HUE044220T2 - Készítmények kollagén-közvetített betegségek kezelésére - Google Patents

Készítmények kollagén-közvetített betegségek kezelésére

Info

Publication number
HUE044220T2
HUE044220T2 HUE12155233A HUE044220T2 HU E044220 T2 HUE044220 T2 HU E044220T2 HU E12155233 A HUE12155233 A HU E12155233A HU E044220 T2 HUE044220 T2 HU E044220T2
Authority
HU
Hungary
Prior art keywords
compositions suitable
mediated diseases
treating collagen
collagen
treating
Prior art date
Application number
Other languages
English (en)
Inventor
Gregory L Sabatino
Tito Del Jr
Philip J Bassett
Hazel A Tharia
Antony G Hitchcock
Original Assignee
Endo Global Ventures
Biospecifics Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Global Ventures, Biospecifics Tech Corp filed Critical Endo Global Ventures
Publication of HUE044220T2 publication Critical patent/HUE044220T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • C12N9/20Triglyceride splitting, e.g. by means of lipase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24007Interstitial collagenase (3.4.24.7), i.e. matrix metalloprotease 1 or MMP1

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE12155233 2006-01-30 2007-01-30 Készítmények kollagén-közvetített betegségek kezelésére HUE044220T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76347006P 2006-01-30 2006-01-30
US78413506P 2006-03-20 2006-03-20
US11/699,302 US7811560B2 (en) 2006-01-30 2007-01-29 Compositions and methods for treating collagen-mediated diseases

Publications (1)

Publication Number Publication Date
HUE044220T2 true HUE044220T2 (hu) 2019-10-28

Family

ID=38328033

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE12155233 HUE044220T2 (hu) 2006-01-30 2007-01-30 Készítmények kollagén-közvetített betegségek kezelésére
HUE07762860A HUE041764T2 (hu) 2006-01-30 2007-01-30 Kollagén-mediálta betegségek kezelésére alkalmas kompozíciók

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE07762860A HUE041764T2 (hu) 2006-01-30 2007-01-30 Kollagén-mediálta betegségek kezelésére alkalmas kompozíciók

Country Status (17)

Country Link
US (16) US7811560B2 (hu)
EP (6) EP4483952A3 (hu)
JP (8) JP5309289B2 (hu)
KR (2) KR20110046537A (hu)
CN (2) CN105999244B (hu)
AU (2) AU2007211313C1 (hu)
BR (1) BRPI0708017A2 (hu)
CA (1) CA2637262C (hu)
DK (2) DK2474321T3 (hu)
ES (3) ES2729941T3 (hu)
HU (2) HUE044220T2 (hu)
IL (6) IL291175B2 (hu)
MX (1) MX2008009756A (hu)
NZ (2) NZ569882A (hu)
PT (2) PT1987141T (hu)
TR (1) TR201903008T4 (hu)
WO (1) WO2007089851A2 (hu)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6958150B2 (en) * 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
US20070224184A1 (en) * 2006-02-22 2007-09-27 The Research Foundation Of The State University Of New York Method for treating cellulite
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US10071143B1 (en) 2007-05-03 2018-09-11 The Research Foundation For The State University Of New York Methods for non-surgical treatment of carpal tunnel syndrome
EP2244735A4 (en) 2007-10-02 2011-02-23 Avaxia Biologics Inc ANTIBODY THERAPY FOR USE IN THE DIGESTIVE TUBE
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
ES2388219T3 (es) * 2008-06-02 2012-10-10 F. Hoffmann-La Roche Ag Purificación mejorada de colagenasas a partir de un cultivo líquido de Clostridium histolyticum
US8236356B2 (en) 2008-06-11 2012-08-07 Roche Diagnostics Operations, Inc. Growth medium for Clostridium histolyticum
US20110229451A2 (en) * 2009-03-06 2011-09-22 Halozyme, Inc. Temperature sensitive mutants of matrix metalloproteases and uses thereof
ES2385239B1 (es) * 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
WO2012125948A1 (en) 2011-03-16 2012-09-20 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
CN103687607B (zh) 2011-07-20 2018-01-30 麦迪伍德有限公司 用于治疗结缔组织疾患的来自菠萝蛋白酶的蛋白水解提取物
AU2012325941A1 (en) * 2011-10-21 2014-05-15 Auxilium International Holdings, Inc. Method of treating or reducing EFP
EP4276180B1 (en) 2012-01-12 2026-04-22 Endo Biologics Limited Clostridium histolyticum enzyme
ITPD20120118A1 (it) 2012-04-18 2013-10-19 Fidia Farmaceutici "nuovo processo di produzione e purificazione dell'enzima collagenasi da vibrio alginolyticus"
CA2872227A1 (en) 2012-05-01 2013-11-07 Proteolease Ltd. Methods for extracting a tooth
BR102012013110A2 (pt) 2012-05-31 2014-05-27 Cristalia Prod Quimicos Farm Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica
WO2014066622A2 (en) 2012-10-24 2014-05-01 The Research Foundation For The State University Of New York Use of collagenase to treat glaucoma
US20150196625A9 (en) 2013-01-07 2015-07-16 Rudolph D. Paladini Metal Sensitive Mutants of Matrix Metalloproteases and uses thereof
US9744138B2 (en) 2013-03-15 2017-08-29 Biospecifics Technologies Corp. Treatment method and product for uterine fibroids using purified collagenase
US20160000890A1 (en) 2013-03-15 2016-01-07 Biospecifics Technologies Corp. Thermosensitive hydrogel collagenase formulations
US9849133B2 (en) * 2013-06-18 2017-12-26 Eton Pharmaceuticals, Inc. Pharmaceutical formulations of xanthine or xanthine derivatives, and their use
US10383875B2 (en) 2013-06-18 2019-08-20 Harrow Ip, Llc Pharmaceutical formulations of xanthine or xanthine derivatives, and their use
US10117892B2 (en) * 2013-08-29 2018-11-06 Allergan, Inc. Devices and methods for reducing the appearance of cellulite
CN103751102A (zh) 2014-01-15 2014-04-30 上海交通大学 一种胶原酶温敏水凝胶及其制备方法和应用
CN105477628B (zh) * 2014-09-19 2021-04-30 山东蓝金生物工程有限公司 抗癌组合物及其用途
CN105412917B (zh) * 2014-09-19 2021-04-30 达森生物药业有限公司 治疗实体瘤的抗癌组合物及其用途
CN105412916B (zh) * 2014-09-19 2021-04-30 达森生物药业有限公司 治疗乳腺癌的组合物及其用途
CN105477627B (zh) * 2014-09-19 2021-04-30 山东蓝金生物工程有限公司 治疗前列腺癌的组合物及其用途
DE202014105440U1 (de) * 2014-11-12 2016-02-15 Bilz Werkzeugfabrik Gmbh & Co. Kg Werkzeugaufnahme
KR101723168B1 (ko) * 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
US10303245B2 (en) * 2015-05-04 2019-05-28 Adobe Inc. Methods and devices for detecting and responding to changes in eye conditions during presentation of video on electronic devices
IL327169A (en) 2017-03-01 2026-05-01 Endo Ventures Ltd A method for assessing and treating cellulite
US11473074B2 (en) 2017-03-28 2022-10-18 Endo Global Aesthetics Limited Method of producing collagenase
WO2020021330A2 (en) 2018-07-12 2020-01-30 Endo Global Aesthetics Limited Injection techniques for the treatment of cellulite
WO2020058755A1 (en) 2018-09-18 2020-03-26 Endo Global Aesthetics Limited Compositions and methods for treating cellulite
CN113382714A (zh) 2019-01-06 2021-09-10 恩多全球美学有限公司 胶原酶制剂及其制备方法
CA3157517A1 (en) 2019-10-15 2021-04-22 The Johns Hopkins University Treatment of uterine fibroids using purified collagenase
JP2025501499A (ja) 2022-01-05 2025-01-22 ノルドマルク ファーマ ゲーエムベーハー Hathewaya histolytica(またはclostridium histolyticum)を増殖させるための、および1種または複数のプロテアーゼの産生のための培養培地
CN116102638B (zh) * 2023-01-09 2025-05-16 中国农业科学院农产品加工研究所 基于亲和吸附富集骨胶原蛋白成骨活性肽的方法
WO2026028155A1 (en) 2024-08-01 2026-02-05 Endo Biologics Limited Methods of treating plantar fasciitis
WO2026094005A1 (en) 2024-11-04 2026-05-07 Endo Biologics Limited Compositions comprising collagenase for use in treatment of plantar fasciitis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61289885A (ja) * 1985-06-14 1986-12-19 Nitta Zerachin Kk コラゲナ−ゼおよびコラゲナ−ゼの製造方法
JP2898022B2 (ja) * 1989-09-05 1999-05-31 株式会社ニッピ コラーゲン分解酵素の製造方法
CA2047306A1 (en) * 1990-07-23 1992-01-24 Milan Holjevac Mutant bacterium clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
US5393792A (en) 1991-11-20 1995-02-28 Advance Biofactures Of Curacao, N.V. High dosage topical forms of collagenase
US5462739A (en) * 1991-11-21 1995-10-31 Yeda Research And Development Co., Ltd. Microdelivery device and method for enhanced drug administration to the eye
EP0654084A4 (en) * 1992-06-22 1996-07-03 Trigen Inc MOLECULAR CLONING OF GENES RESPONSIBLE FOR THE PRODUCTION OF COLLAGENASE FROM -i (CLOSTRIDIUM HISTOLYTICUM).
JP3186881B2 (ja) * 1993-02-18 2001-07-11 倉敷紡績株式会社 肝細胞の分離方法
US5332503A (en) * 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
JP3028852B2 (ja) * 1994-06-24 2000-04-04 ロシュ ダイアグノスティックス コーポレーション ヒストリチクス菌から得られるコラゲナーゼおよび2つの他のプロテアーゼの精製混合物
US5589171A (en) 1994-08-22 1996-12-31 Advance Biofactures Of Curacao Treatment of Dupuytren's disease with collagenase
WO1996028543A1 (de) * 1995-03-16 1996-09-19 Knoll Aktiengesellschaft Neue, definierte enzymmischungen zur zellgewinnung und für die wundbehandlung
US5989888A (en) 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
BR9713108A (pt) 1996-11-19 2004-06-22 Roche Diagnostics Gmbh Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
US5830741A (en) * 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US6086872A (en) 1997-03-27 2000-07-11 Advance Biofactures Of Curacao, Nv Amelioration of dupuytren's disease
JPH10262658A (ja) * 1997-03-28 1998-10-06 Kikkoman Corp ザルコシン・オキシダーゼの結晶、その製造方法及び三次元構造
US6022539A (en) 1999-06-03 2000-02-08 Advance Biofactures Of Curacao Amelioration of peyronie's disease
EP1402008B1 (de) * 2001-07-02 2005-08-24 Nordmark Arzneimittel GmbH & Co.KG Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzyms
EP1462519A1 (en) * 2003-03-24 2004-09-29 Boehringer Ingelheim Austria GmbH Method and devices for producing biomolecules
JP4205496B2 (ja) * 2003-06-19 2009-01-07 三菱化学株式会社 新規カルボニル還元酵素及びこれをコードするdna、ならびにこれらを利用した光学活性アルコールの製造方法
JP4586027B2 (ja) * 2004-01-30 2010-11-24 シャイア ファーマシューティカルズ アイルランド リミテッド 組換えアリールスルファターゼaの製造及び精製
US7355027B2 (en) * 2004-06-16 2008-04-08 Dynport Vaccine Company Llc Bacillus anthracis protective antigen
DK1781697T3 (da) * 2004-07-07 2009-07-06 Lundbeck & Co As H Nyt carbamyleret erythropoietinprotein samt fremstillingsmetode
CA2572765C (en) * 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
CA2593038C (en) * 2005-01-21 2015-03-17 Advance Biofactures Corporation Methods for treating adhesive capsulitis
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases

Also Published As

Publication number Publication date
US20110243908A1 (en) 2011-10-06
EP1987141A4 (en) 2009-11-18
AU2007211313C1 (en) 2014-05-22
IL291175A (en) 2022-05-01
JP2015128447A (ja) 2015-07-16
IL291175B2 (en) 2024-02-01
JP6230200B2 (ja) 2017-11-15
JP2018143258A (ja) 2018-09-20
PT1987141T (pt) 2019-03-04
AU2007211313A1 (en) 2007-08-09
ES2992881T3 (en) 2024-12-19
US20170087229A1 (en) 2017-03-30
IL245434A0 (en) 2016-06-30
MX2008009756A (es) 2008-12-18
JP2012070758A (ja) 2012-04-12
US7811560B2 (en) 2010-10-12
ES2729941T3 (es) 2019-11-07
US20210106659A1 (en) 2021-04-15
IL277322B (en) 2022-04-01
NZ593907A (en) 2013-02-22
CA2637262C (en) 2014-08-19
JP6389493B2 (ja) 2018-09-12
JP5309289B2 (ja) 2013-10-09
US20140004094A1 (en) 2014-01-02
AU2007211313B2 (en) 2011-12-01
US20160000889A1 (en) 2016-01-07
EP4483952A2 (en) 2025-01-01
JP2021113212A (ja) 2021-08-05
JP2017218452A (ja) 2017-12-14
JP7191152B2 (ja) 2022-12-16
US20110243909A1 (en) 2011-10-06
KR20080093142A (ko) 2008-10-20
TR201903008T4 (tr) 2019-03-21
JP6792596B2 (ja) 2020-11-25
AU2012200863A1 (en) 2012-03-08
CN105999244A (zh) 2016-10-12
CN105999244B (zh) 2022-01-11
EP2474321B1 (en) 2019-04-17
EP1987141B8 (en) 2019-03-06
US20110243919A1 (en) 2011-10-06
US20110189153A1 (en) 2011-08-04
AU2012200863B2 (en) 2014-08-28
US20100233151A1 (en) 2010-09-16
IL277322A (en) 2020-10-29
PT2474321T (pt) 2019-07-25
IL291175B1 (en) 2023-10-01
JP6851943B2 (ja) 2021-03-31
IL192878A0 (en) 2009-02-11
BRPI0708017A2 (pt) 2011-05-17
WO2007089851A3 (en) 2008-01-03
EP1987141B1 (en) 2018-12-05
EP2474321A1 (en) 2012-07-11
US20240299508A1 (en) 2024-09-12
EP1987141A2 (en) 2008-11-05
KR20110046537A (ko) 2011-05-04
US20070224183A1 (en) 2007-09-27
CA2637262A1 (en) 2007-08-09
WO2007089851A2 (en) 2007-08-09
IL254184B (en) 2019-02-28
HUE041764T2 (hu) 2019-05-28
US20110189163A1 (en) 2011-08-04
JP6944989B2 (ja) 2021-10-06
EP2474319A1 (en) 2012-07-11
DK2474321T3 (da) 2019-06-03
IL192878A (en) 2013-03-24
CN101400788A (zh) 2009-04-01
EP4483952A3 (en) 2025-04-02
EP3508571A1 (en) 2019-07-10
IL264361A (en) 2019-02-28
DK1987141T3 (en) 2019-03-25
IL264361B (en) 2020-09-30
IL254184A0 (en) 2017-10-31
US20100330065A1 (en) 2010-12-30
JP2009525283A (ja) 2009-07-09
EP3508571B1 (en) 2024-08-21
ES2709202T3 (es) 2019-04-15
IL245434A (en) 2017-10-31
US20110158972A1 (en) 2011-06-30
CN101400788B (zh) 2016-06-29
US20230158127A1 (en) 2023-05-25
EP2474320A1 (en) 2012-07-11
JP2017006143A (ja) 2017-01-12
JP2020039371A (ja) 2020-03-19
US20110243920A1 (en) 2011-10-06
NZ569882A (en) 2012-03-30

Similar Documents

Publication Publication Date Title
IL291175A (en) Compositions and methods for treating collagen-mediated diseases
PL2578081T3 (pl) Kompozycje, sposoby i urządzenia do leczenia chorób wątroby
PL2478907T3 (pl) Kompozycje do leczenia nowotworu
EP2083862A4 (en) COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES AND DISORDERS
EP2152722A4 (en) COMPOSITIONS COMPRISING MIR34 THERAPEUTIC AGENTS FOR TREATING CANCER
IL186749A0 (en) Dihydrothienopyrimidines for the treatment of inflammatory diseases
PL1927363T3 (pl) Ekstrakt do profilaktyki lub leczenia chorób zakrzepowych
ZA200900750B (en) Indazole derivatives for treating HSP90-induced diseases
ZA200809528B (en) Treatment for depressive disorders
EP2244690A4 (en) METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND DRESSES
IL198723A0 (en) Methods and compositions for therapeutic treatment
IL204728A0 (en) Methods and compounds for treating retinol-related diseases
IL197235A0 (en) Therapeutic compositions
GB0909297D0 (en) Composition for the treatment of skin conditions
EP2060264A4 (en) AGENT FOR TREATING OCULAR DISEASES
IL196638A0 (en) Methods and compositions for treating disease
EP2174956A4 (en) COMPOSITIONS FOR ANTIFIBRINOLYSIS THERAPY
SI2216039T1 (sl) Farmacevtski sestavki za zdravljenje anksioznosti
ZA201001779B (en) Compositions and methods for treating collagen-mediated diseases
HK1125400A (en) Compositions and methods for treating collagen-mediated diseases
GB0618309D0 (en) Compositions and methods for the treatment of disease
GB0700578D0 (en) Composition for treating blood conditions
GB0705674D0 (en) Composition for the treatment of halitosis