ID24726A - Antagonis-antagonis reseptor trombin - Google Patents

Antagonis-antagonis reseptor trombin

Info

Publication number
ID24726A
ID24726A IDW20000993A ID20000993A ID24726A ID 24726 A ID24726 A ID 24726A ID W20000993 A IDW20000993 A ID W20000993A ID 20000993 A ID20000993 A ID 20000993A ID 24726 A ID24726 A ID 24726A
Authority
ID
Indonesia
Prior art keywords
receptor antagonists
trombin
trombin receptor
antagonists
receptor
Prior art date
Application number
IDW20000993A
Other languages
English (en)
Indonesian (id)
Inventor
Samuel Chackalamannil
Theodros Asberom
Yan Xia
Dario Doller
Martin C Clasby
Michael F Czarniecki
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ID24726A publication Critical patent/ID24726A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
IDW20000993A 1997-11-25 1998-11-23 Antagonis-antagonis reseptor trombin ID24726A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97797997A 1997-11-25 1997-11-25

Publications (1)

Publication Number Publication Date
ID24726A true ID24726A (id) 2000-08-03

Family

ID=25525702

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20000993A ID24726A (id) 1997-11-25 1998-11-23 Antagonis-antagonis reseptor trombin

Country Status (30)

Country Link
EP (1) EP1036072B1 (fr)
JP (2) JP3449620B2 (fr)
KR (1) KR100393492B1 (fr)
CN (2) CN101274929A (fr)
AR (1) AR017189A1 (fr)
AT (1) ATE266025T1 (fr)
AU (1) AU747204B2 (fr)
BR (1) BR9812793A (fr)
CA (1) CA2309352C (fr)
CO (1) CO4990946A1 (fr)
CZ (1) CZ298578B6 (fr)
DE (1) DE69823694T2 (fr)
DK (1) DK1036072T3 (fr)
ES (1) ES2219919T3 (fr)
HU (1) HUP0100607A3 (fr)
ID (1) ID24726A (fr)
IL (1) IL135797A (fr)
MY (1) MY140887A (fr)
NO (1) NO322022B1 (fr)
NZ (1) NZ504218A (fr)
PE (1) PE133799A1 (fr)
PL (1) PL195027B1 (fr)
PT (1) PT1036072E (fr)
RU (1) RU2204557C2 (fr)
SA (1) SA99190972B1 (fr)
SK (1) SK285153B6 (fr)
TR (1) TR200001480T2 (fr)
TW (1) TWI236476B (fr)
WO (1) WO1999026943A1 (fr)
ZA (1) ZA9810685B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) * 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法
JP4577751B2 (ja) * 1999-09-02 2010-11-10 塩野義製薬株式会社 芳香族ヘテロ環誘導体を含有するインテグラーゼ阻害剤
EP1764366A3 (fr) * 2000-06-15 2007-10-03 Schering Corporation Antagonistes de récepteurs de la thrombine
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US6645987B2 (en) * 2000-06-15 2003-11-11 Schering Corporation Nor-seco himbacine derivatives useful as thrombin receptor antagonists
DE60233043D1 (de) 2001-04-19 2009-09-03 Eisai R&D Man Co Ltd 2-iminoimidazolderivate
WO2003033501A1 (fr) * 2001-10-18 2003-04-24 Schering Corporation Analogues d'himbacine tels que des antagonistes recepteurs de lathrombine
DE60335679D1 (de) * 2002-04-16 2011-02-17 Schering Corp Tricyclischer Thrombinrezeptorantagonist
ES2211315B1 (es) * 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
AU2004218187C1 (en) 2003-02-19 2011-04-07 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
WO2005108370A1 (fr) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. Composés du benzène
MY143987A (en) * 2004-05-28 2011-07-29 Schering Corp Constrained himbacine analogs as thrombin receptor antagonists
CN101072772A (zh) * 2004-10-08 2007-11-14 先灵公司 凝血酶受体拮抗剂
AR052870A1 (es) * 2005-01-14 2007-04-11 Schering Corp Sintesis de analogos de himbacina
CA2594807A1 (fr) * 2005-01-14 2006-07-20 Schering Corporation Synthese exo-selective d'analogues d'himbacine
RS51315B (sr) * 2005-01-14 2010-12-31 Schering Corporation EGZO-i DIASTEREO-SELEKTIVNA SINTEZA ANALOGA HIMBACINA
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
CA2667082A1 (fr) * 2006-10-04 2008-04-10 Schering Corporation Derives bicycliques et tricycliques utilises comme antagonistes du recepteur de la thrombine
PL2558465T3 (pl) 2010-04-16 2015-05-29 Sanofi Sa Trycykliczne pirydylo-winylo-pirole jako inhibitory receptora aktywowanego proteazą 1 (PAR1)
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773792A (en) 1968-03-08 1973-11-20 Itt Rayonier Inc Acetates of plicatic acid and processes for the preparation thereof
US4486445A (en) 1983-01-12 1984-12-04 E. I. Du Pont De Nemours And Company Justicidin insecticidal and antiviral compounds
CA2008116C (fr) * 1989-02-23 2001-11-20 Thomas Weller Derives de glycine
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
JP2003128670A (ja) 2003-05-08
KR20010032439A (ko) 2001-04-25
JP3449620B2 (ja) 2003-09-22
CZ20001856A3 (cs) 2000-10-11
CA2309352C (fr) 2005-01-25
DE69823694D1 (de) 2004-06-09
HUP0100607A3 (en) 2002-06-28
PE133799A1 (es) 2000-01-10
ZA9810685B (en) 1999-12-23
PL341114A1 (en) 2001-03-26
NO20002659D0 (no) 2000-05-24
EP1036072A1 (fr) 2000-09-20
CZ298578B6 (cs) 2007-11-14
IL135797A0 (en) 2001-05-20
AU747204B2 (en) 2002-05-09
ES2219919T3 (es) 2004-12-01
IL135797A (en) 2003-09-17
HUP0100607A2 (hu) 2002-05-29
RU2204557C2 (ru) 2003-05-20
MY140887A (en) 2010-01-29
PL195027B1 (pl) 2007-08-31
CO4990946A1 (es) 2000-12-26
SK285153B6 (sk) 2006-07-07
PT1036072E (pt) 2004-08-31
NZ504218A (en) 2002-04-26
AU1415899A (en) 1999-06-15
EP1036072B1 (fr) 2004-05-06
HK1031726A1 (en) 2001-06-22
JP2001524479A (ja) 2001-12-04
KR100393492B1 (ko) 2003-08-02
NO322022B1 (no) 2006-08-07
AR017189A1 (es) 2001-08-22
DE69823694T2 (de) 2005-04-21
TR200001480T2 (tr) 2000-09-21
CN1290265A (zh) 2001-04-04
TWI236476B (en) 2005-07-21
CA2309352A1 (fr) 1999-06-03
WO1999026943A1 (fr) 1999-06-03
SA99190972B1 (ar) 2006-07-30
ATE266025T1 (de) 2004-05-15
CN101274929A (zh) 2008-10-01
SK7592000A3 (en) 2001-02-12
DK1036072T3 (da) 2004-09-06
NO20002659L (no) 2000-07-24
BR9812793A (pt) 2000-10-17

Similar Documents

Publication Publication Date Title
DE69812096D1 (de) Neuropeptid y rezeptorantagonisten
DE69734833D1 (de) Vitronektin rezeptor antagonisten
DK1009732T3 (da) 1-Amino-alkylcyclohexan NMDA receptor antagonister
ATE315035T1 (de) Ccr-3-rezeptor-antagonisten
NO993586D0 (no) K-8 reseptor antagonister
NO972016D0 (no) Indolyl-Y-reseptorantagonister
NO20001100D0 (no) IL-8 reseptorantagonister
EP0986385A4 (fr) Antagonistes de gonadoliberine
DE69921351D1 (de) 4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
NO993350D0 (no) Vitronectin-reseptor-antagonister
ID24726A (id) Antagonis-antagonis reseptor trombin
EP0885205A4 (fr) Antagonistes des recepteurs de fibrinogenes
ID24162A (id) Antagonis-antagonis reseptor vitronektin
DK0906294T3 (da) Benzoxazinon-dopamin D4-receptor-antagonister
ATE381330T1 (de) Il-8 rezeptor-antagonisten
DE69824837D1 (de) Il-8-rezeptor-antagonisten
ATE303370T1 (de) Il-8 rezeptor antagonisten
ID22978A (id) Antagonis reseptor endotelin
DK1011716T3 (da) Neuromedin B-receptor-antagonister
TR199601082A3 (tr) Entegrin reseptör antagonistleri.
DE69830671D1 (de) Integrin-rezeptor-antagonisten