HUP0301228A3 - 3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them - Google Patents

3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them

Info

Publication number: HUP0301228A3
Authority: HU; Hungary
Prior art keywords: azabicyclo; preparation; pharmaceutical compositions; compositions containing; opioid receptor
Prior art date: 2000-06-23

Application number

HU0301228A

Other languages

English (en)

Hungarian (hu)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-06-07

Publication date

2005-08-29

2001-06-07 Application filed by Pfizer filed Critical Pfizer

2003-08-28 Publication of HUP0301228A2 publication Critical patent/HUP0301228A2/hu

2005-08-29 Publication of HUP0301228A3 publication Critical patent/HUP0301228A3/hu

Links

150000005228 3‐azabicyclo[3.1.0]hexanes Chemical class 0.000 title 1
102000003840 Opioid Receptors Human genes 0.000 title 1
108090000137 Opioid Receptors Proteins 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

HU0301228A 2000-06-23 2001-06-07 3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them HUP0301228A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en)	2000-06-23	2001-06-07	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (2)

Publication Number	Publication Date
HUP0301228A2 HUP0301228A2 (hu)	2003-08-28
HUP0301228A3 true HUP0301228A3 (en)	2005-08-29

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0301228A HUP0301228A3 (en)	2000-06-23	2001-06-07	3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (cs)
JP (1)	JP2004512263A (cs)
KR (1)	KR20040002386A (cs)
CN (1)	CN1639121A (cs)
AP (1)	AP2002002698A0 (cs)
AR (1)	AR028969A1 (cs)
AU (1)	AU781837B2 (cs)
BG (1)	BG107329A (cs)
BR (1)	BR0111867A (cs)
CA (1)	CA2412188A1 (cs)
CZ (1)	CZ20023967A3 (cs)
DO (1)	DOP2001000187A (cs)
DZ (1)	DZ3368A1 (cs)
EA (1)	EA005117B1 (cs)
GB (1)	GB0015562D0 (cs)
HR (1)	HRP20020998A2 (cs)
HU (1)	HUP0301228A3 (cs)
IL (1)	IL153427A0 (cs)
IS (1)	IS6637A (cs)
MA (1)	MA26915A1 (cs)
MX (1)	MXPA02012878A (cs)
NO (1)	NO20026168L (cs)
NZ (1)	NZ523141A (cs)
OA (1)	OA12293A (cs)
PA (1)	PA8519401A1 (cs)
PE (1)	PE20020253A1 (cs)
PL (1)	PL365956A1 (cs)
SK (1)	SK17172002A3 (cs)
TN (1)	TNSN01094A1 (cs)
UA (1)	UA73176C2 (cs)
UY (1)	UY26787A1 (cs)
WO (1)	WO2001098267A1 (cs)
YU (1)	YU91802A (cs)
ZA (1)	ZA200210278B (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA006708B1 (ru) *	2001-10-22	2006-02-24	Пфайзер Продактс Инк.	Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора
WO2003097051A2 (en) *	2002-05-17	2003-11-27	Merck Patent Gmbh	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (de)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivate des Asimadolins mit kovalent gebundenen Säuren
PT1745040E (pt)	2004-02-23	2010-03-08	Glaxo Group Ltd	Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
EP1891056B1 (en) *	2005-06-14	2010-10-13	Glaxo Group Limited	Novel compounds
WO2007113258A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
CA2682608A1 (en)	2007-03-30	2008-10-09	Tioga Pharmaceuticals, Inc.	Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
EP2580201B1 (en)	2010-06-11	2017-08-02	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
CN105764888B (zh) *	2013-11-20	2018-04-06	株式会社三和化学研究所	一种新的3‑氮杂双环[3.1.0]己烷衍生物以及其医药用途
CN107428687B (zh)	2015-05-20	2021-06-11	宇部兴产株式会社	一种3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
CN110446495B (zh)	2017-02-17	2023-09-05	特维娜有限公司	含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
AU2018221148B2 (en)	2017-02-17	2022-05-05	Trevena, Inc.	5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
JPWO2018159716A1 (ja)	2017-03-02	2019-12-26	株式会社三和化学研究所	アルコール使用障害の治療薬
CN108250088B (zh) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) *	2022-10-21	2024-09-20	昆明理工大学	一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
DE3851081T2 (de) *	1987-04-16	1995-02-16	Lilly Co Eli	Piperidine als Opioid-Antagoniste.
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/xx active
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
2002
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
OA12293A (en)	2004-03-18
MXPA02012878A (es)	2003-05-14
TNSN01094A1 (fr)	2005-11-10
SK17172002A3 (sk)	2004-09-08
UA73176C2 (en)	2005-06-15
HUP0301228A2 (hu)	2003-08-28
NO20026168D0 (no)	2002-12-20
HRP20020998A2 (en)	2004-02-29
DOP2001000187A (es)	2002-03-30
KR20040002386A (ko)	2004-01-07
AU6259101A (en)	2002-01-02
MA26915A1 (fr)	2004-12-20
BR0111867A (pt)	2003-07-01
ZA200210278B (en)	2003-12-19
AU781837B2 (en)	2005-06-16
AP2002002698A0 (en)	2002-12-31
NO20026168L (no)	2003-02-18
CA2412188A1 (en)	2001-12-27
AR028969A1 (es)	2003-05-28
PL365956A1 (en)	2005-01-24
GB0015562D0 (en)	2000-08-16
EP1292574A1 (en)	2003-03-19
IS6637A (is)	2002-11-28
PE20020253A1 (es)	2002-04-08
UY26787A1 (es)	2002-01-31
DZ3368A1 (fr)	2001-12-27
NZ523141A (en)	2005-06-24
WO2001098267A1 (en)	2001-12-27
BG107329A (en)	2003-07-31
PA8519401A1 (es)	2002-12-30
IL153427A0 (en)	2003-07-06
WO2001098267A8 (en)	2003-02-27
EA005117B1 (ru)	2004-10-28
CZ20023967A3 (cs)	2004-02-18
YU91802A (sh)	2006-05-25
CN1639121A (zh)	2005-07-13
JP2004512263A (ja)	2004-04-22
EA200201269A1 (ru)	2003-06-26

Legal Events

Date	Code	Title	Description
2006-03-28	FD9A	Lapse of provisional protection due to non-payment of fees

Publication	Publication Date	Title
HUP0402026A3 (en)	2005-08-29	5,6-diaryl-pyrazine-2-amide derivatives as cb1 antagonists, process for their preparation and pharmaceutical compositions containing them
IL150539A0 (en)	2003-02-12	Novel 1,3-dihydro-2h-indol-2-one derivatives, preparation method and pharmaceutical compositions containing them
HUP0300207A3 (en)	2005-07-28	1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes
HUP0204519A3 (en)	2003-07-28	4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, pharmaceutical compositions containing them and process for their preparations
HUP0301187A3 (en)	2010-03-29	Novel benzyl-piperidine-derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0203316A3 (en)	2004-07-28	Amino-triazolopyridine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0301228A3 (en)	2005-08-29	3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them
HUP0203836A3 (en)	2005-03-29	1,3-disubstituted pyrrololidines as alpha-2-adrenoceptor antagonists, process for their preparation and pharmaceutical compositions containing them and their use
HUP0105108A3 (en)	2002-11-28	Amide compounds, process for their preparation and pharmaceutical compositions containing them
HUP0202731A3 (en)	2003-10-28	O-anisamide derivatives, process for their preparation and pharmaceutical compositions containing them
IL154096A0 (en)	2003-07-31	Aporphine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HU0103063D0 (en)	2001-10-28	New 2h-pyridazin-3-one derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0201516A3 (en)	2003-03-28	13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0204157A3 (en)	2005-04-28	1,3-dihydro-2h-indol-2-one derivatives, process for preparation of the compounds and pharmaceutical compositions containing the same
HUP0303156A3 (en)	2004-03-29	Substituted 2-phenylaminoimidazoline derivatives as ip antagonists, process for their preparation and pharmaceutical compositions containing them
HUP0303118A3 (en)	2007-08-28	Novel 1,3-dihydro-2h-indol-one derivatives, method for preparing same and pharmaceutical compositions containing them
HUP0201753A3 (en)	2004-12-28	Pyridopyranoazepine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0201937A3 (en)	2002-12-28	Substituted 1,5-dihydropyrrol-2-on derivatives, process for producing them and pharmaceutical compositions containing them having nmda receptor antagonist effect
HUP0202075A3 (en)	2003-03-28	Substituted 2-dialkylaminoalkylbiphenyl derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HUP0201402A3 (en)	2003-12-29	Bis-sulfonamides, process for their preparation and pharmaceutical compositions containing them
HUP0203184A3 (en)	2004-12-28	Isoxazolecarboxamide derivatives, process for their preparation and pharmaceutical compositions containing them
HU0100489D0 (en)	2001-04-28	New piperidine-4-sulphonamide compounds, process for their preparation and pharmaceutical compositions containing them
HUP0204001A3 (en)	2005-04-28	Substituted aminomethyl-phenyl-cyclohexane derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0302515A3 (en)	2005-06-28	Sulfanidothienopyrimidines, process for their preparation and pharmaceutical compositions containing them
HUP0303361A3 (en)	2007-03-28	Substituted 1-aminobutan-3-ol derivatives, process for their preparation and pharmaceutical compositions containing them