ID18516A - Perbaikan rasa dari agen farmasi - Google Patents

Perbaikan rasa dari agen farmasi

Info

Publication number: ID18516A
Authority: ID; Indonesia
Prior art keywords: opt; pref; polyol; taste; formulation
Prior art date: 1996-05-02

Application number

IDP971460A

Other languages

English (en)

Inventor

Eugen Dr Schwarz

Gernot Moschl

Siva Tallavajhala

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-02

Filing date

1997-05-01

Publication date

1998-04-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7793025&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID18516(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-01 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1998-04-16 Publication of ID18516A publication Critical patent/ID18516A/id

Links

239000008177 pharmaceutical agent Substances 0.000 title 1
239000000203 mixture Substances 0.000 abstract 4
239000004480 active ingredient Substances 0.000 abstract 3
238000009472 formulation Methods 0.000 abstract 3
229920005862 polyol Polymers 0.000 abstract 3
150000003077 polyols Chemical class 0.000 abstract 3
HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Chemical compound CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 abstract 1
108010011485 Aspartame Proteins 0.000 abstract 1
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
239000004386 Erythritol Substances 0.000 abstract 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 abstract 1
239000004376 Sucralose Substances 0.000 abstract 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 1
239000000619 acesulfame-K Substances 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
229940069428 antacid Drugs 0.000 abstract 1
239000003159 antacid agent Substances 0.000 abstract 1
230000001458 anti-acid effect Effects 0.000 abstract 1
239000000605 aspartame Substances 0.000 abstract 1
235000010357 aspartame Nutrition 0.000 abstract 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
229960003438 aspartame Drugs 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
238000004040 coloring Methods 0.000 abstract 1
235000019414 erythritol Nutrition 0.000 abstract 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 abstract 1
229940009714 erythritol Drugs 0.000 abstract 1
238000005469 granulation Methods 0.000 abstract 1
230000003179 granulation Effects 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000000832 lactitol Substances 0.000 abstract 1
235000010448 lactitol Nutrition 0.000 abstract 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 abstract 1
229960003451 lactitol Drugs 0.000 abstract 1
239000000845 maltitol Substances 0.000 abstract 1
235000010449 maltitol Nutrition 0.000 abstract 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 abstract 1
229940035436 maltitol Drugs 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 1
235000010755 mineral Nutrition 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 abstract 1
235000019204 saccharin Nutrition 0.000 abstract 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
229940081974 saccharin Drugs 0.000 abstract 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000600 sorbitol Substances 0.000 abstract 1
235000010356 sorbitol Nutrition 0.000 abstract 1
238000001694 spray drying Methods 0.000 abstract 1
229940013618 stevioside Drugs 0.000 abstract 1
OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 abstract 1
235000019202 steviosides Nutrition 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
235000019408 sucralose Nutrition 0.000 abstract 1
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 abstract 1
239000000892 thaumatin Substances 0.000 abstract 1
235000010436 thaumatin Nutrition 0.000 abstract 1
239000011573 trace mineral Substances 0.000 abstract 1
235000013619 trace mineral Nutrition 0.000 abstract 1
235000013343 vitamin Nutrition 0.000 abstract 1
239000011782 vitamin Substances 0.000 abstract 1
229940088594 vitamin Drugs 0.000 abstract 1
229930003231 vitamin Natural products 0.000 abstract 1
239000000811 xylitol Substances 0.000 abstract 1
235000010447 xylitol Nutrition 0.000 abstract 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 1
229960002675 xylitol Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Zoology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

IDP971460A 1996-05-02 1997-05-01 Perbaikan rasa dari agen farmasi ID18516A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19617487A DE19617487A1 (de)	1996-05-02	1996-05-02	Geschmacksverbesserung von Arzneimittelwirkstoffen

Publications (1)

Publication Number	Publication Date
ID18516A true ID18516A (id)	1998-04-16

Family

ID=7793025

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP971460A ID18516A (id)	1996-05-02	1997-05-01	Perbaikan rasa dari agen farmasi

Country Status (15)

Country	Link
US (1)	US6149941A (id)
EP (1)	EP0904059B2 (id)
JP (1)	JP2000509400A (id)
CN (1)	CN1143673C (id)
AT (1)	ATE243025T1 (id)
CA (1)	CA2253386A1 (id)
CZ (1)	CZ296178B6 (id)
DE (2)	DE19617487A1 (id)
DK (1)	DK0904059T3 (id)
ES (1)	ES2202601T5 (id)
HU (1)	HUP9903613A3 (id)
ID (1)	ID18516A (id)
MY (1)	MY116896A (id)
RU (1)	RU2180560C2 (id)
WO (1)	WO1997041835A1 (id)

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1996
- 1996-05-02 DE DE19617487A patent/DE19617487A1/de not_active Withdrawn
1997
- 1997-04-10 WO PCT/EP1997/001781 patent/WO1997041835A1/de not_active Ceased
- 1997-04-10 ES ES97917302T patent/ES2202601T5/es not_active Expired - Lifetime
- 1997-04-10 AT AT97917302T patent/ATE243025T1/de active
- 1997-04-10 HU HU9903613A patent/HUP9903613A3/hu unknown
- 1997-04-10 CN CNB971942773A patent/CN1143673C/zh not_active Expired - Fee Related
- 1997-04-10 RU RU98121702/14A patent/RU2180560C2/ru not_active IP Right Cessation
- 1997-04-10 DE DE59710309T patent/DE59710309D1/de not_active Expired - Lifetime
- 1997-04-10 DK DK97917302T patent/DK0904059T3/da active
- 1997-04-10 JP JP9539463A patent/JP2000509400A/ja active Pending
- 1997-04-10 CA CA002253386A patent/CA2253386A1/en not_active Abandoned
- 1997-04-10 US US09/180,022 patent/US6149941A/en not_active Expired - Lifetime
- 1997-04-10 CZ CZ0348698A patent/CZ296178B6/cs not_active IP Right Cessation
- 1997-04-10 EP EP97917302.8A patent/EP0904059B2/de not_active Expired - Lifetime
- 1997-04-24 MY MYPI97001792A patent/MY116896A/en unknown
- 1997-05-01 ID IDP971460A patent/ID18516A/id unknown

Also Published As

Publication number	Publication date
RU2180560C2 (ru)	2002-03-20
CA2253386A1 (en)	1997-11-13
CN1216919A (zh)	1999-05-19
HUP9903613A2 (hu)	2000-03-28
EP0904059B2 (de)	2013-06-19
ATE243025T1 (de)	2003-07-15
WO1997041835A1 (de)	1997-11-13
DE59710309D1 (de)	2003-07-24
MY116896A (en)	2004-04-30
DE19617487A1 (de)	1997-11-06
CN1143673C (zh)	2004-03-31
DK0904059T3 (da)	2003-10-06
EP0904059A1 (de)	1999-03-31
HUP9903613A3 (en)	2000-04-28
ES2202601T3 (es)	2004-04-01
JP2000509400A (ja)	2000-07-25
CZ296178B6 (cs)	2006-01-11
EP0904059B1 (de)	2003-06-18
US6149941A (en)	2000-11-21
HK1019141A1 (en)	2000-01-14
ES2202601T5 (es)	2013-09-26

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ID18516A (id)	1998-04-16	Perbaikan rasa dari agen farmasi
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HUP0101427A2 (hu)	2001-08-28	Pezsgő készítmények
US5869095A (en)	1999-02-09	Chewable tablet with an effervescent action
EP2262534B1 (en)	2014-07-16	Palatable solid composition comprising antacid and saliva stimulant
US11612564B2 (en)	2023-03-28	Bilayer adhering lozenge effective to mask undesirable flavor
JPH04327526A (ja)	1992-11-17	経口用固形製剤
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EP1017363B1 (en)	2003-04-23	Taste masking for unpalatable formulations
KR101352689B1 (ko)	2014-01-17	불연속상과 연속상으로 이루어지는 응집단위를 포함하는 마이크로그래뉼 제형
ES3058094T3 (en)	2026-03-06	Orodispersible powder composition comprising an antihistamine compound
ES2223150T3 (es)	2005-02-16	Comprimido efervescente que contiene calcio con un antihistaminico como principio activo.
CA2218370C (en)	2006-10-03	Chewable tablet with effervescent action
KR100381623B1 (ko)	2003-04-26	비우식성 구강적용 제제
ES2934136T3 (es)	2023-02-17	Forma de dosificación oral
KR101499257B1 (ko)	2015-03-05	이소소르비드 제제
KR20000010709A (ko)	2000-02-25	약제학적 활성 성분의 향미 개선
MXPA00011172A (en)	2001-12-04	Effervescent preparations