ID954B - STEROID 3-KARBOKSI TERSUBSTITUSI-17β TAK JENUH - Google Patents

STEROID 3-KARBOKSI TERSUBSTITUSI-17β TAK JENUH

Info

Publication number: ID954B
Authority: ID; Indonesia
Prior art keywords: group; chem; hydrogen; alkyl group; cycloalkyl
Prior art date: 1991-05-24

Application number

IDP308292A

Other languages

English (en)

Inventor

Achille Panzeri

Marcella Nesi

Enrico Di Salle

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-24

Filing date

1992-05-22

Publication date

1996-09-25

1992-05-22 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1996-09-25 Publication of ID954B publication Critical patent/ID954B/id

Links

229920006395 saturated elastomer Polymers 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
229910052757 nitrogen Inorganic materials 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
239000002677 5-alpha reductase inhibitor Substances 0.000 abstract 1
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Details Of Garments (AREA)
Ceramic Products (AREA)
Dental Preparations (AREA)

IDP308292A 1991-05-24 1992-05-22 STEROID 3-KARBOKSI TERSUBSTITUSI-17β TAK JENUH ID954B (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI911432A IT1259419B (it)	1991-05-24	1991-05-24	Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi

Publications (1)

Publication Number	Publication Date
ID954B true ID954B (id)	1996-09-25

Family

ID=11359980

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP308292A ID954B (id)	1991-05-24	1992-05-22	STEROID 3-KARBOKSI TERSUBSTITUSI-17β TAK JENUH

Country Status (26)

Country	Link
US (1)	US5212166A (id)
EP (2)	EP0517047A1 (id)
JP (1)	JP3226919B2 (id)
CN (1)	CN1035055C (id)
AT (1)	ATE155792T1 (id)
AU (1)	AU655280B2 (id)
CA (1)	CA2087953A1 (id)
CZ (1)	CZ281309B6 (id)
DE (1)	DE69221074T2 (id)
DK (1)	DK0540717T3 (id)
ES (1)	ES2106185T3 (id)
FI (1)	FI930277A0 (id)
HU (1)	HUT64083A (id)
ID (1)	ID954B (id)
IE (1)	IE921634A1 (id)
IL (1)	IL101947A (id)
IT (1)	IT1259419B (id)
MX (1)	MX9202438A (id)
MY (1)	MY131089A (id)
NO (1)	NO930244L (id)
NZ (1)	NZ242850A (id)
RU (1)	RU2104283C1 (id)
TW (1)	TW213467B (id)
WO (1)	WO1992020700A1 (id)
YU (1)	YU52992A (id)
ZA (1)	ZA923758B (id)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4291993A (en) *	1992-04-30	1993-11-29	Smithkline Beecham Corporation	17alpha and 17beta -substituted estra-1,3,5(10)-triene-3-carboxylic acid
US5683995A (en) *	1992-11-18	1997-11-04	Smithkline Beecham Corporation	17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) *	1992-11-18	1997-06-24	Smithkline Beecham Corporation	17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
ES2185666T3 (es) *	1993-09-03	2003-05-01	Smithkline Beecham Corp	Formulacion estabilizada para comprimidos.
GB9324371D0 (en) *	1993-11-26	1994-01-12	Erba Carlo Spa	Side chain fluoro substituted 3-carboxysteroids
US5430157A (en) *	1993-12-13	1995-07-04	Eli Lilly And Company	Reduced phenanthrenes
GB9402041D0 (en) *	1994-02-03	1994-03-30	Smithkline Beecham Corp	Compounds
US5714480A (en) *	1994-03-31	1998-02-03	Smithkline Beecham Corporation	Treating cardiovascular disease with steroidal 5-alpha-reductase inhibitors
WO1995028413A1 (en) *	1994-04-15	1995-10-26	Smithkline Beecham Corporation	17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE
GB9415183D0 (en) *	1994-07-28	1994-09-21	Erba Carlo Spa	3-carboxysteroids with a fluorinated side-chain
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6372712B1 (en)	1998-05-22	2002-04-16	The Board Of Trustees Of The Leland Stanford Jr. University	Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
WO2001021642A1 (de) *	1999-09-22	2001-03-29	Aventis Pharma Deutschland Gmbh	4-benzylaminochinoline konjugaten mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung
EP2671508B1 (en)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-informatics system
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors
US5041433A (en) *	1987-04-29	1991-08-20	Smithkline Beecham Corporation	11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
US5032586A (en) *	1989-08-24	1991-07-16	Smithkline Beecham Corporation	7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5091380A (en) *	1990-06-28	1992-02-25	Merck & Co., Inc.	N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
DK0567271T3 (da) *	1992-04-20	1998-02-16	Sankyo Co	Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf

1991
- 1991-05-24 IT ITMI911432A patent/IT1259419B/it active IP Right Grant
1992
- 1992-05-20 YU YU52992A patent/YU52992A/sh unknown
- 1992-05-20 MY MYPI92000863A patent/MY131089A/en unknown
- 1992-05-21 US US07/886,574 patent/US5212166A/en not_active Expired - Lifetime
- 1992-05-21 IL IL10194792A patent/IL101947A/en active IP Right Grant
- 1992-05-21 NZ NZ242850A patent/NZ242850A/en unknown
- 1992-05-22 RU RU93004939A patent/RU2104283C1/ru active
- 1992-05-22 WO PCT/EP1992/001153 patent/WO1992020700A1/en not_active Ceased
- 1992-05-22 TW TW081104019A patent/TW213467B/zh active
- 1992-05-22 MX MX9202438A patent/MX9202438A/es unknown
- 1992-05-22 AU AU17781/92A patent/AU655280B2/en not_active Ceased
- 1992-05-22 CA CA002087953A patent/CA2087953A1/en not_active Abandoned
- 1992-05-22 EP EP92108670A patent/EP0517047A1/en active Pending
- 1992-05-22 CZ CZ93265A patent/CZ281309B6/cs unknown
- 1992-05-22 EP EP92910992A patent/EP0540717B1/en not_active Expired - Lifetime
- 1992-05-22 JP JP50978992A patent/JP3226919B2/ja not_active Expired - Fee Related
- 1992-05-22 HU HU9300176A patent/HUT64083A/hu unknown
- 1992-05-22 ID IDP308292A patent/ID954B/id unknown
- 1992-05-22 AT AT92910992T patent/ATE155792T1/de active
- 1992-05-22 DE DE69221074T patent/DE69221074T2/de not_active Expired - Fee Related
- 1992-05-22 ES ES92910992T patent/ES2106185T3/es not_active Expired - Lifetime
- 1992-05-22 DK DK92910992.4T patent/DK0540717T3/da active
- 1992-05-22 ZA ZA923758A patent/ZA923758B/xx unknown
- 1992-05-23 CN CN92103919A patent/CN1035055C/zh not_active Expired - Fee Related
- 1992-07-01 IE IE163492A patent/IE921634A1/en unknown
1993
- 1993-01-25 NO NO93930244A patent/NO930244L/no unknown
- 1993-05-22 FI FI930277A patent/FI930277A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
HU9300176D0 (en)	1993-04-28
CZ281309B6 (cs)	1996-08-14
TW213467B (id)	1993-09-21
MX9202438A (es)	1992-11-01
JPH06500342A (ja)	1994-01-13
NO930244L (no)	1993-01-27
NZ242850A (en)	1994-01-26
CZ26593A3 (en)	1993-11-17
AU1778192A (en)	1992-12-30
WO1992020700A1 (en)	1992-11-26
US5212166A (en)	1993-05-18
ZA923758B (en)	1993-01-27
NO930244D0 (no)	1993-01-25
ITMI911432A1 (it)	1992-11-24
ITMI911432A0 (it)	1991-05-24
DE69221074T2 (de)	1997-11-13
IT1259419B (it)	1996-03-18
MY131089A (en)	2007-07-31
DE69221074D1 (de)	1997-09-04
CA2087953A1 (en)	1992-11-25
HUT64083A (en)	1993-11-29
AU655280B2 (en)	1994-12-15
ATE155792T1 (de)	1997-08-15
CN1067057A (zh)	1992-12-16
RU2104283C1 (ru)	1998-02-10
FI930277A7 (fi)	1993-01-22
EP0540717B1 (en)	1997-07-23
IL101947A (en)	1996-01-19
EP0540717A1 (en)	1993-05-12
DK0540717T3 (da)	1997-08-18
FI930277A0 (fi)	1993-01-22
IE921634A1 (en)	1992-12-02
JP3226919B2 (ja)	2001-11-12
EP0517047A1 (en)	1992-12-09
CN1035055C (zh)	1997-06-04
YU52992A (sh)	1995-03-27
ES2106185T3 (es)	1997-11-01

Publication	Publication Date	Title
NO930244D0 (no)	1993-01-25	Umettede 17beta-substituerte 3-karboksysteroider
FI865037A7 (fi)	1988-06-11	Mikrobicida kompositioner.
HUP0302468A2 (hu)	2003-11-28	Alfa V integrin receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
HUP0004845A2 (hu)	2001-05-28	PPAR-gamma agonista aktivitással rendelkező szubsztituált 4-hidroxi-fenil-alkánsav-származékok és ezeket tartalmazó gyógyszerkészítmények
CA2423103A1 (en)	2002-03-28	N-acylsulfonamide apoptosis promoters
ATE103812T1 (de)	1994-04-15	Zusammensetzung zur behandlung von ischaemischen stoerungen in organen.
KR920014810A (ko)	1992-08-25	항균제
MY101849A (en)	1992-01-31	Improvements in or relating to cyanopyrazole herbicides.
CO4910142A1 (es)	2000-04-24	Compuestos de furano nitrona
DK627088A (da)	1989-06-22	Forbindelser beslaegtet med avermectiner og milbemyciner, antiparasitiske praeparater indeholdende disse og fremgangsmaade til bekaempelse af parasitangreb
BG60285B2 (en)	1994-04-25	Method and herbicide for unwanted vegetation control
HUT75647A (en)	1997-05-28	Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia
AU703163B2 (en)	1999-03-18	Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions
EP0798298A4 (en)	1998-03-25	THIAZOLIDINONE COMPOUNDS OR MEDICAMENT FOR PREVENTING OR CURING ANGINA OF CHEST CONTAINING THESE COMPOUNDS AS ACTIVE INGREDIENT
NZ512803A (en)	2002-12-20	Cyclic guanidine derivatives useful as pesticides
BG46157A3 (bg)	1989-10-16	Метод за получаване на n-алкил(ен)-n-(о,о-дву- заместен тиофосфорил- n', n' - двузаместени глицинамиди