DK0535231T3 - Pyrimidinnucleosid-derivater - Google Patents

Pyrimidinnucleosid-derivater

Info

Publication number: DK0535231T3
Authority: DK; Denmark
Prior art keywords: pyrimidine nucleoside; nucleoside derivatives; hydroxy; hydrogen; represent
Prior art date: 1990-06-15

Application number

DK91911192.2T

Other languages

Danish (da)

English (en)

Inventor

Tohru Ueda

Akira Matsuda

Takuma Sasaki

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-15

Filing date

1991-06-13

Publication date

1995-08-21

1991-06-13 Application filed by Sankyo Co filed Critical Sankyo Co

1995-08-21 Application granted granted Critical

1995-08-21 Publication of DK0535231T3 publication Critical patent/DK0535231T3/da

Links

150000003833 nucleoside derivatives Chemical class 0.000 title abstract 2
239000002718 pyrimidine nucleoside Substances 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK91911192.2T 1990-06-15 1991-06-13 Pyrimidinnucleosid-derivater DK0535231T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP15668890		1990-06-15

Publications (1)

Publication Number	Publication Date
DK0535231T3 true DK0535231T3 (da)	1995-08-21

Family

ID=15633157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91911192.2T DK0535231T3 (da)	1990-06-15	1991-06-13	Pyrimidinnucleosid-derivater

Country Status (13)

Country	Link
US (2)	US5616567A (de)
EP (1)	EP0535231B1 (de)
JP (1)	JP2559917B2 (de)
KR (1)	KR970011306B1 (de)
AT (1)	ATE122041T1 (de)
CA (1)	CA2085345C (de)
DE (1)	DE69109482T2 (de)
DK (1)	DK0535231T3 (de)
ES (1)	ES2074719T3 (de)
HK (1)	HK1005871A1 (de)
HU (1)	HU218924B (de)
RU (1)	RU2116306C1 (de)
WO (1)	WO1991019713A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2085557C1 (ru) *	1991-09-30	1997-07-27	Санкио Компани Лимитед	Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
CA2133961C (en)	1992-05-12	1998-03-31	James R. Mccarthy	A process for the preparation of ribonucleotide reductase inhibitors
KR20080021797A (ko) *	2000-05-26	2008-03-07	이데닉스(케이만)리미티드	플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
JP3748536B2 (ja) *	2001-02-09	2006-02-22	三共株式会社	ピリミジンヌクレオシド誘導体の結晶
TW200637870A (en) *	2005-01-31	2006-11-01	Taiho Pharmaceutical Co Ltd	Novel pyrimidine nucleoside compound and salt thereof
KR101312417B1 (ko) *	2005-05-11	2013-09-27	니폰 가야꾸 가부시끼가이샤	시티딘계 대사길항제의 고분자 유도체
GB0523041D0 (en) *	2005-11-11	2005-12-21	Cyclacel Ltd	Combination
GB0526419D0 (en) *	2005-12-23	2006-02-08	Cyclacel Ltd	Formulation
US20100216736A2 (en)	2006-07-21	2010-08-26	Taiho Pharmaceutical Co., Ltd.	2'-cyanopyrimidine nucleoside compound
US8912321B2 (en) *	2006-10-10	2014-12-16	Gilead Pharmasset Llc	Preparation of nucleosides ribofuranosyl pyrimidines
GB0625283D0 (en)	2006-12-19	2007-01-24	Cyclacel Ltd	Combination
UA99308C2 (ru) *	2007-09-26	2012-08-10	Маунт Синай Скул Оф Медсин	Аналог азацитидина и его применение
US8124593B2 (en)	2007-11-05	2012-02-28	Cyclacel Limited	Methods of treatment using sapacitabine
US7863255B2 (en) *	2008-04-29	2011-01-04	Taiho Pharmaceutical Co., Ltd.	Methods of administering antitumor agent comprising deoxycytidine derivative
GB0808357D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
GB0808359D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
NZ589719A (en)	2008-06-09	2012-08-31	Cyclacel Ltd	Combinations of sapacitabine or cndac with dna methyltransferase inhibitors such as decitabine and procaine
EP2431376B2 (de) *	2009-05-15	2024-02-07	Delta-Fly Pharma, Inc.	Neuer stabiler kristall aus 1-(2'-cyan-2'-desoxy-beta-d-arabinofuranosyl)cytosin-monohydrochlorid
HUE046177T2 (hu)	2011-04-14	2020-02-28	Cyclacel Ltd	Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére
UA117095C2 (uk)	2011-12-22	2018-06-25	Аліос Біофарма, Інк.	Нуклеозидна сполука або її фармацевтично прийнятна сіль
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
WO2013171473A1 (en)	2012-05-15	2013-11-21	Cyclacel Limited	Dosage regimen for sapacitabine and seliciclib
WO2019081951A1 (en)	2017-10-27	2019-05-02	Cyclacel Limited	DOSAGE REGIME
CN113727719A (zh)	2020-07-17	2021-11-30	德尔塔菲制药股份有限公司	血癌的新型治疗方法及新型治疗剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2007094A6 (es) *	1987-07-29	1989-06-01	Consejo Superior Investigacion	Procedimiento para la preparacion de 3 -c- ciano-2,3 -didesoxinucleosido.

1991
- 1991-06-11 JP JP3138859A patent/JP2559917B2/ja not_active Expired - Lifetime
- 1991-06-13 RU RU92016591/04A patent/RU2116306C1/ru active
- 1991-06-13 DE DE69109482T patent/DE69109482T2/de not_active Expired - Lifetime
- 1991-06-13 HU HU9203967A patent/HU218924B/hu unknown
- 1991-06-13 EP EP91911192A patent/EP0535231B1/de not_active Expired - Lifetime
- 1991-06-13 KR KR1019920703246A patent/KR970011306B1/ko not_active Expired - Lifetime
- 1991-06-13 ES ES91911192T patent/ES2074719T3/es not_active Expired - Lifetime
- 1991-06-13 CA CA002085345A patent/CA2085345C/en not_active Expired - Lifetime
- 1991-06-13 AT AT91911192T patent/ATE122041T1/de not_active IP Right Cessation
- 1991-06-13 DK DK91911192.2T patent/DK0535231T3/da active
- 1991-06-13 WO PCT/JP1991/000797 patent/WO1991019713A1/ja not_active Ceased
1994
- 1994-09-07 US US08/301,720 patent/US5616567A/en not_active Expired - Lifetime
1995
- 1995-06-01 US US08/457,510 patent/US5654420A/en not_active Expired - Lifetime
1998
- 1998-06-05 HK HK98104955A patent/HK1005871A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU218924B (hu)	2000-12-28
CA2085345A1 (en)	1991-12-16
EP0535231B1 (de)	1995-05-03
HUT62582A (en)	1993-05-28
JP2559917B2 (ja)	1996-12-04
HU9203967D0 (en)	1993-03-29
ES2074719T3 (es)	1995-09-16
KR970011306B1 (ko)	1997-07-09
RU2116306C1 (ru)	1998-07-27
WO1991019713A1 (fr)	1991-12-26
JPH04235182A (ja)	1992-08-24
US5616567A (en)	1997-04-01
CA2085345C (en)	2001-08-07
DE69109482T2 (de)	1996-02-15
ATE122041T1 (de)	1995-05-15
EP0535231A1 (de)	1993-04-07
DE69109482D1 (en)	1995-06-08
KR930700485A (ko)	1993-03-15
HK1005871A1 (en)	1999-01-29
US5654420A (en)	1997-08-05
EP0535231A4 (en)	1993-06-30

Publication	Publication Date	Title
DK0535231T3 (da)	1995-08-21	Pyrimidinnucleosid-derivater
DE69840296D1 (de)	2009-01-15	Phenylethylenamin-derivate
DE3851179D1 (de)	1994-09-29	Oxetanocin.
FI952101A0 (fi)	1995-05-03	Merkaptanfoerening
MX9101232A (es)	1992-05-04	Derivados de benceno,piridina y pirimidina
DK0784055T3 (da)	2003-06-02	Pyrimidinylpyrazolderivater
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
DE69208400D1 (de)	1996-03-28	Mono- und Bis-Alkylaminoanthracycline
ES2096572T3 (es)	1997-03-16	Nuevos derivados de glucosidos de antraciclina y procedimiento para su preparacion.
NO904187L (no)	1991-04-02	Benzanilider.
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
DE69303847D1 (de)	1996-09-05	Indolderivate
DE69231244D1 (de)	2000-08-17	Pyrazolothiazolopyrimidin-derivate
GB0217638D0 (en)	2002-09-11	Total synthesis of myriaporones