HRP990077B1 - Pyrazolopyrimidines and pyrazolotriazines - Google Patents

Pyrazolopyrimidines and pyrazolotriazines

Info

Publication number
HRP990077B1
HRP990077B1 HR990077A HRP990077A HRP990077B1 HR P990077 B1 HRP990077 B1 HR P990077B1 HR 990077 A HR990077 A HR 990077A HR P990077 A HRP990077 A HR P990077A HR P990077 B1 HRP990077 B1 HR P990077B1
Authority
HR
Croatia
Prior art keywords
pyrazolotriazines
pyrazolopyrimidines
Prior art date
Application number
HR990077A
Other languages
English (en)
Inventor
Michael Boes
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HRP990077A2 publication Critical patent/HRP990077A2/hr
Publication of HRP990077B1 publication Critical patent/HRP990077B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HR990077A 1998-03-11 1999-03-11 Pyrazolopyrimidines and pyrazolotriazines HRP990077B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (2)

Publication Number Publication Date
HRP990077A2 HRP990077A2 (en) 2000-02-29
HRP990077B1 true HRP990077B1 (en) 2003-08-31

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
HR990077A HRP990077B1 (en) 1998-03-11 1999-03-11 Pyrazolopyrimidines and pyrazolotriazines

Country Status (33)

Country Link
US (1) US6194410B1 (de)
EP (1) EP0941994B1 (de)
JP (1) JP3231288B2 (de)
KR (1) KR100313181B1 (de)
CN (1) CN1118468C (de)
AR (1) AR016453A1 (de)
AT (1) ATE240332T1 (de)
AU (1) AU752408B2 (de)
BR (1) BR9901095A (de)
CA (1) CA2265095C (de)
CZ (1) CZ291514B6 (de)
DE (1) DE69907784T2 (de)
DK (1) DK0941994T3 (de)
ES (1) ES2198095T3 (de)
HR (1) HRP990077B1 (de)
HU (1) HUP9900589A1 (de)
ID (1) ID23575A (de)
IL (1) IL128869A (de)
MA (1) MA26612A1 (de)
MY (1) MY119536A (de)
NO (1) NO312297B1 (de)
NZ (1) NZ334526A (de)
PE (1) PE20000337A1 (de)
PL (1) PL331875A1 (de)
PT (1) PT941994E (de)
RU (1) RU2218340C2 (de)
SG (1) SG78336A1 (de)
SI (1) SI0941994T1 (de)
TR (1) TR199900531A3 (de)
TW (1) TW585865B (de)
UY (1) UY25419A1 (de)
YU (1) YU12099A (de)
ZA (1) ZA991946B (de)

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WO2000059907A2 (en) * 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
DE19956791A1 (de) 1999-11-25 2001-05-31 Merck Patent Gmbh Neue Sulfonyloxazolamine
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
DE60218434T2 (de) * 2001-03-13 2007-11-08 Bristol-Myers Squibb Pharma Co. 4-(2-BUTYLAMINO)-2,7-DIMETHYL-8-(2-METHYL-6-METHOXYPYRID-3-YL) PYRAZOLO- 1,5-Aö-1,3,5-TRIAZIN, SEINE ENANTIOMEREN UND PHARMAZEUTISCH ANNEHMBARE SALZE ALS CORTICOTROPIN-RELEASING-FACTOR-REZEPTOR-LIGANDEN
MXPA03011244A (es) 2001-06-07 2004-02-27 Hoffmann La Roche Nuevos derivados de indol con afinidad por el receptor 5-ht6.
KR20040010709A (ko) 2001-06-15 2004-01-31 에프. 호프만-라 로슈 아게 5-ht6 수용체 친화력을 갖는 4-피페라지닐인돌 유도체
WO2003013510A1 (en) * 2001-08-07 2003-02-20 Smithkline Beecham P.L.C. 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
WO2003053433A1 (en) * 2001-12-20 2003-07-03 Wyeth Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
DE60332846D1 (de) * 2002-09-04 2010-07-15 Pharmacopeia Llc Zur behandlung von krebserkrankungen geeignete pyrazolopyrimidine
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
EP1592690A1 (de) * 2003-02-14 2005-11-09 Wyeth Heterocyclyl-3-sulfonylazaindol- oder -azaindazolderivate als 5-hydroxytryptamin-6-liganden
WO2004076458A1 (en) 2003-02-28 2004-09-10 Teijin Pharma Limited Pyrazolo[1,5-a]pyrimidine derivatives
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005112936A1 (en) * 2004-05-14 2005-12-01 The Regents Of The University Of Michigan Compositions and methods relating to protein kinase inhibitors
SI1812440T1 (sl) * 2004-11-04 2011-04-29 Vertex Pharma Pirazolo(1,5-a)pirimidini, uporabni kot inhibitorji protein kinaz
RU2390523C2 (ru) * 2005-10-21 2010-05-27 Мицубиси Танабе Фарма Корпорейшн ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА
RU2330854C2 (ru) * 2006-03-15 2008-08-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
KR20100119777A (ko) * 2008-01-24 2010-11-10 알라 캠, 엘엘씨 치환된 사이클로알카노[e 및 d] 피라졸로 [1,5―A]피리미딘/세로토닌 5―HT6 수용체의 길항제 및 이의 제조방법 및 이의 용도
RU2369600C1 (ru) * 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
EP2248817B1 (de) * 2008-01-24 2015-01-07 Alla Chem, LLC. Substituierte 2-amino-3-sulfonylpyrazolo[1,5-a]pyrimidine/antagonisten von serotonin-5-ht6-rezeptoren, verfahren zu deren herstellung und deren verwendung
WO2009093209A2 (ru) 2008-01-24 2009-07-30 Alla Chem, Llc 2-AЛKИЛAMИHO-3-APИЛCУЛЬФOHИЛ-ЦИKЛOAЛKAHO [e ИЛИ d] ПИPAЗOЛO [1,5-a] ПИPИMИДИHЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
JP2012504663A (ja) 2008-10-06 2012-02-23 アンドレイ・アレクサンドロビッチ・イワシェンコ 置換された3−アリールスルホニル−ピラゾロ[1,5−a]ピリミジン、セロトニン5−HT6受容体アンタゴニスト、その調製のための方法及び使用
JP5747331B2 (ja) * 2008-11-27 2015-07-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 6,7,8,9−テトラヒドロ−5H−1,4,7,10a−テトラアザ−シクロヘプタ[f]インデン誘導体、これらの化合物を含有する医薬組成物、それらの使用及びそれらの調製方法
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
MX342177B (es) 2011-09-30 2016-09-20 Ipsen Pharma Sas Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.
TR201808280T4 (tr) * 2012-03-09 2018-07-23 Lexicon Pharmaceuticals Inc Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri.
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并[1,5-a]嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶1之抑制劑、包含其之組成物、及其使用方法
TW201625639A (zh) 2014-09-17 2016-07-16 腫瘤設計公司 巨環lrrk2激酶抑制劑
JP6789962B2 (ja) 2015-03-09 2020-11-25 オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited CDK阻害剤としてのピラゾロ[1,5−a][1,3,5]トリアジンとピラゾロ[1,5−a]ピリミジン誘導体
WO2017052394A1 (en) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
MX2018005342A (es) 2015-11-02 2018-08-15 Janseen Pharmaceutica Nv Compuesto de [1,2,4]triazolo[1,5-a]pirimidin-7-ilo.
CN109937202B (zh) 2016-11-02 2022-12-30 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
TWI764950B (zh) 2016-11-02 2022-05-21 比利時商健生藥品公司 Pde2抑制劑
WO2018083101A1 (en) 2016-11-02 2018-05-11 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
JP7671425B2 (ja) 2019-05-05 2025-05-02 ジェネンテック,インコーポレーテッド Cdk阻害剤
CN112142744A (zh) 2019-06-28 2020-12-29 上海瑛派药业有限公司 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用
CN115209952B (zh) 2020-01-13 2025-05-30 维基分析有限公司 经取代的吡唑并嘧啶及其用途

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EP0994862B1 (de) 1997-07-11 2005-06-01 SmithKline Beecham plc Sulfonamid-derivate als 5-ht6 receptor antagonisten und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
CA2265095C (en) 2008-07-22
DE69907784T2 (de) 2004-03-25
KR19990077741A (ko) 1999-10-25
IL128869A (en) 2003-09-17
ID23575A (id) 2000-05-04
MA26612A1 (fr) 2004-12-20
SI0941994T1 (en) 2003-10-31
BR9901095A (pt) 2000-05-02
NO991150L (no) 1999-09-13
HRP990077A2 (en) 2000-02-29
KR100313181B1 (ko) 2001-11-05
NZ334526A (en) 2000-07-28
JP2000186090A (ja) 2000-07-04
ES2198095T3 (es) 2004-01-16
IL128869A0 (en) 2000-01-31
TR199900531A2 (xx) 1999-10-21
JP3231288B2 (ja) 2001-11-19
CN1118468C (zh) 2003-08-20
SG78336A1 (en) 2001-02-20
AU752408B2 (en) 2002-09-19
NO312297B1 (no) 2002-04-22
HK1023343A1 (en) 2000-09-08
HUP9900589A1 (hu) 2000-03-28
CZ82599A3 (cs) 1999-09-15
RU2218340C2 (ru) 2003-12-10
NO991150D0 (no) 1999-03-10
ZA991946B (en) 1999-09-13
DE69907784D1 (de) 2003-06-18
EP0941994B1 (de) 2003-05-14
EP0941994A1 (de) 1999-09-15
ATE240332T1 (de) 2003-05-15
PL331875A1 (en) 1999-09-13
CA2265095A1 (en) 1999-09-11
AR016453A1 (es) 2001-07-04
MY119536A (en) 2005-06-30
CN1236780A (zh) 1999-12-01
AU2038399A (en) 1999-09-23
PT941994E (pt) 2003-09-30
YU12099A (sh) 2000-10-30
US6194410B1 (en) 2001-02-27
HU9900589D0 (en) 1999-05-28
TW585865B (en) 2004-05-01
DK0941994T3 (da) 2003-09-08
TR199900531A3 (tr) 1999-10-21
CZ291514B6 (cs) 2003-03-12
UY25419A1 (es) 2001-11-30
PE20000337A1 (es) 2000-05-13

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