HU218924B - Pirimidin-nukleozid-származékok, ezeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására - Google Patents
Pirimidin-nukleozid-származékok, ezeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására Download PDFInfo
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- HU218924B HU218924B HU9203967A HU396792A HU218924B HU 218924 B HU218924 B HU 218924B HU 9203967 A HU9203967 A HU 9203967A HU 396792 A HU396792 A HU 396792A HU 218924 B HU218924 B HU 218924B
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- 238000000034 method Methods 0.000 title claims description 35
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 239000004480 active ingredient Substances 0.000 title claims 5
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- 239000002718 pyrimidine nucleoside Substances 0.000 title abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 196
- 239000001257 hydrogen Substances 0.000 claims abstract description 28
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 28
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 21
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- 239000007858 starting material Substances 0.000 claims description 23
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- 238000002360 preparation method Methods 0.000 claims description 18
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- 125000003277 amino group Chemical group 0.000 claims description 15
- 239000000969 carrier Substances 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims description 13
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- KPMKNHGAPDCYLP-UHFFFAOYSA-N nimustine hydrochloride Chemical compound Cl.CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 KPMKNHGAPDCYLP-UHFFFAOYSA-N 0.000 description 1
- 150000002828 nitro derivatives Chemical class 0.000 description 1
- MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 description 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical class NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 1
- GRSBAMVBFWRBBH-UHFFFAOYSA-N o-ethyl chloromethanethioate Chemical compound CCOC(Cl)=S GRSBAMVBFWRBBH-UHFFFAOYSA-N 0.000 description 1
- HXFVUECWGARNTL-UHFFFAOYSA-N o-methyl chloromethanethioate Chemical compound COC(Cl)=S HXFVUECWGARNTL-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000003444 phase transfer catalyst Substances 0.000 description 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 1
- 125000003884 phenylalkyl group Chemical group 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 150000003057 platinum Chemical group 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 239000005051 trimethylchlorosilane Substances 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15668890 | 1990-06-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9203967D0 HU9203967D0 (en) | 1993-03-29 |
| HUT62582A HUT62582A (en) | 1993-05-28 |
| HU218924B true HU218924B (hu) | 2000-12-28 |
Family
ID=15633157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9203967A HU218924B (hu) | 1990-06-15 | 1991-06-13 | Pirimidin-nukleozid-származékok, ezeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5616567A (de) |
| EP (1) | EP0535231B1 (de) |
| JP (1) | JP2559917B2 (de) |
| KR (1) | KR970011306B1 (de) |
| AT (1) | ATE122041T1 (de) |
| CA (1) | CA2085345C (de) |
| DE (1) | DE69109482T2 (de) |
| DK (1) | DK0535231T3 (de) |
| ES (1) | ES2074719T3 (de) |
| HK (1) | HK1005871A1 (de) |
| HU (1) | HU218924B (de) |
| RU (1) | RU2116306C1 (de) |
| WO (1) | WO1991019713A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2085557C1 (ru) * | 1991-09-30 | 1997-07-27 | Санкио Компани Лимитед | Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения |
| DK0640092T3 (da) | 1992-05-12 | 1996-12-30 | Merrell Pharma Inc | Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer |
| JP5230052B2 (ja) * | 2000-05-26 | 2013-07-10 | イデニクス（ケイマン）リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
| JP3748536B2 (ja) * | 2001-02-09 | 2006-02-22 | 三共株式会社 | ピリミジンヌクレオシド誘導体の結晶 |
| TW200637870A (en) * | 2005-01-31 | 2006-11-01 | Taiho Pharmaceutical Co Ltd | Novel pyrimidine nucleoside compound and salt thereof |
| US7700709B2 (en) * | 2005-05-11 | 2010-04-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of cytidine metabolic antagonist |
| GB0523041D0 (en) * | 2005-11-11 | 2005-12-21 | Cyclacel Ltd | Combination |
| GB0526419D0 (en) * | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
| TW200817426A (en) | 2006-07-21 | 2008-04-16 | Taiho Pharmaceutical Co Ltd | 2'-cyanopyrimidine nucleoside compound |
| BRPI0719174A2 (pt) * | 2006-10-10 | 2017-06-13 | Hoffmann La Roche | preparação de pirimidinas ribofuranosil nucleosídeos |
| GB0625283D0 (en) | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
| UA99308C2 (ru) * | 2007-09-26 | 2012-08-10 | Маунт Синай Скул Оф Медсин | Аналог азацитидина и его применение |
| US8124593B2 (en) | 2007-11-05 | 2012-02-28 | Cyclacel Limited | Methods of treatment using sapacitabine |
| US7863255B2 (en) * | 2008-04-29 | 2011-01-04 | Taiho Pharmaceutical Co., Ltd. | Methods of administering antitumor agent comprising deoxycytidine derivative |
| GB0808359D0 (en) * | 2008-05-08 | 2008-06-18 | Cyclacel Ltd | Process |
| GB0808357D0 (en) * | 2008-05-08 | 2008-06-18 | Cyclacel Ltd | Process |
| PL2307002T3 (pl) | 2008-06-09 | 2013-05-31 | Cyclacel Ltd | Kombinacje sapacytabiny lub cndac z inhibitorami metylotransferazy dna, takimi jak decytabina i prokaina |
| EP2431376B2 (de) * | 2009-05-15 | 2024-02-07 | Delta-Fly Pharma, Inc. | Neuer stabiler kristall aus 1-(2'-cyan-2'-desoxy-beta-d-arabinofuranosyl)cytosin-monohydrochlorid |
| US10226478B2 (en) | 2011-04-14 | 2019-03-12 | Cyclacel Limited | Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia |
| SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2874631A1 (de) | 2012-05-15 | 2015-05-27 | Cyclacel Limited | Dosierungsschema für sapacitabin und seliciclib |
| WO2019081951A1 (en) | 2017-10-27 | 2019-05-02 | Cyclacel Limited | DOSAGE REGIME |
| US11957701B2 (en) | 2020-07-17 | 2024-04-16 | Delta-Fly Pharma, Inc. | Therapy and new therapeutic agent for blood cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2007094A6 (es) * | 1987-07-29 | 1989-06-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de 3 -c- ciano-2,3 -didesoxinucleosido. |
-
1991
- 1991-06-11 JP JP3138859A patent/JP2559917B2/ja not_active Expired - Lifetime
- 1991-06-13 ES ES91911192T patent/ES2074719T3/es not_active Expired - Lifetime
- 1991-06-13 HU HU9203967A patent/HU218924B/hu unknown
- 1991-06-13 KR KR1019920703246A patent/KR970011306B1/ko not_active Expired - Lifetime
- 1991-06-13 DK DK91911192.2T patent/DK0535231T3/da active
- 1991-06-13 DE DE69109482T patent/DE69109482T2/de not_active Expired - Lifetime
- 1991-06-13 RU RU92016591/04A patent/RU2116306C1/ru active
- 1991-06-13 AT AT91911192T patent/ATE122041T1/de not_active IP Right Cessation
- 1991-06-13 EP EP91911192A patent/EP0535231B1/de not_active Expired - Lifetime
- 1991-06-13 WO PCT/JP1991/000797 patent/WO1991019713A1/ja not_active Ceased
- 1991-06-13 CA CA002085345A patent/CA2085345C/en not_active Expired - Lifetime
-
1994
- 1994-09-07 US US08/301,720 patent/US5616567A/en not_active Expired - Lifetime
-
1995
- 1995-06-01 US US08/457,510 patent/US5654420A/en not_active Expired - Lifetime
-
1998
- 1998-06-05 HK HK98104955A patent/HK1005871A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9203967D0 (en) | 1993-03-29 |
| ES2074719T3 (es) | 1995-09-16 |
| KR930700485A (ko) | 1993-03-15 |
| RU2116306C1 (ru) | 1998-07-27 |
| WO1991019713A1 (fr) | 1991-12-26 |
| DE69109482T2 (de) | 1996-02-15 |
| JP2559917B2 (ja) | 1996-12-04 |
| ATE122041T1 (de) | 1995-05-15 |
| CA2085345A1 (en) | 1991-12-16 |
| US5654420A (en) | 1997-08-05 |
| EP0535231B1 (de) | 1995-05-03 |
| HUT62582A (en) | 1993-05-28 |
| US5616567A (en) | 1997-04-01 |
| JPH04235182A (ja) | 1992-08-24 |
| EP0535231A1 (de) | 1993-04-07 |
| DK0535231T3 (da) | 1995-08-21 |
| HK1005871A1 (en) | 1999-01-29 |
| KR970011306B1 (ko) | 1997-07-09 |
| EP0535231A4 (en) | 1993-06-30 |
| CA2085345C (en) | 2001-08-07 |
| DE69109482D1 (en) | 1995-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HPC4 | Succession in title of patentee |
Owner name: MATSUDA, AKIRA, JP Owner name: SASAKI, TAKUMA, JP |
|
| HPC4 | Succession in title of patentee |
Owner name: TAIHO PHARMACEUTICAL CO., LTD., JP |