11 Pyrazolopyrimidines and pyrazolotriazines

Country Status (33)

Country Link
US (1) US6194410B1 (da)
EP (1) EP0941994B1 (da)
JP (1) JP3231288B2 (da)
KR (1) KR100313181B1 (da)
CN (1) CN1118468C (da)
AR (1) AR016453A1 (da)
AT (1) ATE240332T1 (da)
AU (1) AU752408B2 (da)
BR (1) BR9901095A (da)
CA (1) CA2265095C (da)
CZ (1) CZ291514B6 (da)
DE (1) DE69907784T2 (da)
DK (1) DK0941994T3 (da)
ES (1) ES2198095T3 (da)
HR (1) HRP990077B1 (da)
HU (1) HUP9900589A1 (da)
ID (1) ID23575A (da)
IL (1) IL128869A (da)
MA (1) MA26612A1 (da)
MY (1) MY119536A (da)
NO (1) NO312297B1 (da)
NZ (1) NZ334526A (da)
PE (1) PE20000337A1 (da)
PL (1) PL331875A1 (da)
PT (1) PT941994E (da)
RU (1) RU2218340C2 (da)
SG (1) SG78336A1 (da)
SI (1) SI0941994T1 (da)
TR (1) TR199900531A3 (da)
TW (1) TW585865B (da)
UY (1) UY25419A1 (da)
YU (1) YU12099A (da)
ZA (1) ZA991946B (da)

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WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
DE19956791A1 (de) * 1999-11-25 2001-05-31 Merck Patent Gmbh Neue Sulfonyloxazolamine
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
IL157615A0 (en) * 2001-03-13 2004-03-28 Bristol Myers Squibb Co 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
JP4187642B2 (ja) 2001-06-07 2008-11-26 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ６受容体親和性を有する新規インドール誘導体
ES2268113T3 (es) 2001-06-15 2007-03-16 F. Hoffmann-La Roche Ag Derivados de 4-piperazinilindol con afinidad al receptor 5-ht6.
JP2005527463A (ja) * 2001-08-07 2005-09-15 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン
AU2002357270B2 (en) * 2001-12-20 2007-06-14 Wyeth Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
RU2380369C9 (ru) * 2002-09-04 2011-07-10 Шеринг Корпорейшн Новые пиразолопиримидины как ингибиторы циклин-зависимой киназы
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
AU2004213375A1 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-Hydroxytryptamine-6 ligands
EP1599482A4 (en) 2003-02-28 2008-10-01 Teijin Pharma Ltd PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005112936A1 (en) * 2004-05-14 2005-12-01 The Regents Of The University Of Michigan Compositions and methods relating to protein kinase inhibitors
EP1812440B1 (en) * 2004-11-04 2010-09-22 Vertex Pharmaceuticals, Inc. Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
RU2390523C2 (ru) * 2005-10-21 2010-05-27 Мицубиси Танабе Фарма Корпорейшн ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА
RU2330854C2 (ru) * 2006-03-15 2008-08-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
JP5584626B2 (ja) * 2008-01-24 2014-09-03 アンドレイ・アレクサンドロビッチ・イワシェンコ ２−アルキルアミノ−３−（アリールスルホニル）−シクロアルキル［ｅ又はｄ］ピラゾロ［１，５−ａ］ピリミジン−セロトニン５−ＨＴ６受容体アンタゴニスト、その調製の方法及び使用
EA017968B1 (ru) 2008-01-24 2013-04-30 Андрей Александрович ИВАЩЕНКО ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
US8629154B2 (en) * 2008-01-24 2014-01-14 Andrey Alexandrovich Ivashchenko Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof
RU2369600C1 (ru) 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2010041983A1 (ru) 2008-10-06 2010-04-15 Алла Хем, Ллс Замещенные 3-арилсульфoнил-пиpaзoлo[1,5-a]пиpимидины, антагонисты серотониновых 5-ht6 рецепторов, способы их получения и применения
EP2384328B1 (en) 2008-11-27 2013-02-13 Boehringer Ingelheim International GmbH 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
NZ610315A (en) 2010-11-15 2015-08-28 Univ Leuven Kath Antiviral condensed heterocyclic compounds
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
MX342177B (es) 2011-09-30 2016-09-20 Ipsen Pharma Sas Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.
CN104302649B (zh) 2012-03-09 2017-06-23 莱西肯医药有限公司 基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法
BR112017005299A2 (pt) 2014-09-17 2017-12-12 Ipsen Pharma Sas inibidores de lrrk2 cinase macrocíclicos
CA2978170C (en) 2015-03-09 2024-02-27 Aurigene Discovery Technologies Limited Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors
WO2017052394A1 (en) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
ES2765738T3 (es) 2015-11-02 2020-06-10 Janssen Pharmaceutica Nv Compuesto de [1,2,4]triazolo[1,5-a]pirimidin-7-ilo
EP3535269B1 (en) 2016-11-02 2020-12-09 Janssen Pharmaceutica NV [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
UA125302C2 (uk) 2016-11-02 2022-02-16 Янссен Фармацевтика Нв Похідні [1,2,4]триазоло[1,5-a]піримідину як інгібітори pde2
KR20190067788A (ko) 2016-11-02 2019-06-17 얀센 파마슈티카 엔.브이. Pde2 억제제로서의 [1,2,4]트리아졸로[1,5-a]피리미딘 화합물
WO2020224568A1 (en) 2019-05-05 2020-11-12 Qilu Regor Therapeutics Inc. Cdk inhibitors
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KR20220140515A (ko) 2020-01-13 2022-10-18 버지 애널리틱스, 인크. 치환된 피라졸로-피리미딘 및 그의 용도

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JP2002511097A (ja) 1997-07-11 2002-04-09 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ▲下６▼レセプターアンタゴニストであるスルホンアミド誘導体およびその製造方法

Also Published As

Publication number Publication date
HK1023343A1 (en) 2000-09-08
TR199900531A2 (xx) 1999-10-21
KR19990077741A (ko) 1999-10-25
JP2000186090A (ja) 2000-07-04
PT941994E (pt) 2003-09-30
BR9901095A (pt) 2000-05-02
NO991150L (no) 1999-09-13
DE69907784D1 (de) 2003-06-18
AU752408B2 (en) 2002-09-19
HUP9900589A1 (hu) 2000-03-28
UY25419A1 (es) 2001-11-30
ID23575A (id) 2000-05-04
CN1236780A (zh) 1999-12-01
PE20000337A1 (es) 2000-05-13
CA2265095A1 (en) 1999-09-11
US6194410B1 (en) 2001-02-27
ZA991946B (en) 1999-09-13
IL128869A0 (en) 2000-01-31
ES2198095T3 (es) 2004-01-16
NO991150D0 (no) 1999-03-10
DK0941994T3 (da) 2003-09-08
CZ82599A3 (cs) 1999-09-15
HRP990077A2 (en) 2000-02-29
DE69907784T2 (de) 2004-03-25
SI0941994T1 (en) 2003-10-31
CZ291514B6 (cs) 2003-03-12
AR016453A1 (es) 2001-07-04
CA2265095C (en) 2008-07-22
NZ334526A (en) 2000-07-28
PL331875A1 (en) 1999-09-13
HU9900589D0 (en) 1999-05-28
CN1118468C (zh) 2003-08-20
EP0941994A1 (en) 1999-09-15
MA26612A1 (fr) 2004-12-20
YU12099A (sh) 2000-10-30
TW585865B (en) 2004-05-01
ATE240332T1 (de) 2003-05-15
EP0941994B1 (en) 2003-05-14
TR199900531A3 (tr) 1999-10-21
AU2038399A (en) 1999-09-23
RU2218340C2 (ru) 2003-12-10
MY119536A (en) 2005-06-30
JP3231288B2 (ja) 2001-11-19
IL128869A (en) 2003-09-17
KR100313181B1 (ko) 2001-11-05
NO312297B1 (no) 2002-04-22
SG78336A1 (en) 2001-02-20

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