DK0941994T3 - Pyrazolopyrimidiner og pyrazolotriaziner med 5-HT6 receptoraffinitet - Google Patents

Pyrazolopyrimidiner og pyrazolotriaziner med 5-HT6 receptoraffinitet

Info

Publication number: DK0941994T3
Authority: DK; Denmark
Prior art keywords: pyrazolotriazines; pyrazolopyrimidines; receptor affinity; affinity; receptor
Prior art date: 1998-03-11

Application number

DK99102872T

Other languages

English (en)

Inventor

Michael Boes

Claus Riemer

Heinz Stadler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-11

Filing date

1999-03-03

Publication date

2003-09-08

1999-03-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-09-08 Application granted granted Critical

2003-09-08 Publication of DK0941994T3 publication Critical patent/DK0941994T3/da

Links

APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
108091005435 5-HT6 receptors Proteins 0.000 title 1
PEYVWBGHBCDXRT-UHFFFAOYSA-N N1=NNC2=CN=NC2=C1 Chemical class N1=NNC2=CN=NC2=C1 PEYVWBGHBCDXRT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Psychiatry (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK99102872T 1998-03-11 1999-03-03 Pyrazolopyrimidiner og pyrazolotriaziner med 5-HT6 receptoraffinitet DK0941994T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP98104346		1998-03-11

Publications (1)

Publication Number	Publication Date
DK0941994T3 true DK0941994T3 (da)	2003-09-08

Family

ID=8231568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99102872T DK0941994T3 (da)	1998-03-11	1999-03-03	Pyrazolopyrimidiner og pyrazolotriaziner med 5-HT6 receptoraffinitet

Country Status (33)

Country	Link
US (1)	US6194410B1 (da)
EP (1)	EP0941994B1 (da)
JP (1)	JP3231288B2 (da)
KR (1)	KR100313181B1 (da)
CN (1)	CN1118468C (da)
AR (1)	AR016453A1 (da)
AT (1)	ATE240332T1 (da)
AU (1)	AU752408B2 (da)
BR (1)	BR9901095A (da)
CA (1)	CA2265095C (da)
CZ (1)	CZ291514B6 (da)
DE (1)	DE69907784T2 (da)
DK (1)	DK0941994T3 (da)
ES (1)	ES2198095T3 (da)
HR (1)	HRP990077B1 (da)
HU (1)	HUP9900589A1 (da)
ID (1)	ID23575A (da)
IL (1)	IL128869A (da)
MA (1)	MA26612A1 (da)
MY (1)	MY119536A (da)
NO (1)	NO312297B1 (da)
NZ (1)	NZ334526A (da)
PE (1)	PE20000337A1 (da)
PL (1)	PL331875A1 (da)
PT (1)	PT941994E (da)
RU (1)	RU2218340C2 (da)
SG (1)	SG78336A1 (da)
SI (1)	SI0941994T1 (da)
TR (1)	TR199900531A3 (da)
TW (1)	TW585865B (da)
UY (1)	UY25419A1 (da)
YU (1)	YU12099A (da)
ZA (1)	ZA991946B (da)

Families Citing this family (49)

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AU4331500A (en)	1999-04-06	2000-10-23	Du Pont Pharmaceuticals Company	Pyrazolotriazines as crf antagonists
DE19956791A1 (de)	1999-11-25	2001-05-31	Merck Patent Gmbh	Neue Sulfonyloxazolamine
PE20020394A1 (es)	2000-08-18	2002-06-21	Agouron Pharma	Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
NZ528207A (en) *	2001-03-13	2006-02-24	Bristol Myers Squibb Pharma Co	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-A]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
BR0210929A (pt)	2001-06-07	2004-06-08	Hoffmann La Roche	Derivados de indol com afinidade para o receptor 5-ht6
ES2268113T3 (es)	2001-06-15	2007-03-16	F. Hoffmann-La Roche Ag	Derivados de 4-piperazinilindol con afinidad al receptor 5-ht6.
EP1414442A1 (en) *	2001-08-07	2004-05-06	Smithkline Beecham Plc	3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
ATE335477T1 (de) *	2001-12-20	2006-09-15	Wyeth Corp	Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden
US6642381B2 (en) *	2001-12-27	2003-11-04	Hoffman-La Roche Inc.	Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) *	2002-02-05	2002-03-20	Glaxo Group Ltd	Novel compounds
UA78999C2 (en) *	2002-06-04	2007-05-10	Wyeth Corp	1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en)	2002-07-26	2005-04-05	Bristol-Myers Squibb Company	Pyridopyrimidine derivatives as 5-HT6 antagonists
US7196078B2 (en) *	2002-09-04	2007-03-27	Schering Corpoartion	Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
PL224879B1 (pl) *	2002-09-04	2017-02-28	Pharmacopeia Drug Discovery Inc	Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja
US7329658B2 (en) *	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
WO2004074286A1 (en) *	2003-02-14	2004-09-02	Wyeth	Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
US7557110B2 (en)	2003-02-28	2009-07-07	Teijin Pharma Limited	Pyrazolo[1,5-A] pyrimidine derivatives
GB0305559D0 (en) *	2003-03-11	2003-04-16	Teijin Ltd	Compounds
US7585881B2 (en) *	2004-02-18	2009-09-08	Astrazeneca Ab	Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US20080287405A1 (en) *	2004-05-14	2008-11-20	Thannickal Victor J	Compositions and Methods Relating to Protein Kinase Inhibitors
PT1812440E (pt) *	2004-11-04	2011-01-25	Vertex Pharma	Pirazolo[1,5-a]pirimidinas úteis enquanto inibidores de proteínas cinases
RU2390523C2 (ru) *	2005-10-21	2010-05-27	Мицубиси Танабе Фарма Корпорейшн	ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА
RU2330854C2 (ru) *	2006-03-15	2008-08-10	Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава")	Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
KR20100119776A (ko)	2008-01-24	2010-11-10	알라 캠, 엘엘씨	2-알킬아미노-3-아릴설포닐-사이클로알카노[ｅ 또는 ｄ]피라졸로[1,5-Ａ]피리미딘/세로토닌 5-ＨＴ6 수용체의 길항제, 이의 제조방법 및 이의 용도
US8309559B2 (en) *	2008-01-24	2012-11-13	Nikolay Filippovich Savchuk	(EN) substituted 2-amino-3-sulfonyl-pyrazolo[1,5-A] pyrimidines/antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
US8629154B2 (en) *	2008-01-24	2014-01-14	Andrey Alexandrovich Ivashchenko	Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof
RU2369600C1 (ru)	2008-01-24	2009-10-10	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
RU2384581C2 (ru)	2008-05-07	2010-03-20	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EA017630B1 (ru) *	2008-10-06	2013-01-30	Андрей Александрович ИВАЩЕНКО	ЗАМЕЩЕННЫЕ 3-АРИЛСУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ, АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT-РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EP2384328B1 (en)	2008-11-27	2013-02-13	Boehringer Ingelheim International GmbH	6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0908394D0 (en)	2009-05-15	2009-06-24	Univ Leuven Kath	Novel viral replication inhibitors
GB0913636D0 (en)	2009-08-05	2009-09-16	Univ Leuven Kath	Novel viral replication inhibitors
KR20140003438A (ko)	2010-11-15	2014-01-09	카톨리에케 유니버시테이트 루벤	항바이러스성 축합 헤테로사이클릭 화합물
RU2443697C1 (ru)	2010-12-21	2012-02-27	Александр Васильевич Иващенко	Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
HUE029728T2 (en)	2011-09-30	2017-03-28	Ipsen Pharma Sas	Macrocyclic LRRK2 kinase inhibitors
CN104302649B (zh) *	2012-03-09	2017-06-23	莱西肯医药有限公司	基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
TW201542550A (zh) *	2013-09-06	2015-11-16	Lexicon Pharmaceuticals Inc	吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) *	2014-03-17	2016-06-16	雷西肯製藥股份有限公司	銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法
ES2717510T3 (es)	2014-09-17	2019-06-21	Oncodesign Sa	Inhibidores macrocíclicos de cinasa LRRK2
ES2899196T3 (es)	2015-03-09	2022-03-10	Aurigene Discovery Tech Ltd	Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK
WO2017052394A1 (en) *	2015-09-23	2017-03-30	Uniwersytet Jagielloński	Imidazopyridine compounds and their use as 5-ht6 receptor ligands
ES2765738T3 (es)	2015-11-02	2020-06-10	Janssen Pharmaceutica Nv	Compuesto de [1,2,4]triazolo[1,5-a]pirimidin-7-ilo
CA3038916A1 (en)	2016-11-02	2018-05-11	Janssen Pharmaceutica Nv	[1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
AU2017353313C1 (en)	2016-11-02	2022-06-09	Janssen Pharmaceutica Nv	(1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors
MX385576B (es)	2016-11-02	2025-03-18	Janssen Pharmaceutica Nv	Derivados de [1,2,4]triazol[1,5-a]pirimidina como inhibidores de pde2
MA55909A (fr)	2019-05-05	2022-03-16	Qilu Regor Therapeutics Inc	Inhibiteurs de cdk
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1999
- 1999-02-24 US US09/256,927 patent/US6194410B1/en not_active Expired - Fee Related
- 1999-03-03 DE DE69907784T patent/DE69907784T2/de not_active Expired - Fee Related
- 1999-03-03 EP EP99102872A patent/EP0941994B1/en not_active Expired - Lifetime
- 1999-03-03 ES ES99102872T patent/ES2198095T3/es not_active Expired - Lifetime
- 1999-03-03 SI SI9930320T patent/SI0941994T1/xx unknown
- 1999-03-03 AT AT99102872T patent/ATE240332T1/de not_active IP Right Cessation
- 1999-03-03 DK DK99102872T patent/DK0941994T3/da active
- 1999-03-03 PT PT99102872T patent/PT941994E/pt unknown
- 1999-03-08 PE PE1999000183A patent/PE20000337A1/es not_active Application Discontinuation
- 1999-03-08 CA CA002265095A patent/CA2265095C/en not_active Expired - Fee Related
- 1999-03-08 MA MA25485A patent/MA26612A1/fr unknown
- 1999-03-08 NZ NZ334526A patent/NZ334526A/xx unknown
- 1999-03-08 YU YU12099A patent/YU12099A/sh unknown
- 1999-03-08 IL IL12886999A patent/IL128869A/xx not_active IP Right Cessation
- 1999-03-09 UY UY25419A patent/UY25419A1/es unknown
- 1999-03-09 MY MYPI99000853A patent/MY119536A/en unknown
- 1999-03-09 SG SG1999001080A patent/SG78336A1/en unknown
- 1999-03-09 AR ARP990100990A patent/AR016453A1/es unknown
- 1999-03-09 JP JP06114999A patent/JP3231288B2/ja not_active Expired - Fee Related
- 1999-03-10 CZ CZ1999825A patent/CZ291514B6/cs not_active IP Right Cessation
- 1999-03-10 PL PL99331875A patent/PL331875A1/xx unknown
- 1999-03-10 BR BR9901095-0A patent/BR9901095A/pt not_active Application Discontinuation
- 1999-03-10 TW TW088103692A patent/TW585865B/zh not_active IP Right Cessation
- 1999-03-10 ID IDP990198D patent/ID23575A/id unknown
- 1999-03-10 ZA ZA9901946A patent/ZA991946B/xx unknown
- 1999-03-10 HU HU9900589A patent/HUP9900589A1/hu not_active Application Discontinuation
- 1999-03-10 NO NO19991150A patent/NO312297B1/no unknown
- 1999-03-10 RU RU99105137/04A patent/RU2218340C2/ru active
- 1999-03-10 KR KR1019990007881A patent/KR100313181B1/ko not_active Expired - Fee Related
- 1999-03-11 TR TR1999/00531A patent/TR199900531A3/tr unknown
- 1999-03-11 HR HR990077A patent/HRP990077B1/xx not_active IP Right Cessation
- 1999-03-11 CN CN99105964A patent/CN1118468C/zh not_active Expired - Fee Related
- 1999-03-11 AU AU20383/99A patent/AU752408B2/en not_active Ceased

Also Published As

Publication number	Publication date
TR199900531A2 (xx)	1999-10-21
CA2265095A1 (en)	1999-09-11
IL128869A (en)	2003-09-17
TW585865B (en)	2004-05-01
HUP9900589A1 (hu)	2000-03-28
ZA991946B (en)	1999-09-13
ATE240332T1 (de)	2003-05-15
UY25419A1 (es)	2001-11-30
NO312297B1 (no)	2002-04-22
KR100313181B1 (ko)	2001-11-05
TR199900531A3 (tr)	1999-10-21
DE69907784T2 (de)	2004-03-25
AR016453A1 (es)	2001-07-04
NO991150L (no)	1999-09-13
IL128869A0 (en)	2000-01-31
JP3231288B2 (ja)	2001-11-19
EP0941994B1 (en)	2003-05-14
RU2218340C2 (ru)	2003-12-10
DE69907784D1 (de)	2003-06-18
PL331875A1 (en)	1999-09-13
NO991150D0 (no)	1999-03-10
BR9901095A (pt)	2000-05-02
HU9900589D0 (en)	1999-05-28
MA26612A1 (fr)	2004-12-20
US6194410B1 (en)	2001-02-27
CN1236780A (zh)	1999-12-01
KR19990077741A (ko)	1999-10-25
PT941994E (pt)	2003-09-30
ES2198095T3 (es)	2004-01-16
SI0941994T1 (en)	2003-10-31
MY119536A (en)	2005-06-30
PE20000337A1 (es)	2000-05-13
CN1118468C (zh)	2003-08-20
JP2000186090A (ja)	2000-07-04
ID23575A (id)	2000-05-04
NZ334526A (en)	2000-07-28
YU12099A (sh)	2000-10-30
AU2038399A (en)	1999-09-23
AU752408B2 (en)	2002-09-19
HRP990077A2 (en)	2000-02-29
CZ291514B6 (cs)	2003-03-12
EP0941994A1 (en)	1999-09-15
HRP990077B1 (en)	2003-08-31
SG78336A1 (en)	2001-02-20
HK1023343A1 (en)	2000-09-08
CA2265095C (en)	2008-07-22
CZ82599A3 (cs)	1999-09-15

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