ID24616A - Derivat-derivat (benzodioksan, benzofuran atau benzopiran) yang mempunyai sifat-sifat relaksasi fundik - Google Patents

Derivat-derivat (benzodioksan, benzofuran atau benzopiran) yang mempunyai sifat-sifat relaksasi fundik

Info

Publication number: ID24616A
Authority: ID; Indonesia
Prior art keywords: benzodioksan; benzopiran; derivates; benzofuran; relaxation properties
Prior art date: 1997-12-05

Application number

IDW20001041D

Other languages

English (en)

Indonesian (id)

Inventor

Piet Tom Bert Paul Wigerinck

Wim Gaston Verschueren

Marc Francis Josephin Schroven

Bruyn Marcel Frans Leopold De

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

1998-11-27

Publication date

2000-07-27

1998-11-27 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2000-07-27 Publication of ID24616A publication Critical patent/ID24616A/id

Links

IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IDW20001041D 1997-12-05 1998-11-27 Derivat-derivat (benzodioksan, benzofuran atau benzopiran) yang mempunyai sifat-sifat relaksasi fundik ID24616A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97203808		1997-12-05

Publications (1)

Publication Number	Publication Date
ID24616A true ID24616A (id)	2000-07-27

Family

ID=8229014

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW20001041D ID24616A (id)	1997-12-05	1998-11-27	Derivat-derivat (benzodioksan, benzofuran atau benzopiran) yang mempunyai sifat-sifat relaksasi fundik

Country Status (31)

Country	Link
US (4)	US6133277A (pl)
EP (1)	EP1036073B8 (pl)
JP (1)	JP2001525407A (pl)
KR (1)	KR100591605B1 (pl)
CN (1)	CN1155597C (pl)
AR (1)	AR017195A1 (pl)
AT (1)	ATE334125T1 (pl)
AU (1)	AU748669B2 (pl)
BG (1)	BG64624B1 (pl)
BR (1)	BR9814256A (pl)
CA (1)	CA2311669C (pl)
CO (1)	CO5011114A1 (pl)
CZ (1)	CZ297895B6 (pl)
DE (1)	DE69835372T2 (pl)
EA (1)	EA003365B1 (pl)
EE (1)	EE04438B1 (pl)
ES (1)	ES2270541T3 (pl)
HR (1)	HRP20000340B1 (pl)
HU (1)	HU224813B1 (pl)
ID (1)	ID24616A (pl)
IL (1)	IL136529A (pl)
MY (1)	MY124586A (pl)
NO (1)	NO320727B1 (pl)
NZ (1)	NZ503603A (pl)
PL (1)	PL191144B1 (pl)
SK (1)	SK286268B6 (pl)
TR (1)	TR200001542T2 (pl)
TW (1)	TW577886B (pl)
UA (1)	UA70308C2 (pl)
WO (1)	WO1999029687A1 (pl)
ZA (1)	ZA9811081B (pl)

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US6133277A (en)	1997-12-05	2000-10-17	Janssen Pharmaceutica N.V.	(Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
UA73122C2 (en) *	1999-06-02	2005-06-15	Janssen Pharmaceutica Nv	Derivatives of benzodioxane, benzofuran or benzopyran substituted by aminoalkyl
KR100702526B1 (ko) *	1999-06-02	2007-04-04	얀센 파마슈티카 엔.브이.	피롤리디닐, 피페리디닐 또는 호모피페리디닐 치환된(벤조디옥산, 벤조푸란 또는 벤조피란) 유도체
JO2352B1 (en) *	2000-06-22	2006-12-12	جانسين فارماسيوتيكا ان. في	Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en)	2000-09-04	2012-06-17	شركة جانسين فارماسوتيكا ان. في	Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) *	2000-11-21	2007-06-17	شركة جانسين فارماسوتيكا ان. في	Second-phenyl carboxy amides are useful as lipid-lowering agents
US6688079B2 (en)	2001-04-18	2004-02-10	Kraft Foods Holdings, Inc.	Method for manufacturing flexible packages having slide closures
EP1445324A4 (en) *	2001-11-09	2005-02-16	Kaneka Corp	PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMAN DERIVATIVE AND INTERMEDIATE PRODUCT
ES2199086B1 (es)	2002-07-31	2005-06-01	Cepa Schwarz Pharma Sl	Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
US7071821B2 (en) *	2003-05-14	2006-07-04	Bellsouth Intellectual Property Corporation	Method and system for alerting a person to a situation
ITTO20030140U1 (it) *	2003-09-16	2005-03-17	Interfila Srl	Matita cosmetica
WO2005033092A1 (en)	2003-09-19	2005-04-14	Galileo Pharmaceuticals, Inc.	Chroman derivatives
NZ546991A (en)	2003-11-20	2010-01-29	Janssen Pharmaceutica Nv	6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors
NZ546990A (en)	2003-11-20	2010-03-26	Janssen Pharmaceutica Nv	7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors
ES2238015B1 (es) *	2004-01-30	2006-11-01	Cepa Schwarz Pharma, S.L.	Derivados de cicloalcanodionas con actividad neuroprotectora.
JP5100376B2 (ja) *	2004-06-30	2012-12-19	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体
CA2568835C (en)	2004-06-30	2014-05-27	Janssen Pharmaceutica N.V.	Quinazolinone derivatives as parp inhibitors
WO2006003147A1 (en)	2004-06-30	2006-01-12	Janssen Pharmaceutica N.V.	Phthalazine derivatives as parp inhibitors
DE102004032277A1 (de) *	2004-07-02	2006-01-19	Basell Polyolefine Gmbh	Verfahren zur racemoselektiven Synthese von ansa-Metallocenen
JP2008504331A (ja) *	2004-07-02	2008-02-14	バーゼル、ポリオレフィン、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング	アンサ−メタロセンをラセモ選択的に合成する方法
JP2008530229A (ja)	2005-02-17	2008-08-07	ワイス	シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
JP2008538576A (ja) *	2005-04-22	2008-10-30	ワイス	クロマンおよびクロメン誘導体およびその使用
WO2008015538A2 (en) *	2006-07-31	2008-02-07	Schwarz Pharma S.L.	Use of diaza- and thiaza-cycloalkanediones for preventing and/or treating pain and /or migraine
US20080033050A1 (en)	2006-08-04	2008-02-07	Richards Patricia Allison Tewe	Method of treating thermoregulatory disfunction with paroxetine
US8503431B2 (en) *	2006-08-25	2013-08-06	Wireless Wonders Ltd.	Mobile phone related indirect communication system and method
JP5545955B2 (ja)	2007-03-08	2014-07-09	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
JP5017703B2 (ja) *	2007-05-16	2012-09-05	住友ゴム工業株式会社	ビードエイペックスおよびタイヤ
WO2009053373A1 (en)	2007-10-26	2009-04-30	Janssen Pharmaceutica Nv	Quinolinone derivatives as parp inhibitors
WO2009118384A1 (en)	2008-03-27	2009-10-01	Janssen Pharmaceutica Nv	Quinazolinone derivatives as tubulin polymerization inhibitors
DK2271626T3 (en)	2008-03-27	2015-02-23	Janssen Pharmaceutica Nv	TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN
KR102041154B1 (ko)	2012-02-24	2019-11-07	루핀 리미티드	칼슘 감지 수용체 조절자로서의 치환 크로만 화합물
DE102012206062B4 (de)	2012-04-13	2019-09-12	Adidas Ag	Schuhoberteil
US9040533B2 (en)	2012-12-27	2015-05-26	Purdue Pharma L.P.	Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
DE102013207163B4 (de)	2013-04-19	2022-09-22	Adidas Ag	Schuhoberteil
DE102013207156B4 (de)	2013-04-19	2025-12-24	Adidas Ag	Schuh, insbesondere ein Sportschuh
DE102014220087B4 (de)	2014-10-02	2016-05-12	Adidas Ag	Flachgestricktes Schuhoberteil für Sportschuhe
US20190290656A1 (en)	2015-12-30	2019-09-26	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd	Pt(iv) prodrugs
CN119462701A (zh) *	2024-10-11	2025-02-18	合肥工业大学	一种四吡啶草酸铜金属配合物的制备及用途

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US3910930A (en) *	1973-01-04	1975-10-07	Janssen Pharmaceutica Nv	1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
US3929801A (en) *	1973-11-20	1975-12-30	Janssen Pharmaceutica Nv	2-Benzimidazolinones
GB1599296A (en) *	1977-07-06	1981-09-30	Brewster D L	Ice making machine
GR71865B (pl) *	1978-03-20	1983-07-07	Ciba Geigy
DE2852945A1 (de) *	1978-12-07	1980-06-26	Boehringer Sohn Ingelheim	Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
US4239348A (en) *	1979-11-30	1980-12-16	Hughes Aircraft Company	High resolution AC silicon MOS light-valve substrate
DE3901814A1 (de) *	1988-07-28	1990-02-01	Bayer Ag	Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
DE4140540A1 (de)	1991-12-09	1993-06-17	Bayer Ag	Neue azaheterocyclylmethyl-chromane
SI9300097B (en) *	1992-02-27	2001-12-31	Janssen Pharmaceutica Nv	(benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
DE4319038A1 (de) *	1993-06-08	1994-12-15	Bayer Ag	Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung
ATE256130T1 (de) *	1993-08-19	2003-12-15	Janssen Pharmaceutica Nv	Gefässverengende dihydrobenzopyranderivate
US5541199A (en) *	1995-06-02	1996-07-30	American Home Products Corporation	Chroman-2-ylmethylamino derivatives
FR2744451B1 (fr) *	1996-02-01	1998-04-24	Pf Medicament	Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
US5696653A (en) *	1996-12-13	1997-12-09	Phase Metrics	Tooling for holding a head gimbal assembly
US6133277A (en)	1997-12-05	2000-10-17	Janssen Pharmaceutica N.V.	(Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties

1998
- 1998-11-16 US US09/192,686 patent/US6133277A/en not_active Expired - Lifetime
- 1998-11-25 TW TW087119526A patent/TW577886B/zh not_active IP Right Cessation
- 1998-11-27 CZ CZ20002018A patent/CZ297895B6/cs not_active IP Right Cessation
- 1998-11-27 SK SK803-2000A patent/SK286268B6/sk not_active IP Right Cessation
- 1998-11-27 ID IDW20001041D patent/ID24616A/id unknown
- 1998-11-27 PL PL341007A patent/PL191144B1/pl not_active IP Right Cessation
- 1998-11-27 AT AT98966603T patent/ATE334125T1/de not_active IP Right Cessation
- 1998-11-27 EP EP98966603A patent/EP1036073B8/en not_active Expired - Lifetime
- 1998-11-27 CN CNB988118319A patent/CN1155597C/zh not_active Expired - Fee Related
- 1998-11-27 KR KR1020007003796A patent/KR100591605B1/ko not_active Expired - Fee Related
- 1998-11-27 ES ES98966603T patent/ES2270541T3/es not_active Expired - Lifetime
- 1998-11-27 AU AU24127/99A patent/AU748669B2/en not_active Ceased
- 1998-11-27 HR HR20000340A patent/HRP20000340B1/xx not_active IP Right Cessation
- 1998-11-27 WO PCT/EP1998/007771 patent/WO1999029687A1/en not_active Ceased
- 1998-11-27 CA CA2311669A patent/CA2311669C/en not_active Expired - Lifetime
- 1998-11-27 TR TR2000/01542T patent/TR200001542T2/xx unknown
- 1998-11-27 JP JP2000524281A patent/JP2001525407A/ja active Pending
- 1998-11-27 IL IL13652998A patent/IL136529A/xx not_active IP Right Cessation
- 1998-11-27 UA UA2000053031A patent/UA70308C2/uk unknown
- 1998-11-27 EA EA200000616A patent/EA003365B1/ru not_active IP Right Cessation
- 1998-11-27 HU HU0004492A patent/HU224813B1/hu not_active IP Right Cessation
- 1998-11-27 BR BR9814256-9A patent/BR9814256A/pt not_active Application Discontinuation
- 1998-11-27 NZ NZ503603A patent/NZ503603A/en unknown
- 1998-11-27 DE DE69835372T patent/DE69835372T2/de not_active Expired - Lifetime
- 1998-11-27 EE EEP200000328A patent/EE04438B1/xx not_active IP Right Cessation
- 1998-12-01 MY MYPI98005442A patent/MY124586A/en unknown
- 1998-12-01 CO CO98071204A patent/CO5011114A1/es unknown
- 1998-12-03 ZA ZA9811081A patent/ZA9811081B/xx unknown
- 1998-12-04 AR ARP980106182A patent/AR017195A1/es active IP Right Grant
2000
- 2000-04-19 NO NO20002074A patent/NO320727B1/no not_active IP Right Cessation
- 2000-04-24 BG BG104372A patent/BG64624B1/bg unknown
- 2000-08-18 US US09/641,485 patent/US6495547B1/en not_active Expired - Lifetime
2002
- 2002-04-03 US US10/116,590 patent/US6747045B2/en not_active Expired - Lifetime
- 2002-09-05 US US10/235,623 patent/US6852714B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1036073B1 (en)	2006-07-26
EA200000616A1 (ru)	2000-12-25
EA003365B1 (ru)	2003-04-24
US20030149093A1 (en)	2003-08-07
CN1155597C (zh)	2004-06-30
AU748669B2 (en)	2002-06-06
ES2270541T3 (es)	2007-04-01
JP2001525407A (ja)	2001-12-11
US6133277A (en)	2000-10-17
DE69835372D1 (de)	2006-09-07
SK286268B6 (sk)	2008-06-06
KR100591605B1 (ko)	2006-06-20
CN1280577A (zh)	2001-01-17
NO20002074D0 (no)	2000-04-19
ATE334125T1 (de)	2006-08-15
PL191144B1 (pl)	2006-03-31
HU224813B1 (en)	2006-02-28
IL136529A (en)	2003-03-12
PL341007A1 (en)	2001-03-12
BG104372A (en)	2000-12-29
NO20002074L (no)	2000-06-02
DE69835372T2 (de)	2007-08-09
HUP0004492A3 (en)	2002-04-29
CO5011114A1 (es)	2001-02-28
SK8032000A3 (en)	2001-02-12
CZ20002018A3 (cs)	2000-10-11
NZ503603A (en)	2001-10-26
CZ297895B6 (cs)	2007-04-25
AR017195A1 (es)	2001-08-22
BG64624B1 (bg)	2005-09-30
HRP20000340A2 (en)	2001-04-30
IL136529A0 (en)	2001-06-14
WO1999029687A8 (en)	2000-04-13
EE200000328A (et)	2001-08-15
EP1036073B8 (en)	2006-11-15
HK1028400A1 (en)	2001-02-16
CA2311669C (en)	2010-04-27
KR20010031010A (ko)	2001-04-16
UA70308C2 (uk)	2004-10-15
US6747045B2 (en)	2004-06-08
ZA9811081B (en)	2000-06-22
BR9814256A (pt)	2000-10-03
TW577886B (en)	2004-03-01
CA2311669A1 (en)	1999-06-17
US6852714B2 (en)	2005-02-08
TR200001542T2 (tr)	2001-01-22
EE04438B1 (et)	2005-02-15
AU2412799A (en)	1999-06-28
NO320727B1 (no)	2006-01-23
HUP0004492A2 (hu)	2002-03-28
MY124586A (en)	2006-06-30
US6495547B1 (en)	2002-12-17
WO1999029687A1 (en)	1999-06-17
US20030083365A1 (en)	2003-05-01
HRP20000340B1 (hr)	2008-12-31
EP1036073A1 (en)	2000-09-20

Publication	Publication Date	Title
IL136529A0 (en)	2001-06-14	(benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
ID18189A (id)	1998-03-12	Dervat-derivat 6,6-hetero-bisiklik yang disubstitusi
ID17980A (id)	1998-02-12	Pirimido atau pirido tersubsitusi yang mengandung turunan-turunan 6,6-atau 6,7-bisiklis
DE59910409D1 (de)	2004-10-07	Distraktionsvorrichtung
ID24530A (id)	2000-07-20	Turunan-turunan makrolidan yang tersubstitusi c-4
DE59912839D1 (de)	2005-12-29	Distraktionsvorrichtung
ID28723A (id)	2001-06-28	Turunan-turunan fenil yantin
ID27168A (id)	2001-03-08	Derivat-derivat diasilhidrazin
ID16298A (id)	1997-09-18	Turunan-turunan 1,2,3,4-tetrahidronaftalena yang disubstitusi
ID23216A (id)	2000-03-30	Peralatan penurun air-dalam
ID27846A (id)	2001-04-26	Derivat-derivat bifenil
ID21770A (id)	1999-07-22	Plester yang mengandung felbinak
ZA992773B (en)	2002-07-16	Substituted tricyclics.
DE69936851D1 (de)	2007-09-27	Persönliches kommunikationsssystem
IT1306892B1 (it)	2001-10-11	Estensore.
ITRM980013A0 (it)	1998-01-12	Apparecchio rotativo di intrecciamento.
ID27152A (id)	2001-03-08	Derivat-derivat bifenil
ID28719A (id)	2001-06-28	Perangko yang dipersonalisasikan
ID29823A (id)	2001-10-11	Mengirimkan nomor yang diputar
ITBO970602A0 (it)	1997-10-07	Apparecchiatura per trattamento di dialisi.
IT1304368B1 (it)	2001-03-15	Attrezzatura da pesca.
ID27863A (id)	2001-04-26	Derivat-derivat 2-okso-2h-quinolin
ITDP980001A1 (it)	1998-05-04	Eleva persona anatomico.
ITDP980001U1 (it)	1998-05-04	Eleva persona anatomico.
ES1039590Y (es)	1999-06-01	Equipo multipersonal de buceo.