HU203670B - Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus - Google Patents

Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus Download PDF

Info

Publication number: HU203670B
Authority: HU; Hungary
Prior art keywords: formula; compound; pharmaceutically acceptable; active ingredient; medicament
Prior art date: 1988-08-13

Application number

HU894148A

Other languages

English (en)

Hungarian (hu)

Other versions

HUT50443A (en

Inventor

Michael Doerschug

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-13

Filing date

1989-08-11

Publication date

1991-09-30

1989-08-11 Application filed by Hoechst Ag filed Critical Hoechst Ag

1990-02-28 Publication of HUT50443A publication Critical patent/HUT50443A/hu

1991-09-30 Publication of HU203670B publication Critical patent/HU203670B/hu

Links

238000000034 method Methods 0.000 title claims description 17
230000008569 process Effects 0.000 title claims description 10
239000008194 pharmaceutical composition Substances 0.000 title claims description 9
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 title 1
206010012601 diabetes mellitus Diseases 0.000 title 1
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150000001875 compounds Chemical class 0.000 claims description 34
239000001257 hydrogen Substances 0.000 claims description 13
229910052739 hydrogen Inorganic materials 0.000 claims description 13
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
150000003839 salts Chemical class 0.000 claims description 13
239000000460 chlorine Chemical group 0.000 claims description 12
229910052801 chlorine Inorganic materials 0.000 claims description 12
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230000001404 mediated effect Effects 0.000 claims description 10
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239000003814 drug Substances 0.000 claims description 9
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 8
239000004480 active ingredient Substances 0.000 claims description 8
125000001309 chloro group Chemical group Cl* 0.000 claims description 8
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NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
239000003797 essential amino acid Substances 0.000 description 1
235000020776 essential amino acid Nutrition 0.000 description 1
229960005293 etodolac Drugs 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000013213 extrapolation Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000004678 hydrides Chemical class 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
229960000905 indomethacin Drugs 0.000 description 1
230000036512 infertility Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
150000002617 leukotrienes Chemical class 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
208000028169 periodontal disease Diseases 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
229910052573 porcelain Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
235000008476 powdered milk Nutrition 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000001698 pyrogenic effect Effects 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000001525 receptor binding assay Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
239000000523 sample Substances 0.000 description 1
230000037390 scarring Effects 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
241000894007 species Species 0.000 description 1
210000001562 sternum Anatomy 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
208000008732 thymoma Diseases 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000001262 western blot Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Obesity (AREA)
Hematology (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HU894148A 1988-08-13 1989-08-11 Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus HU203670B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3827533A DE3827533A1 (de)	1988-08-13	1988-08-13	Pharmazeutische zubereitung zur behandlung des diabetes mellitus

Publications (2)

Publication Number	Publication Date
HUT50443A HUT50443A (en)	1990-02-28
HU203670B true HU203670B (en)	1991-09-30

Family

ID=6360797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU894148A HU203670B (en)	1988-08-13	1989-08-11	Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus

Country Status (18)

Country	Link
US (1)	US5177058A (2)
EP (1)	EP0357978B1 (2)
JP (1)	JPH02101022A (2)
KR (1)	KR900002801A (2)
AT (1)	ATE75945T1 (2)
AU (1)	AU621648B2 (2)
CA (1)	CA1332354C (2)
DE (2)	DE3827533A1 (2)
DK (1)	DK395689A (2)
ES (1)	ES2039773T3 (2)
FI (1)	FI95202C (2)
GR (1)	GR3005326T3 (2)
HU (1)	HU203670B (2)
IE (1)	IE61266B1 (2)
NO (1)	NO178914C (2)
NZ (1)	NZ230280A (2)
PT (1)	PT91420B (2)
ZA (1)	ZA896149B (2)

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US6875589B1 (en) *	1988-06-23	2005-04-05	Hoechst Aktiengesellschaft	Mini-proinsulin, its preparation and use
DE4024434A1 (de) *	1990-08-01	1992-02-13	Fresenius Ag	Vorrichtung zur ultrafiltrationskontrolle bzw. ultrafiltrationsregelung bei blutreinigungsverfahren
NZ250844A (en) *	1993-04-07	1996-03-26	Pfizer	Treatment of non-insulin dependant diabetes with peptides; composition
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
YU18596A (sh) *	1995-03-31	1998-07-10	Eli Lilly And Company	Analogne formulacije monomernog insulina
DK0821006T3 (da) *	1996-07-26	2004-08-16	Aventis Pharma Gmbh	Insulinderivater med öget zinkbinding
EP1044016B1 (en) *	1998-01-09	2005-03-16	Novo Nordisk A/S	Stabilised insulin compositions
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
PL374949A1 (en) *	2001-12-20	2005-11-14	Eli Lilly And Company	Insulin molecule having protracted time action
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
US20060217290A1 (en) *	2003-04-29	2006-09-28	Kohn Wayne D	Insulin analogs having protracted time action
MXPA06001283A (es) *	2003-08-05	2006-04-11	Novo Nordisk As	Derivados de insulina novedosos.
BRPI0513508B1 (pt)	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
JP4808785B2 (ja)	2005-12-28	2011-11-02	ノボ・ノルデイスク・エー／エス	インスリン組成物および組成物の製造方法
US9034818B2 (en) *	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
JP5868594B2 (ja) *	2007-10-16	2016-02-24	バイオコン・リミテッドＢｉｏｃｏｎＬｉｍｉｔｅｄ	経口投与可能な固形医薬組成物及びそのプロセス
CN102256618A (zh)	2008-10-17	2011-11-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
AU2009309623B9 (en) *	2008-10-30	2014-10-02	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
PL2451437T3 (pl)	2009-07-06	2017-05-31	Sanofi-Aventis Deutschland Gmbh	Wodne preparaty insuliny zawierające metioninę
NZ599847A (en)	2009-11-13	2013-09-27	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr)	2009-11-13	2018-07-23	Sanofi Aventis Deutschland	Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation

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Publication number	Priority date	Publication date	Assignee	Title
US2143591A (en) *	1936-09-26	1939-01-10	Univ Alberta	Therapeutic preparation and process of making and using it
US2354211A (en) *	1940-07-02	1944-07-25	Burroughs Wellcome Co	Insulin preparation
DOP1982004086A (es) *	1981-08-27	1988-03-22	Lilly Co Eli	Formula farmaceutica que comprende insulina humana y proinsulina humana
DE3326473A1 (de) *	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider
DK347086D0 (da) *	1986-07-21	1986-07-21	Novo Industri As	Novel peptides

1988
- 1988-08-13 DE DE3827533A patent/DE3827533A1/de not_active Withdrawn
1989
- 1989-08-08 ES ES89114617T patent/ES2039773T3/es not_active Expired - Lifetime
- 1989-08-08 EP EP89114617A patent/EP0357978B1/de not_active Expired - Lifetime
- 1989-08-08 AT AT89114617T patent/ATE75945T1/de not_active IP Right Cessation
- 1989-08-08 DE DE8989114617T patent/DE58901401D1/de not_active Expired - Lifetime
- 1989-08-10 FI FI893783A patent/FI95202C/fi not_active IP Right Cessation
- 1989-08-10 PT PT91420A patent/PT91420B/pt not_active IP Right Cessation
- 1989-08-11 HU HU894148A patent/HU203670B/hu unknown
- 1989-08-11 AU AU39514/89A patent/AU621648B2/en not_active Expired
- 1989-08-11 CA CA000608115A patent/CA1332354C/en not_active Expired - Lifetime
- 1989-08-11 US US07/392,559 patent/US5177058A/en not_active Expired - Lifetime
- 1989-08-11 IE IE259489A patent/IE61266B1/en not_active IP Right Cessation
- 1989-08-11 ZA ZA896149A patent/ZA896149B/xx unknown
- 1989-08-11 KR KR1019890011430A patent/KR900002801A/ko not_active Withdrawn
- 1989-08-11 NO NO893239A patent/NO178914C/no unknown
- 1989-08-11 DK DK395689A patent/DK395689A/da not_active Application Discontinuation
- 1989-08-11 NZ NZ230280A patent/NZ230280A/xx unknown
- 1989-08-11 JP JP1207057A patent/JPH02101022A/ja active Pending
1992
- 1992-07-31 GR GR920401367T patent/GR3005326T3/el unknown

Also Published As

Publication number	Publication date
ZA896149B (en)	1990-04-25
DK395689A (da)	1990-02-14
IE892594L (en)	1990-02-13
DE58901401D1 (de)	1992-06-17
NO893239D0 (no)	1989-08-11
FI95202C (fi)	1996-01-10
EP0357978B1 (de)	1992-05-13
FI95202B (fi)	1995-09-29
AU621648B2 (en)	1992-03-19
HUT50443A (en)	1990-02-28
GR3005326T3 (2)	1993-05-24
US5177058A (en)	1993-01-05
IE61266B1 (en)	1994-10-19
JPH02101022A (ja)	1990-04-12
NO178914B (no)	1996-03-25
ES2039773T3 (es)	1996-07-16
EP0357978A1 (de)	1990-03-14
PT91420A (pt)	1990-03-08
DK395689D0 (da)	1989-08-11
KR900002801A (ko)	1990-03-23
PT91420B (pt)	1995-05-04
NO178914C (no)	1996-07-03
FI893783A0 (fi)	1989-08-10
AU3951489A (en)	1990-02-15
CA1332354C (en)	1994-10-11
FI893783L (fi)	1990-02-14
NZ230280A (en)	1991-09-25
ATE75945T1 (de)	1992-05-15
NO893239L (no)	1990-02-14
DE3827533A1 (de)	1990-02-15

Publication	Publication Date	Title
HU203670B (en)	1991-09-30	Process for producing pharmaceutical composition containing basically modificated insuline derivatives and zinc-ions for treating diabetes mellitus
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CA2432504A1 (en)	2002-07-11	Methods and compositions for treating periodontal disease
Signore et al.	1985	Inhibition of the receptor for interleukin-2 induced by carbimazole: relevance for the therapy of autoimmune thyroid disease
JPH1067653A (ja)	1998-03-10	関節疾患治療剤
US5071852A (en)	1991-12-10	Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
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GOTSHALK et al.	1940	ACUTE ARTHRITIS ASSOCIATED WITH MYOCARDITIS SIMULATING ACUTE LUPUS ERYTHEMATOSUS: REPORT OF A CASE