ID22499A - Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut - Google Patents

Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut

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Publication number
ID22499A
ID22499A IDW990396A ID990396A ID22499A ID 22499 A ID22499 A ID 22499A ID W990396 A IDW990396 A ID W990396A ID 990396 A ID990396 A ID 990396A ID 22499 A ID22499 A ID 22499A
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Indonesia
Prior art keywords
group
amino
alkyl
hydrogen
carbon atoms
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IDW990396A
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English (en)
Indonesian (id)
Inventor
Eli Lilly And Company
Jing Wu
Jay S Tung
Jeffrey S Nissen
Thomas E Mabry
Lee H Latimer
Clark Norman Eid
James E Audia
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Elan Pharmaceuticals Inc Cs
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Publication of ID22499A publication Critical patent/ID22499A/id

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/37—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/39—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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IDW990396A 1996-11-22 1997-11-21 Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut ID22499A (id)

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US75489596A 1996-11-22 1996-11-22
US80753897A 1997-02-28 1997-02-28

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IDW990396A ID22499A (id) 1996-11-22 1997-11-21 Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut

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AU (1) AU729133B2 (de)
BR (1) BR9713351A (de)
CA (1) CA2272065A1 (de)
DE (1) DE69733432T2 (de)
ID (1) ID22499A (de)
IL (1) IL129504A0 (de)
NO (1) NO992381L (de)
NZ (1) NZ335280A (de)
PL (1) PL334516A1 (de)
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CA2272065A1 (en) 1998-05-28
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DE69733432T2 (de) 2006-05-04
NZ335280A (en) 2001-05-25
AU729133B2 (en) 2001-01-25
ATE296797T1 (de) 2005-06-15
NO992381D0 (no) 1999-05-18
BR9713351A (pt) 2000-01-25
AU5267798A (en) 1998-06-10
TR199901603T2 (xx) 2000-02-21
EP0946499B1 (de) 2005-06-01
WO1998022433A1 (en) 1998-05-28
IL129504A0 (en) 2000-02-29
CN1238760A (zh) 1999-12-15
KR20000069075A (ko) 2000-11-25
JP2001504498A (ja) 2001-04-03
PL334516A1 (en) 2000-02-28
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